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Volumn 7, Issue 9, 2015, Pages 957-966

Targeting IL-17 with ixekizumab in patients with psoriasis

Author keywords

IL 17A; IL 17F; IL 22; ixekizumab; psoriasis

Indexed keywords

IMMUNOGLOBULIN G4; INTERLEUKIN 17; INTERLEUKIN 17F; IXEKIZUMAB; MONOCLONAL ANTIBODY;

EID: 84947554133     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.15.63     Document Type: Article
Times cited : (9)

References (53)
  • 1
    • 84872620069 scopus 로고    scopus 로고
    • Global epidemiology of psoriasis: A systematic review of incidence and prevalence
    • Parisi R, Symmons DPM, Griffiths CEM, Ashcroft DM. Global epidemiology of psoriasis: A systematic review of incidence and prevalence. J. Invest. Dermatol. 133(2), 377-385 (2013).
    • (2013) J. Invest. Dermatol. , vol.133 , Issue.2 , pp. 377-385
    • Parisi, R.1    Symmons, D.P.M.2    Griffiths, C.E.M.3    Ashcroft, D.M.4
  • 2
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine functional properties
    • Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 3
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150(12), 5445-5456 (1993).
    • (1993) J. Immunol. , vol.150 , Issue.12 , pp. 5445-5456
    • Rouvier, E.1    Luciani, M.F.2    Mattéi, M.G.3    Denizot, F.4    Golstein, P.5
  • 4
    • 80053600391 scopus 로고    scopus 로고
    • Recent advances in the IL-17 cytokine family
    • Gaffen SL. Recent advances in the IL-17 cytokine family. Curr. Opin. Immunol. 23(5), 613-619 (2011).
    • (2011) Curr. Opin. Immunol. , vol.23 , Issue.5 , pp. 613-619
    • Gaffen, S.L.1
  • 5
    • 0028858556 scopus 로고
    • Human IL-17: A novel cytokine derived from T cells
    • Yao Z, Painter SL, Fanslow WC et al. Human IL-17: A novel cytokine derived from T cells. J. Immunol. 155, 5483-5486 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 5483-5486
    • Yao, Z.1    Painter, S.L.2    Fanslow, W.C.3
  • 6
    • 15844402155 scopus 로고    scopus 로고
    • T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
    • Fossiez F, Djossou O, Chomarat P et al. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183(6), 2593-2603 (1996).
    • (1996) J. Exp. Med. , vol.183 , Issue.6 , pp. 2593-2603
    • Fossiez, F.1    Djossou, O.2    Chomarat, P.3
  • 7
    • 78649666553 scopus 로고    scopus 로고
    • Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis
    • Res PCM, Piskin G, de Boer OJ et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS ONE 5(11), e14108 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.11 , pp. e14108
    • Res, P.C.M.1    Piskin, G.2    De Boer, O.J.3
  • 8
    • 80755180843 scopus 로고    scopus 로고
    • Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation
    • Cai Y, Shen X, Ding C et al. Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity 35(4), 596-610 (2011).
    • (2011) Immunity , vol.35 , Issue.4 , pp. 596-610
    • Cai, Y.1    Shen, X.2    Ding, C.3
  • 9
    • 84922507921 scopus 로고    scopus 로고
    • Innate lymphoid cells in the skin
    • Kim BS. Innate lymphoid cells in the skin. J. Invest. Dermatol. 135(3), 673-678 (2014).
    • (2014) J. Invest. Dermatol. , vol.135 , Issue.3 , pp. 673-678
    • Kim, B.S.1
  • 10
    • 33745297345 scopus 로고    scopus 로고
    • Cutting edge: Interleukin 17 signals through a heteromeric receptor complex
    • Toy D, Kugler D, Wolfson M et al. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J. Immunol. 177(1), 36-39 (2006).
