β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Breast Cancer Research

Volumn 17, Issue 1, 2015, Pages

  Creed, Sarah J ^a   Le, Caroline P ^a   Hassan, Mona ^a   Pon, Cindy K ^a   Albold, Sabine ^a   Chan, Keefe T ^b,f   Berginski, Matthew E ^c   Huang, Zhendong ^d   Bear, James E ^b   Lane, J Robert ^a   Halls, Michelle L ^a   Ferrari, Davide ^d   Nowell, Cameron J ^a   Sloan, Erica K ^a,e,f  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Duke University   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; FORMOTEROL; ISOPRENALINE; L 748337; NEUROTRANSMITTER; PROPRANOLOL; PROTEIN TYROSINE KINASE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT;

ARTICLE; BREAST CANCER; CANCER CELL; CELL ASSAY; CELL INVASION; CELL STRESS; CONTROLLED STUDY; CYTOPLASM; EXTRACELLULAR MATRIX; FOCAL ADHESION; HUMAN; HUMAN CELL; IN VIVO STUDY; INVADOPODIA; METASTASIS; MOUSE MODEL; PRIMARY TUMOR; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION; TUMOR CELL; BREAST TUMOR; CANCER TRANSPLANTATION; CELL SURFACE; FEMALE; METABOLISM; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURFACE EXTENSIONS; FEMALE; FOCAL ADHESIONS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 84947914536     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/s13058-015-0655-3     Document Type: Article

References (47)

