Morphogenesis of the thyroid gland

Molecular and Cellular Endocrinology

Volumn 323, Issue 1, 2010, Pages 35-54

  Fagman, Henrik ^a   Nilsson, Mikael ^b  

^a Grande Ospedale Metropolitano   (Italy)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

C cells; Development; Endoderm; Thyroid dysgenesis; Thyroid gland

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXE1; TRANSCRIPTION FACTOR HHEX; TRANSCRIPTION FACTOR HOXA3; TRANSCRIPTION FACTOR NKX2 1; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG;

ATHYREOSIS; C CELL PRECURSOR; CELL BUDDING; CELL DIFFERENTIATION; CELL FATE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHROMATIN ASSEMBLY AND DISASSEMBLY; CLINICAL FEATURE; CONGENITAL HYPOTHYROIDISM; CYTOSKELETON; DEVELOPMENT; ENDODERM; ENDOTHELIUM CELL; EXPERIMENTAL MOUSE; GENE REGULATORY NETWORK; HEART DEVELOPMENT; MORPHOGENESIS; NEURAL CREST; NONHUMAN; ORGANOGENESIS; PATHOGENESIS; PRIMORDIUM; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; THYROID DISEASE; THYROID DYSGENESIS; THYROID GLAND; THYROID HEMIAGENESIS; THYROID PROGENITOR CELL; THYROID WEIGHT; TISSUE GROWTH; ZEBRA FISH;

ANIMALS; BONE MORPHOGENETIC PROTEINS; CHICK EMBRYO; CONGENITAL HYPOTHYROIDISM; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; HUMANS; MICE; MORPHOGENESIS; NEURAL CREST; ORGAN SIZE; THYROID DYSGENESIS; THYROID GLAND; TRANSCRIPTION FACTORS; ZEBRAFISH;

EID: 77952888303     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.12.008     Document Type: Review

References (197)

1. Abe M., Tamamura Y., Yamagishi H., Maeda T., Kato J., Tabata M.J., Srivastava D., Wakisaka S., et al. Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Cell Tissue Res. 2002, 310:201-212.
2. Al Taji E., Biebermann H., Limanova Z., Hnikova O., Zikmund J., Dame C., Gruters A., Lebl J., et al. Screening for mutations in transcription factors in a Czech cohort of 170 patients with congenital and early-onset hypothyroidism: identification of a novel PAX8 mutation in dominantly inherited early-onset non-autoimmune hypothyroidism. Eur. J. Endocrinol. 2007, 156:521-529.
3. Alt B., Elsalini O.A., Schrumpf P., Haufs N., Lawson N.D., Schwabe G.C., Mundlos S., Gruters A., et al. Arteries define the position of the thyroid gland during its developmental relocalisation. Development 2006, 133:3797-3804.
4. Alt B., Reibe S., Feitosa N.M., Elsalini O.A., Wendl T., Rohr K.B. Analysis of origin and growth of the thyroid gland in zebrafish. Dev. Dyn. 2006, 235:1872-1883.
5. Amendola E., De Luca P., Macchia P.E., Terracciano D., Rosica A., Chiappetta G., Kimura S., Mansouri A., et al. A mouse model demonstrates a multigenic origin of congenital hypothyroidism. Endocrinology 2005, 146:5038-5047.
6. Andrew A., Kramer B., Rawdon B.B. The origin of gut and pancreatic neuroendocrine (APUD) cells--the last word?. J. Pathol. 1998, 186:117-118.
7. Aoki T.O., David N.B., Minchiotti G., Saint-Etienne L., Dickmeis T., Persico G.M., Strahle U., Mourrain P., et al. Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation. Development 2002, 129:275-286.
8. Apelqvist A., Ahlgren U., Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr. Biol. 1997, 7:801-804.
9. Arnold M.B., Arulanantham K., Bapat V., Bennett A., Bigos S.T., Bode H.H., Brown R., Crawford J.D., et al. Effects of neonatal screening for hypothyroidism: prevention of mental retardation by treatment before clinical manifestations. New England congenital hypothyroidism collaborative. Lancet 1981, 2:1095-1098.
10. Bachiller D., Klingensmith J., Shneyder N., Tran U., Anderson R., Rossant J., De Robertis E.M. The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. Development 2003, 130:3567-3578.
11. Baum B., Settleman J., Quinlan M.P. Transitions between epithelial and mesenchymal states in development and disease. Semin. Cell Dev. Biol. 2008, 19:294-308.
12. Bianco A., Poukkula M., Cliffe A., Mathieu J., Luque C.M., Fulga T.A., Rorth P. Two distinct modes of guidance signalling during collective migration of border cells. Nature 2007, 448:362-365.
