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Volumn 14, Issue 11, 2015, Pages 1749-1758

Hydroxyurea therapy for sickle cell anemia

Author keywords

fetal hemoglobin; hemoglobinopathies; hydroxyurea; sickle cell anemia

Indexed keywords

ALANINE AMINOTRANSFERASE; CREATININE; HYDROXYUREA; ANTISICKLING AGENT;

EID: 84947494332     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2015.1088827     Document Type: Review
Times cited : (179)

References (71)
  • 1
    • 77949482609 scopus 로고    scopus 로고
    • Population estimates of sickle cell disease in the U. S
    • Hassell KL. Population Estimates of Sickle Cell Disease in the U.S. Am J Prev Med 2010;38(4):S512-21
    • (2010) Am J Prev Med , vol.38 , Issue.4 , pp. S512-S521
    • Hassell, K.L.1
  • 2
    • 84881220584 scopus 로고    scopus 로고
    • Global burden of sickle cell anaemia in children under five, 2010-2050: Modelling based on demographics, excess mortality, and interventions
    • Piel FB, Hay SI, Gupta S, et al. Global Burden of Sickle Cell Anaemia in Children under Five, 2010-2050: Modelling Based on Demographics, Excess Mortality, and Interventions. PLoS Med 2013;10(7):e1001484
    • (2013) PLoS Med , vol.10 , Issue.7 , pp. e1001484
    • Piel, F.B.1    Hay, S.I.2    Gupta, S.3
  • 3
    • 77951712618 scopus 로고    scopus 로고
    • Improved survival of children and adolescents with sickle cell disease
    • Quinn CT, Rogers ZR, McCavit TL, Buchanan GR. Improved survival of children and adolescents with sickle cell disease. Blood 2010;115(17):3447-52
    • (2010) Blood , vol.115 , Issue.17 , pp. 3447-3452
    • Quinn, C.T.1    Rogers, Z.R.2    McCavit, T.L.3    Buchanan, G.R.4
  • 4
    • 34548753905 scopus 로고    scopus 로고
    • Clinical outcomes in children with sickle cell disease living in England: A neonatal cohort in East London
    • Telfer P, Coen P, Chakravorty S, et al. Clinical outcomes in children with sickle cell disease living in England: A neonatal cohort in East London. Haematologica 2007;92(7):905-12
    • (2007) Haematologica , vol.92 , Issue.7 , pp. 905-912
    • Telfer, P.1    Coen, P.2    Chakravorty, S.3
  • 5
    • 84903385956 scopus 로고    scopus 로고
    • Sickle cell anemia: An underappreciated and unaddressed contributor to global childhood mortality
    • McGann PT. Sickle cell anemia: an underappreciated and unaddressed contributor to global childhood mortality. J Pediatr 2014;165(1):18-22
    • (2014) J Pediatr , vol.165 , Issue.1 , pp. 18-22
    • McGann, P.T.1
  • 6
    • 81355163446 scopus 로고    scopus 로고
    • Sickle cell disease in Africa: A neglected cause of early childhood mortality
    • Grosse SD, Odame I, Atrash HK, et al. Sickle cell disease in Africa: A neglected cause of early childhood mortality. Am J Prev Med 2011;41(6 Suppl 4):S398-405
    • (2011) Am J Prev Med , vol.41 , Issue.6 , pp. S398-405
    • Grosse, S.D.1    Odame, I.2    Atrash, H.K.3
  • 7
    • 0021330872 scopus 로고
    • Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea
    • Letvin NL, Linch DC, Beardsley GP, et al. Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by Hydroxyurea. N Engl J Med 1984;310(14):869-73
    • (1984) N Engl J Med , vol.310 , Issue.14 , pp. 869-873
    • Letvin, N.L.1    Linch, D.C.2    Beardsley, G.P.3
  • 8
    • 0021286875 scopus 로고
    • Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia
    • Platt OS, Orkin SH, Dover G, et al. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest 1984;74:652-6
    • (1984) J Clin Invest , vol.74 , pp. 652-656
