Epidemiology, management, and risk-adjusted mortality of ICU-acquired enterococcal bacteremia

Clinical Infectious Diseases

Volumn 61, Issue 9, 2015, Pages 1413-1420

  Ong, David S Y ^a   Bonten, Marc J M ^a   Safdari, Khatera ^a   Spitoni, Cristian ^a,b   Frencken, Jos F ^a   Witteveen, Esther ^c   Horn, Janneke ^c   Klein Klouwenberg, Peter M C ^a   Cremer, Olaf L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

bacteremia; bloodstream infection; enterococcus; intensive care unit; mortality

Indexed keywords

AMOXICILLIN; VANCOMYCIN;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTERY CATHETER; ARTICLE; ATTRIBUTABLE RISK; BACTEREMIA; BLOOD CULTURE; CANDIDA; CATHETER INFECTION; CATHETER REMOVAL; CENTRAL VENOUS CATHETER; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; ENTEROCOCCAL INFECTION; ENTEROCOCCUS; FATALITY; FEMALE; HOSPITAL INFECTION; HUMAN; INDWELLING CATHETER; INFECTION RISK; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NETHERLANDS; NONHUMAN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; CROSS INFECTION; GRAM-POSITIVE BACTERIAL INFECTIONS; ISOLATION AND PURIFICATION; MIDDLE AGED; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BACTEREMIA; CROSS INFECTION; ENTEROCOCCUS; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MORTALITY; NETHERLANDS; PROSPECTIVE STUDIES;

EID: 84946726626     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ560     Document Type: Article

References (29)

1. Vincent J-L, Sakr Y, Sprung CL, et al. Sepsis in European intensive care units: results of the SOAP study . Crit Care Med 2006; 34:344-53.
2. Blot SI, Depuydt P, Annemans L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis 2005; 41:1591-8.
3. Deliberato RO, Marra AR, Corrêa TD, et al. Catheter related bloodstream infection (CR-BSI) in ICU patients: making the decision to remove or not to remove the central venous catheter. PLoS One 2012; 7:e32687.
4. Corona A. Variability of treatment duration for bacteraemia in the critically ill: a multinational survey. J Antimicrob Chemother 2003; 52:849-52.
5. Corona A, Bertolini G, Lipman J, Wilson AP, Singer M. Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC). J Antimicrob Chemother 2010; 65:1276-85.
6. Raad I, Hanna H, Maki D. Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 2007; 7:645-57.
7. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49:1-45.
8. Timsit J-F, Laupland KB. Update on bloodstream infections in ICUs. Curr Opin Crit Care 2012; 18:479-86.
9. Caballero-Granado FJ, Becerril B, Cuberos L, Bernabeu M, Cisneros JM, Pachón J. Attributable mortality rate and duration of hospital stay associated with enterococcal bacteremia. Clin Infect Dis 2001; 32:587-94.
10. McBride SJ, Upton A, Roberts SA. Clinical characteristics and outcomes of patients with vancomycin-susceptible Enterococcus faecalis and Enterococcus faecium bacteraemia-A five-year retrospective review. Eur J Clin Microbiol Infect Dis 2010; 29:107-14.
11. Bar K, Wisplinghoff H, Wenzel RP, Bearman GM, Edmond MB. Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infections due to enterococci. BMC Infect Dis 2006; 6:145.
12. Arias CA, Murray BE. The rise of the Enterococcus: beyond vancomycin resistance. Nat Publishing Group 2012; 10:266-78.
13. Klein Klouwenberg PMC, Ong DSY, Bos LDJ, et al. Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients. Crit Care Med 2013; 41:2373-8.
14. Oostdijk EAN, Kesecioglu J, Schultz MJ, et al. Effects of decontamination of the oropharynx and intestinal tract on antibiotic resistance in ICUs: a randomized clinical trial. JAMA 2014; 312:1429-37.
15. Wolkewitz M, Cooper BS, Bonten MJM, Barnett AG, Schumacher M. Interpreting and comparing risks in the presence of competing events. BMJ 2014; 349:g5060.
16. Beyersmann J, Schumacher M. Time-dependent covariates in the proportional subdistribution hazards model for competing risks. Biostatistics 2008; 9:765-76.
17. Prowle JR, Echeverri JE, Ligabo EV, et al. Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality. Crit Care 2011; 15:R100.
18. Laupland KB, Gregson DB, Zygun DA, Doig CJ, Mortis G, Church DL. Severe bloodstream infections: a population-based assessment. Crit Care Med 2004; 32:992-7.
19. Robins JM, Hernán MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology 2000; 11:550-60.
20. Bekaert M, Timsit J-F, Vansteelandt S, et al. Attributable mortality of ventilator-Associated pneumonia. Am J Respir Crit Care Med 2011; 184:1133-9.
21. Becker K, Heilmann C, Peters G. Coagulase-negative staphylococci. Clin Microbiol Rev 2014; 27:870-926.
22. Schumacher M, Wangler M, Wolkewitz M, Beyersmann J. Attributable mortality due to nosocomial infections. Methods Inf Med 2007; 46: 595-600.
23. Coeurjolly J-F, Nguile-Makao M, Timsit J-F, Liquet B. Attributable risk estimation for adjusted disability multistate models: application to nosocomial infections. Biom J 2012; 54:600-16.
24. Solomkin JS, Mazuski JE, Bradley JS, et al. Diagnosis and management of complicated intra-Abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010; 50:133-64.
25. Havey TC, Fowler RA, Daneman N. Duration of antibiotic therapy for bacteremia: a systematic review and meta-Analysis. Crit Care 2011; 15: R267.
26. Sawyer RG, Claridge JA, Nathens AB, et al. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med 2015; 372:1996-2005.
27. de Smet AMGA, Kluytmans JAJW, Cooper BS, et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009; 360:20-31.
28. Rello J, Ricart M, Mirelis B, et al. Nosocomial bacteremia in a medicalsurgical intensive care unit: epidemiologic characteristics and factors influencing mortality in 111 episodes. Intensive Care Med 1994; 20:94-8.
29. Laupland KB, Zygun DA, Davies HD, Church DL, Louie TJ, Doig CJ. Population-based assessment of intensive care unit-Acquired bloodstream infections in adults: incidence, risk factors, and associated mortality rate. Crit Care Med 2002; 30:2462-7.