    • (2006) J. Immunol. , vol.177 , Issue.1 , pp. 36-39
    • Toy, D.1    Kugler, D.2    Wolfson, M.3
  • 11
    • 0031282513 scopus 로고    scopus 로고
    • Molecular characterization of the human interleukin (IL)-17 receptor
    • Yao Z, Spriggs MK, Derry JM et al. Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9(11), 794-800 (1997).
    • (1997) Cytokine , vol.9 , Issue.11 , pp. 794-800
    • Yao, Z.1    Spriggs, M.K.2    Derry, J.M.3
  • 12
    • 70449718758 scopus 로고    scopus 로고
    • Structural basis of receptor sharing by interleukin 17 cytokines
    • Ely LK, Fischer S, Garcia KC. Structural basis of receptor sharing by interleukin 17 cytokines. Nat. Immunol. 10(12), 1245-1251 (2009).
    • (2009) Nat. Immunol. , vol.10 , Issue.12 , pp. 1245-1251
    • Ely, L.K.1    Fischer, S.2    Garcia, K.C.3
  • 13
    • 67649835097 scopus 로고    scopus 로고
    • Expression of interleukin-17RC protein in normal human tissues
    • Ge D, You Z. Expression of interleukin-17RC protein in normal human tissues. Int. Arch. Med. 1(1), 19 (2008).
    • (2008) Int. Arch. Med. , vol.1 , Issue.1 , pp. 19
    • Ge, D.1    You, Z.2
  • 14
    • 38949194566 scopus 로고    scopus 로고
    • Structure-function relationships in the IL-17 receptor: Implications for signal transduction and therapy
    • Shen F, Gaffen SL. Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy. Cytokine 41(2), 92-104 (2008).
    • (2008) Cytokine , vol.41 , Issue.2 , pp. 92-104
    • Shen, F.1    Gaffen, S.L.2
  • 16
    • 0031691282 scopus 로고    scopus 로고
    • Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes
    • Teunissen MBM, Koomen CW, de Waal Malefyt R, Wierenga EA, Bos JD. Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111(4), 645-649 (1998).
    • (1998) J. Invest. Dermatol. , vol.111 , Issue.4 , pp. 645-649
    • Teunissen, M.B.M.1    Koomen, C.W.2    De Waal Malefyt, R.3    Wierenga, E.A.4    Bos, J.D.5
  • 17
    • 58849143880 scopus 로고    scopus 로고
    • IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes
    • Peric M, Koglin S, Kim S-M et al. IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes. J. Immunol. 181(12), 8504-8512 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.12 , pp. 8504-8512
    • Peric, M.1    Koglin, S.2    Kim, S.-M.3
  • 18
    • 54249130813 scopus 로고    scopus 로고
    • Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways
    • Nograles KE, Zaba LC, Guttman-Yassky E et al. Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br. J. Dermatol. 159(5), 1092-1102 (2008).
    • (2008) Br. J. Dermatol. , vol.159 , Issue.5 , pp. 1092-1102
    • Nograles, K.E.1    Zaba, L.C.2    Guttman-Yassky, E.3
  • 19
    • 84857511355 scopus 로고    scopus 로고
    • IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway
    • Cho K-A, Suh JW, Lee KH, Kang JL, Woo S-Y. IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway. Int. Immunol. 24(3), 147-158 (2012).
    • (2012) Int. Immunol. , vol.24 , Issue.3 , pp. 147-158
    • Cho, K.-A.1    Suh, J.W.2    Lee, K.H.3    Kang, J.L.4    Woo, S.-Y.5
  • 20
    • 84900862778 scopus 로고    scopus 로고
    • Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis
    • Kim T-G, Jee H, Fuentes-Duculan J et al. Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis. J. Invest. Dermatol. 134(5), 1462-1465 (2014).
    • (2014) J. Invest. Dermatol. , vol.134 , Issue.5 , pp. 1462-1465
    • Kim, T.-G.1    Jee, H.2    Fuentes-Duculan, J.3
  • 22
    • 84874256199 scopus 로고    scopus 로고
    • Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation
    • Johnston A, Fritz Y, Dawes SM et al. Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation. J. Immunol. 190(5), 2252-2262 (2013).
