Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival

ACS Chemical Biology

Volumn 10, Issue 4, 2015, Pages 925-932

  Chang, Jae Won ^a   Zuhl, Andrea M ^a   Speers, Anna E ^a   Niessen, Sherry ^a   Brown, Steven J ^b   Mulvihill, Melinda M ^e   Fan, Yi Chiao ^f   Spicer, Timothy P ^c   Southern, Mark ^c   Scampavia, Louis ^c   Fernandez Vega, Virneliz ^c   Dix, Melissa M ^a   Cameron, Michael D ^d   Hodder, Peter S ^c   Rosen, Hugh ^b   Nomura, Daniel K ^e   Kwon, Ohyun ^f   Hsu, Ku Lung ^a,g   Cravatt, Benjamin F ^a  

^a Skaggs Institute for Chemical Biology   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Lead Identification Division Molecular Screening Center   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ESTERASE INHIBITOR; JW1036; JW1038; JW1039; JW1041; JW1043; JW1058; JW1061; JW1068; PLATELET ACTIVATING FACTOR ACETYLHYDROLASES 1B2 INHIBITOR; PLATELET ACTIVATING FACTOR ACETYLHYDROLASES 1B3 INHIBITOR; UNCLASSIFIED DRUG; MOLECULAR LIBRARY; PAFAH1B2 PROTEIN, MOUSE; PAFAH1B3 PROTEIN, MOUSE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CLICK CHEMISTRY; CONTROLLED STUDY; CROSS REACTION; DRUG CONJUGATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC50; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CELL LINE; CHEMISTRY; DRUG EFFECTS; FLUORESCENCE POLARIZATION; GENETICS; LUNG NEOPLASMS; METABOLISM; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; PRECLINICAL STUDY; PROCEDURES; PROTEOMICS; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ANIMALS; BRAIN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE POLARIZATION; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MICE; PROTEOMICS; PYRIDINES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84928156712     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500893q     Document Type: Article

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