Increased circulating interleukin-17 levels in preeclampsia

Journal of Reproductive Immunology

Volumn 112, Issue , 2015, Pages 53-57

  Molvarec, Attila ^a   Czegle, Ibolya ^b   Szijártó, János ^c   Rigó, János ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c NATIONAL INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Hungary)

Author keywords

Angiogenesis; Inflammation; Interleukin 17; Preeclampsia; Pregnancy; Th17

Indexed keywords

INTERLEUKIN 17; PLACENTAL GROWTH FACTOR; PROTEIN TYROSINE KINASE; SOLUBLE FMS LIKE TYROSINE KINASE 1; UNCLASSIFIED DRUG; FLT1 PROTEIN, HUMAN; IL17A PROTEIN, HUMAN; MEMBRANE PROTEIN; PIGF PROTEIN, HUMAN; VASCULOTROPIN RECEPTOR 1;

ADULT; ARTICLE; CASE CONTROL STUDY; CHEMILUMINESCENCE IMMUNOASSAY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; PATHOGENESIS; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; BLOOD; CLINICAL TRIAL; IMMUNOLOGY; PREGNANCY; RISK FACTOR;

ADULT; FEMALE; HUMANS; INTERLEUKIN-17; MEMBRANE PROTEINS; PRE-ECLAMPSIA; PREGNANCY; RISK FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84947766427     PISSN: 01650378     EISSN: 18727603     Source Type: Journal    
DOI: 10.1016/j.jri.2015.05.007     Document Type: Article

References (32)