13. Biben C., Wang C.C., Harvey R.P. NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis. Int. J. Dev. Biol. 2002, 46:415-422.
14. Blixt A., Mahlapuu M., Aitola M., Pelto-Huikko M., Enerback S., Carlsson P. A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev. 2000, 14:245-254.
15. Bockman D.E., Kirby M.L. Dependence of thymus development on derivatives of the neural crest. Science 1984, 223:498-500.
16. Bockman D.E., Redmond M.E., Waldo K., Davis H., Kirby M.L. Effect of neural crest ablation on development of the heart and arch arteries in the chick. Am. J. Anat. 1987, 180:332-341.
17. Bohinski R.J., Di Lauro R., Whitsett J.A. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell. Biol. 1994, 14:5671-5681.
18. Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S. Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev. Biol. 2006, 290:44-56.
19. Bubuteishvili L., Garel C., Czernichow P., Leger J. Thyroid abnormalities by ultrasonography in neonates with congenital hypothyroidism. J. Pediatr. 2003, 143:759-764.
20. Cai C.L., Liang X., Shi Y., Chu P.H., Pfaff S.L., Chen J., Evans S. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev. Cell 2003, 5:877-889.
21. Capen C.C. Comparative anatomy and physiology. Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text 2000, 20-44. Lipincott, Williams & Williams, Philadelphia. L.E. Braverman, R.D. Utiger (Eds.).
22. Casanova J.B., Daly R.C., Edwards B.S., Tazelaar H.D., Thompson G.B. Intracardiac ectopic thyroid. Ann. Thorac. Surg. 2000, 70:1694-1696.
23. Castanet M., Leenhardt L., Leger J., Simon-Carre A., Lyonnet S., Pelet A., Czernichow P., Polak M. Thyroid hemiagenesis is a rare variant of thyroid dysgenesis with a familial component but without Pax8 mutations in a cohort of 22 cases. Pediatr. Res. 2005, 57:908-913.
24. Castanet M., Polak M., Bonaiti-Pellie C., Lyonnet S., Czernichow P., Leger J. Nineteen years of national screening for congenital hypothyroidism: familial cases with thyroid dysgenesis suggest the involvement of genetic factors. J. Clin. Endocrinol. Metab. 2001, 86:2009-2014.
25. Castanet M., Polak M., Leger J. Familial forms of thyroid dysgenesis. Endocr. Dev. 2007, 10:15-28.
26. Celli G., LaRochelle W.J., Mackem S., Sharp R., Merlino G. Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J. 1998, 17:1642-1655.
27. Clark N.B. The ultimobranchial body of reptiles. J. Exp. Zool. 1971, 178:115-124.
28. Clark O.H., Lambert W.R., Cavalieri R.R., Rapoport B., Hammond M.E., Ingbar S.H. Compensatory thyroid hypertrophy after hemithyroidectomy in rats. Endocrinology 1976, 99:988-995.
29. Clifton-Bligh R.J., Wentworth J.M., Heinz P., Crisp M.S., John R., Lazarus J.H., Ludgate M., Chatterjee V.K. Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia. Nat. Genet. 1998, 19:399-401.
30. Clouthier D.E., Hosoda K., Richardson J.A., Williams S.C., Yanagisawa H., Kuwaki T., Kumada M., Hammer R.E., et al. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 1998, 125:813-824.
31. Cooley M.A., Kern C.B., Fresco V.M., Wessels A., Thompson R.P., McQuinn T.C., Twal W.O., Mjaatvedt C.H., et al. Fibulin-1 is required for morphogenesis of neural crest-derived structures. Dev. Biol. 2008, 319:336-345.
32. D'Andrea B., Iacone R., Di Palma T., Nitsch R., Baratta M.G., Nitsch L., Di Lauro R., Zannini M. Functional inactivation of the transcription factor Pax8 through oligomerization chain reaction. Mol. Endocrinol. 2006, 20:1810-1824.
33. De Felice M., Di Lauro R. Thyroid development and its disorders: genetics and molecular mechanisms. Endocr. Rev. 2004, 25:722-746.
34. De Felice M., Di Lauro R. Murine models for the study of thyroid gland development. Endocr. Dev. 2007, 10:1-14.
35. De Felice M., Ovitt C., Biffali E., Rodriguez-Mallon A., Arra C., Anastassiadis K., Macchia P.E., Mattei M.G., et al. A mouse model for hereditary thyroid dysgenesis and cleft palate. Nat. Genet. 1998, 19:395-398.
