메뉴 건너뛰기




Volumn 60, Issue 6, 2014, Pages 2040-2051

Integrated metabolic spatial-temporal model for the prediction of ammonia detoxification during liver damage and regeneration

(13)  Schliess, Freimut a,h   Hoehme, Stefan b   Henkel, Sebastian G c   Ghallab, Ahmed d,i   Driesch, Dominik c   Böttger, Jan b   Guthke, Reinhard e   Pfaff, Michael c,j   Hengstler, Jan G d   Gebhardt, Rolf b   Häussinger, Dieter a   Drasdo, Dirk b,f,g   Zellmer, Sebastian b,k  

f INRIA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA;

EID: 84901262468     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27136     Document Type: Article
Times cited : (100)

References (28)
  • 1
    • 85080034819 scopus 로고    scopus 로고
    • Pathogenetic mechanisms of hepatic encephalopathy
    • Häussinger D, Schliess F. Pathogenetic mechanisms of hepatic encephalopathy. Gut 2008;57:1156-1165.
    • (2008) Gut , vol.57 , pp. 1156-1165
    • Häussinger, D.1    Schliess, F.2
  • 2
    • 0020617293 scopus 로고
    • Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver
    • Häussinger D. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur J Biochem 1983;133:269-275.
    • (1983) Eur J Biochem , vol.133 , pp. 269-275
    • Häussinger, D.1
  • 3
    • 0020699358 scopus 로고
    • Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture
    • Gebhardt R, Mecke D. Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J 1983;2:567-570.
    • (1983) EMBO J , vol.2 , pp. 567-570
    • Gebhardt, R.1    Mecke, D.2
  • 4
    • 17844375087 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat
    • Görg B, Wettstein M, Metzger S, Schliess F, Häussinger D. Lipopolysaccharide-induced tyrosine nitration and inactivation of hepatic glutamine synthetase in the rat. Hepatology 2005;41:1065-1073.
    • (2005) Hepatology , vol.41 , pp. 1065-1073
    • Görg, B.1    Wettstein, M.2    Metzger, S.3    Schliess, F.4    Häussinger, D.5
  • 5
    • 0021329772 scopus 로고
    • 4 induced liver cell necrosis with no effect on urea synthesis
    • 4 induced liver cell necrosis with no effect on urea synthesis. Chem Biol Interact 1984;48:191-194.
    • (1984) Chem Biol Interact , vol.48 , pp. 191-194
    • Häussinger, D.1    Gerok, W.2
  • 6
    • 0027055347 scopus 로고
    • Hepatocyte heterogeneity in the metabolism of amino acids and ammonia
    • Häussinger D, Lamers WH, Moorman AFM. Hepatocyte heterogeneity in the metabolism of amino acids and ammonia. Enzyme 1992;46:72-93.
    • (1992) Enzyme , vol.46 , pp. 72-93
    • Häussinger, D.1    Lamers, W.H.2    Moorman, A.F.M.3
  • 7
    • 33947139689 scopus 로고    scopus 로고
    • Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver
    • Gebhardt R, Baldysiak-Figiel A, Krügel V, Ueberham E, Gaunitz F. Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Prog Histochem Cytochem 2007;41:201-266.
    • (2007) Prog Histochem Cytochem , vol.41 , pp. 201-266
    • Gebhardt, R.1    Baldysiak-Figiel, A.2    Krügel, V.3    Ueberham, E.4    Gaunitz, F.5
  • 8
    • 0028051606 scopus 로고
    • Hepatic glutaminase mRNA is confined to part of the urea cycle domain in the adult rodent liver lobule
    • Moorman AFM, de Boer PAJ, Watford M, Dingemanse MA, Lamers WH. Hepatic glutaminase mRNA is confined to part of the urea cycle domain in the adult rodent liver lobule. FEBS Lett 1994;356:76-80.
    • (1994) FEBS Lett , vol.356 , pp. 76-80
    • Moorman, A.F.M.1    de Boer, P.A.J.2    Watford, M.3    Dingemanse, M.A.4    Lamers, W.H.5
  • 9
    • 34249792922 scopus 로고    scopus 로고
