Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Matsuo, Takehiko ^a,b,c   Masumoto, Hidetoshi ^a,b,c   Tajima, Shuhei ^b   Ikuno, Takeshi ^a,b,c   Katayama, Shiori ^a,b   Minakata, Kenji ^c   Ikeda, Tadashi ^c   Yamamizu, Kohei ^a,b   Tabata, Yasuhiko ^b   Sakata, Ryuzo ^c   Yamashita, Jun K ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GELATIN; HYDROGEL; MICROSPHERE;

ANIMAL; CARDIAC MUSCLE CELL; CELL CULTURE; CELL TRANSPLANTATION; CONFOCAL MICROSCOPY; CYTOLOGY; ENDOTHELIUM CELL; FISCHER 344 RAT; FLUORESCENCE IN SITU HYBRIDIZATION; GRAFT SURVIVAL; HEART FUNCTION TEST; HYDROGEL; MALE; METABOLISM; MYOCARDIAL INFARCTION; NONOBESE DIABETIC MOUSE; NUDE RAT; PATHOPHYSIOLOGY; PLURIPOTENT STEM CELL; PROCEDURES; SCID MOUSE; TIME FACTOR; TISSUE ENGINEERING; XENOGRAFT;

ANIMALS; CELL TRANSPLANTATION; CELLS, CULTURED; ENDOTHELIAL CELLS; GELATIN; GRAFT SURVIVAL; HEART FUNCTION TESTS; HYDROGEL; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE, INBRED NOD; MICE, SCID; MICROSCOPY, CONFOCAL; MICROSPHERES; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; PLURIPOTENT STEM CELLS; RATS, INBRED F344; RATS, NUDE; TIME FACTORS; TISSUE ENGINEERING; TRANSPLANTATION, HETEROLOGOUS;

EID: 84947801842     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16842     Document Type: Article

References (48)