36. Deladoey J., Vassart G., Van Vliet G. Possible non-Mendelian mechanisms of thyroid dysgenesis. Endocr. Dev. 2007, 10:29-42.
37. Delcore R., Friesen S.R. Embryologic concepts in the APUD system. Semin. Surg. Oncol. 1993, 9:349-361.
38. Dentice M., Cordeddu V., Rosica A., Ferrara A.M., Santarpia L., Salvatore D., Chiovato L., Perri A., et al. Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis. J. Clin. Endocrinol. Metab. 2006, 91:1428-1433.
39. Desai T.J., Malpel S., Flentke G.R., Smith S.M., Cardoso W.V. Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut. Dev. Biol. 2004, 273:402-415.
40. Dessimoz J., Opoka R., Kordich J.J., Grapin-Botton A., Wells J.M. FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mech. Dev. 2006, 123:42-55.
41. Deutsch G., Jung J., Zheng M., Lora J., Zaret K.S. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 2001, 128:871-881.
42. Devos H., Rodd C., Gagne N., Laframboise R., Van Vliet G. A search for the possible molecular mechanisms of thyroid dysgenesis: sex ratios and associated malformations. J. Clin. Endocrinol. Metab. 1999, 84:2502-2506.
43. Di Palma T., Nitsch R., Mascia A., Nitsch L., Di Lauro R., Zannini M. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J. Biol. Chem. 2003, 278:3395-3402.
44. Douarin N.M. An experimental analysis of liver development. Med. Biol. 1975, 53:427-455.
45. Edsbagge J., Johansson J.K., Esni F., Luo Y., Radice G.L., Semb H. Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development 2005, 132:1085-1092.
46. El-Hodiri H.M., Seufert D.W., Nekkalapudi S., Prescott N.L., Kelly L.E., Jamrich M. Xenopus laevis FoxE1 is primarily expressed in the developing pituitary and thyroid. Int. J. Dev. Biol. 2005, 49:881-884.
47. Elsalini O.A., Rohr K.B. Phenylthiourea disrupts thyroid function in developing zebrafish. Dev. Genes Evol. 2003, 212:593-598.
48. Elsalini O.A., von Gartzen J., Cramer M., Rohr K.B. Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors. Dev. Biol. 2003, 263:67-80.
49. Eyuboglu E., Kapan M., Ipek T., Ersan Y., Oz F. Ectopic thyroid in the abdomen: report of a case. Surg. Today 1999, 29:472-474.
50. Fagman H., Andersson L., Nilsson M. The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation. Dev. Dyn. 2006, 235:444-455.
51. Fagman H., Grande M., Edsbagge J., Semb H., Nilsson M. Expression of classical cadherins in thyroid development: maintenance of an epithelial phenotype throughout organogenesis. Endocrinology 2003, 144:3618-3624.
52. Fagman H., Grande M., Gritli-Linde A., Nilsson M. Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse. Am. J. Pathol. 2004, 164:1865-1872.
53. Fagman H., Liao J., Westerlund J., Andersson L., Morrow B.E., Nilsson M. The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Hum. Mol. Genet. 2007, 16:276-285.
54. Franklin V., Khoo P.L., Bildsoe H., Wong N., Lewis S., Tam P.P. Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo. Mech. Dev. 2008, 125:587-600.
55. Franz T. Persistent truncus arteriosus in the Splotch mutant mouse. Anat. Embryol. (Berl.) 1989, 180:457-464.
56. Friedl P., Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat. Rev. Mol. Cell. Biol. 2009, 10:445-457.
57. -/- mouse model of congenital hypothyroidism. Endocrinology 2003, 144:777-784.
58. -/- mouse model of congenital hypothyroidism. Endocrinology 2004, 145:1276-1283.
59. Gasser R.F. Evidence that some events of mammalian embryogenesis can result from differential growth, making migration unnecessary. Anat. Rec. B: New Anat. 2006, 289:53-63.
60. Goldin G.V., Hindman H.M., Wessells N.K. The role of cell proliferation and cellular shape change in branching morphogenesis of the embryonic mouse lung: analysis using aphidicolin and cytochalasins. J. Exp. Zool. 1984, 232:287-296.
61. Gotz M., Huttner W.B. The cell biology of neurogenesis. Nat. Rev. Mol. Cell. Biol. 2005, 6:777-788.
62. Gritli-Linde A., Lewis P., McMahon A.P., Linde A. The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev. Biol. 2001, 236:364-386.
63. Gualdi R., Bossard P., Zheng M., Hamada Y., Coleman J.R., Zaret K.S. Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. Genes Dev. 1996, 10:1670-1682.