    • Glutamine metabolism and signaling in the liver
    • Häussinger D, Schliess F. Glutamine metabolism and signaling in the liver. Front Biosci 2007;12:371-391.
    • (2007) Front Biosci , vol.12 , pp. 371-391
    • Häussinger, D.1    Schliess, F.2
  • 10
    • 0023789866 scopus 로고
    • Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonemia in chronic liver disease
    • Kaiser S, Gerok W, Häussinger D. Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonemia in chronic liver disease. Eur J Clin Invest 1988;18:535-542.
    • (1988) Eur J Clin Invest , vol.18 , pp. 535-542
    • Kaiser, S.1    Gerok, W.2    Häussinger, D.3
  • 11
    • 20544461328 scopus 로고    scopus 로고
    • The pathophysiology of brain edema in acute liver failure
    • Blei AT. The pathophysiology of brain edema in acute liver failure. Neurochem Int 2005;47:71-77.
    • (2005) Neurochem Int , vol.47 , pp. 71-77
    • Blei, A.T.1
  • 12
    • 0017662002 scopus 로고
    • Simulation of urea cycle: correlation of effects due to inborn errors in catalytic properties of enzymes with clinical-biochemical observations
    • Kuchel PW, Roberts DV, Nichol LW. Simulation of urea cycle: correlation of effects due to inborn errors in catalytic properties of enzymes with clinical-biochemical observations. Immunol Cell Biol 1977;55:309-326.
    • (1977) Immunol Cell Biol , vol.55 , pp. 309-326
    • Kuchel, P.W.1    Roberts, D.V.2    Nichol, L.W.3
  • 13
    • 34249828147 scopus 로고    scopus 로고
    • Control of acid-base and ammonia homeostasis by the liver
    • Fellenz W, Häussinger D. Control of acid-base and ammonia homeostasis by the liver. WSEAS Transact Biol Biomed 2004;1:294-297.
    • (2004) WSEAS Transact Biol Biomed , vol.1 , pp. 294-297
    • Fellenz, W.1    Häussinger, D.2
  • 14
    • 77957786145 scopus 로고    scopus 로고
    • A cell-based simulation software for multi-cellular systems
    • Hoehme S, Drasdo D. A cell-based simulation software for multi-cellular systems. Bioinformatics 2010;26:2641-2642.
    • (2010) Bioinformatics , vol.26 , pp. 2641-2642
    • Hoehme, S.1    Drasdo, D.2
  • 15
    • 77953771023 scopus 로고    scopus 로고
    • Prediction and validation of cell alignment along micro-vessels as order principle to restore tissue architecture in liver regeneration
    • Hoehme S, Brulport M, Bauer A, Bedawy E, Schormann W, Hermes M, et al. Prediction and validation of cell alignment along micro-vessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci U S A 2010;107:10371-10376.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10371-10376
    • Hoehme, S.1    Brulport, M.2    Bauer, A.3    Bedawy, E.4    Schormann, W.5    Hermes, M.6
  • 17
    • 0030941434 scopus 로고    scopus 로고
    • Experimental methods in hepatology. Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion-technique and applications
    • vom Dahl S, Häussinger D. Experimental methods in hepatology. Guidelines of the German Association for the Study of the Liver (GASL). Liver perfusion-technique and applications. Z Gastroenterol 1997;35:221-226.
    • (1997) Z Gastroenterol , vol.35 , pp. 221-226
    • vom Dahl, S.1    Häussinger, D.2
  • 18
    • 33847295750 scopus 로고    scopus 로고
    • An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver
    • Gohla A, Klement K, Piekorz RP, Pexa K, vom Dahl S, Spicher K, et al. An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver. Proc Natl Acad Sci U S A 2007;104:3003-3008.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3003-3008