    • (2013) J. Immunol. , vol.190 , Issue.5 , pp. 2252-2262
    • Johnston, A.1    Fritz, Y.2    Dawes, S.M.3
  • 23
    • 0347285359 scopus 로고    scopus 로고
    • Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris
    • Lee E, Trepicchio WL, Oestreicher JL et al. Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris. J. Exp. Med. 199(1), 125-130 (2004).
    • (2004) J. Exp. Med. , vol.199 , Issue.1 , pp. 125-130
    • Lee, E.1    Trepicchio, W.L.2    Oestreicher, J.L.3
  • 24
    • 33749151636 scopus 로고    scopus 로고
    • An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis
    • Toichi E, Torres G, McCormick TS et al. An anti-IL-12p40 antibody down-regulates type 1 cytokines, chemokines, and IL-12/IL-23 in psoriasis. J. Immunol. 177(7), 4917-4926 (2006).
    • (2006) J. Immunol. , vol.177 , Issue.7 , pp. 4917-4926
    • Toichi, E.1    Torres, G.2    McCormick, T.S.3
  • 25
    • 74249094930 scopus 로고    scopus 로고
    • Comparison of ustekinumab and etanercept for moderate-tosevere psoriasis
    • Griffiths CEM, Strober BE, van de Kerkhof P et al. Comparison of ustekinumab and etanercept for moderate-tosevere psoriasis. N. Engl. J. Med. 362(2), 118-128 (2010).
    • (2010) N. Engl. J. Med. , vol.362 , Issue.2 , pp. 118-128
    • Griffiths, C.E.M.1    Strober, B.E.2    Van De Kerkhof, P.3
  • 27
    • 85027922751 scopus 로고    scopus 로고
    • Population exposure-response model to support dosing evaluation of ixekizumab in patients with chronic plaque psoriasis
    • Tham L-S, Tang C-C, Choi S-L, Satterwhite JH, Cameron GS, Banerjee S. Population exposure-response model to support dosing evaluation of ixekizumab in patients with chronic plaque psoriasis. J. Clin. Pharmacol. 54(10), 1117-1124 (2014).
    • (2014) J. Clin. Pharmacol. , vol.54 , Issue.10 , pp. 1117-1124
    • Tham, L.-S.1    Tang, C.-C.2    Choi, S.-L.3    Satterwhite, J.H.4    Cameron, G.S.5    Banerjee, S.6
  • 28
    • 84903478179 scopus 로고    scopus 로고
    • A Phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors
    • Genovese MC, Greenwald M, Cho C-S et al. A Phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors. Arthritis Rheumatol. 66(7), 1693-1704 (2014).
    • (2014) Arthritis Rheumatol. , vol.66 , Issue.7 , pp. 1693-1704
    • Genovese, M.C.1    Greenwald, M.2    Cho, C.-S.3
  • 29
    • 84862860846 scopus 로고    scopus 로고
    • IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis
    • e9
    • Krueger JG, Fretzin S, Suárez-Fariñas M et al. IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis. J. Allergy Clin. Immunol. 130(1), 145-154; e9 (2012).
    • (2012) J. Allergy Clin. Immunol. , vol.130 , Issue.1 , pp. 145-154
    • Krueger, J.G.1    Fretzin, S.2    Suárez-Fariñas, M.3
  • 30
    • 84859073115 scopus 로고    scopus 로고
    • Antiinterleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C, Matheson R, Zachariae C et al. Antiinterleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N. Engl. J. Med. 366(13), 1190-1199 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.13 , pp. 1190-1199
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3
  • 31
    • 84919783193 scopus 로고    scopus 로고
    • A 52-week, open-label study of the efficacy and safety of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with chronic plaque psoriasis
    • Gordon KB, Leonardi CL, Lebwohl M et al. A 52-week, open-label study of the efficacy and safety of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with chronic plaque psoriasis. J. Am. Acad. Dermatol. 71(6), 1176-1182 (2014).
