메뉴 건너뛰기




Volumn 10, Issue 9, 2015, Pages

Resistance-associated NS5A variants of hepatitis C virus are susceptible to interferon-based therapy

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON; RIBAVIRIN; SIMEPREVIR; VIRUS RNA; ANTIVIRUS AGENT; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRAL PROTEIN;

EID: 84947461016     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0138060     Document Type: Article
Times cited : (18)

References (36)
  • 1
    • 84925649961 scopus 로고    scopus 로고
    • Hepatitis C
    • 25687730 Feb 13
    • Webster DP, Klenerman P, Dusheiko GM. Hepatitis C. Lancet. 2015 Feb 13; 385(9973):1124-35. doi: 10.1016/S0140-6736(14)62401-6 PMID: 25687730
    • (2015) Lancet , vol.385 , Issue.9973 , pp. 1124-1135
    • Webster, D.P.1    Klenerman, P.2    Dusheiko, G.M.3
  • 2
    • 84903186698 scopus 로고    scopus 로고
    • Antiviral therapy for chronic hepatitis C in 2014
    • 24939471 Jul
    • Nookathota M, Mukherjee S. Antiviral therapy for chronic hepatitis C in 2014. Expert Rev Clin Pharmacol. 2014 Jul; 7(4):499-505. doi: 10.1586/17512433.2014.915737 PMID: 24939471
    • (2014) Expert Rev Clin Pharmacol , vol.7 , Issue.4 , pp. 499-505
    • Nookathota, M.1    Mukherjee, S.2
  • 3
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • 20006612 Feb
    • Sarrazin C, Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology. 2010 Feb; 138(2):447-62. doi: 10.1053/j.gastro.2009.11.055 PMID: 20006612
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 4
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • 21374691 May
    • Pawlotsky J-M. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology. 2011 May; 53(5):1742-51. doi: 10.1002/hep.24262 PMID: 21374691
    • (2011) Hepatology , vol.53 , Issue.5 , pp. 1742-1751
    • Pawlotsky, J.-M.1
  • 5
    • 84938949283 scopus 로고    scopus 로고
    • Recommendations on Treatment of Hepatitis C 2015. Available: http://www.easl.eu/research/ourcontributions/clinical-practice-guidelines/detail/recommendations-on-treatment-of-hepatitis-c-2015
    • (2015) Recommendations on Treatment of Hepatitis C
  • 6
    • 84901595218 scopus 로고    scopus 로고
    • Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection
    • 24604476 Jun
    • Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, et al. Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. Hepatology. 2014 Jun; 59(6):2083-91. doi: 10.1002/hep.27113 PMID: 24604476
    • (2014) Hepatology , vol.59 , Issue.6 , pp. 2083-2091
    • Kumada, H.1    Suzuki, Y.2    Ikeda, K.3    Toyota, J.4    Karino, Y.5    Chayama, K.6
  • 7
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
    • 24725239 May 15
    • Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15; 370(20):1889-98. doi: 10.1056/NEJMoa1402454 PMID: 24725239
    • (2014) N Engl J Med. , vol.370 , Issue.20 , pp. 1889-1898
    • Afdhal, N.1    Zeuzem, S.2    Kwo, P.3    Chojkier, M.4    Gitlin, N.5    Puoti, M.6
  • 8
    • 84901044326 scopus 로고    scopus 로고
    • ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV
    • 24795200 May 22
    • Ferenci P, Bernstein D, Lalezari J, Cohen D, Luo Y, Cooper C, et al. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014 May 22; 370(21):1983-92. doi: 10.1056/NEJMoa1402338 PMID: 24795200
    • (2014) N Engl J Med. , vol.370 , Issue.21 , pp. 1983-1992
    • Ferenci, P.1    Bernstein, D.2    Lalezari, J.3    Cohen, D.4    Luo, Y.5    Cooper, C.6
