Cancer therapy related complications in the liver, pancreas, and biliary system: an imaging perspective

Insights into Imaging

Volumn 6, Issue 6, 2015, Pages 665-677

  Ngo, Danny ^a   Jia, Jemianne Bautista ^b   Green, Christopher S ^b   Gulati, Anjalie T ^b   Lall, Chandana ^b  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Biliary toxicity; Cancer therapy; Drug associated adverse effects; Hepatic toxicity; Pancreatic toxicity

Indexed keywords

EID: 84947911671     PISSN: None     EISSN: 18694101     Source Type: Journal    
DOI: 10.1007/s13244-015-0436-7     Document Type: Review

References (76)

1. Robinson SM, Scott J, Manas DM SA White (2013) The assessment and management of chemotherapy associated liver injury, hepatic surgery. Prof. Hesham Abdeldayem (ed) ISBN: 978-953-51-0965-5. INTECH, doi:10.5772/53915
2. King PD, Perry MC (2001) Hepatotoxicity of chemotherapy. Oncologist 6:162–176
3. Robinson PJ (2009) The effects of chemotherapy on liver imaging. Eur Radiol 19:1752–1762
4. Sharma A, Houshyar R, Bhosale P, Choi J, Gulati R, Lall C (2014) Chemotherapy induced liver abnormalities: an imaging perspective. Clin Mol Hepatol 20:317–326
5. Hamer OW, Aguirre DA, Casola G, Lavine JE, Woenckhaus M, Sirlin CB (2006) Fatty liver: imaging patterns and pitfalls. Radiographics 26(6):1637–1653
6. Décarie PO, Lepanto L, Billiard JS, Olivié D, Lavallée JM, Kauffmann C et al (2011) Fatty liver deposition and sparing: a pictorial review. Insights Imaging 2(5):533–538
7. Torrisi JM, Schwartz LH, Gollub MJ, Ginsberg MS, Bosl GJ, Hricak H (2011) CT findings of chemotherapy-induced toxicity. Radiology 258:41–56
8. Maor Y, Malnick S (2013) Liver injury induced by anticancer chemotherapy and radiation therapy. Int J Hepatol 2013, Article ID 815105. doi:10.1155/2013/815105, 8 pages
9. Kalil AN, Coral GP, Santos FA, Gonzalez MC, Neutzling CB (2014) The association between preoperative chemotherapy and the prevalence of hepatic steatosis in hepatectomy for metastatic colorectal cancer. Arq Bras Cir Dig 27(2):120–125
10. Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M et al (2015) Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives—a position statement from the European Society for Bone and Marrow Transplantation (EBMT). Bone Marrow Transplant
11. Ikezoe T, Togitani K, Komatsu N, Isaka M, Yokoyama A (2010) Successful treatment of sinusoidal obstruction syndrome after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. Bone Marrow Transplant 45:783–785
12. DeLeve LD, Shulman HM, McDonald GB (2002) Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 22:27–42
13. Seo AN, Kim H (2014) Sinusoidal obstruction syndrome after oxaliplatin-based chemotherapy. Clin Mol Hepatol 20:81–84
14. Stoneham S, Lennard L, Coen P, Lilleyman J, Saha V (2003) Veno-occlusive disease in patients receiving thiopurines during maintenance therapy for childhood acute lymphoblastic leukemia. Br J Haematol 123:100–102
15. Fan CQ, Crawford JM (2014) Sinusoidal obstruction syndrome (hepatic veno-occlusive disease). J Clin Exp Hepatol 4(4):332–346
16. Zhou H, Wang Y, Lou H, Xu X, Zhang M (2014) Hepatic sinusoidal obstruction syndrome caused by herbal medicine: CT and MRI features. Korean J Radiol 15(2):218–225
17. Sangisetty SL, Miner TJ (2012) Malignant ascites: a review of prognostic factors, pathophysiology, and therapeutic measures. World J Gastrointest Surg 4(4):87–95