    • (2014) J. Am. Acad. Dermatol. , vol.71 , Issue.6 , pp. 1176-1182
    • Gordon, K.B.1    Leonardi, C.L.2    Lebwohl, M.3
  • 32
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A Phase i randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese MC, Van den Bosch F, Roberson SA et al. LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A Phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheumatol. 62(4), 929-939 (2010).
    • (2010) Arthritis Rheumatol. , vol.62 , Issue.4 , pp. 929-939
    • Genovese, M.C.1    Van Den Bosch, F.2    Roberson, S.A.3
  • 33
    • 84894251636 scopus 로고    scopus 로고
    • Antidrug antibodies in psoriasis: A systematic review
    • Hsu L, Snodgrass BT, Armstrong AW. Antidrug antibodies in psoriasis: A systematic review. Br. J. Dermatol. 170, 261-273 (2014).
    • (2014) Br. J. Dermatol. , vol.170 , pp. 261-273
    • Hsu, L.1    Snodgrass, B.T.2    Armstrong, A.W.3
  • 34
    • 84865011015 scopus 로고    scopus 로고
    • The role of IgG4 in cutaneous pathology
    • Fernandez-Flores a. The role of IgG4 in cutaneous pathology. Rom. J. Morphol. Embryol. 53(2), 221-231 (2012).
    • (2012) Rom. J. Morphol. Embryol. , vol.53 , Issue.2 , pp. 221-231
    • Fernandez-Flores, A.1
  • 37
    • 71749085498 scopus 로고    scopus 로고
    • Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes
    • Zaba LC, Suárez-Fariñas M, Fuentes-Duculan J et al. Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes. J. Allergy Clin. Immunol. 124(5), 1022-1030.e395 (2009).
    • (2009) J. Allergy Clin. Immunol. , vol.124 , Issue.5 , pp. 1022e395-1030e395
    • Zaba, L.C.1    Suárez-Fariñas, M.2    Fuentes-Duculan, J.3
  • 38
    • 84940438565 scopus 로고    scopus 로고
    • Improvement of scalp and nail lesions with ixekizumab in a Phase 2 trial in patients with chronic plaque psoriasis
    • Epub ahead of print
    • Langley RG, Rich P, Menter A et al. Improvement of scalp and nail lesions with ixekizumab in a Phase 2 trial in patients with chronic plaque psoriasis. J. Eur. Acad. Dermatol. Venereol. doi:10.1111/jdv.12996 (2015) (Epub ahead of print).
    • (2015) J. Eur. Acad. Dermatol. Venereol.
    • Langley, R.G.1    Rich, P.2    Menter, A.3
  • 39
    • 84929630475 scopus 로고    scopus 로고
    • Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis
    • Saeki H, Nakagawa H, Ishii T et al. Efficacy and safety of open-label ixekizumab treatment in Japanese patients with moderate-to-severe plaque psoriasis, erythrodermic psoriasis and generalized pustular psoriasis. J. Eur. Acad. Dermatol. Venereol. 29(6), 1148-1155 (2015).
    • (2015) J. Eur. Acad. Dermatol. Venereol. , vol.29 , Issue.6 , pp. 1148-1155
    • Saeki, H.1    Nakagawa, H.2    Ishii, T.3
  • 40
    • 84945472756 scopus 로고    scopus 로고
    • Clinical efficacy and safety of anti-IL-17 agents for the treatment of patients with psoriasis
    • Chen Y, Qian T, Zhang D, Yan H, Hao F. Clinical efficacy and safety of anti-IL-17 agents for the treatment of patients with psoriasis. Immunotherapy 9, 1-15 (2015).