64. Gungor B., Kebat T., Ozaslan C., Akilli S. Intra-abdominal ectopic thyroid presenting with hyperthyroidism: report of a case. Surg. Today 2002, 32:148-150.
65. Hebrok M., Kim S.K., Melton D.A. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 1998, 12:1705-1713.
66. Hilfer S.R., Brown J.W. The development of pharyngeal endocrine organs in mouse and chick embryos. Scan. Electron Microsc. 1984, 2009-2022.
67. Hilfer S.R., Marrero L., Sheffield J.B. Patterns of cell movement in early organ primordia of the chick embryo. Anat. Rec. 1990, 227:508-517.
68. Hilfer S.R., Palmatier B.Y., Fithian E.M. Precocious evagination of the embryonic chick thyroid in ATP-containing medium. J. Embryol. Exp. Morphol. 1977, 42:163-175.
69. Hiruta J., Mazet F., Yasui K., Zhang P., Ogasawara M. Comparative expression analysis of transcription factor genes in the endostyle of invertebrate chordates. Dev. Dyn. 2005, 233:1031-1037.
70. Jiang X., Rowitch D.H., Soriano P., McMahon A.P., Sucov H.M. Fate of the mammalian cardiac neural crest. Development 2000, 127:1607-1616.
71. Jung J., Zheng M., Goldfarb M., Zaret K.S. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 1999, 284:1998-2003.
72. Kameda Y. Evidence to support the distal vagal ganglion as the origin of C cells of the ultimobranchial gland in the chick. J. Comp. Neurol. 1995, 359:1-14.
73. Kameda Y., Ito M., Nishimaki T., Gotoh N. FRS2alpha is required for the separation, migration, and survival of pharyngeal-endoderm derived organs including thyroid, ultimobranchial body, parathyroid, and thymus. Dev. Dyn. 2009, 238:503-513.
74. Kameda Y., Nishimaki T., Chisaka O., Iseki S., Sucov H.M. Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J. Histochem. Cytochem. 2007, 55:1075-1088.
75. Kameda Y., Nishimaki T., Miura M., Jiang S.X., Guillemot F. Mash1 regulates the development of C cells in mouse thyroid glands. Dev. Dyn. 2007, 236:262-270.
76. Kameda Y., Nishimaki T., Takeichi M., Chisaka O. Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos. Dev. Biol. 2002, 247:197-209.
77. Kanai-Azuma M., Kanai Y., Gad J.M., Tajima Y., Taya C., Kurohmaru M., Sanai Y., Yonekawa H., et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 2002, 129:2367-2379.
78. Kiehart D.P., Galbraith C.G., Edwards K.A., Rickoll W.L., Montague R.A. Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila. J. Cell Biol. 2000, 149:471-490.
79. Kim S.K., Melton D.A. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:13036-13041.
80. Kimmel C.B., Ballard W.W., Kimmel S.R., Ullmann B., Schilling T.F. Stages of embryonic development of the zebrafish. Dev. Dyn. 1995, 203:253-310.
81. Kimura J., Deutsch G.H. Key mechanisms of early lung development. Pediatr. Dev. Pathol. 2007, 10:335-347.
82. Kimura S., Hara Y., Pineau T., Fernandez-Salguero P., Fox C.H., Ward J.M., Gonzalez F.J. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 1996, 10:60-69.
83. Kimura S., Ward J.M., Minoo P. Thyroid-specific enhancer-binding protein/thyroid transcription factor 1 is not required for the initial specification of the thyroid and lung primordia. Biochimie 1999, 81:321-327.
84. Kinebrew G.M., Hilfer S.R. Cellular dynamics during evagination of the thyroid primordium in the chick embryo. Anat. Rec. 2001, 264:146-156.
85. Kirby M.L., Gale T.F., Stewart D.E. Neural crest cells contribute to normal aorticopulmonary septation. Science 1983, 220:1059-1061.
86. Kirby M.L., Lawson A., Stadt H.A., Kumiski D.H., Wallis K.T., McCraney E., Waldo K.L., Li Y.X., et al. Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development. Dev. Biol. 2003, 253:175-188.
87. Klein A.H., Meltzer S., Kenny F.M. Improved prognosis in congenital hypothyroidism treated before age three months. J. Pediatr. 1972, 81:912-915.
88. Knospe C., Seichert V., Rychter Z. The topogenesis of the thyroid in chick embryos. Eur. J. Morphol. 1991, 29:291-296.
89. Korpal-Szczyrska M., Kosiak W., Swieton D. Prevalence of thyroid hemiagenesis in an asymptomatic schoolchildren population. Thyroid 2008, 18:637-639.
