-
2
-
-
84878334638
-
-
Boehringer Ingelheim Pharmaceuticals, Inc, Available at, Accessed January 21, 2013
-
Boehringer Ingelheim Pharmaceuticals, Inc.: Pradaxa (Dabigatran Etexilate Mesylate) Prescribing Information, 2012. Available at: www.pradaxa.com. Accessed January 21, 2013
-
(2012)
Pradaxa (Dabigatran Etexilate Mesylate) Prescribing Information
-
-
-
3
-
-
70349306707
-
RE-LY Steering Committee and Investigators: Dabigatran versus warfarin in patients with atrial fibrillation
-
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators: Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361: 1139-1151, 2009
-
(2009)
N Engl J Med
, vol.361
, pp. 1139-1151
-
-
Connolly, S.J.1
Ezekowitz, M.D.2
Yusuf, S.3
Eikelboom, J.4
Oldgren, J.5
Parekh, A.6
Pogue, J.7
Reilly, P.A.8
Themeles, E.9
Varrone, J.10
Wang, S.11
Alings, M.12
Xavier, D.13
Zhu, J.14
Diaz, R.15
Lewis, B.S.16
Darius, H.17
Diener, H.C.18
Joyner, C.D.19
Wallentin, L.20
more..
-
4
-
-
79958126202
-
Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
-
Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J, Yang S, Alings M, Kaatz S, Hohnloser SH, Diener HC, Franzosi MG, Huber K, Reilly P, Varrone J, Yusuf S: Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation 123: 2363-2372, 2011
-
(2011)
Circulation
, vol.123
, pp. 2363-2372
-
-
Eikelboom, J.W.1
Wallentin, L.2
Connolly, S.J.3
Ezekowitz, M.4
Healey, J.S.5
Oldgren, J.6
Yang, S.7
Alings, M.8
Kaatz, S.9
Hohnloser, S.H.10
Diener, H.C.11
Franzosi, M.G.12
Huber, K.13
Reilly, P.14
Varrone, J.15
Yusuf, S.16
-
5
-
-
37149005153
-
Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
-
Stangier J, Stahle H, Rathgen K, Fuhr R: Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects. Clin Pharmacokinet 47: 47-59, 2008
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 47-59
-
-
Stangier, J.1
Stahle, H.2
Rathgen, K.3
Fuhr, R.4
-
6
-
-
41949116970
-
Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
-
Stangier J: Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. Clin Pharmacokinet 47: 285-295, 2008
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 285-295
-
-
Stangier, J.1
-
7
-
-
77952167209
-
Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
-
Stangier J, Clemens A: Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost 15[Suppl 1]: 9S-16S, 2009
-
(2009)
Clin Appl Thromb Hemost
, vol.15
, Issue.SUPPL. 1
-
-
Stangier, J.1
Clemens, A.2
-
10
-
-
82555172355
-
Dabigatran: Review of pharmacology and management of bleeding complications of this novel oral anticoagulant
-
Ganetsky M, Babu KM, Salhanick SD, Brown RS, Boyer EW: Dabigatran: Review of pharmacology and management of bleeding complications of this novel oral anticoagulant. J Med Toxicol 7: 281-287, 2011
-
(2011)
J Med Toxicol
, vol.7
, pp. 281-287
-
-
Ganetsky, M.1
Babu, K.M.2
Salhanick, S.D.3
Brown, R.S.4
Boyer, E.W.5
-
11
-
-
80053559490
-
Reversal of new oral anticoagulants
-
Battinelli EM: Reversal of new oral anticoagulants. Circulation 124: 1508-1510, 2011
-
(2011)
Circulation
, vol.124
, pp. 1508-1510
-
-
Battinelli, E.M.1
-
12
-
-
84871342313
-
-
May 31, 2012: New Data from 2011 Quarters 3-4. QuarterWatch 2012, 2012. Available at, Accessed January 21
-
Moore TJ, Furberg CD, Cohen MR: Anticoagulants: The Leading Reported Drug Risk in 2011: May 31, 2012: New Data from 2011 Quarters 3-4. QuarterWatch 2012, 2012. Available at: www.ismp.org/quarterwatch/pdfs/2011Q4.pdf. Accessed January 21, 2013
-
(2013)
Anticoagulants: The Leading Reported Drug Risk In 2011
-
-
Moore, T.J.1
Furberg, C.D.2
Cohen, M.R.3
-
13
-
-
84867699158
-
Hemorrhagic complications associated with dabigatran use
-
Chen BC, Viny AD, Garlich FM, Basciano P, Howland MA, Smith SW, Hoffman RS, Nelson LS: Hemorrhagic complications associated with dabigatran use. Clin Toxicol (Phila) 50: 854-857, 2012
-
(2012)
Clin Toxicol (Phila)
, vol.50
, pp. 854-857
-
-
Chen, B.C.1
Viny, A.D.2
Garlich, F.M.3
Basciano, P.4
Howland, M.A.5
Smith, S.W.6
