-
1
-
-
84925649961
-
Hepatitis C
-
25687730 Feb 13
-
Webster DP, Klenerman P, Dusheiko GM. Hepatitis C. Lancet. 2015 Feb 13; 385(9973):1124-35. doi: 10.1016/S0140-6736(14)62401-6 PMID: 25687730
-
(2015)
Lancet
, vol.385
, Issue.9973
, pp. 1124-1135
-
-
Webster, D.P.1
Klenerman, P.2
Dusheiko, G.M.3
-
2
-
-
84903186698
-
Antiviral therapy for chronic hepatitis C in 2014
-
24939471 Jul
-
Nookathota M, Mukherjee S. Antiviral therapy for chronic hepatitis C in 2014. Expert Rev Clin Pharmacol. 2014 Jul; 7(4):499-505. doi: 10.1586/17512433.2014.915737 PMID: 24939471
-
(2014)
Expert Rev Clin Pharmacol
, vol.7
, Issue.4
, pp. 499-505
-
-
Nookathota, M.1
Mukherjee, S.2
-
3
-
-
75149151884
-
Resistance to direct antiviral agents in patients with hepatitis C virus infection
-
20006612 Feb
-
Sarrazin C, Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology. 2010 Feb; 138(2):447-62. doi: 10.1053/j.gastro.2009.11.055 PMID: 20006612
-
(2010)
Gastroenterology
, vol.138
, Issue.2
, pp. 447-462
-
-
Sarrazin, C.1
Zeuzem, S.2
-
4
-
-
79955103901
-
Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
-
21374691 May
-
Pawlotsky J-M. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology. 2011 May; 53(5):1742-51. doi: 10.1002/hep.24262 PMID: 21374691
-
(2011)
Hepatology
, vol.53
, Issue.5
, pp. 1742-1751
-
-
Pawlotsky, J.-M.1
-
5
-
-
84938949283
-
-
Recommendations on Treatment of Hepatitis C 2015. Available: http://www.easl.eu/research/ourcontributions/clinical-practice-guidelines/detail/recommendations-on-treatment-of-hepatitis-c-2015
-
(2015)
Recommendations on Treatment of Hepatitis C
-
-
-
6
-
-
84901595218
-
Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection
-
24604476 Jun
-
Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, et al. Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. Hepatology. 2014 Jun; 59(6):2083-91. doi: 10.1002/hep.27113 PMID: 24604476
-
(2014)
Hepatology
, vol.59
, Issue.6
, pp. 2083-2091
-
-
Kumada, H.1
Suzuki, Y.2
Ikeda, K.3
Toyota, J.4
Karino, Y.5
Chayama, K.6
-
7
-
-
84900339263
-
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
-
24725239 May 15
-
Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15; 370(20):1889-98. doi: 10.1056/NEJMoa1402454 PMID: 24725239
-
(2014)
N Engl J Med.
, vol.370
, Issue.20
, pp. 1889-1898
-
-
Afdhal, N.1
Zeuzem, S.2
Kwo, P.3
Chojkier, M.4
Gitlin, N.5
Puoti, M.6
-
8
-
-
84901044326
-
ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV
-
24795200 May 22
-
Ferenci P, Bernstein D, Lalezari J, Cohen D, Luo Y, Cooper C, et al. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014 May 22; 370(21):1983-92. doi: 10.1056/NEJMoa1402338 PMID: 24795200
-
(2014)
N Engl J Med.