    • Platt, O.S.1    Orkin, S.H.2    Dover, G.3
  • 9
    • 0026631318 scopus 로고
    • Hydroxyurea: Effects on hemoglobin F production in patients with sickle cell anemia
    • Charache S, Dover GJ, Moore RD, et al. Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. Blood 1992;79(10):2255-65
    • (1992) Blood , vol.79 , Issue.10 , pp. 2255-2265
    • Charache, S.1    Dover, G.J.2    Moore, R.D.3
  • 10
    • 84907016412 scopus 로고    scopus 로고
    • Management of sickle cell disease: Summary of the 2014 evidence-based report by expert panel members
    • Yawn BP, Buchanan GR, Afenyi-Annan AN, et al. Management of Sickle Cell Disease: Summary of the 2014 Evidence-Based Report by Expert Panel Members. JAMA 2014;312(10):1033-48
    • (2014) JAMA , vol.312 , Issue.10 , pp. 1033-1048
    • Yawn, B.P.1    Buchanan, G.R.2    Afenyi-Annan, A.N.3
  • 11
    • 79955909191 scopus 로고    scopus 로고
    • Hydroxycarbamide in very young children with sickle-cell anaemia: A multicentre, randomised, controlled trial (BABY HUG)
    • Wang WC, Ware RE, Miller ST, et al. Hydroxycarbamide in very young children with sickle-cell anaemia: A multicentre, randomised, controlled trial (BABY HUG). Lancet 2011;377(9778):1663-72
    • (2011) Lancet , vol.377 , Issue.9778 , pp. 1663-1672
    • Wang, W.C.1    Ware, R.E.2    Miller, S.T.3
  • 12
    • 0029025475 scopus 로고
    • Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia
    • Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Engl J Med 1995;332(20):1317-22
    • (1995) N Engl J Med , vol.332 , Issue.20 , pp. 1317-1322
    • Charache, S.1    Terrin, M.L.2    Moore, R.D.3
  • 13
    • 0037414164 scopus 로고    scopus 로고
    • Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: Risks and benefits up to 9 years of treatment
    • Steinberg MH, Barton F, Castro O, et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. JAMA 2003;289(13):1645-51
    • (2003) JAMA , vol.289 , Issue.13 , pp. 1645-1651
    • Steinberg, M.H.1    Barton, F.2    Castro, O.3
  • 14
    • 13044277572 scopus 로고    scopus 로고
    • Safety of Hydroxyurea in Children with Sickle Cell Anemia: Results of the HUG-KIDS Study, a Phase I/II Trial
    • Kinney TR, Helms RW, O'Branski EE, et al. Safety of Hydroxyurea in Children With Sickle Cell Anemia: Results of the HUG-KIDS Study, a Phase I/II Trial. Blood 1999;94(5):1550-4
    • (1999) Blood , vol.94 , Issue.5 , pp. 1550-1554
    • Kinney, T.R.1    Helms, R.W.2    O'Branski, E.E.3
  • 15
    • 37549007933 scopus 로고    scopus 로고
    • Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea
    • Hankins JS, Helton KJ, McCarville MB, et al. Preservation of spleen and brain function in children with sickle cell anemia treated with hydroxyurea. Pediatr Blood Cancer 2008;50(2):293-7
    • (2008) Pediatr Blood Cancer , vol.50 , Issue.2 , pp. 293-297
    • Hankins, J.S.1    Helton, K.J.2    McCarville, M.B.3
  • 16
    • 0035666461 scopus 로고    scopus 로고
    • A two-year pilot trial of hydroxyurea in very young children with sickle-cell anemia
    • Wang WC, Wynn LW, Rogers ZR, et al. A two-year pilot trial of hydroxyurea in very young children with sickle-cell anemia. J Pediatr 2001;139(6):790-6
    • (2001) J Pediatr , vol.139 , Issue.6 , pp. 790-796
    • Wang, W.C.1    Wynn, L.W.2    Rogers, Z.R.3
  • 17
    • 1542373662 scopus 로고    scopus 로고
    • Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease
    • Zimmerman SA, Schultz WH, Davis JS, et al. Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease. Blood 2004;103(6):2039-45