18. Jeong WK, Choi SY, Kim J (2013) Pseudocirrhosis as a complication after chemotherapy for hepatic metastasis from breast cancer. Clin Mol Hepatol 19:190–194
19. Lee SM, Chang ED, Na SJ, Kim JS, An HJ, Ko YH et al (2014) Pseudocirrhosis of breast cancer metastases to the liver treated by chemotherapy. Cancer Res Treat 46:98–103
20. Qayyum A, Lee GK, Yeh BM, Allen JN, Venook AP, Coakley FV (2007) Frequency of hepatic contour abnormalities and signs of portal hypertension at CT in patients receiving chemotherapy for breast cancer metastatic to the liver. Clin Imaging 31:6–10
21. Jha P, Poder L, Wang ZJ, Westphalen AC, Yeh BM, Coakley FV (2010) Radiologic mimics of cirrhosis. Am J Roentgenol 190:993–999
22. Lee SL, Chang ED, Na SJ, Kim JS, An HJ, Ko YH et al (2014) Pseudocirrhosis of breast cancer metastases to the liver treated by chemotherapy. Cancer Res Treat 46(1):98–103
23. Lau GK (2008) Hepatitis b reactivation after chemotherapy: two decades of clinical research. Hepatol Int 2(2):152–162
24. Mahale P, Kontoyiannis DP, Chemaly RF, Jiang Y, Hwang JP, Davila M et al (2012) Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients. J Hepatol 57:1177–1185
25. Abu-Judeh HH (2002) The “starry sky” liver with right-sided heart failure. AJR Am J Roentgenol 178:78
26. Park SJ, Kim JD, Seo YS, Park BJ, Kim MJ, Um SH et al (2013) Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis. World J Gastroenterol 19(16):2543–2549
27. Morgan C, Tillett T, Braybrooke J, Ajithkumar T (2011) Management of uncommon chemotherapy-induced emergencies. Lancet Oncol 12:806–814
28. Singh V, Devata S, Cheng YC (2010) Carboplatin and docetaxel-induced acute pancreatitis: brief report. Int J Clin Oncol 15(6):642–644
29. Viswanathan C, Truong MT, Sagebiel TL, Bronstein Y, Vikram R, Patnana M (2014) Abdominal and pelvic complications of nonoperative oncologic therapy. RadioGraphics 34:941–961
30. Motzer RJ, Rini BI, Bukowski RM, Curti BD, George DJ, Hudes GR et al (2006) Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295(21):2516–2524
31. Saadati H, Saif MW (2010) Sorafenib-induced acute pancreatitis. JOP 11(3):283–284
32. Kobayashi Y, Kanemitu T, Kamoto A, Satoh M, Mori N, Yoshioka T et al (2011) Painless acute pancreatitis associated with sorafenib treatment: a case report. Med Oncol 28(2):463–465
33. Li M, Srinivas S (2007) Acute pancreatitis associated with sorafenib. South Med J 100(9):909–911
34. Ganeshan DM, Salem U, Viswanathan C, Balachandran A, Garg N, Silverman P et al (2013) Complications of oncologic therapy in abdomen and pelvis: a review. Abdom Imaging 38:1–21
35. Calculli L, Pezzilli R, Casadi R, Fiscaletti M, Gavelli G (2005) Imaging techniques for acute necrotizing pancreatitis: multidetector computed tomography. 7:104–109
36. Shyu JY, Sainani NI, Sahni VA, Chick JF, Chauhan NR, Conwell DL et al (2014) Necrotizing pancreatitis: diagnosis, imaging, and intervention. RadioGraphics 34:1218–1239
37. Miller FH, Keppke AL, Dala K, Ly JN, Kamler VA, Sica GT (2004) MRI of pancreatitis and its complications: part 1, acute pancreatitis. Am J Roentgenol 183(6):1637–1644
38. Xiao B, Zhang XM (2010) Magnetic resonance imaging for acute pancreatitis. World J Radiol 28(8):298–308
39. O’connor OJ, McWilliam S, Maher MM (2011) Imaging of acute pancreatitis. Am J Roentgenol 197:221–225
40. Ganten MK, Schuessler M, Bruckner T, Ganten TM, Koschny R (2015) Pancreatic atrophy in hepatocellular carcinoma patients receiving long-term treatment with sorafenib. Oncology