, vol.370
, Issue.21
, pp. 1983-1992
-
-
Ferenci, P.1
Bernstein, D.2
Lalezari, J.3
Cohen, D.4
Luo, Y.5
Cooper, C.6
-
9
-
-
84925423399
-
Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): A rando
-
25467560 Nov 11
-
Sulkowski M, Hezode C, Gerstoft J, Vierling JM, Mallolas J, Pol S, et al. Efficacy and safety of 8 weeks versus 12 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin in patients with hepatitis C virus genotype 1 mono-infection and HIV/hepatitis C virus co-infection (C-WORTHY): a rando. Lancet. 2014 Nov 11; 385(9973):1087-97. doi: 10.1016/S0140-6736(14) 61793-1 PMID: 25467560
-
(2014)
Lancet
, vol.385
, Issue.9973
, pp. 1087-1097
-
-
Sulkowski, M.1
Hezode, C.2
Gerstoft, J.3
Vierling, J.M.4
Mallolas, J.5
Pol, S.6
-
10
-
-
84880299420
-
NS5A inhibitors in the treatment of hepatitis C
-
European Association for the Study of the Liver
-
Pawlotsky J-M. NS5A inhibitors in the treatment of hepatitis C. J Hepatol. European Association for the Study of the Liver; 2013; 59(2):375-82. doi: 10.1016/j.jhep.2013.03.030
-
(2013)
J Hepatol
, vol.59
, Issue.2
, pp. 375-382
-
-
Pawlotsky, J.-M.1
-
11
-
-
84896460675
-
Hepatitis C virus NS5A inhibitors and drug resistance mutations
-
24659881 Mar 21
-
Nakamoto S, Kanda T, Wu S, Shirasawa H, Yokosuka O. Hepatitis C virus NS5A inhibitors and drug resistance mutations. World J Gastroenterol. 2014 Mar 21; 20(11):2902-12. doi: 10.3748/wjg.v20.i11.2902 PMID: 24659881
-
(2014)
World J Gastroenterol
, vol.20
, Issue.11
, pp. 2902-2912
-
-
Nakamoto, S.1
Kanda, T.2
Wu, S.3
Shirasawa, H.4
Yokosuka, O.5
-
12
-
-
84896055529
-
Approaches to hepatitis C treatment and cure using NS5A inhibitors
-
24623983 Jan
-
Kohler JJ, Nettles JH, Amblard F, Hurwitz SJ, Bassit L, Stanton RA, et al. Approaches to hepatitis C treatment and cure using NS5A inhibitors. Infect Drug Resist. 2014 Jan; 7:41-56. doi: 10.2147/IDR.S36247 PMID: 24623983
-
(2014)
Infect Drug Resist
, vol.7
, pp. 41-56
-
-
Kohler, J.J.1
Nettles, J.H.2
Amblard, F.3
Hurwitz, S.J.4
Bassit, L.5
Stanton, R.A.6
-
13
-
-
84939174987
-
Naturally occurring, resistance-associated hepatitis C virus NS5A variants are linked to IL28B genotype and are sensitive to interferon-based therapy
-
Jan 6, In Press
-
Itakura J, Kurosaki M, Takada H, Nakakuki N, Matsuda S, Gondou K, et al. Naturally occurring, resistance-associated hepatitis C virus NS5A variants are linked to IL28B genotype and are sensitive to interferon-based therapy. Hepatol Res. 2015 Jan 6, In Press. doi: 10.1111/hepr.12474
-
(2015)
Hepatol Res.
