Optimality in the zonation of ammonia detoxification in rodent liver

Archives of Toxicology

Volumn 89, Issue 11, 2015, Pages 2069-2078

  Bartl, Martin ^a,b,c   Pfaff, Michael ^b,d   Ghallab, Ahmed ^e,f   Driesch, Dominik ^b   Henkel, Sebastian G ^b   Hengstler, Jan G ^e   Schuster, Stefan ^a   Kaleta, Christoph ^a,g   Gebhardt, Rolf ^h   Zellmer, Sebastian ^h,i   Li, Pu ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b BIOCONTROL JENA GMBH   (Germany)

^c ILMENAU UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF APPLIED SCIENCES JENA   (Germany)

^e LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^f SOUTH VALLEY UNIVERSITY   (Egypt)

^g UNIVERSITY OF KIEL   (Germany)

^h UNIVERSITY OF LEIPZIG   (Germany)

ⁱ FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Ammonia metabolism; Glutamine synthetase; Liver zonation; Optimization; Systems biology

Indexed keywords

AMMONIA; CARBAMOYL PHOSPHATE SYNTHASE; CARBON TETRACHLORIDE; GLUTAMATE AMMONIA LIGASE; GLUTAMINASE; GLUTAMINE; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTOXICATION; LIVER; LIVER CELL; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; UREA CYCLE; ZONATION; ANIMAL; C57BL MOUSE; COMPUTER SIMULATION; DRUG INACTIVATION; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; VALIDATION STUDY;

AMMONIA; ANIMALS; CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA); COMPUTER SIMULATION; GLUTAMATE-AMMONIA LIGASE; GLUTAMINASE; GLUTAMINE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; INACTIVATION, METABOLIC; LIVER; MALE; MICE; MICE, INBRED C57BL; UREA;

EID: 84947617871     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1596-4     Document Type: Article

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