1. Abalos E., Cuesta C., Grosso A.L., Chou D., Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013, 170:1-7.
2. Cornelius D.C., Hogg J.P., Scott J., Wallace K., Herse F., Moseley J., et al. Administration of interleukin-17 soluble receptor C suppresses TH17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy. Hypertension 2013, 62:1068-1073.
3. Cornelius D.C., Wallace K., Kiprono L., Dhillon P., Moseley J., LaMarca B. Endothelin-1 is not a mechanism of IL-17 induced hypertension during pregnancy. Med. J. Obstet. Gynecol. 2013, 1:1006.
4. Darmochwal-Kolarz D., Kludka-Sternik M., Tabarkiewicz J., Kolarz B., Rolinski J., Leszczynska-Gorzelak B., et al. The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia. J. Reprod. Immunol. 2012, 93:75-81.
5. Derzsy Z., Prohaszka Z., Rigo J., Fust G., Molvarec A. Activation of the complement system in normal pregnancy and preeclampsia. Mol. Immunol. 2010, 47:1500-1506.
6. Dhillion P., Wallace K., Herse F., Scott J., Wallukat G., Heath J., et al. IL-17-mediated oxidative stress is an important stimulator of AT1-AA and hypertension during pregnancy. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2012, 303:R353-R358.
7. Gaffen S.L. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 2009, 9:556-567.
8. Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 2005, 6:1123-1132.
9. Jianjun Z., Yali H., Zhiqun W., Mingming Z., Xia Z. Imbalance of T-cell transcription factors contributes to the Th1 type immunity predominant in pre-eclampsia. Am. J. Reprod. Immunol. 2010, 63:38-45.
10. Jonsson Y., Ruber M., Matthiesen L., Berg G., Nieminen K., Sharma S., et al. Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J. Reprod. Immunol. 2006, 70:83-91.
11. Martinez-Garcia E.A., Chavez-Robles B., Sanchez-Hernandez P.E., Nunez-Atahualpa L., Martin-Maquez B.T., Munoz-Gomez A., et al. IL-17 increased in the third trimester in healthy women with term labor. Am. J. Reprod. Immunol. 2011, 65:99-103.
12. Maynard S.E., Min J.Y., Merchan J., Lim K.H., Li J., Mondal S., et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 2003, 111:649-658.
13. Molvarec A., Prohaszka Z., Nagy B., Kalabay L., Szalay J., Fust G., et al. Association of increased serum heat shock protein 70 and C-reactive protein concentrations and decreased serum alpha(2)-HS glycoprotein concentration with the syndrome of hemolysis, elevated liver enzymes, and low platelet count. J. Reprod. Immunol. 2007, 73:172-179.
14. Molvarec A., Jermendy A., Nagy B., Kovacs M., Varkonyi T., Hupuczi P., et al. Association between tumor necrosis factor (TNF)-alpha G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction. Clin. Chim. Acta 2008, 392:52-57.
15. Molvarec A., Kalabay L., Derzsy Z., Szarka A., Halmos A., Stenczer B., et al. Preeclampsia is associated with decreased serum alpha(2)-HS glycoprotein (fetuin-A) concentration. Hypertens. Res. 2009, 32:665-669.
16. Molvarec A., Rigo J., Lazar L., Balogh K., Mako V., Cervenak L., et al. Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia. Cell Stress Chaperones 2009, 14:151-159.
17. Molvarec A., Ito M., Shima T., Yoneda S., Toldi G., Stenczer B., et al. Decreased proportion of peripheral blood vascular endothelial growth factor-expressing T and natural killer cells in preeclampsia. Am. J. Obstet. Gynecol. 2010, 567(203):e561-e568.
18. Molvarec A., Szarka A., Walentin S., Szucs E., Nagy B., Rigo J. Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia. Hypertens. Res. 2010, 33:892-898.
19. O'Quinn D.B., Palmer M.T., Lee Y.K., Weaver C.T. Emergence of the Th17 pathway and its role in host defense. Adv. Immunol. 2008, 99:115-163.
20. Onishi R.M., Gaffen S.L. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 2010, 129:311-321.
21. Ozkan Z.S., Simsek M., Ilhan F., Deveci D., Godekmerdan A., Sapmaz E. Plasma IL-17, IL-35, interferon-gamma, SOCS3 and TGF-beta levels in pregnant women with preeclampsia, and their relation with severity of disease. J. Matern. Fetal Neonatal Med. 2014, 27:1513-1517.
22. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 2005, 6:1133-1141.
23. Phillips J.K., Janowiak M., Badger G.J., Bernstein I.M. Evidence for distinct preterm and term phenotypes of preeclampsia. J. Matern. Fetal Neonatal Med. 2010, 23:622-626.
24. Redman C.W., Sacks G.P., Sargent I.L. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am. J. Obstet. Gynecol. 1999, 180:499-506.
25. Rosta K., Molvarec A., Enzsoly A., Nagy B., Ronai Z., Fekete A., et al. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009, 142:134-138.
26. Saito S., Sakai M., Sasaki Y., Tanebe K., Tsuda H., Michimata T. Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia. Clin. Exp. Immunol. 1999, 117:550-555.
27. Saito S., Umekage H., Sakamoto Y., Sakai M., Tanebe K., Sasaki Y., et al. Increased T-helper-1-type immunity and decreased T-helper-2-type immunity in patients with preeclampsia. Am. J. Reprod. Immunol. 1999, 41:297-306.
28. Saito S., Shiozaki A., Nakashima A., Sakai M., Sasaki Y. The role of the immune system in preeclampsia. Mol. Aspects Med. 2007, 28:192-209.
29. Santner-Nanan B., Peek M.J., Khanam R., Richarts L., Zhu E., Fazekas de St Groth B., et al. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J. Immunol. 2009, 183:7023-7030.
30. Szarka A., Rigo J., Lazar L., Beko G., Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol. 2010, 11:59.
31. Toldi G., Rigo J., Stenczer B., Vasarhelyi B., Molvarec A. Increased prevalence of IL-17-producing peripheral blood lymphocytes in pre-eclampsia. Am. J. Reprod. Immunol. 2011, 66:223-229.
32. Vatten L.J., Skjaerven R. Is pre-eclampsia more than one disease?. BJOG 2004, 111:298-302.