-
-
Itakura, J.1
Kurosaki, M.2
Takada, H.3
Nakakuki, N.4
Matsuda, S.5
Gondou, K.6
-
14
-
-
84905825880
-
Efficacy of daclatasvir in hepatitis C virus
-
25059552 Sep
-
Izumi N. Efficacy of daclatasvir in hepatitis C virus. Expert Rev Anti Infect Ther. 2014 Sep; 12(9):1025-31. doi: 10.1586/14787210.2014.942282 PMID: 25059552
-
(2014)
Expert Rev Anti Infect Ther
, vol.12
, Issue.9
, pp. 1025-1031
-
-
Izumi, N.1
-
15
-
-
84921433851
-
Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1
-
24943406 Feb
-
Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, et al. Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1. J Viral Hepat. 2015 Feb; 22(2):158-65. doi: 10.1111/jvh.12271 PMID: 24943406
-
(2015)
J Viral Hepat
, vol.22
, Issue.2
, pp. 158-165
-
-
Kosaka, K.1
Imamura, M.2
Hayes, C.N.3
Abe, H.4
Hiraga, N.5
Yoshimi, S.6
-
16
-
-
84940582565
-
Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy
-
May 8, In Press
-
Yoshimi S, Imamura M, Murakami E, Hiraga N, Tsuge M, Kawakami Y, et al. Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy. J Med Virol. 2015 May 8, In Press. doi: 10.1002/jmv.24255
-
(2015)
J Med Virol
-
-
Yoshimi, S.1
Imamura, M.2
Murakami, E.3
Hiraga, N.4
Tsuge, M.5
Kawakami, Y.6
-
17
-
-
84906814530
-
All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: A multinational, phase 3, multicohort study
-
25078304 Nov 1
-
Manns M, Pol S, Jacobson IM, Marcellin P, Gordon SC, Peng C-Y, et al. All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study. Lancet. 2014 Nov 1; 384(9954):1597-605. doi: 10.1016/S0140-6736(14)61059-X PMID: 25078304
-
(2014)
Lancet
, vol.384
, Issue.9954
, pp. 1597-1605
-
-
Manns, M.1
Pol, S.2
Jacobson, I.M.3
Marcellin, P.4
Gordon, S.C.5
Peng, C.-Y.6
-
18
-
-
84918525841
-
Deep sequencing analysis of variants resistant to the non-structural 5A inhibitor daclatasvir in patients with genotype 1b hepatitis C virus infection
-
24612030 Dec
-
Miura M, Maekawa S, Sato M, Komatsu N, Tatsumi A, Takano S, et al. Deep sequencing analysis of variants resistant to the non-structural 5A inhibitor daclatasvir in patients with genotype 1b hepatitis C virus infection. Hepatol Res. 2014 Dec; 44(14):E360-7. doi: 10.1111/hepr.12316 PMID: 24612030
-
(2014)
Hepatol Res.
, vol.44
, Issue.14
, pp. E360-E367
-
-
Miura, M.1
Maekawa, S.2
Sato, M.3
Komatsu, N.4
Tatsumi, A.5
Takano, S.6
-
19
-
-
84896740050
-
Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes
-
24311440 Mar
-
Honda M, Shirasaki T, Shimakami T, Sakai A, Horii R, Arai K, et al. Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes. Hepatology. 2014 Mar; 59(3):828-38. doi: 10.1002/hep.26788 PMID: 24311440
-
(2014)
Hepatology
, vol.59
, Issue.3
, pp. 828-838
-
-
Honda, M.1
Shirasaki, T.2
Shimakami, T.3
Sakai, A.4
Horii, R.5
Arai, K.6
-
20
-
-
0032475822
-
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
-
9756471 Oct 2
-
Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science. 1998 Oct 2; 282(5386):103-7. PMID: 9756471
-
(1998)
Science
, vol.282
, Issue.5386
, pp. 103-107
-
-
Neumann, A.U.1
Lam, N.P.2
Dahari, H.3
Gretch, D.R.4
Wiley, T.E.5
Layden, T.J.6
-
21
-
-
49149090985
-
Early and accurate prediction of Peg-IFNs/ribavirin therapy outcome in the individual patient with chronic hepatitis C by modeling the dynamics of the infected cells
-
18388885 Aug
-