  • 9
    • 84925423399 scopus 로고    scopus 로고
    • Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): A rando
    • 25467560 Nov 11
    • Sulkowski M, Hezode C, Gerstoft J, Vierling JM, Mallolas J, Pol S, et al. Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a rando. Lancet. 2014 Nov 11; 385(9973):1087-97. doi: 10.1016/S0140-6736(14) 61793-1 PMID: 25467560
    • (2014) Lancet , vol.385 , Issue.9973 , pp. 1087-1097
    • Sulkowski, M.1    Hezode, C.2    Gerstoft, J.3    Vierling, J.M.4    Mallolas, J.5    Pol, S.6
  • 10
    • 84880299420 scopus 로고    scopus 로고
    • NS5A inhibitors in the treatment of hepatitis C
    • European Association for the Study of the Liver
    • Pawlotsky J-M. NS5A inhibitors in the treatment of hepatitis C. J Hepatol. European Association for the Study of the Liver; 2013; 59(2):375-82. doi: 10.1016/j.jhep.2013.03.030
    • (2013) J Hepatol , vol.59 , Issue.2 , pp. 375-382
    • Pawlotsky, J.-M.1
  • 11
    • 84896460675 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A inhibitors and drug resistance mutations
    • 24659881 Mar 21
    • Nakamoto S, Kanda T, Wu S, Shirasawa H, Yokosuka O. Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J Gastroenterol. 2014 Mar 21; 20(11):2902-12. doi: 10.3748/wjg.v20.i11.2902 PMID: 24659881
    • (2014) World J Gastroenterol , vol.20 , Issue.11 , pp. 2902-2912
    • Nakamoto, S.1    Kanda, T.2    Wu, S.3    Shirasawa, H.4    Yokosuka, O.5
  • 13
    • 84939174987 scopus 로고    scopus 로고
    • Naturally occurring, resistance-associated hepatitis C virus NS5A variants are linked to IL28B genotype and are sensitive to interferon-based therapy
    • Jan 6, In Press
    • Itakura J, Kurosaki M, Takada H, Nakakuki N, Matsuda S, Gondou K, et al. Naturally occurring, resistance-associated hepatitis C virus NS5A variants are linked to IL28B genotype and are sensitive to interferon-based therapy. Hepatol Res. 2015 Jan 6, In Press. doi: 10.1111/hepr.12474
    • (2015) Hepatol Res.
    • Itakura, J.1    Kurosaki, M.2    Takada, H.3    Nakakuki, N.4    Matsuda, S.5    Gondou, K.6
  • 14
    • 84905825880 scopus 로고    scopus 로고
    • Efficacy of daclatasvir in hepatitis C virus
    • 25059552 Sep
    • Izumi N. Efficacy of daclatasvir in hepatitis C virus. Expert Rev Anti Infect Ther. 2014 Sep; 12(9):1025-31. doi: 10.1586/14787210.2014.942282 PMID: 25059552
    • (2014) Expert Rev Anti Infect Ther , vol.12 , Issue.9 , pp. 1025-1031
    • Izumi, N.1
  • 15
    • 84921433851 scopus 로고    scopus 로고
    • Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1
    • 24943406 Feb
    • Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, et al. Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1. J Viral Hepat. 2015 Feb; 22(2):158-65. doi: 10.1111/jvh.12271 PMID: 24943406
    • (2015) J Viral Hepat , vol.22 , Issue.2 , pp. 158-165
    • Kosaka, K.1    Imamura, M.2    Hayes, C.N.3    Abe, H.4    Hiraga, N.5    Yoshimi, S.6
  • 16
    • 84940582565 scopus 로고    scopus 로고
    • Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy
    • May 8, In Press
    • Yoshimi S, Imamura M, Murakami E, Hiraga N, Tsuge M, Kawakami Y, et al. Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy. J Med Virol. 2015 May 8, In Press. doi: 10.1002/jmv.24255
    • (2015) J Med Virol
    • Yoshimi, S.1    Imamura, M.2    Murakami, E.3    Hiraga, N.4    Tsuge, M.5    Kawakami, Y.6