    • (2004) Blood , vol.103 , Issue.6 , pp. 2039-2045
    • Zimmerman, S.A.1    Schultz, W.H.2    Davis, J.S.3
  • 18
    • 84978198317 scopus 로고    scopus 로고
    • Higher fetal hemoglobin following escalation of hydroxyurea to maximum tolerated dose provides clinical benefit to children with sickle cell anemia
    • ASH Annual Meeting Abstract
    • Estepp JH, Smeltzer MP, Kang G, et al. Higher Fetal Hemoglobin Following Escalation of Hydroxyurea to Maximum Tolerated Dose Provides Clinical Benefit to Children with Sickle Cell Anemia. Blood 2014;124(21); ASH Annual Meeting Abstract
    • (2014) Blood , vol.124 , Issue.21
    • Estepp, J.H.1    Smeltzer, M.P.2    Kang, G.3
  • 19
    • 27144448031 scopus 로고    scopus 로고
    • Long-term hydroxyurea therapy for infants with sickle cell anemia: The HUSOFT extension study
    • Hankins JS, Ware RE, Rogers ZR, et al. Long-term hydroxyurea therapy for infants with sickle cell anemia: The HUSOFT extension study. Blood 2005;106(7):2269-75
    • (2005) Blood , vol.106 , Issue.7 , pp. 2269-2275
    • Hankins, J.S.1    Ware, R.E.2    Rogers, Z.R.3
  • 20
    • 84878516824 scopus 로고    scopus 로고
    • The effect of hydroxcarbamide therapy on survival of children with sickle cell disease
    • Lopes de Castro Lobo C, Pinto JFC, Nascimento EM, et al. The effect of hydroxcarbamide therapy on survival of children with sickle cell disease. Br J Haematol 2013;161(6):852-60
    • (2013) Br J Haematol , vol.161 , Issue.6 , pp. 852-860
    • De Castro Lobo, L.C.1    Pinto, J.F.C.2    Nascimento, E.M.3
  • 21
    • 77950622293 scopus 로고    scopus 로고
    • The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: Results of a 17-year, single-center trial (LaSHS)
    • Voskaridou E, Christoulas D, Bilalis A, et al. The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). Blood 2010;115(12):2354-63
    • (2010) Blood , vol.115 , Issue.12 , pp. 2354-2363
    • Voskaridou, E.1    Christoulas, D.2    Bilalis, A.3
  • 22
    • 77953057530 scopus 로고    scopus 로고
    • The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17. 5 year follow-up
    • Steinberg MH, McCarthy WF, Castro O, et al. The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up. Am J Hematol 2010;85(6):403-8
    • (2010) Am J Hematol , vol.85 , Issue.6 , pp. 403-408
    • Steinberg, M.H.1    McCarthy, W.F.2    Castro, O.3
  • 23
    • 84942162711 scopus 로고    scopus 로고
    • Survival among children and adults with sickle cell disease in Belgium: Benefit from hydroxyurea treatment
    • ub ahead of print
    • Lê Q, Gulbus B, Dedeken L, et al. Survival among children and adults with sickle cell disease in Belgium: Benefit from hydroxyurea treatment. Pediatr Blood Cancer 2015; doi: 10.1002/pbc.25608. [Epub ahead of print]
    • (2015) Pediatr Blood Cancer
    • Lê, Q.1    Gulbus, B.2    Dedeken, L.3
  • 25
    • 79953865198 scopus 로고    scopus 로고
    • The rationale for using hydroxycarbamide in the treatment of sickle cell disease
    • Rees DC. The rationale for using hydroxycarbamide in the treatment of sickle cell disease. Haematologica 2011;96(4):488-91
    • (2011) Haematologica , vol.96 , Issue.4 , pp. 488-491
    • Rees, D.C.1
  • 26
    • 33748320512 scopus 로고
    • Clinical results with hydroxyurea in cancer chemotherapy
    • Cole DR, Beckloff GL, Rousselot LM. Clinical results with hydroxyurea in cancer chemotherapy. NY State J Med 1965;65:2132-6
    • (1965) NY State J Med , vol.65 , pp. 2132-2136
    • Cole, D.R.1    Beckloff, G.L.2    Rousselot, L.M.3