Hoffman, R.S.7
Nelson, L.S.8
-
14
-
-
79960955075
-
The use of dabigatran in elderly patients
-
Legrand M, Mateo J, Aribaud A, Ginisty S, Eftekhari P, Huy PT, Drouet L, Payen D: The use of dabigatran in elderly patients. Arch Intern Med 171: 1285-1286, 2011
-
(2011)
Arch Intern Med
, vol.171
, pp. 1285-1286
-
-
Legrand, M.1
Mateo, J.2
Aribaud, A.3
Ginisty, S.4
Eftekhari, P.5
Huy, P.T.6
Drouet, L.7
Payen, D.8
-
15
-
-
84857853180
-
Bleeding risk with dabigatran in the frail elderly
-
Harper P, Young L, Merriman E: Bleeding risk with dabigatran in the frail elderly. N Engl J Med 366: 864-866, 2012
-
(2012)
N Engl J Med
, vol.366
, pp. 864-866
-
-
Harper, P.1
Young, L.2
Merriman, E.3
-
16
-
-
84857759555
-
Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
-
Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW: Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. Blood 119: 2172-2174, 2012
-
(2012)
Blood
, vol.119
, pp. 2172-2174
-
-
Warkentin, T.E.1
Margetts, P.2
Connolly, S.J.3
Lamy, A.4
Ricci, C.5
Eikelboom, J.W.6
-
17
-
-
84859549864
-
Clinical challenges in a patient with dabigatran-induced fatal hemorrhage
-
Cano EL, Miyares MA: Clinical challenges in a patient with dabigatran-induced fatal hemorrhage. Am J Geriatr Pharmacother 10: 160-163, 2012
-
(2012)
Am J Geriatr Pharmacother
, vol.10
, pp. 160-163
-
-
Cano, E.L.1
Miyares, M.A.2
-
18
-
-
84859703006
-
Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
-
Wychowski MK, Kouides PA: Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment. Ann Pharmacother 46: e10, 2012
-
(2012)
Ann Pharmacother
, vol.46
-
-
Wychowski, M.K.1
Kouides, P.A.2
-
19
-
-
84876398583
-
Treatment of dabigatranassociated bleeding: Case report and review of the literature
-
published online ahead of print November 16
-
Harinstein LM, Morgan JW, Russo N: Treatment of dabigatranassociated bleeding: Case report and review of the literature [published online ahead of print November 16, 2012]. J Pharm Pract
-
(2012)
J Pharm Pract
-
-
Harinstein, L.M.1
Morgan, J.W.2
Russo, N.3
-
20
-
-
84870220837
-
Direct thrombin inhibitors: A case indicating benefit from 'plasmapheresis' in toxicity: A call for establishing "guidelines" in overdose and to find an antidote!
-
Kamboj J, Kottalgi M, Cirra VR, Shah N, Kamboj R: Direct thrombin inhibitors: A case indicating benefit from 'plasmapheresis' in toxicity: A call for establishing "guidelines" in overdose and to find an "antidote!" Am J Ther 19: e182-e185, 2012
-
(2012)
Am J Ther
, vol.19
-
-
Kamboj, J.1
Kottalgi, M.2
Cirra, V.R.3
Shah, N.4
Kamboj, R.5
-
22
-
-
77949421739
-
Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, singlecentre study
-
Stangier J, Rathgen K, Stahle H, Mazur D: Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, singlecentre study. Clin Pharmacokinet 49: 259-268, 2010
-
(2010)
Clin Pharmacokinet
, vol.49
, pp. 259-268
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Mazur, D.4
-
23
-
-
84875926001
-
Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease
-
Khadzhynov D, Wagner F, Formella S, Wiegert E, Moschetti V, Slowinski T, Neumayer HH, Liesenfeld KH, Lehr T, Hartter S, Friedman J, Peters H, Clemens A: Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb Haemost 109: 596-605, 2013
-
(2013)
Thromb Haemost
, vol.109
, pp. 596-605
-
-
Khadzhynov, D.1
Wagner, F.2
Formella, S.3
Wiegert, E.4
Moschetti, V.5
Slowinski, T.6
Neumayer, H.H.7
Liesenfeld, K.H.8
Lehr, T.9
Hartter, S.10
Friedman, J.11
Peters, H.12
Clemens, A.13
-
24
-
-
84867022051
-
Anticoagulants in atrial fibrillation patients with chronic kidney disease
-
Hart RG, Eikelboom JW, Ingram AJ, Herzog CA: Anticoagulants in atrial fibrillation patients with chronic kidney disease. Nat Rev Nephrol 8: 569-578, 2012
-
(2012)
Nat Rev Nephrol
, vol.8
, pp. 569-578
-
-
Hart, R.G.1
Eikelboom, J.W.2
Ingram, A.J.3
Herzog, C.A.4
-
25
-
-
77953168824
-
Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
-
