Exposure to hydroxyurea and pregnancy outcomes in patients with sickle cell anemia

Journal of the National Medical Association

Volumn 101, Issue 10, 2009, Pages 1046-1051

  Ballas, Samir K ^a   McCarthy, William F ^b   Guo, Nan ^b   DeCastro, Laura ^c   Bellevue, Rita ^d   Barton, Bruce A ^b   Waclawiw, Myron A ^e  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b MARYLAND MEDICAL RESEARCH INSTITUTE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d NEW YORK METHODIST HOSPITAL   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Hydroxyurea; Obstetrics gynecology; Sickle cell anemia

Indexed keywords

HYDROXYUREA; OPIATE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FETUS; FOLLOW UP; GENDER; HUMAN; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PARENT; PREGNANCY OUTCOME; PREMATURITY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SICKLE CELL ANEMIA; SURVIVOR; TERATOGENESIS;

ANEMIA, SICKLE CELL; ANTISICKLING AGENTS; FEMALE; FETUS; HUMANS; HYDROXYUREA; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY OUTCOME; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 70350637293     PISSN: 00279684     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-9684(15)31072-5     Document Type: Article

References (32)

1. Charache S, Terrin MD, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Eng J Med. 1995;332:1317-1322.
2. Adlard BPF, Dobbing J. Maze learning by adult rats after inhibition of neuronal multiplication in utero. Peciatr Res. 1975;9:139-142.
3. DePass LR, Weaver EV. Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains. J Toxicol Environ Health. 1982;10:297-305.
4. DeSesso JM, Goeringer GC. The nature of the embryo-protective interaction of propyl gallate with hydroxyurea. Reprod Toxicol. 1990;4:145-152
5. Evenson DP, Jost LK. Hydroxyurea exposure alters mouse testicular kinetics and sperm chromatin structure. Cell Prolif. 1993;26:147-159.
6. Ferm VH. Severe developmental malformations: malformations induced by urethane and hydroxyurea in the hamster. Arch Pathol. 1966;81:174-177.
7. Lanzkron S, Strouse JJ, Wilson M, et al. Systematic Review: Hydroxyurea for the treatment of adults with sickle cell disease. Ann Int Med. 2007;148:939-955.
8. Strouse JJ, Lanzhorn S, Beach MC, et al. Hydroxyurea for sickle cell disease: A Systemic Review for the efficacy and toxicity in children. Pediatrics. 2008;122:1332-1342.
9. Adam S, Jonassaint J, Kruger H, et al. Surgical and obstetric outcomes in adults with sickle cell disease. Am J Med. 2008;121:916-921.
10. Doll DC, Ringenberg S, Yarbro JW. Management of cancer during pregnancy. Arch Intern Med. 1988;148:2058-2064.
11. Hassell K. Sickle cell disease population estimation: application of available contemporary data to traditional methods [Abstract]. Presented at the 35th Anniversary Convention of the National Sickle Cell Disease Program, 17-22 September 2007, Washington, DC. Baltimore: Sickle Cell Disease Assoc of America; 2007:173. Abstract no. 275.
12. Koshy M, Burd L. Management of pregnancy in sickle cell syndromes. Hematol Oncol Clin N Am. 1991;5:585-596.
13. Powars DR, Sandhu M, Niland-Weiss J, et al. Pregnancy in sickle cell disease. Obstet Gynecol. 1986;67:217-228. (Pubitemid 16135568)
14. Smith JA, Espeland M, Bellevue R, et al. Pregnancy in sickle cell disease: experience of the cooperative study of sickle cell disease. Obstet Gynecol. 1996;87:199-204. (Pubitemid 26033131)
15. Chaube S, Murphy ML. The effects of hydroxyurea and related compounds on the rat fetus. Cancer Res. 1966;26:1448-1457.
16. Khera KS. A teratogenicity study on hydroxyurea and diphenylhydantoin in cats. Teratology. 1979;20:447-452.
17. Wilson JG, Scott WJ, Ritter EJ, et al. Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys. Teratology. 1975;11:169-178.
18. Cinkotai KI, Wood P, Donnai P, et al. Pregnancy after treatment with hydroxyurea in a patient with primary thrombocythaemia and a history of recurrent abortion. J Clin Pathol. 1994;47:769-770.
19. Dell'Isola A, De Rosa G, Catalano D. Essential thrombocythemia in pregnancy. A case report and general considerations. Minerva Ginecol. 1997; 49:165-172 (in Italian).
20. Delmier A, Rio B, Bauduer F, et al. Pregnancy during myelosuppressive treatment for chronic myelogenous leukaemia. Br J Haematol. 1992;82:783-784. (Pubitemid 23011997)
21. Diave-Citrin O, Hunnisett L, Sher GD, et al. Hydroxyurea use during pregnancy: A case report in sickle cell disease and review of the literature. Am J Hematol. 1999;60:148-150. (Pubitemid 29047437)
22. Doney KC, Kraemer KG, Shepard TH. Combination chemotherapy for acute myelocytic leukemia during pregnancy: three case reports. Cancer Treat Rep. 1979;63:369-371. (Pubitemid 9192237)
23. Fernandez H. Essential thrombocythemia and pregnancy [letter]. J Gynecol Obstet Biol Reprod. 1994;23:103-104 (in French).
24. Fitzgerald JM, McCann SR. The combination of hydroxyurea and leucapheresis in the treatment of chronic myeloid leukaemia in pregnancy. Clin Lab Haematol. 1993;15:63-65.
25. Jackson N, Shukri A, Ali K. Hydroxyurea treatment for chronic myeloid leukaemia during pregnancy. Br J Haematol. 1993;85:203-204. (Pubitemid 23291500)
26. Szanto F, Kovacs L. Successful delivery following continuous cytostatic therapy of a leukemic pregnant woman. Ovr Hetil. 1994;134:527-529 (in Hungarian).
27. Tertian G, Tchernia G, Papiernik E, et al. Hydroxyurea and pregnancy. Am J Obstet Gynecol. 1992;166:1868-1868
28. Thauvin-Robinet C, Maingueneau C, Robert E, et al. Exposure to hydroxyurea during pregnancy: a case series [letter]. Leukemia. 2001;15:1309-1311. (Pubitemid 32776461)
29. Smaith JA, Espeland M, Bellevue R, et al. Pregnancy in sickle cell disease: experience of the cooperative study of sickle cell disease. Obstet Gynecol. 1996;2:1278-1285. (Pubitemid 26033131)
30. Serjeant GR, Loy LL, Crowther M, Hambleton IR and Thame M. Outcome of pregnancy in homozygous sickle cell disease. Obstet Gynecol. 2004;103:6:1278-1285. (Pubitemid 40458962)
31. Whitcomb BW, Schisterman EF, Luo X, et al. Maternal serum granulocyte colony-stimulating factor levels and spontaneous preterm birth. J Women's Health. 2009;18:73-74.
32. Ballas SK. The sickle cell painful crisis in adults: Phases and objective signs. Hemoglobin. 1995;19(6):323-333.