  • 27
    • 0041295500 scopus 로고
    • Phase II studies of hydroxyurea (NSC-32065) in adults: Miscellaneous tumors
    • Bloedow CE. Phase II studies of hydroxyurea (NSC-32065) in adults: miscellaneous tumors. Cancer Chemother Rep 1964;40:39-41
    • (1964) Cancer Chemother Rep , vol.40 , pp. 39-41
    • Bloedow, C.E.1
  • 28
    • 0015499836 scopus 로고
    • Long-term effects of hydroxyurea in psoriasis
    • Dahl M, Comaish JS. Long-term effects of hydroxyurea in psoriasis. BMJ 1972;5840:585-7
    • (1972) BMJ , vol.5840 , pp. 585-587
    • Dahl, M.1    Comaish, J.S.2
  • 29
    • 0015319148 scopus 로고
    • Hydroxyurea therapy in chronic myelogenous leukemia
    • Kennedy BJ. Hydroxyurea therapy in chronic myelogenous leukemia. Cancer 1972;29(4):1052-6
    • (1972) Cancer , vol.29 , Issue.4 , pp. 1052-1056
    • Kennedy, B.J.1
  • 30
    • 0021723120 scopus 로고
    • Treatment of polycythemia vera with hydroxyurea
    • Donovan PB, Kaplan ME, Goldberg JD, et al. Treatment of polycythemia vera with hydroxyurea. Am J Hematol 1984;7(4):329-34
    • (1984) Am J Hematol , vol.7 , Issue.4 , pp. 329-334
    • Donovan, P.B.1    Kaplan, M.E.2    Goldberg, J.D.3
  • 31
    • 0027948936 scopus 로고
    • Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
    • Lori F, Malykh A, Cara A, et al. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 1994;5186:801-5
    • (1994) Science , vol.5186 , pp. 801-805
    • Lori, F.1    Malykh, A.2    Cara, A.3
  • 33
    • 0014142031 scopus 로고
    • Treatment of malignant melanoma with hydroxyurea
    • Cassileth PA, Hyman GA. Treatment of malignant melanoma with hydroxyurea. Cancer Res 1967;27(10):1843-5
    • (1967) Cancer Res , vol.27 , Issue.10 , pp. 1843-1845
    • Cassileth, P.A.1    Hyman, G.A.2
  • 35
    • 77956840802 scopus 로고    scopus 로고
    • Hydroxyurea Therapy Requires HbF Induction for Clinical Benefit in a Sickle Cell Mouse Model
    • Lebensburger JD, Pestina TI, Ware RE, et al. Hydroxyurea Therapy Requires HbF Induction for Clinical Benefit in a Sickle Cell Mouse Model. Haematalogica 2010;95(9):1599-603
    • (2010) Haematalogica , vol.95 , Issue.9 , pp. 1599-1603
    • Lebensburger, J.D.1    Pestina, T.I.2    Ware, R.E.3
  • 36
    • 0014409894 scopus 로고
    • Effect of hydroxyurea on ribonucleotide reductase
    • Elford HL. Effect of hydroxyurea on ribonucleotide reductase. Biochem Biophys Res Commun 1968;33(1):129-35
    • (1968) Biochem Biophys Res Commun , vol.33 , Issue.1 , pp. 129-135
    • Elford, H.L.1
  • 37
    • 34548789595 scopus 로고    scopus 로고
    • Replication in Hydroxyurea: It's a Matter of Time
    • Alvino GM, Collingwood D, Murphy JM, et al. Replication in Hydroxyurea: It's a Matter of Time. Mol Cell Biol 2007;27(18):6396-406
    • (2007) Mol Cell Biol , vol.27 , Issue.18 , pp. 6396-6406
    • Alvino, G.M.1    Collingwood, D.2    Murphy, J.M.3
  • 38
    • 0345791546 scopus 로고    scopus 로고
    • Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools
    • Koç A, Wheeler LJ, Mathews CK, Merrill GF. Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools. J Biol Chem 2004;279(1):223-30
    • (2004) J Biol Chem , vol.279 , Issue.1 , pp. 223-230
    • Koç, A.1    Wheeler, L.J.2    Mathews, C.K.3    Merrill, G.F.4
  • 39
    • 0033784055 scopus 로고    scopus 로고
    • Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors
    • Baliga BS, Pace BS, Chen HH, et al. Mechanism for fetal hemoglobin induction by hydroxyurea in sickle cell erythroid progenitors. Am J Hematol 2000;65(3):227-33