90. Kreisner E., Camargo-Neto E., Maia C.R., Gross J.L. Accuracy of ultrasonography to establish the diagnosis and aetiology of permanent primary congenital hypothyroidism. Clin. Endocrinol. (Oxf.) 2003, 59:361-365.
91. Krude H., Schutz B., Biebermann H., von Moers A., Schnabel D., Neitzel H., Tonnies H., Weise D., et al. Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency. J. Clin. Invest. 2002, 109:475-480.
92. Kurihara Y., Kurihara H., Maemura K., Kuwaki T., Kumada M., Yazaki Y. Impaired development of the thyroid and thymus in endothelin-1 knockout mice. J. Cardiovasc. Pharmacol. 1995, 26(Suppl. 3):S13-S16.
93. Kusakabe T., Hoshi N., Kimura S. Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid. Dev. Dyn. 2006, 235:1300-1309.
94. Lammert E., Cleaver O., Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001, 294:564-567.
95. Lania G., Zhang Z., Huynh T., Caprio C., Moon A.M., Vitelli F., Baldini A. Early thyroid development requires a Tbx1-Fgf8 pathway. Dev. Biol. 2009, 328:109-117.
96. Lawson K.A., Pedersen R.A. Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 1987, 101:627-652.
97. Lazzaro D., Price M., de Felice M., Di Lauro R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 1991, 113:1093-1104.
98. Le Lievre C.S., Le Douarin N.M. Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos. J. Embryol. Exp. Morphol. 1975, 34:125-154.
99. Lee C.S., Friedman J.R., Fulmer J.T., Kaestner K.H. The initiation of liver development is dependent on Foxa transcription factors. Nature 2005, 435:944-947.
100. Lewis S.L., Tam P.P. Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function. Dev. Dyn. 2006, 235:2315-2329.
101. Lien C.L., Wu C., Mercer B., Webb R., Richardson J.A., Olson E.N. Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer. Development 1999, 126:75-84.
102. Lindsay E.A., Vitelli F., Su H., Morishima M., Huynh T., Pramparo T., Jurecic V., Ogunrinu G., et al. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature 2001, 410:97-101.
103. Lough J., Sugi Y. Endoderm and heart development. Dev. Dyn. 2000, 217:327-342.
104. Lu J., Izvolsky K.I., Qian J., Cardoso W.V. Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis. J. Biol. Chem. 2005, 280:4834-4841.
105. Macatee T.L., Hammond B.P., Arenkiel B.R., Francis L., Frank D.U., Moon A.M. Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development 2003, 130:6361-6374.
106. Macchia P.E., Lapi P., Krude H., Pirro M.T., Missero C., Chiovato L., Souabni A., Baserga M., et al. PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat. Genet. 1998, 19:83-86.
107. Maiorana R., Carta A., Floriddia G., Leonardi D., Buscema M., Sava L., Calaciura F., Vigneri R. Thyroid hemiagenesis: prevalence in normal children and effect on thyroid function. J. Clin. Endocrinol. Metab. 2003, 88:1534-1536.
108. Manley N.R., Capecchi M.R. The role of Hoxa-3 in mouse thymus and thyroid development. Development 1995, 121:1989-2003.
109. Manley N.R., Capecchi M.R. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev. Biol. 1998, 195:1-15.
110. Mansouri A., Chowdhury K., Gruss P. Follicular cells of the thyroid gland require Pax8 gene function. Nat. Genet. 1998, 19:87-90.
111. Martin A.C., Kaschube M., Wieschaus E.F. Pulsed contractions of an actin-myosin network drive apical constriction. Nature 2008.
112. Martinez Barbera J.P., Clements M., Thomas P., Rodriguez T., Meloy D., Kioussis D., Beddington R.S. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development 2000, 127:2433-2445.
113. Matsumoto K., Yoshitomi H., Rossant J., Zaret K.S. Liver organogenesis promoted by endothelial cells prior to vascular function. Science 2001, 294:559-563.
114. Medina-Martinez O., Brownell I., Amaya-Manzanares F., Hu Q., Behringer R.R., Jamrich M. Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol. Cell. Biol. 2005, 25:8854-8863.
115. Michael L., Davies J.A. Pattern and regulation of cell proliferation during murine ureteric bud development. J. Anat. 2004, 204:241-255.
116. Michael L., Sweeney D.E., Davies J.A. A role for microfilament-based contraction in branching morphogenesis of the ureteric bud. Kidney Int. 2005, 68:2010-2018.
117. Minoo P., Hamdan H., Bu D., Warburton D., Stepanik P., deLemos R. TTF-1 regulates lung epithelial morphogenesis. Dev. Biol. 1995, 172:694-698.