41. Hescot S, Vignaux O, Goldwasser F (2013) Pancreatic atrophy—a new late toxic effect of sorafenib. N Engl J Med 369:1475–1476
42. Stratton A, Murphy T, Laczek J (2012) Atrophic-appearing pancreas on magnetic resonance cholangiopancreatography as initial presentation of cystic fibrosis. Hawaii J Med Public Health 71(6):151–154
43. Djuric-Stefanovic A, Masulovic D, Kostic J, Randjic K, Saranovic D (2012) CT volumetry of normal pancreas: correlation with the pancreatic diameters measurable by the cross-sectional imaging, and relationship with the gender, age, and body constitution. Surg Radiol Anat 34:811–817
44. Syed AB, Mahal RS, Schumm LP, Dachman AH (2012) Pancreas size and volume on computed tomography in normal adults. 41(4):589–595
45. Cetin B, Coskun U, Yildiz R, Buyukberber S, Baykara M, Benekli M (2010) Acute cholecystitis in a patient with metastatic renal cell carcinoma treated with everolimus: a case report. J Oncol Pharm Pract 17(3):274–278
46. Gomez-Abuin G, Karam AA, Mezzadri NA, Bas CA (2009) Acalculous cholecystitis in a patient with metastatic renal cell carcinoma treated with sunitinib. Clin Genitourin Cancer 7:62–63
47. Tirumani SH, Krajewski KM, Shinagare AB, Jagannathan JP, Ramaiya NK (2014) Gallbladder complications associated with molecular targeted therapies:clinical and imaging features. Clin Imaging 38:50–55
48. O’Connor OJ, Maher MM (2011) Imaging of cholecystitis. Am J Roentgenol 196(4):367–374
49. Superfin D, Iannuci AA, Davies AM (2007) Oncologic drugs in patients with organ dysfunction: a summary. Oncologist 12:1070–1083
50. Hohn D, Melnick J, Stagg R, Altman D, Friedman M, Ignoffo R et al (1985) Biliary sclerosis in patients receiving hepatic arterial infusions of floxuridine. J Clin Oncol 3(1):98–102
51. Ito K, Ito H, Kemeny NE, Gonen M, Allen PJ, Paty PB et al (2012) Biliary sclerosis after hepatic arterial infusion pump chemotherapy for patients with colorectal cancer liver metastasis: incidence, clinical features, and risk factors. Ann Surg Oncol 19:1609–1617
52. Enns R (2008) The use of ERCP versus MRCP in primary sclerosing cholangitis. Gastroenterol Hepatol 4(12):852–854
53. Rogoveanu I, Ghenoea DI, Saftoiu A, Ciurea T (2006) The role of imaging methods in identifying the causes of extrahepatic cholestasis. Clin Imaging 15:265–271
54. Padda MS, Sanchez M, Akhtar AJ, Boyer JL (2011) Drug induced cholestasis. Hepatology 53:1377–1387
55. Agnello F, Salvaggio G, Cabibbo G, Maida M, Lagalla R, Midiri M et al (2013) Imaging appearance of treated hepatocellular carcinoma. World J Hepatol 5(8):417–424
56. Kim HC, Kim AY, Han JK, Chung JW, Lee JY, Park JH et al (2002) Hepatic arterial and portal venous phase helical CT in patients treated with transcatheter arterial chemoembolization for hepatocellular carcinoma: added value of unenhanced images. Radiology 225(3):773–780
57. Kloeckner R, Otto G, Biesterfeld S, Oberholzer K, Dueber C, Pitton MB (2010) MDCT versus MRI assessment of tumor response after transarterial chemoembolization for the treatment of hepatocellular carcinoma. Cardiovasc Intervent Radiol 33(3):532–540
58. Yaghmai V, Besa C, Kim E, Gatlin JL, Siddiqui NA, Taouli B (2013) Imaging assessment of hepatocellular carcinoma response to locoregional and systemic therapy. AJR Am J Roentgenol 201:80–96
59. Poggi G, Pozzi E, Riccardi A, Tonini S, Montagna B, Quaretti P et al (2010) Complications of image-guided transcatheter hepatic chemoembolization of primary and secondary tumours of the liver. Anticancer Res 30:5159–5164