    • (2000) Am J Hematol , vol.65 , Issue.3 , pp. 227-233
    • Baliga, B.S.1    Pace, B.S.2    Chen, H.H.3
  • 40
    • 0021894839 scopus 로고
    • Production in stressed erythropoiesis: Observations and kinetic models
    • Stamatoyannopoulos G, Veith R, Galanello R, et al. Production in Stressed Erythropoiesis: Observations and Kinetic Models. Ann NY Acad Sci 1985;445:188-97
    • (1985) Ann NY Acad Sci , vol.445 , pp. 188-197
    • Stamatoyannopoulos, G.1    Veith, R.2    Galanello, R.3
  • 41
    • 10544232620 scopus 로고    scopus 로고
    • A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy
    • Bridges KR, Barabino GD, Brugnara C, et al. A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Blood 1996;88(12):4701-10
    • (1996) Blood , vol.88 , Issue.12 , pp. 4701-4710
    • Bridges, K.R.1    Barabino, G.D.2    Brugnara, C.3
  • 42
    • 0037237980 scopus 로고    scopus 로고
    • Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase
    • Cokic VP, Smith RD, Beleslin-Cokic BB, et al. Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J Clin Invest 2003;111(2):231-9
    • (2003) J Clin Invest , vol.111 , Issue.2 , pp. 231-239
    • Cokic, V.P.1    Smith, R.D.2    Beleslin-Cokic, B.B.3
  • 43
    • 84867291404 scopus 로고    scopus 로고
    • Hydroxyurea and a cGMPamplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice
    • Almeida CB, Scheiermann C, Jang JE, et al. Hydroxyurea and a cGMPamplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice. Blood 2012;120(14):2879-88
    • (2012) Blood , vol.120 , Issue.14 , pp. 2879-2888
    • Almeida, C.B.1    Scheiermann, C.2    Jang, J.E.3
  • 44
    • 4444309490 scopus 로고    scopus 로고
    • Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy
    • Ware RE, Zimmerman SA, Sylvestre PB, et al. Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy. J Pediatr 2004;145(3):346-52
    • (2004) J Pediatr , vol.145 , Issue.3 , pp. 346-352
    • Ware, R.E.1    Zimmerman, S.A.2    Sylvestre, P.B.3
  • 45
    • 84860348352 scopus 로고    scopus 로고
    • Stroke with Transfusions Changing to Hydroxyurea (SWiTCH)
    • Ware RE, Helms RW; SWiTCH Investigators. Stroke With Transfusions Changing to Hydroxyurea (SWiTCH). Blood 2012;119(17):3925-32
    • (2012) Blood , vol.119 , Issue.17 , pp. 3925-3932
    • SWiTCH Investigators1    Ware, R.E.2    Helms, R.W.3
  • 46
    • 84920198857 scopus 로고    scopus 로고
    • From infancy to adolescence: Fifteen years of continuous treatment with hydroxyurea in sickle cell anemia
    • Hankins JS, Aygun B, Nottage K, et al. From infancy to adolescence: fifteen years of continuous treatment with hydroxyurea in sickle cell anemia. Medicine 2014;93(28):e215
    • (2014) Medicine , vol.93 , Issue.28 , pp. e215
    • Hankins, J.S.1    Aygun, B.2    Nottage, K.3
  • 47
    • 77955905049 scopus 로고    scopus 로고
    • How i use hydroxyurea to treat young patients with sickle cell anemia
    • Ware RE. How I use hydroxyurea to treat young patients with sickle cell anemia. Blood 2010;115(26):5300-11
    • (2010) Blood , vol.115 , Issue.26 , pp. 5300-5311
    • Ware, R.E.1
  • 48
    • 80855133522 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia
    • Ware RE, Despotovic JM, Mortier NA, et al. Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia. Blood 2011;118(18):4985-91
    • (2011) Blood , vol.118 , Issue.18 , pp. 4985-4991
    • Ware, R.E.1    Despotovic, J.M.2    Mortier, N.A.3
  • 49
    • 33845951118 scopus 로고    scopus 로고
