Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 137-148

  Venkatasubbu, Gopinath Devanand ^a   Ramasamy, S ^b   Gaddam, Pramod Reddy ^c   Kumar, J ^b  

^a UNIVERSITY OF MADRAS   (India)

^b ANNA UNIVERSITY   (India)

^c Siddha Central Research Institute   (India)

Author keywords

Acute and subchronic toxicology; Biochemical analysis; Hematological analysis; Histopathology

Indexed keywords

ALKALINE PHOSPHATASE; FOLIC ACID; HYDROXYAPATITE; MACROGOL; PACLITAXEL; TITANIUM DIOXIDE NANOPARTICLE; NANOPARTICLE; POLYMER; TITANIUM; TITANIUM DIOXIDE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CHRONIC TOXICITY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG RESPONSE; DRUG SAFETY; FEMALE; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; ANIMAL; BLOOD ANALYSIS; CHEMISTRY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; PATHOLOGY;

ANIMALS; BLOOD CHEMICAL ANALYSIS; DRUG DELIVERY SYSTEMS; DURAPATITE; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; MALE; MICE; NANOPARTICLES; PACLITAXEL; POLYMERS; RATS; TITANIUM;

EID: 84947559780     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S79991     Document Type: Article

References (28)

1. Sekhon BS, Kamboj SR. Inorganic nanomedicine – part 2. Nanomedicine. 2010;6:612–618.
2. Park JH, Lee S, Kim JH, Park K, Kim K, Kwon IC. Polymeric nanomedicine for cancer therapy. Prog Polym Sci. 2008;33:113–137.
3. Cirstoiu-Hapca A, Buchegger F, Bossy L, Kosinski M, Gurny R, Delie F. Nanomedicines for active targeting: physico-chemical characterization of paclitaxel-loaded anti-HER2 immunonanoparticles and in vitro functional studies on target cells. Eur J Pharm Sci. 2009;38:230–237.
4. Kunzmann A, Andersson B, Thurnherr T, Krug H, Scheynius A, Fadeel B. Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation. Biochim Biophys Acta. 2011; 1810(3):361–373.
5. Devanand Venkatasubbu G, Ramasamy S, Avadhani GS, Palanikumar L, Kumar J. Size-mediated cytotoxicity of nanocrystalline titanium dioxide, pure and zinc-doped hydroxyapatite nanoparticles in human hepatoma cells. J Nanopart Res. 2012;14:819.
6. 4 nanoparticles for reduced non-specific uptake by macrophage cells. Adv Mater. 2007;19:3163–3166.
7. Park DL, Bae JW, Park KD, et al. Surface modification of polyurethane using sulfonated PEG grafted polyrotaxane for improved biocompatibility. Macromol Res. 2006;14:73–80.
8. Kim SY, Cho SH, Lee YM, Chu LY. Biotin-conjugated block copoly-meric nanoparticles as tumor-targeted drug delivery systems. Macromol Res. 2007;15:646–655.
9. Lee D, Singha K, Park J, Jo S, Kim WJ. Enhanced gene delivery by palmitic acid-conjugated low molecular weight polyethylenimine. Macromol Res. 2012;20:244–249.
10. Mamaghani MY, Pishvaei M, Kaffashi B. Synthesis of latex based antibacterial acrylate polymer/nanosilver via in situ miniemulsion polymerization. Macromol Res. 2011;19:243–249.
11. Mulder GJ, Dencker L, editors. Pharmaceutical Toxicology. London: Pharmaceutical Press; 2006.
12. Dandekar P, Dhumal R, Jain R, Tiwari D, Vanage G, Patravale V. Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies. Food Chem Toxicol. 2010;48: 2073–2089.
13. Olmedo DG, Tasat DR, Guglielmotti MB, Cabrini RL. Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: an experimental study in rats. J Biomed Mater Res A. 2005;73(2):142–149.
14. Syahmi AR, Vijayarathna S, Sasidharan S, et al. Acute oral toxicity and brine shrimp lethality of Elaeis guineensis Jacq., (oil palm leaf) methanol extract. Molecules. 2010;15:8111–8121.
15. Becker S. Nanotechnology in the marketplace: how the nanotechnology industry views risk. J Nanopart Res. 2013;15:1426.
16. Devanand Venkatasubbu G, Ramasamy S, Avadhani GS, Ramakrishnan V, Kumar J. Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. Powder Technol. 2013;235:437–442.
17. Devanand Venkatasubbu G, Ramasamy S, Ramakrishnan V, Kumar J. Folate targeted PEGylated titanium dioxide nanoparticles as a nanocarrier for targeted paclitaxel drug delivery. Adv Powder Technol. 2013; 24:947–954.
18. Venkatasubbu GD, Ramasamy S, Reddy GP, Kumar J. In vitro and in vivo anticancer activity of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles. Biomed Microdevices. 2013;15:711–726.
19. Rauckman EJ, Soiefer AI. Acute toxicology. In: Jacobson-Kram D, Keller KA, editors. Toxicological Testing Handbook: Principles, Applications and Data Interpretation. New York, NY: Informa Healthcare USA, Inc.,; 2006:135–146.
20. Ansah C, Oppong E, Woode E. Subacute oral toxicity assessment of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) extract in rats. Trop J Pharm Res. 2011;10:587–594.
21. Taniyama K, Fujiwara H, Kuno T, et al. Acute and subacute toxicity of 10B-paraboronophenylalanine. Pigment Cell Res. 1989;2:291–296.
22. Limpeanchob N, Tiyaboonchai W, Lamlertthon S, Viyoch J, Jaipan S. Efficacy and toxicity of amphotericin B-chitosan nanoparticles in mice with induced systemic candidiasis. Naresuan University Journal. 2006;14:27–34.
23. 2 particles. Biol Trace Elem Res. 2009;129: 170–180.
24. 2 to mice: liver injury, oxidative stress. Toxicol Environ Chem. 2010; 92:175–186.
25. Wang J, Zhou G, Chen C, et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett. 2007;168:176–185.
26. International Programme on Chemical Safety (IPCS). Environmental Health Criteria 24: Titanium. Geneva: World Health Organization (WHO); 1982.
27. Keller KA, Banks C. Multidose general toxicology studies. In: Jacobson- Kram D, Keller KA, editors. Toxicological Testing Handbook: Principles, Applications and Data Interpretation. New York, NY: Informa Healthcare USA, Inc.; 2006:149–181.
28. Duan Y, Liu J, Ma L, et al. Toxicological characteristics of nano-particulate anatase titanium dioxide in mice. Biomaterials. 2010;31: 894–899.