    • Gohla, A.1    Klement, K.2    Piekorz, R.P.3    Pexa, K.4    vom Dahl, S.5    Spicher, K.6
  • 19
    • 0013857328 scopus 로고
    • Control of the levels of free amino acids in plasma by the liver
    • Schimassek H, Gerok W. Control of the levels of free amino acids in plasma by the liver. Biochem Z 1965;343:407-415.
    • (1965) Biochem Z , vol.343 , pp. 407-415
    • Schimassek, H.1    Gerok, W.2
  • 20
    • 0021102455 scopus 로고
    • Characteristics of the activation of glutaminase by ammonia in sonicated rat liver mitochondria
    • McGivan JD, Bradford NM. Characteristics of the activation of glutaminase by ammonia in sonicated rat liver mitochondria. Biochim Biophys Acta 1983;759:296-302.
    • (1983) Biochim Biophys Acta , vol.759 , pp. 296-302
    • McGivan, J.D.1    Bradford, N.M.2
  • 21
    • 0021248977 scopus 로고
    • Partial purification and properties of rat liver glutaminase
    • Patel M, McGivan JD. Partial purification and properties of rat liver glutaminase. Biochem J 1984;220:583-590.
    • (1984) Biochem J , vol.220 , pp. 583-590
    • Patel, M.1    McGivan, J.D.2
  • 23
    • 58349118790 scopus 로고    scopus 로고
    • A hybrid multiscale model of solid tumor growth and invasion: evolution and the microenvironment
    • In: Anderson ARA, Chaplain MAJ, Rejniak KA, eds, Basel, Switzerland: Birkhäuser; :-.
    • Anderson ARA. A hybrid multiscale model of solid tumor growth and invasion: evolution and the microenvironment. In: Anderson ARA, Chaplain MAJ, Rejniak KA, eds. Single-Cell-Based Models in Biology and Medicine. Basel, Switzerland: Birkhäuser; 2007:3-28.
    • (2007) Single-Cell-Based Models in Biology and Medicine , pp. 3-28
    • Anderson, A.R.A.1
  • 24
    • 79960959491 scopus 로고    scopus 로고
    • Center-based single-cell models: an approach to multi-cellular organization based on a conceptual analogy to colloidal particles
    • In: Anderson ARA, Chaplain MAJ, Rejniak KA, eds, Basel, Switzerland: Birkhäuser; :-.
    • Drasdo D. Center-based single-cell models: an approach to multi-cellular organization based on a conceptual analogy to colloidal particles. In: Anderson ARA, Chaplain MAJ, Rejniak KA, eds. Single-Cell-Based Models in Biology and Medicine. Basel, Switzerland: Birkhäuser; 2007:171-196.
    • (2007) Single-Cell-Based Models in Biology and Medicine , pp. 171-196
    • Drasdo, D.1
  • 25
    • 26944481103 scopus 로고    scopus 로고
    • A single-cell-based model of tumor growth in vitro: monolayers and spheroids
    • Drasdo D, Hoehme S. A single-cell-based model of tumor growth in vitro: monolayers and spheroids. Phys Biol 2005;2:133-147.
    • (2005) Phys Biol , vol.2 , pp. 133-147
    • Drasdo, D.1    Hoehme, S.2
  • 26
    • 0033427390 scopus 로고    scopus 로고
    • Liver microvascular architecture: an insight into the pathophysiology of portal hypertension
    • Ekataksin W, Kaneda K. Liver microvascular architecture: an insight into the pathophysiology of portal hypertension. Semin Liver Dis 1999;19:359-382.
    • (1999) Semin Liver Dis , vol.19 , pp. 359-382
    • Ekataksin, W.1    Kaneda, K.2
  • 27
    • 0019003243 scopus 로고
    • Blood flow rate and cellular influx of glucose and arginine in mouse liver in vivo
    • Cornford EM, Braun LD, Pardridge WM, Oldendorf WH. Blood flow rate and cellular influx of glucose and arginine in mouse liver in vivo. Am J Physiol 1980;238:H553-H560.
    • (1980) Am J Physiol , vol.238 , pp. H553-H560
    • Cornford, E.M.1    Braun, L.D.2    Pardridge, W.M.3    Oldendorf, W.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.