Colombatto P, Ciccorossi P, Maina AM, Civitano L, Oliveri F, Coco B, et al. Early and accurate prediction of Peg-IFNs/ribavirin therapy outcome in the individual patient with chronic hepatitis C by modeling the dynamics of the infected cells. Clin Pharmacol Ther. 2008 Aug; 84(2):212-5. doi: 10.1038/clpt.2008.21 PMID: 18388885
-
(2008)
Clin Pharmacol Ther
, vol.84
, Issue.2
, pp. 212-215
-
-
Colombatto, P.1
Ciccorossi, P.2
Maina, A.M.3
Civitano, L.4
Oliveri, F.5
Coco, B.6
-
22
-
-
0033429914
-
Molecular virology of the hepatitis C virus
-
10622560 Jan
-
De Francesco R. Molecular virology of the hepatitis C virus. J Hepatol. 1999 Jan; 31 Suppl 1:47-53. PMID: 10622560
-
(1999)
J Hepatol
, vol.31
, pp. 47-53
-
-
De Francesco, R.1
-
23
-
-
78649430973
-
Hepatitis C virus nonstructural protein 5A: Biochemical characterization of a novel structural class of RNA-binding proteins
-
20926572 Dec
-
Hwang J, Huang L, Cordek DG, Vaughan R, Reynolds SL, Kihara G, et al. Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteins. J Virol. 2010 Dec; 84(24):12480-91. doi: 10.1128/JVI.01319-10 PMID: 20926572
-
(2010)
J Virol
, vol.84
, Issue.24
, pp. 12480-12491
-
-
Hwang, J.1
Huang, L.2
Cordek, D.G.3
Vaughan, R.4
Reynolds, S.L.5
Kihara, G.6
-
24
-
-
84865735115
-
Correlation between NS5A dimerization and hepatitis C virus replication
-
22801423 Aug 31
-
Lim PJ, Chatterji U, Cordek D, Sharma SD, Garcia-Rivera JA, Cameron CE, et al. Correlation between NS5A dimerization and hepatitis C virus replication. J Biol Chem. 2012 Aug 31; 287(36):30861-73. doi: 10.1074/jbc.M112.376822 PMID: 22801423
-
(2012)
J Biol Chem
, vol.287
, Issue.36
, pp. 30861-30873
-
-
Lim, P.J.1
Chatterji, U.2
Cordek, D.3
Sharma, S.D.4
Garcia-Rivera, J.A.5
Cameron, C.E.6
-
25
-
-
84899059740
-
Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA
-
24755925 Jan
-
Ascher DB, Wielens J, Nero TL, Doughty L, Morton CJ, Parker MW. Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci Rep. 2014 Jan; 4:4765. doi: 10.1038/srep04765 PMID: 24755925
-
(2014)
Sci Rep.
, vol.4
, pp. 4765
-
-
Ascher, D.B.1
Wielens, J.2
Nero, T.L.3
Doughty, L.4
Morton, C.J.5
Parker, M.W.6
-
26
-
-
84923171513
-
Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes
-
25552726 Dec 31
-
Ross-Thriepland D, Mankouri J, Harris M. Serine phosphorylation of the hepatitis C virus NS5A protein controls the establishment of replication complexes. J Virol. 2014 Dec 31; 89(6):3123-35. doi: 10.1128/JVI.02995-14 PMID: 25552726
-
(2014)
J Virol
, vol.89
, Issue.6
, pp. 3123-3135
-
-
Ross-Thriepland, D.1
Mankouri, J.2
Harris, M.3
-
27
-
-
84931275564
-
Cyclophilin and NS5A inhibitors, but not other antihepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories
-
25666154 May
-
Chatterji U, Bobardt M, Tai A, Wood M, Gallay PA. Cyclophilin and NS5A inhibitors, but not other antihepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factories. Antimicrob Agents Chemother. 2015 May; 59(5):2496-507. doi: 10.1128/AAC.04958-14 PMID: 25666154
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.5
, pp. 2496-2507
-
-
Chatterji, U.1
Bobardt, M.2
Tai, A.3
Wood, M.4
Gallay, P.A.5
-
28
-
-
42949130180
-
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
-
18369481 Mar
-
Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, et al. Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog. 2008 Mar; 4 (3):e1000035. doi: 10.1371/journal.ppat.1000035 PMID: 18369481