van Ryn J, Stangier J, Haertter S, Liesenfeld KH, Wienen W, Feuring M, Clemens A: Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 103: 1116-1127, 2010
-
(2010)
Thromb Haemost
, vol.103
, pp. 1116-1127
-
-
van Ryn, J.1
Stangier, J.2
Haertter, S.3
Liesenfeld, K.H.4
Wienen, W.5
Feuring, M.6
Clemens, A.7
-
26
-
-
79954456496
-
Dabigatran etexilate: A new oral thrombin inhibitor
-
Hankey GJ, Eikelboom JW: Dabigatran etexilate: A new oral thrombin inhibitor. Circulation 123: 1436-1450, 2011
-
(2011)
Circulation
, vol.123
, pp. 1436-1450
-
-
Hankey, G.J.1
Eikelboom, J.W.2
-
27
-
-
84861034872
-
The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: Guideline methodology
-
Lavergne V, Nolin TD, Hoffman RS, Roberts D, Gosselin S, Goldfarb DS, Kielstein JT, Mactier R, Maclaren R, Mowry JB, Bunchman TE, Juurlink D, Megarbane B, Anseeuw K, Winchester JF, Dargan PI, Liu KD, Hoegberg LC, Li Y, Calello DP, Burdmann EA, Yates C, Laliberté M, Decker BS, Mello-Da-Silva CA, Lavonas E, Ghannoum M: The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: Guideline methodology. Clin Toxicol (Phila) 50: 403-413, 2012
-
(2012)
Clin Toxicol (Phila)
, vol.50
, pp. 403-413
-
-
Lavergne, V.1
Nolin, T.D.2
Hoffman, R.S.3
Roberts, D.4
Gosselin, S.5
Goldfarb, D.S.6
Kielstein, J.T.7
Mactier, R.8
Maclaren, R.9
Mowry, J.B.10
Bunchman, T.E.11
Juurlink, D.12
Megarbane, B.13
Anseeuw, K.14
Winchester, J.F.15
Dargan, P.I.16
Liu, K.D.17
Hoegberg, L.C.18
Li, Y.19
Calello, D.P.20
Burdmann, E.A.21
Yates, C.22
Laliberté, M.23
Decker, B.S.24
Mello-Da-Silva, C.A.25
Lavonas, E.26
Ghannoum, M.27
more..
-
28
-
-
0018233405
-
Pharmacokinetic evaluation of hemodialysis in acute drug overdose
-
Takki S, Gambertoglio JG, Honda DH, Tozer TN: Pharmacokinetic evaluation of hemodialysis in acute drug overdose. J Pharmacokinet Biopharm 6: 427-442, 1978
-
(1978)
J Pharmacokinet Biopharm
, vol.6
, pp. 427-442
-
-
Takki, S.1
Gambertoglio, J.G.2
Honda, D.H.3
Tozer, T.N.4
-
29
-
-
1842502925
-
Extracorporeal management of valproic acid overdose: A large regional experience
-
Singh SM, McCormick BB, Mustata S, Thompson M, Prasad GV: Extracorporeal management of valproic acid overdose: A large regional experience. J Nephrol 17: 43-49, 2004
-
(2004)
J Nephrol
, vol.17
, pp. 43-49
-
-
Singh, S.M.1
McCormick, B.B.2
Mustata, S.3
Thompson, M.4
Prasad, G.V.5
-
31
-
-
33750023407
-
Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: A population model analysis
-
Liesenfeld KH, Schafer HG, Trocóniz IF, Tillmann C, Eriksson BI, Stangier J: Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: A population model analysis. Br J Clin Pharmacol 62: 527-537, 2006
-
(2006)
Br J Clin Pharmacol
, vol.62
, pp. 527-537
-
-
Liesenfeld, K.H.1
Schafer, H.G.2
Trocóniz, I.F.3
Tillmann, C.4
Eriksson, B.I.5
Stangier, J.6
-
32
-
-
84867758291
-
Interference of the new oral anticoagulant dabigatran with frequently used coagulation tests
-
Halbmayer WM, Weigel G, Quehenberger P, Tomasits J, Haushofer AC, Aspoeck G, Loacker L, Schnapka-Koepf M, Goebel G, Griesmacher A: Interference of the new oral anticoagulant dabigatran with frequently used coagulation tests. Clin Chem Lab Med 50: 1601-1605, 2012
-
(2012)
Clin Chem Lab Med
, vol.50
, pp. 1601-1605
-
-
Halbmayer, W.M.1
Weigel, G.2
Quehenberger, P.3
Tomasits, J.4
Haushofer, A.C.5
Aspoeck, G.6
Loacker, L.7
Schnapka-Koepf, M.8
Goebel, G.9
Griesmacher, A.10
-
33
-
-
10844233894
-
The ecarin clotting time, a universal method to quantify direct thrombin inhibitors
-
Nowak G: The ecarin clotting time, a universal method to quantify direct thrombin inhibitors. Pathophysiol Haemost Thromb 33: 173-183, 2003
-
(2003)
Pathophysiol Haemost Thromb
, vol.33
, pp. 173-183
-
-
Nowak, G.1
-
34
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
Stangier J, Rathgen K, Stahle H, Gansser D, Roth W: The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 64: 292-303, 2007
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Gansser, D.4
Roth, W.5
|