118. Mittag J., Winterhager E., Bauer K., Grummer R. Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy. Endocrinology 2007, 148:719-725.
119. Moore-Scott B.A., Manley N.R. Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs. Dev. Biol. 2005, 278:323-335.
120. Morreale de Escobar G. The role of thyroid hormone in fetal neurodevelopment. J. Pediatr. Endocrinol. Metab. 2001, 14(Suppl. 6):1453-1462.
121. Muratovska A., Zhou C., He S., Goodyer P., Eccles M.R. Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene 2003, 22:7989-7997.
122. Muzza M., Persani L., de Filippis T., Gastaldi R., Vigone M.C., Sala D., Weber G., Lorini R., et al. Absence of sonic hedgehog (Shh) germline mutations in patients with thyroid dysgenesis. Clin. Endocrinol. (Oxf.) 2008, 69:828-829.
123. Nakada C., Iida A., Tabata Y., Watanabe S. Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish. J. Exp. Zool. B: Mol. Dev. Evol. 2009.
124. Nogawa H., Morita K., Cardoso W.V. Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro. Dev. Dyn. 1998, 213:228-235.
125. O'Rahilly R. The timing and sequence of events in the development of the human endocrine system during the embryonic period proper. Anat. Embryol. (Berl.) 1983, 166:439-451.
126. Ogasawara M., Satou Y. Expression of FoxE and FoxQ genes in the endostyle of Ciona intestinalis. Dev. Genes Evol. 2003, 213:416-419.
127. Ohuchi H., Hori Y., Yamasaki M., Harada H., Sekine K., Kato S., Itoh N. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem. Biophys. Res. Commun. 2000, 277:643-649.
128. Olivieri A., Stazi M.A., Mastroiacovo P., Fazzini C., Medda E., Spagnolo A., De Angelis S., Grandolfo M.E., et al. A population-based study on the frequency of additional congenital malformations in infants with congenital hypothyroidism: data from the Italian Registry for Congenital Hypothyroidism (1991-1998). J. Clin. Endocrinol. Metab. 2002, 87:557-562.
129. Park S.M., Chatterjee V.K. Genetics of congenital hypothyroidism. J. Med. Genet. 2005, 42:379-389.
130. Park W.Y., Miranda B., Lebeche D., Hashimoto G., Cardoso W.V. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev. Biol. 1998, 201:125-134.
131. Parlato R., Rosica A., Rodriguez-Mallon A., Affuso A., Postiglione M.P., Arra C., Mansouri A., Kimura S., et al. An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev. Biol. 2004, 276:464-475.
132. Pearse A.G. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J. Histochem. Cytochem. 1969, 17:303-313.
133. Pearse A.G., Carvalheira A.F. Cytochemical evidence for an ultimobranchial origin of rodent thyroid C cells. Nature 1967, 214:929-930.
134. Pearse A.G., Polak J.M. Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas. Gut 1971, 12:783-788.
135. Pera E.M., Kessel M. Demarcation of ventral territories by the homeobox gene NKX2.1 during early chick development. Dev. Genes Evol. 1998, 208:168-171.
136. Perl A.K., Wert S.E., Nagy A., Lobe C.G., Whitsett J.A. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10482-10487.
137. Peters H., Neubuser A., Kratochwil K., Balling R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998, 12:2735-2747.
138. Petryk A., Anderson R.M., Jarcho M.P., Leaf I., Carlson C.S., Klingensmith J., Shawlot W., O'Connor M.B. The mammalian twisted gastrulation gene functions in foregut and craniofacial development. Dev. Biol. 2004, 267:374-386.
139. Plachov D., Chowdhury K., Walther C., Simon D., Guenet J.L., Gruss P. Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 1990, 110:643-651.
140. Pohlenz J., Dumitrescu A., Zundel D., Martine U., Schonberger W., Koo E., Weiss R.E., Cohen R.N., et al. Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice. J. Clin. Invest. 2002, 109:469-473.
141. Polak J.M., Pearse A.G., Le Lievre C., Fontaine J., Le Douarin N.M. Immunocytochemical confirmation of the neural crest origin of avian calcitonin-producing cells. Histochemistry 1974, 40:209-214.
142. Porazzi P., Calebiro D., Benato F., Tiso N., Persani L. Thyroid gland development and function in the zebrafish model. Mol. Cell. Endocrinol. 2009, 312:14-23.
143. Postiglione M.P., Parlato R., Rodriguez-Mallon A., Rosica A., Mithbaokar P., Maresca M., Marians R.C., Davies T.F., et al. Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:15462-15467.