    • Pharmacokinetics of hydroxyurea 1,000 mg coated breakable tablets and 500 mg capsules in pediatric and adult patients with sickle cell disease
    • de Montalembert M, Bachir D, Hulin A, et al. Pharmacokinetics of hydroxyurea 1,000 mg coated breakable tablets and 500 mg capsules in pediatric and adult patients with sickle cell disease. Haematologica 2006;91(12):1685-8
    • (2006) Haematologica , vol.91 , Issue.12 , pp. 1685-1688
    • De Montalembert, M.1    Bachir, D.2    Hulin, A.3
  • 50
    • 0032030674 scopus 로고    scopus 로고
    • A bioavailability and pharmacokinetic study of oral and intravenous hydroxyurea
    • Rodriguez GI, Kuhn JG, Weiss GR, et al. A bioavailability and pharmacokinetic study of oral and intravenous hydroxyurea. Blood 1998;91(5):1533-41
    • (1998) Blood , vol.91 , Issue.5 , pp. 1533-1541
    • Rodriguez, G.I.1    Kuhn, J.G.2    Weiss, G.R.3
  • 51
    • 84947492803 scopus 로고    scopus 로고
    • Hydroxyurea pharmacokinetics for predicting maximum tolerated dose in children with sickle cell anemia
    • ASH Annual Meeting Abstract
    • McGann PT, Sparreboom A, Mortier NA, et al. Hydroxyurea Pharmacokinetics for Predicting Maximum Tolerated Dose in Children with Sickle Cell Anemia. Blood 2014;124(21):2707; (ASH Annual Meeting Abstract)
    • (2014) Blood , vol.124 , Issue.21 , pp. 2707
    • McGann, P.T.1    Sparreboom, A.2    Mortier, N.A.3
  • 53
    • 0028276190 scopus 로고
    • Acute leukaemia after hydroxyurea therapy in polycythaemia vera and allied disorders: Prospective study of efficacy and leukaemogenicity with therapeutic implications
    • Weinfeld A, Swolin B, Westin J. Acute leukaemia after hydroxyurea therapy in polycythaemia vera and allied disorders: prospective study of efficacy and leukaemogenicity with therapeutic implications. Eur J Haematol 1994;52(3):134-9
    • (1994) Eur J Haematol , vol.52 , Issue.3 , pp. 134-139
    • Weinfeld, A.1    Swolin, B.2    Westin, J.3
  • 54
    • 79959203501 scopus 로고    scopus 로고
    • Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms
    • Bjorkholm M, Derolf AR, Hultcrantz M, et al. Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms. J Clin Oncol 2011;29(17):2410-15
    • (2011) J Clin Oncol , vol.29 , Issue.17 , pp. 2410-2415
    • Bjorkholm, M.1    Derolf, A.R.2    Hultcrantz, M.3
  • 55
    • 0344443803 scopus 로고    scopus 로고
    • Malignancy in patients with sickle cell disease
    • Schulz WH, Ware RE. Malignancy in patients with sickle cell disease. Am J Hematol 2003;7(4):249-53
    • (2003) Am J Hematol , vol.7 , Issue.4 , pp. 249-253
    • Schulz, W.H.1    Ware, R.E.2
  • 56
    • 0023716777 scopus 로고
    • Fertility studies in sickle cell disease: Semen analysis in adult male patients
    • Agbaraji VO, Scott RB, Leto S. Fertility studies in sickle cell disease: semen analysis in adult male patients. Int J Fertil 1988;33(5):347-52
    • (1988) Int J Fertil , vol.33 , Issue.5 , pp. 347-352
    • Agbaraji, V.O.1    Scott, R.B.2    Leto, S.3
  • 57
    • 84924025724 scopus 로고    scopus 로고
    • Erectile dysfunction after sickle cell disease-associated recurrent ischemic priapism: Profile and risk factors
    • Anele UA, Burnett AL. Erectile Dysfunction after Sickle Cell Disease-Associated Recurrent Ischemic Priapism: Profile and Risk Factors. J Sex Med 2015;12(3):713-19
    • (2015) J Sex Med , vol.12 , Issue.3 , pp. 713-719
    • Anele, U.A.1    Burnett, A.L.2
  • 58
    • 84930947847 scopus 로고    scopus 로고
    • Is testosterone deficiency a possible risk factor for priapism associated with sicklecell disease?