1. Atala, A., Kasper, F. K. & Mikos, A. G. Engineering complex tissues. Sci Trancl Med. 4, 160rv112 (2012).
2. Matsa, E., Sallam, K. & Wu, J. C. Cardiac stem cell biology: glimpse of the past, present, and future. Circ Res. 114, 21-27 (2014).
3. Sanganalmath, S. K. & Bolli, R. Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res. 113, 810-834 (2013).
4. Bae, H. et al. Building vascular networks. Sci Transl Med. 4, 160ps123 (2012).
5. Doppler, S. A., Deutsch, M. A., Lange, R. & Krane, M. Cardiac regeneration: current therapies-future concepts. J Thorac Dis. 5, 683-697 (2013).
6. Emmert, M. Y., Hitchcock, R. W. & Hoerstrup, S. P. Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration. Adv Drug Deliv Rev. 69-70, 254-269 (2014).
7. Malda, J., Klein, T. J. & Upton, Z. The roles of hypoxia in the in vitro engineering of tissues. Tissue Eng. 13, 2153-2162 (2007).
8. Novosel, E. C., Kleinhans, C. & Kluger, P. J. Vascularization is the key challenge in tissue engineering. Adv Drug Deliv Rev. 63, 300-31 (2011).
9. Chien, K. R., Domian, I. J. & Parker, K. K. Cardiogenesis and the complex biology of regenerative cardiovascular medicine. Science. 322, 1494-1497 (2008).
10. Laflamme, M. A. & Murry, C. E. Heart regeneration. Nature. 473, 326-335 (2011).
11. Segers, V. F. & Lee, R. T. Stem-cell therapy for cardiac disease. Nature. 451, 937-942 (2008).
12. Xin, M., Olson, E. N. & Bassel-Duby, R. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat Rev Mol Cell Biol. 14, 529-541 (2013).
13. Garbern, J. C. & Lee, R. T. Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell. 12, 689-698 (2014).
14. Okano, T., Yamada, N., Sakai, H. & Sakurai, Y. A novel recovery system for cultured cells using plasma-treated polystyrene dishes grafted with poly(N-isopropylacrylamide). J Biomed Mater Res. 27, 1243-1251 (1993).
15. Shimizu, T. et al. Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circ Res. 90, e40 (2002).
16. Masumoto, H. et al. Pluripotent stem cell-engineered cell sheets reassembled with defined cardiovascular populations ameliorate reduction in infarct heart function through cardiomyocyte-mediated neovascularization. Stem Cells. 30, 1196-1205 (2012).
17. Masumoto, H. et al. Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration. Sci Rep. 4, 6716 (2014).
18. Shimizu, T. et al. Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues. FASEB J. 20, 708-710 (2006).
19. Narazaki, G. et al. Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation. 118, 498-506 (2008).
20. Yamamizu, K. et al. Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1. Blood. 114, 3707-3716 (2009).
21. Yamamizu, K. et al. Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors. J Cell Biol. 189, 325-338 (2010).
22. Yamamizu, K. et al. Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a. Cell Stem Cell. 10, 759-770 (2012).
23. Yamashita, J. et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature. 408, 92-96 (2000).
24. Yamashita, J. K. et al. Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction. FASEB J. 19, 1534-1536 (2005).
25. Uosaki, H. et al. Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLos One. 6, e23657 (2011).
26. Tabata, Y. & Nagano, A. Biodegradation of hydrogel carrier incorporating fibroblast growth factor. Tissue Eng. 5, 127-138 (1999).
27. Hayashi, K. & Tabata, Y. Preparation of stem cell aggregates with gelatin microspheres to enhance biological functions. Acta Biomater. 7, 2797-2803 (2011).
28. Tabata, Y. Biomaterials Design of Culture Substrates for Cell Research. Inflamm Regen. 31, 137-145 (2011).
29. Young, S., Wong, M., Tabata, Y. & Mikos, A. G. Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release. 109, 256-274 (2005).
30. Yan, P. et al. Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. Biochem Biophys Res Commun. 379, 115-120 (2009).
31. Yurugi-Kobayashi, T. et al. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol. 26, 1977-1984 (2006).
32. Tabata, Y. et al. Surfactant-Free Preparation of Biodegradable Hydrogel Microspheres for Protein Release. J Bioact Compat Polym. 14, 371-384 (1999).
33. Nishina, T. et al. Initial effects of the left ventricular repair by plication may not last long in a rat ischemic cardiomyopathy model. Circulation. 104, I241-245 (2001).
34. Sakakibara, Y. et al. Combined procedure of surgical repair and cell transplantation for left ventricular aneurysm: an experimental study. Circulation. 106, I193-197 (2002).
35. Nishiyama, N. et al. The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro. Stem Cells. 25, 2017-2024 (2007).
36. Young, D. M., Greulich, K. M. & Weier, H. G. Species-specific in situ hybridization with fluorochrome-labeled DNA probes to study vascularization of human skin grafts on athymic mice. J Burn Care Rehabil. 17, 305-310 (1996).
37. Kawamura, M. et al. Feasibility, safety, and therapeutic efficacy of human induced pluripotent stem cell-derived cardiomyocyte sheets in a porcine ischemic cardiomyopathy model. Circulation. 126, S29-37 (2012).
38. Kumagai, M. et al. Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia. Heart Vessels. (2015), doi: 10.1007/s00380-015-0677-x.
39. Laflamme, M. A., Zbinden, S., Epstein, S. E. & Murry, C. E. Cell-based therapy for myocardial ischemia and infarction: pathophysiological mechanisms. Annu Rev Pathol. 2, 307-339 (2007).
40. Takebe, T. et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 499, 481-484 (2013).
41. Takeuchi, R. et al. In vivo vascularization of cell sheets provided zbetter long-term tissue survival than injection of cell suspension. J Tissue Eng Regen Med. (2014), doi: 10.1002/term.1854.
42. Chong, J. J. et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 510, 273-277 (2014).
43. Laflamme, M. A. et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 25, 1015-1024 (2007).
44. Sakaguchi, K. et al. In vitro engineering of vascularized tissue surrogates. Sci Rep. 3, 1316 (2013).
45. Sekine, H. et al. In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels. Nat Commun. 4, 1399 (2013).
46. Taguchi, A. et al. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell. 14, 53-67 (2014).
47. Tabata, Y. Current status of regenerative medical therapy based on drug delivery technology. Reprod Biomed Online. 16, 70-80 (2008).
48. Tabata, Y. Biomaterial technology for tissue engineering applications. J R Soc Interface. 6 (Suppl 3) S311-324 (2009).