    • (2015) Immunotherapy , vol.9 , pp. 1-15
    • Chen, Y.1    Qian, T.2    Zhang, D.3    Yan, H.4    Hao, F.5
  • 41
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp KA, Leonardi C, Menter A et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N. Engl. J. Med. 366(13), 1181-1189 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , Issue.13 , pp. 1181-1189
    • Papp, K.A.1    Leonardi, C.2    Menter, A.3
  • 42
    • 84873124241 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderateto-severe plaque psoriasis: A randomized, double-blind, placebo-controlled Phase II dose-ranging study
    • Papp KA, Langley RG, Sigurgeirsson B et al. Efficacy and safety of secukinumab in the treatment of moderateto-severe plaque psoriasis: A randomized, double-blind, placebo-controlled Phase II dose-ranging study. Br. J. Dermatol. 168(2), 412-421 (2013).
    • (2013) Br. J. Dermatol. , vol.168 , Issue.2 , pp. 412-421
    • Papp, K.A.1    Langley, R.G.2    Sigurgeirsson, B.3
  • 43
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    • Aujla SJ, Chan YR, Zheng M et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat. Med. 14(3), 275-281 (2008).
    • (2008) Nat. Med. , vol.14 , Issue.3 , pp. 275-281
    • Aujla, S.J.1    Chan, Y.R.2    Zheng, M.3
  • 44
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye P, Rodriguez FH, Kanaly S et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194(4), 519-528 (2001).
    • (2001) J. Exp. Med. , vol.194 , Issue.4 , pp. 519-528
    • Ye, P.1    Rodriguez, F.H.2    Kanaly, S.3
  • 45
    • 58149231532 scopus 로고    scopus 로고
    • Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses
    • Ishigame H, Kakuta S, Nagai T et al. Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30(1), 108-119 (2009).
    • (2009) Immunity , vol.30 , Issue.1 , pp. 108-119
    • Ishigame, H.1    Kakuta, S.2    Nagai, T.3
  • 46
    • 79953284685 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    • Puel A, Cypowyj S, Bustamante J et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 332(6025), 65-68 (2011).
    • (2011) Science , vol.332 , Issue.6025 , pp. 65-68
    • Puel, A.1    Cypowyj, S.2    Bustamante, J.3
  • 47
    • 84885865938 scopus 로고    scopus 로고
    • An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis
    • Boisson B, Wang C, Pedergnana V et al. An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. Immunity 39(4), 676-686 (2013).
    • (2013) Immunity , vol.39 , Issue.4 , pp. 676-686
    • Boisson, B.1    Wang, C.2    Pedergnana, V.3
  • 48
    • 84925226246 scopus 로고    scopus 로고
    • Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment
    • Papp K, Leonardi C, Menter A et al. Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment. J. Am. Acad. Dermatol. 71(6), 1183-1190.e3 (2014).
    • (2014) J. Am. Acad. Dermatol. , vol.71 , Issue.6 , pp. 1183e3-1190e3
    • Papp, K.1    Leonardi, C.2    Menter, A.3
  • 51
    • 84925430776 scopus 로고    scopus 로고
    • PASI90 response: The new standard in therapeutic efficacy for psoriasis
    • Puig L. PASI90 response: The new standard in therapeutic efficacy for psoriasis. J. Eur. Acad. Dermatol. Venereol. 29(4), 645-648 (2015).
    • (2015) J. Eur. Acad. Dermatol. Venereol. , vol.29 , Issue.4 , pp. 645-648
    • Puig, L.1
  • 52
    • 84929899736 scopus 로고    scopus 로고
    • Brodalumab-an IL-17RA monoclonal antibody for psoriasis and psoriatic arthritis
    • Bauer E, Lucier J, Furst DE. Brodalumab-an IL-17RA monoclonal antibody for psoriasis and psoriatic arthritis. Expert Opin. Biol. Ther. 15(6), 883-893 (2015).
    • (2015) Expert Opin. Biol. Ther. , vol.15 , Issue.6 , pp. 883-893
    • Bauer, E.1    Lucier, J.2    Furst, D.E.3
  • 53
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W, Sands BE, Lewitzky S et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61(12), 1693-1700 (2012).
    • (2012) Gut , vol.61 , Issue.12 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3


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