    • Morrison BF, Anele UA, Reid ME, et al. Is testosterone deficiency a possible risk factor for priapism associated with sicklecell disease? Int Urol Nephrol 2014;47(1):47-52
    • (2014) Int Urol Nephrol , vol.47 , Issue.1 , pp. 47-52
    • Morrison, B.F.1    Anele, U.A.2    Reid, M.E.3
  • 59
    • 34247476032 scopus 로고    scopus 로고
    • Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease
    • Zemel BS, Kawchak DA, Ohene-Frempong K, et al. Effects of delayed pubertal development, nutritional status, and disease severity on longitudinal patterns of growth failure in children with sickle cell disease. Pediatr Res 2007;61:607-13
    • (2007) Pediatr Res , vol.61 , pp. 607-613
    • Zemel, B.S.1    Kawchak, D.A.2    Ohene-Frempong, K.3
  • 60
    • 80051649155 scopus 로고    scopus 로고
    • Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos. Nigeria
    • Abudu EK, Akanmu SA, Soriyan OO, et al. Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos. Nigeria. BMC Res Notes 2011;4:298
    • (2011) BMC Res Notes , vol.4 , pp. 298
    • Abudu, E.K.1    Akanmu, S.A.2    Soriyan, O.O.3
  • 61
    • 0019412760 scopus 로고
    • Fertility in males with sickle cell disease
    • Osegbe DN, Akinyanju O, Amaku EO. Fertility in males with sickle cell disease. Lancet 1981;2(8241):275-6
    • (1981) Lancet , vol.2 , Issue.8241 , pp. 275-276
    • Osegbe, D.N.1    Akinyanju, O.2    Amaku, E.O.3
  • 62
    • 84911375168 scopus 로고    scopus 로고
    • Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: A review
    • DeBaun MR. Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: A review. Expert Rev Hematol 2014;7(6):767-73
    • (2014) Expert Rev Hematol , vol.7 , Issue.6 , pp. 767-773
    • DeBaun, M.R.1
  • 63
    • 67649233786 scopus 로고    scopus 로고
    • Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints
    • Jones KM, Niaz MS, Brooks CM, et al. Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints. Int J Environ Res Public Helath 2009;6(3):1124-44
    • (2009) Int J Environ Res Public Helath , vol.6 , Issue.3 , pp. 1124-1144
    • Jones, K.M.1    Niaz, M.S.2    Brooks, C.M.3
  • 64
    • 46849120215 scopus 로고    scopus 로고
    • Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males
    • Berthaut I, Guignedoux G, Kirsch-Noir F, et al. Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males. Haematologica 2008;93(7):988-93
    • (2008) Haematologica , vol.93 , Issue.7 , pp. 988-993
    • Berthaut, I.1    Guignedoux, G.2    Kirsch-Noir, F.3
  • 65
    • 70350637293 scopus 로고    scopus 로고
    • Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia
    • Ballas SK, McCarthy WF, Guo N, et al. Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia. J National Med Assoc 2009;101(10):1046-51
    • (2009) J National Med Assoc , vol.101 , Issue.10 , pp. 1046-1051
    • Ballas, S.K.1    McCarthy, W.F.2    Guo, N.3
  • 66
    • 84929998848 scopus 로고    scopus 로고
    • Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: Systematic review and meta-analysis
    • Oteng-Ntim E, Meeks D, Seet PT, et al. Adverse maternal and perinatal outcomes in pregnant women with sickle cell disease: systematic review and meta-analysis. Blood 2015;125(21):3316-25
    • (2015) Blood , vol.125 , Issue.21 , pp. 3316-3325
    • Oteng-Ntim, E.1    Meeks, D.2    Seet, P.T.3
  • 69
    • 84983095657 scopus 로고    scopus 로고
    • Hydroxyurea therapy for children with sickle cell anemia: Rationale and design of the REACH trial
    • in press
    • McGann PT, Tshilolo L, Santos B, et al. Hydroxyurea Therapy for Children with Sickle Cell Anemia: Rationale and Design of the REACH Trial. Pediatr Blood Cancer 2015; in press
    • (2015) Pediatr Blood Cancer
    • McGann, P.T.1    Tshilolo, L.2    Santos, B.3
  • 70
    • 84928718664 scopus 로고    scopus 로고
    • Proportion of adults with sickle cell anemia and pain crises receiving hydroxyurea
    • Stettler N, McKiernan CM, Melin CQ, et al. Proportion of adults with sickle cell anemia and pain crises receiving hydroxyurea. JAMA 2015;313(16):1671-2
    • (2015) JAMA , vol.313 , Issue.16 , pp. 1671-1672
    • Stettler, N.1    McKiernan, C.M.2    Melin, C.Q.3
  • 71
    • 0020323557 scopus 로고
    • The cooperative study of sickle cell disease Review of study design and objectives
    • Gaston M, Rosse W. The cooperative study of sickle cell disease Review of study design and objectives. Am J Pediatr Hematol/Oncol 1982;4(2):197-201
    • (1982) Am J Pediatr Hematol/Oncol , vol.4 , Issue.2 , pp. 197-201
    • Gaston, M.1    Rosse, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.