Aniline is rapidly converted into paracetamol impairing male reproductive development

Toxicological Sciences

Volumn 148, Issue 1, 2015, Pages 288-298

  Holm, Jacob Bak ^a   Chalmey, Clementine ^b   Modick, Hendrik ^c   Jensen, Lars Skovgaard ^d   Dierkes, Georg ^c   Weiss, Tobias ^c   Jensen, Benjamin Anderschou Holbech ^a   Nørregård, Mette Marie ^a   Borkowski, Kamil ^a   Styrishave, Bjarne ^d   Martin Koch, Holger ^c   Mazaud Guittot, Severine ^b   Jegou, Bernard ^b,e   Kristiansen, Karsten ^a   Kristensen, David Møbjerg ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITÉ DE RENNES 1   (France)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e EHESP SCHOOL OF PUBLIC HEALTH   (France)

Author keywords

acetaminophen; Aniline; endocrine disruptors; paracetamol; reproduction; testosterone

Indexed keywords

ANDROGEN; ANILINE; ENDOCRINE DISRUPTOR; PARACETAMOL; STEROID 21 MONOOXYGENASE; TESTOSTERONE; ANILINE DERIVATIVE; CARCINOGEN; PROGESTERONE;

ADULT; ANOGENITAL DISTANCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EX VIVO STUDY; HUMAN; HUMAN CELL; INTESTINE FLORA; LIVER PERFUSION; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; PERITONEAL CAVITY; PROGENY; REPRODUCTION; REPRODUCTIVE TOXICITY; STEROIDOGENESIS; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOTRANSFORMATION; C57BL MOUSE; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FEMALE; FETOMATERNAL TRANSFUSION; FETUS DEVELOPMENT; IN VITRO STUDY; LIVER; MALE; MALE INFERTILITY; METABOLISM; PATHOLOGY; PREGNANCY; SEXUAL DEVELOPMENT; TOXICOKINETICS; TUMOR CELL LINE;

ACETAMINOPHEN; ANILINE COMPOUNDS; ANIMALS; BIOTRANSFORMATION; CARCINOGENS, ENVIRONMENTAL; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; FEMALE; FETAL DEVELOPMENT; HUMANS; IN VITRO TECHNIQUES; INFERTILITY, MALE; LIVER; MALE; MATERNAL-FETAL EXCHANGE; MICE, INBRED C57BL; PREGNANCY; PROGESTERONE; SEXUAL DEVELOPMENT; TESTOSTERONE; TOXICOKINETICS;

EID: 84947795780     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv179     Document Type: Article

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