60. Clark T (2006) Complications of hepatic chemoembolization. Semin Interv Radiol 23:119–125
61. Marelli L, Stigliano R, Triantos C, Senzolo M, Cholangitas E, Davies N et al (2007) Transarterial therapy for hepatocellular carcinoma: which techinique is more effective? a systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol 30(1):6–25
62. VanderWalde A (2009) Liver abscess as a complication of hepatic transarterial chemoembolization: a case report, literature review, and clinical recommendations. Gastrointest Cancer Res 3(6):247–251
63. Woo S, Chung JW, Hur S, Joo SM, Kim HC, Jae HJ et al (2013) Liver abscess after transarterial chemoembolization in patients with bilioenteric anastomosis: frequency and risk factors. AJR Am J Roentgenol 200(6):1370–1377
64. Wang CL, Guo XJ, Qui SB, Lei Y, Yuan ZD, Dong HB et al (2007) Diagnosis of bacterial hepatic abscess by CT. Hepatobiliary Pancreat Dis Int 6:271–275
65. Elsayes KM, Narra VR, Yin Y, Mukundan G, Lammle M, Brown JJ (2005) Focal hepatic lesions: diagnostic value of enhancement pattern approach with contrast-enhanced 3D gradient-echo MR imaging. Radiographics 25(5):1299–1320
66. Huang YS, Chiang JH, Wu JC, Chang FY, Lee SD (2002) Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular carcinoma: predictive value of monoethylglycinexylidide test. Am J Gastroenterol 97:1223–1227
67. Larson AM (2010) Diagnosis and management of acute liver failure. Curr Opin Gastroenterol 26(3):214–221
68. Romero M, Palmer SL, Kahn JA, Ihde L, Lin LM, Kosco A et al (2014) Imaging appearance in acute liver failure: correlation with clinical and pathology findings. Dig Dis Sci 59(8):1987–1995
69. Bae SI, Yeon JE, Lee JM, Kim JH, Lee HJ, Lee SJ et al (2012) A case of necrotizing pancreatitis subsequent to transcatheter arterial chemoembolization in a patient with hepatocellular carcinoma. Clin Mol Hepatol 18(3):321–325
70. Ozçinar B, Güven K, Poyanli A, Ozden I (2009) Necrotizing pancreatitis after transcathether arterial chemoembolization for hepatocellular carcinoma. Diagn Interv Radiol 15(1):36–38
71. López-Benítez R, Radeleff BA, Barragán-Campos HM, Noeldge G, Grenacher L, Richter GM et al (2007) Acute pancreatits after embolization of liver tumors:frequency and associated risk factors. Pancreatology 7:53–62
72. Sakamoto I, Iwanaga S, Nagaoki K, Matsuoka Y, Ashizawa K, Uetani M et al (2003) Intraheptaic biloma formation (bile duct necrosis) after transcatheter arterial chemoembolization. Am J Roentgenol 181:79–87
73. Miyayama S, Yamashiro M, Okuda M, Yoshie Y, Nakashima Y, Ikeno H et al (2010) Main bile duct stricture occurring after transcatheter arterial chemoembolization for hepatocellular carcinoma. Cardiovasc Intervent Radiol 33(6):1168–1179
74. Pelletier AL, Hammel P, Zappa M, Bedossa P, Rebours V, Hentic O et al (2008) Fatal bile duct necrosis: a rare complication of transcatheter arterial chemoembolization in a patient with endocrine hepatic metastasis. Case Rep Gastroenterol 2:356–362
75. Yu JS, Kim KW, Park MS, Yoon SW (2001) Bile duct injuries leading to portal vein obliteration after transcatheter arterial chemoembolization in the liver: CT findings and initial observations. Radiology 221:429–436
76. Thompson CM, Saad NE, Quazi RR, Darcy MD, Picus DD, Menias CO (2013) Management of iatrogenic bile duct injuries: role of the interventional radiologist. RadioGraphics 33(1):117–134