144. Puppin C., D'Elia A.V., Pellizzari L., Russo D., Arturi F., Presta I., Filetti S., Bogue C.W., et al. Thyroid-specific transcription factors control Hex promoter activity. Nucleic Acids Res. 2003, 31:1845-1852.
145. Puppin C., Presta I., D'Elia A.V., Tell G., Arturi F., Russo D., Filetti S., Damante G. Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter. Mol. Cell. Endocrinol. 2004, 214:117-125.
146. Pyati U.J., Look A.T., Hammerschmidt M. Zebrafish as a powerful vertebrate model system for in vivo studies of cell death. Semin. Cancer Biol. 2007, 17:154-165.
147. Reifers F., Walsh E.C., Leger S., Stainier D.Y., Brand M. Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar). Development 2000, 127:225-235.
148. Reiter J.F., Kikuchi Y., Stainier D.Y. Multiple roles for Gata5 in zebrafish endoderm formation. Development 2001, 128:125-135.
149. Rohr K.B., Concha M.L. Expression of nk2.1a during early development of the thyroid gland in zebrafish. Mech. Dev. 2000, 95:267-270.
150. Romert P., Gauguin J. The early development of the median thyroid gland of the mouse. A light-, electron-microscopic and histochemical study. Z. Anat. Entwicklungsgesch. 1973, 139:319-336.
151. Rorth P. Collective guidance of collective cell migration. Trends Cell Biol. 2007, 17:575-579.
152. Rossi J.M., Dunn N.R., Hogan B.L., Zaret K.S. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev. 2001, 15:1998-2009.
153. Sakiyama J., Yamagishi A., Kuroiwa A. Tbx4-Fgf10 system controls lung bud formation during chicken embryonic development. Development 2003, 130:1225-1234.
154. Sala F.G., Curtis J.L., Veltmaat J.M., Del Moral P.M., Le L.T., Fairbanks T.J., Warburton D., Ford H., et al. Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev. Biol. 2006, 299:373-385.
155. Schultheiss T.M., Xydas S., Lassar A.B. Induction of avian cardiac myogenesis by anterior endoderm. Development 1995, 121:4203-4214.
156. Serls A.E., Doherty S., Parvatiyar P., Wells J.M., Deutsch G.H. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 2005, 132:35-47.
157. Shabana W., Delange F., Freson M., Osteaux M., De Schepper J. Prevalence of thyroid hemiagenesis: ultrasound screening in normal children. Eur. J. Pediatr. 2000, 159:456-458.
158. Shain W.G., Hilfer S.R., Fonte V.G. Early organogenesis of the embryonic chick thyroid. I. Morphology and biochemistry. Dev. Biol. 1972, 28:202-218.
159. Shiraishi T., Imai H., Fukutome K., Watanabe M., Yatani R. Ectopic thyroid in the adrenal gland. Hum. Pathol. 1999, 30:105-108.
160. Sinner D., Rankin S., Lee M., Zorn A.M. Sox17 and beta-catenin cooperate to regulate the transcription of endodermal genes. Development 2004, 131:3069-3080.
161. Smuts M.S., Hilfer S.R., Searls R.L. Patterns of cellular proliferation during thyroid organogenesis. J. Embryol. Exp. Morphol. 1978, 48:269-286.
162. Spagnoli F.M. From endoderm to pancreas: a multistep journey. Cell. Mol. Life Sci. 2007, 64:2378-2390.
163. Sprinzl G.M., Koebke J., Wimmers-Klick J., Eckel H.E., Thumfart W.F. Morphology of the human thyroglossal tract: a histologic and macroscopic study in infants and children. Ann. Otol. Rhinol. Laryngol. 2000, 109:1135-1139.
164. Stafford D., Prince V.E. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr. Biol. 2002, 12:1215-1220.
165. Stanger B.Z., Tanaka A.J., Melton D.A. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 2007, 445:886-891.
166. Strohschneider T., Timm D., Worbes C. Ectopic thyroid gland tissue in the liver. Chirurg 1993, 64:751-753.
167. Tam P.P., Kanai-Azuma M., Kanai Y. Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr. Opin. Genet. Dev. 2003, 13:393-400.
168. Tanaka H., Yanagisawa K., Shinjo K., Taguchi A., Maeno K., Tomida S., Shimada Y., Osada H., et al. Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res. 2007, 67:6007-6011.
169. Teillet M.A., Ziller C., Le Douarin N.M. Quail-chick chimeras. Methods Mol. Biol. 2008, 461:337-350.
170. Thomas P.Q., Brown A., Beddington R.S. Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 1998, 125:85-94.
171. Toublanc J.E. Comparison of epidemiological data on congenital hypothyroidism in Europe with those of other parts in the world. Horm. Res. 1992, 38:230-235.
