Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 46, 2012, Pages 18791-18796

  Nenci, Simone ^a   Piano, Valentina ^a   Rosati, Sara ^b   Aliverti, Alessandro ^c   Pandini, Vittorio ^c   Fraaije, Marco W ^d   Heck, Albert J R ^b   Edmondson, Dale E ^e   Mattevi, Andrea ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Peroxisomal disorder; Phospholipid biosynthesis; Plasmalogen; Rhizomelic chondrodysplasia punctata

Indexed keywords

ALKYL GROUP; ALKYLGLYCERONE PHOSPHATE SYNTHASE; DIHYDROXYACETONE PHOSPHATE; ETHER PHOSPHOLIPID; FLAVINE ADENINE NUCLEOTIDE; FLAVOPROTEIN; SYNTHETASE; UNCLASSIFIED DRUG;

ABSORPTION; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; INBORN ERROR OF METABOLISM; MASS SPECTROMETRY; MUTAGENESIS; MUTATION; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; SYNTHESIS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CATALYSIS; CATALYTIC DOMAIN; FLAVOPROTEINS; GUINEA PIGS; LIPID METABOLISM DISORDERS; MUTATION; OXIDATION-REDUCTION; PEROXISOMES; PHOSPHOLIPIDS;

EID: 84869210790     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1215128109     Document Type: Article

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