Ether lipid generating enzyme AGPS alters the balance of structural and signaling lipids to fuel cancer pathogenicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 37, 2013, Pages 14912-14917

  Benjamin, Daniel I ^a   Cozzo, Alyssa ^a   Ji, Xiaodan ^b   Roberts, Lindsay S ^a   Louie, Sharon M ^a   Mulvihill, Melinda M ^a   Luo, Kunxin ^b   Nomura, Daniel K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer metabolism; Eicosanoids; Lipid signaling lysophosphatidic acid; Metabolomics

Indexed keywords

ARACHIDONIC ACID; ETHER LIPID; FATTY ACID; GLYCEROPHOSPHOLIPID; ICOSANOID; LYSOPHOSPHATIDIC ACID; PALMITIC ACID; SHORT HAIRPIN RNA; SYNTHETASE;

AGGRESSIVENESS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL STRAIN HEK293; CELL STRAIN LNCAP; CELL SURVIVAL; CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME INDUCTION; ENZYME SYNTHESIS; FATTY ACID METABOLISM; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPID METABOLISM; METABOLITE; METABOLOMICS; MOUSE; NEOPLASM; NONHUMAN; ONCOGENE; PATHOGENICITY; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE LEVEL; TUMOR GROWTH; TUMOR XENOGRAFT;

CANCER METABOLISM; EICOSANOIDS; LIPID SIGNALING LYSOPHOSPHATIDIC ACID; METABOLOMICS;

ALKYL AND ARYL TRANSFERASES; CELL LINE, TUMOR; ETHERS; FATTY ACIDS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; LIPID METABOLISM; MALE; METABOLOME; NEOPLASM INVASIVENESS; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 84883819129     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310894110     Document Type: Article

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