172. Tourneux J.E., Verdun P. Sur les premièrs développements de la thyroide, du thymus et des glandules parathyroidennes chez l'hommes. J. Anat. 1897, 33:305-325.
173. Tremblay K.D., Zaret K.S. Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev. Biol. 2005, 280:87-99.
174. Waldo K.L., Kumiski D., Kirby M.L. Cardiac neural crest is essential for the persistence rather than the formation of an arch artery. Dev. Dyn. 1996, 205:281-292.
175. van den Brink G.R. Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol. Rev. 2007, 87:1343-1375.
176. Van Vliet G. Development of the thyroid gland: lessons from congenitally hypothyroid mice and men. Clin. Genet. 2003, 63:445-455.
177. Warga R.M., Nusslein-Volhard C. Origin and development of the zebrafish endoderm. Development 1999, 126:827-838.
178. Washington Smoak I., Byrd N.A., Abu-Issa R., Goddeeris M.M., Anderson R., Morris J., Yamamura K., Klingensmith J., et al. Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. Dev. Biol. 2005, 283:357-372.
179. Wells J.M., Melton D.A. Vertebrate endoderm development. Annu. Rev. Cell Dev. Biol. 1999, 15:393-410.
180. Wells J.M., Melton D.A. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 2000, 127:1563-1572.
181. Venditti M., Hay R.W., Kulaga A., Demetrick D.J. Diagnosis of ectopic tissue versus contamination by genetic fingerprinting in a routine surgical pathology specimen. Hum. Pathol. 2007, 38:378-382.
182. Wendl T., Adzic D., Schoenebeck J.J., Scholpp S., Brand M., Yelon D., Rohr K.B. Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development 2007, 134:2871-2879.
183. Wendl T., Lun K., Mione M., Favor J., Brand M., Wilson S.W., Rohr K.B. Pax2.1 is required for the development of thyroid follicles in zebrafish. Development 2002, 129:3751-3760.
184. Wessells N.K., Sponner B.S., Ash J.F., Bradley M.O., Luduena M.A., Taylor E.L., Wrenn J.T., Yamada K.M. Microfilaments in cellular and developmental processes. Science 1971, 171:135-143.
185. Westerlund J., Andersson L., Carlsson T., Zoppoli P., Fagman H., Nilsson M. Expression of Islet1 in thyroid development related to budding, migration, and fusion of primordia. Dev. Dyn. 2008, 237:3820-3829.
186. Wetzel B.K., Wollman S.H. Fine structure of a second kind of thyroid follicle in the C3H mouse. Endocrinology 1969, 84:563-578.
187. Wheelock M.J., Shintani Y., Maeda M., Fukumoto Y., Johnson K.R. Cadherin switching. J. Cell Sci. 2008, 121:727-735.
188. Williams R.J., Lindop G., Butler J. Ectopic thyroid tissue on the ascending aorta: an operative finding. Ann. Thorac. Surg. 2002, 73:1642-1643.
189. -/- mice are infertile despite adequate treatment with thyroid hormone. J. Endocrinol. 2007, 192:99-109.
190. Vitelli F., Taddei I., Morishima M., Meyers E.N., Lindsay E.A., Baldini A. A genetic link between Tbx1 and fibroblast growth factor signaling. Development 2002, 129:4605-4611.
191. Wurdak H., Ittner L.M., Sommer L. DiGeorge syndrome and pharyngeal apparatus development. Bioessays 2006, 28:1078-1086.
192. Xing Y., Li C., Hu L., Tiozzo C., Li M., Chai Y., Bellusci S., Anderson S., et al. Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten. Dev. Biol. 2008.
193. Xu P.X., Zheng W., Laclef C., Maire P., Maas R.L., Peters H., Xu X. Eya1 is required for the morphogenesis of mammalian thymus, parathyroid and thyroid. Development 2002, 129:3033-3044.
194. Yanagisawa H., Hammer R.E., Richardson J.A., Williams S.C., Clouthier D.E., Yanagisawa M. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J. Clin. Invest. 1998, 102:22-33.
195. Yoshitomi H., Zaret K.S. Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 2004, 131:807-817.
196. Yu J.K., Holland L.Z., Jamrich M., Blitz I.L., Hollan N.D. AmphiFoxE4, an amphioxus winged helix/forkhead gene encoding a protein closely related to vertebrate thyroid transcription factor-2: expression during pharyngeal development. Evol. Dev. 2002, 4:9-15.
197. Zannini M., Avantaggiato V., Biffali E., Arnone M.I., Sato K., Pischetola M., Taylor B.A., Phillips S.J., et al. TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J. 1997, 16:3185-3197.