Discovery of Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anti-Cancer Agents

ACS Chemical Biology

Volumn 10, Issue 11, 2015, Pages 2589-2597

  Piano, Valentina ^a   Benjamin, Daniel I ^b   Valente, Sergio ^c   Nenci, Simone ^a   Marrocco, Biagina ^c   Mai, Antonello ^c,d   Aliverti, Alessandro ^e   Nomura, Daniel K ^b   Mattevi, Andrea ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d Pasteur Institute   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL GLYCERONE PHOSPHATE SYNTHASE; ALKYL GLYCERONE PHOSPHATE SYNTHASE INHIBITOR; ANTIMYCIN A1; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; ETHER LIPID; SYNTHETASE; UNCLASSIFIED DRUG; ZINC 69435460; ALKYLGLYCERONE-PHOSPHATE SYNTHASE; MOLECULAR LIBRARY; TRANSFERASE;

ARTICLE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG DEVELOPMENT; ENANTIOMER; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; ICOSANOID METABOLISM; LIPOGENESIS; MIGRATION INHIBITION; PEROXISOMAL TARGETING SIGNAL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG STABILITY; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOLOGY; PIG; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SMALL MOLECULE LIBRARIES; SWINE; TEMPERATURE;

EID: 84947909618     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00466     Document Type: Article

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