1. Weigelt B, Peterse JL, Van't Veer LJ. Breast cancer metastasis: markers and models. Nat Rev Cancer. 2005;5(8):591-602.
2. Baldassarre M, Ayala I, Beznoussenko G, Giacchetti G, Machesky LM, Luini A, et al. Actin dynamics at sites of extracellular matrix degradation. Eur J Cell Biol. 2006;85(12):1217-31.
3. Chen WT, Chen JM, Parsons SJ, Parsons JT. Local degradation of fibronectin at sites of expression of the transforming gene product pp60src. Nature. 1985;316(6024):156-8.
4. Chen WT. Proteolytic activity of specialized surface protrusions formed at rosette contact sites of transformed cells. J Exp Zool. 1989;251(2):167-85.
5. Brabek J, Constancio SS, Shin NY, Pozzi A, Weaver AM, Hanks SK. CAS promotes invasiveness of Src-transformed cells. Oncogene. 2004;23(44):7406-15.
6. Chan KT, Cortesio CL, Huttenlocher A. FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. The Journal of cell biology. 2009;185(2):357-70.
7. Quail DF, Joyce JA. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19(11):1423-37.
8. Shi M, Liu D, Duan H, Qian L, Wang L, Niu L, et al. The beta2-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells. Breast Cancer Res Treat. 2011;125(2):351-62.
9. Powe DG, Voss MJ, Habashy HO, Zanker KS, Green AR, Ellis IO, et al. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast Cancer Res Treat. 2011;130(2):457-63.
10. Kobilka B. Adrenergic receptors as models for G protein-coupled receptors. Annu Rev Neurosci. 1992;15:87-114.
11. Landen Jr CN, Lin YG, Armaiz Pena GN, Das PD, Arevalo JM, Kamat AA, et al. Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer. Cancer Res. 2007;67(21):10389-96.
12. Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer research. 2010;70(18):7042-52.
13. Lamkin DM, Sung HY, Yang GS, David JM, Ma JC, Cole SW, et al. alpha2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression. Psychoneuroendocrinology. 2015;51:262-70.
14. Kim-Fuchs C, Le CP, Pimentel MA, Shackleford D, Ferrari D, Angst E, et al. Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment. Brain, behavior, and immunity. 2014;40:40-7.
15. Armaiz-Pena GN, Allen JK, Cruz A, Stone RL, Nick AM, Lin YG, et al. Src activation by beta-adrenoreceptors is a key switch for tumour metastasis. Nature Communications. 2013;4:1403.
16. Du J, Li L, Ou Z, Kong C, Zhang Y, Dong Z, et al. FOXC1, a target of polycomb, inhibits metastasis of breast cancer cells. Breast Cancer Res Treat. 2012;131(1):65-73.
17. Kaminskas LM, Ascher DB, McLeod VM, Herold MJ, Le CP, Sloan EK, et al. PEGylation of interferon alpha2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. J Control Release. 2013;168(2):200-8.
18. Eckhardt BL, Parker BS, van Laar RK, Restall CM, Natoli AL, Tavaria MD, et al. Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol Cancer Res. 2005;3(1):1-13.
19. Berginski ME, Creed SJ, Cochran S, Roadcap DW, Bear JE, Gomez SM. Automated analysis of invadopodia dynamics in live cells. PeerJ. 2014;2:e462.
20. Kim JH, Lee SR, Li LH, Park HJ, Park JH, Lee KY, et al. High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. PLoS One. 2011;6(4):e18556.
21. Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE. Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cell. 2007;128(5):915-29.
22. Dobson AJ, Barnett AG. An Introduction to Generalized Linear Models. CRC Press; 2008.
23. Hsu J. Multiple Comparisons: Theory and Methods. CRC Press; 1996.
24. Becker RA, Chambers AM, Wilks AR. The new S language: a programming environment for data analysis and graphics Wadsworth and Brooks/Cole Advanced Books & Software Monterey. USA: CA; 1988.
25. Bretz F, Hothorn T, Westfall P. Multiple Comparisons using R. CRC Press; 2010.
26. Kolak M, Yki-Jarvinen H, Kannisto K, Tiikkainen M, Hamsten A, Eriksson P, et al. Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J Clin Endocrinol Metab. 2007;92(2):720-4.
27. Jung KM, Clapper JR, Fu J, D'Agostino G, Guijarro A, Thongkham D, et al. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metab. 2012;15(3):299-310.
28. Slotkin TA, Zhang J, Dancel R, Garcia SJ, Willis C, Seidler FJ. Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells. Breast Cancer Res Treat. 2000;60(2):153-66.
29. Ren XD, Kiosses WB, Sieg DJ, Otey CA, Schlaepfer DD, Schwartz MA. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci. 2000;113(Pt 20):3673-8.
30. Yamanaka Y, Mammoto T, Kirita T, Mukai M, Mashimo T, Sugimura M, et al. Epinephrine inhibits invasion of oral squamous carcinoma cells by modulating intracellular cAMP. Cancer Lett. 2002;176(2):143-8.
31. Pullar CE, Le Provost GS, O'Leary AP, Evans SE, Baier BS. Isseroff RR: beta2AR antagonists and beta2AR gene deletion both promote skin wound repair processes. J Invest Dermatol. 2012;132(8):2076-84.
32. Iseri OD, Sahin FI, Terzi YK, Yurtcu E, Erdem SR, Sarialioglu F. beta-Adrenoreceptor antagonists reduce cancer cell proliferation, invasion, and migration. Pharm Biol 2014:1-8.
33. Stock AM, Powe DG, Hahn SA, Troost G, Niggemann B, Zanker KS, et al. Norepinephrine inhibits the migratory activity of pancreatic cancer cells. Exp Cell Res. 2013;319(12):1744-58.
34. Sood AK, Armaiz-Pena GN, Halder J, Nick AM, Stone RL, Hu W, et al. Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest. 2010;120(5):1515-23.
35. Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nature medicine. 2006;12(8):939-44.
36. Lamkin DM, Sloan EK, Patel AJ, Chiang BS, Pimentel MA, Ma JC, et al. Chronic stress enhances progression of acute lymphoblastic leukemia via beta-adrenergic signaling. Brain, behavior, and immunity. 2012;26(4):635-41.
37. Wyckoff JB, Jones JG, Condeelis JS, Segall JE. A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res. 2000;60(9):2504-11.
38. Fidler IJ. Metastasis: guantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst. 1970;45(4):773-82.
39. Chiang AC, Massague J. Molecular basis of metastasis. N Engl J Med. 2008;359(26):2814-23.
40. Chambers AF, Naumov GN, Varghese HJ, Nadkarni KV, MacDonald IC, Groom AC. Critical steps in hematogenous metastasis: an overview. Surg Oncol Clin N Am. 2001;10(2):243-55. vii.
41. Melhem-Bertrandt A, Chavez-Macgregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, et al. Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol. 2011;29(19):2645-52.
42. Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K. Beta blockers and breast cancer mortality: a population- based study. J Clin Oncol. 2011;29(19):2635-44.
43. Botteri E, Munzone E, Rotmensz N, Cipolla C, De Giorgi V, Santillo B, et al. Therapeutic effect of beta-blockers in triple-negative breast cancer postmenopausal women. Breast Cancer Res Treat. 2013;140(3):567-75.
44. Le CP, Karnezis T, Achen MG, Stacker SA, Sloan EK. Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches. Best practice & research Clinical anaesthesiology. 2013;27(4):409-25.
45. Arcangelo V, Peterson A. Pharmacotherapeutics for Advanced Practice: A Practical Approach. Lippincott Williams and Wilkins; 2006.
46. Chida Y, Hamer M, Wardle J, Steptoe A. Do stress-related psychosocial factors contribute to cancer incidence and survival? Nat Clin Pract Oncol. 2008.
47. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, et al. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013;123(2):874-86.