  • 17
    • 84906814530 scopus 로고    scopus 로고
    • All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: A multinational, phase 3, multicohort study
    • 25078304 Nov 1
    • Manns M, Pol S, Jacobson IM, Marcellin P, Gordon SC, Peng C-Y, et al. All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study. Lancet. 2014 Nov 1; 384(9954):1597-605. doi: 10.1016/S0140-6736(14)61059-X PMID: 25078304
    • (2014) Lancet , vol.384 , Issue.9954 , pp. 1597-1605
    • Manns, M.1    Pol, S.2    Jacobson, I.M.3    Marcellin, P.4    Gordon, S.C.5    Peng, C.-Y.6
  • 18
    • 84918525841 scopus 로고    scopus 로고
    • Deep sequencing analysis of variants resistant to the non-structural 5A inhibitor daclatasvir in patients with genotype 1b hepatitis C virus infection
    • 24612030 Dec
    • Miura M, Maekawa S, Sato M, Komatsu N, Tatsumi A, Takano S, et al. Deep sequencing analysis of variants resistant to the non-structural 5A inhibitor daclatasvir in patients with genotype 1b hepatitis C virus infection. Hepatol Res. 2014 Dec; 44(14):E360-7. doi: 10.1111/hepr.12316 PMID: 24612030
    • (2014) Hepatol Res. , vol.44 , Issue.14 , pp. E360-E367
    • Miura, M.1    Maekawa, S.2    Sato, M.3    Komatsu, N.4    Tatsumi, A.5    Takano, S.6
  • 19
    • 84896740050 scopus 로고    scopus 로고
    • Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes
    • 24311440 Mar
    • Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, et al. Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes. Hepatology. 2014 Mar; 59(3):828-38. doi: 10.1002/hep.26788 PMID: 24311440
    • (2014) Hepatology , vol.59 , Issue.3 , pp. 828-838
    • Honda, M.1    Shirasaki, T.2    Shimakami, T.3    Sakai, A.4    Horii, R.5    Arai, K.6
  • 20
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • 9756471 Oct 2
    • Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science. 1998 Oct 2; 282(5386):103-7. PMID: 9756471
    • (1998) Science , vol.282 , Issue.5386 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6
  • 21
    • 49149090985 scopus 로고    scopus 로고
    • Early and accurate prediction of Peg-IFNs/ribavirin therapy outcome in the individual patient with chronic hepatitis C by modeling the dynamics of the infected cells
    • 18388885 Aug
    • Colombatto P, Ciccorossi P, Maina AM, Civitano L, Oliveri F, Coco B, et al. Early and accurate prediction of Peg-IFNs/ribavirin therapy outcome in the individual patient with chronic hepatitis C by modeling the dynamics of the infected cells. Clin Pharmacol Ther. 2008 Aug; 84(2):212-5. doi: 10.1038/clpt.2008.21 PMID: 18388885
    • (2008) Clin Pharmacol Ther , vol.84 , Issue.2 , pp. 212-215
    • Colombatto, P.1    Ciccorossi, P.2    Maina, A.M.3    Civitano, L.4    Oliveri, F.5    Coco, B.6
  • 22
    • 0033429914 scopus 로고    scopus 로고
    • Molecular virology of the hepatitis C virus
    • 10622560 Jan
    • De Francesco R. Molecular virology of the hepatitis C virus. J Hepatol. 1999 Jan; 31 Suppl 1:47-53. PMID: 10622560
    • (1999) J Hepatol , vol.31 , pp. 47-53
    • De Francesco, R.1
  • 23
    • 78649430973 scopus 로고    scopus 로고
    • Hepatitis C virus nonstructural protein 5A: Biochemical characterization of a novel structural class of RNA-binding proteins
    • 20926572 Dec
    • Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, et al. Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol. 2010 Dec; 84(24):12480-91. doi: 10.1128/JVI.01319-10 PMID: 20926572
    • (2010) J Virol , vol.84 , Issue.24 , pp. 12480-12491
    • Hwang, J.1    Huang, L.2    Cordek, D.G.3    Vaughan, R.4    Reynolds, S.L.5    Kihara, G.6
  • 24
    • 84865735115 scopus 로고    scopus 로고
    • Correlation between NS5A dimerization and hepatitis C virus replication
    • 22801423 Aug 31
    • Lim PJ, Chatterji U, Cordek D, Sharma SD, Garcia-Rivera JA, Cameron CE, et al. Correlation between NS5A dimerization and hepatitis C virus replication. J Biol Chem. 2012 Aug 31; 287(36):30861-73. doi: 10.1074/jbc.M112.376822 PMID: 22801423
    • (2012) J Biol Chem , vol.287 , Issue.36 , pp. 30861-30873
    • Lim, P.J.1    Chatterji, U.2    Cordek, D.3    Sharma, S.D.4    Garcia-Rivera, J.A.5    Cameron, C.E.6
  • 25
    • 84899059740 scopus 로고    scopus 로고
    • Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
    • 24755925 Jan
    • Ascher DB, Wielens J, Nero TL, Doughty L, Morton CJ, Parker MW. Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci Rep. 2014 Jan; 4:4765. doi: 10.1038/srep04765 PMID: 24755925
    • (2014) Sci Rep. , vol.4 , pp. 4765
    • Ascher, D.B.1    Wielens, J.2    Nero, T.L.3    Doughty, L.4    Morton, C.J.5    Parker, M.W.6
  • 26
    • 84923171513 scopus 로고    scopus 로고
    • Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes
    • 25552726 Dec 31
    • Ross-Thriepland D, Mankouri J, Harris M. Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes. J Virol. 2014 Dec 31; 89(6):3123-35. doi: 10.1128/JVI.02995-14 PMID: 25552726
    • (2014) J Virol , vol.89 , Issue.6 , pp. 3123-3135
    • Ross-Thriepland, D.1    Mankouri, J.2    Harris, M.3
  • 27
    • 84931275564 scopus 로고    scopus 로고
    • Cyclophilin and NS5A inhibitors, but not other antihepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories
    • 25666154 May
    • Chatterji U, Bobardt M, Tai A, Wood M, Gallay PA. Cyclophilin and NS5A inhibitors, but not other antihepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories. Antimicrob Agents Chemother. 2015 May; 59(5):2496-507. doi: 10.1128/AAC.04958-14 PMID: 25666154
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.5 , pp. 2496-2507
    • Chatterji, U.1    Bobardt, M.2    Tai, A.3    Wood, M.4    Gallay, P.A.5
  • 28
    • 42949130180 scopus 로고    scopus 로고
    • Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
    • 18369481 Mar
    • Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, et al. Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog. 2008 Mar; 4 (3):e1000035. doi: 10.1371/journal.ppat.1000035 PMID: 18369481
    • (2008) PLoS Pathog , vol.4 , Issue.3 , pp. e1000035
    • Appel, N.1    Zayas, M.2    Miller, S.3    Krijnse-Locker, J.4    Schaller, T.5    Friebe, P.6
  • 29
    • 84904730378 scopus 로고    scopus 로고
    • Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors
    • 24768676 Aug; e7
    • McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, et al. Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors. Gastroenterology. 2014 Aug; 147 (2):453-62.e7. doi: 10.1053/j.gastro.2014.04.021 PMID: 24768676
    • (2014) Gastroenterology , vol.147 , Issue.2 , pp. 453-462
    • McGivern, D.R.1    Masaki, T.2    Williford, S.3    Ingravallo, P.4    Feng, Z.5    Lahser, F.6
  • 30
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • 9143277 Apr 14
    • Gale MJ, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology. 1997 Apr 14; 230(2):217-27. doi: 10.1006/viro.1997.8493 PMID: 9143277
    • (1997) Virology , vol.230 , Issue.2 , pp. 217-227
    • Gale, M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.L.4    Hopkins, D.A.5    Dever, T.E.6
  • 31
    • 84863150484 scopus 로고    scopus 로고
    • Hepatitis C virus proteins inhibit C3 complement production
    • 22171262 Feb
    • Mazumdar B, Kim H, Meyer K, Bose SK, Di Bisceglie AM, Ray RB, et al. Hepatitis C virus proteins inhibit C3 complement production. J Virol. 2012 Feb; 86(4):2221-8. doi: 10.1128/JVI.06577-11 PMID: 22171262
    • (2012) J Virol , vol.86 , Issue.4 , pp. 2221-2228
    • Mazumdar, B.1    Kim, H.2    Meyer, K.3    Bose, S.K.4    Di Bisceglie, A.M.5    Ray, R.B.6
  • 32
    • 84891334795 scopus 로고    scopus 로고
    • Hepatitis C virus impairs TLR3 signaling and inhibits IFN-λ 1 expression in human hepatoma cell line
    • 23529855 Jan
    • Wang Y, Li J, Wang X, Ye L, Zhou Y, Thomas RM, et al. Hepatitis C virus impairs TLR3 signaling and inhibits IFN-λ 1 expression in human hepatoma cell line. Innate Immun. 2014 Jan; 20(1):3-11. doi: 10.1177/1753425913478991 PMID: 23529855
    • (2014) Innate Immun , vol.20 , Issue.1 , pp. 3-11
    • Wang, Y.1    Li, J.2    Wang, X.3    Ye, L.4    Zhou, Y.5    Thomas, R.M.6
  • 33
    • 70350493684 scopus 로고    scopus 로고
    • The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo
    • 19674968 Oct 9
    • Kriegs M, Bürckstümmer T, Himmelsbach K, Bruns M, Frelin L, Ahlén G, et al. The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo. J Biol Chem. 2009 Oct 9; 284(41):28343-51. doi: 10.1074/jbc.M109.038877 PMID: 19674968
    • (2009) J Biol Chem , vol.284 , Issue.41 , pp. 28343-28351
    • Kriegs, M.1    Bürckstümmer, T.2    Himmelsbach, K.3    Bruns, M.4    Frelin, L.5    Ahlén, G.6
  • 34
    • 66149115122 scopus 로고    scopus 로고
    • Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
    • 19244328 May
    • Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN. Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus. J Virol. 2009 May; 83(9):4395-403. doi: 10.1128/JVI.02352-08 PMID: 19244328
    • (2009) J Virol. , vol.83 , Issue.9 , pp. 4395-4403
    • Love, R.A.1    Brodsky, O.2    Hickey, M.J.3    Wells, P.A.4    Cronin, C.N.5
  • 35
    • 84901598261 scopus 로고    scopus 로고
    • The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors
    • 24639329 Jun
    • Lambert SM, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, et al. The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors. Protein Sci. 2014 Jun; 23(6):723-34. doi: 10.1002/pro.2456 PMID: 24639329
    • (2014) Protein Sci. , vol.23 , Issue.6 , pp. 723-734
    • Lambert, S.M.1    Langley, D.R.2    Garnett, J.A.3    Angell, R.4    Hedgethorne, K.5    Meanwell, N.A.6
  • 36
    • 4644260669 scopus 로고    scopus 로고
    • Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A
    • 15247283 Sep 24
    • Penin F, Brass V, Appel N, Ramboarina S, Montserret R, Ficheux D, et al. Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem. 2004 Sep 24; 279 (39):40835-43. doi: 10.1074/jbc.M404761200 PMID: 15247283
    • (2004) J Biol Chem. , vol.279 , Issue.39 , pp. 40835-40843
    • Penin, F.1    Brass, V.2    Appel, N.3    Ramboarina, S.4    Montserret, R.5    Ficheux, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.