-
(2008)
PLoS Pathog
, vol.4
, Issue.3
, pp. e1000035
-
-
Appel, N.1
Zayas, M.2
Miller, S.3
Krijnse-Locker, J.4
Schaller, T.5
Friebe, P.6
-
29
-
-
84904730378
-
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors
-
24768676 Aug; e7
-
McGivern DR, Masaki T, Williford S, Ingravallo P, Feng Z, Lahser F, et al. Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors. Gastroenterology. 2014 Aug; 147 (2):453-62.e7. doi: 10.1053/j.gastro.2014.04.021 PMID: 24768676
-
(2014)
Gastroenterology
, vol.147
, Issue.2
, pp. 453-462
-
-
McGivern, D.R.1
Masaki, T.2
Williford, S.3
Ingravallo, P.4
Feng, Z.5
Lahser, F.6
-
30
-
-
0343924357
-
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
-
9143277 Apr 14
-
Gale MJ, Korth MJ, Tang NM, Tan SL, Hopkins DA, Dever TE, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology. 1997 Apr 14; 230(2):217-27. doi: 10.1006/viro.1997.8493 PMID: 9143277
-
(1997)
Virology
, vol.230
, Issue.2
, pp. 217-227
-
-
Gale, M.J.1
Korth, M.J.2
Tang, N.M.3
Tan, S.L.4
Hopkins, D.A.5
Dever, T.E.6
-
31
-
-
84863150484
-
Hepatitis C virus proteins inhibit C3 complement production
-
22171262 Feb
-
Mazumdar B, Kim H, Meyer K, Bose SK, Di Bisceglie AM, Ray RB, et al. Hepatitis C virus proteins inhibit C3 complement production. J Virol. 2012 Feb; 86(4):2221-8. doi: 10.1128/JVI.06577-11 PMID: 22171262
-
(2012)
J Virol
, vol.86
, Issue.4
, pp. 2221-2228
-
-
Mazumdar, B.1
Kim, H.2
Meyer, K.3
Bose, S.K.4
Di Bisceglie, A.M.5
Ray, R.B.6
-
32
-
-
84891334795
-
Hepatitis C virus impairs TLR3 signaling and inhibits IFN-λ 1 expression in human hepatoma cell line
-
23529855 Jan
-
Wang Y, Li J, Wang X, Ye L, Zhou Y, Thomas RM, et al. Hepatitis C virus impairs TLR3 signaling and inhibits IFN-λ 1 expression in human hepatoma cell line. Innate Immun. 2014 Jan; 20(1):3-11. doi: 10.1177/1753425913478991 PMID: 23529855
-
(2014)
Innate Immun
, vol.20
, Issue.1
, pp. 3-11
-
-
Wang, Y.1
Li, J.2
Wang, X.3
Ye, L.4
Zhou, Y.5
Thomas, R.M.6
-
33
-
-
70350493684
-
The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo
-
19674968 Oct 9
-
Kriegs M, Bürckstümmer T, Himmelsbach K, Bruns M, Frelin L, Ahlén G, et al. The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo. J Biol Chem. 2009 Oct 9; 284(41):28343-51. doi: 10.1074/jbc.M109.038877 PMID: 19674968
-
(2009)
J Biol Chem
, vol.284
, Issue.41
, pp. 28343-28351
-
-
Kriegs, M.1
Bürckstümmer, T.2
Himmelsbach, K.3
Bruns, M.4
Frelin, L.5
Ahlén, G.6
-
34
-
-
66149115122
-
Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus
-
19244328 May
-
Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN. Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C virus. J Virol. 2009 May; 83(9):4395-403. doi: 10.1128/JVI.02352-08 PMID: 19244328
-
(2009)
J Virol.
, vol.83
, Issue.9
, pp. 4395-4403
-
-
Love, R.A.1
Brodsky, O.2
Hickey, M.J.3
Wells, P.A.4
Cronin, C.N.5
-
35
-
-
84901598261
-
The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors
-
24639329 Jun
-
Lambert SM, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, et al. The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors. Protein Sci. 2014 Jun; 23(6):723-34. doi: 10.1002/pro.2456 PMID: 24639329
-
(2014)
Protein Sci.
, vol.23
, Issue.6
, pp. 723-734
-
-
Lambert, S.M.1
Langley, D.R.2
Garnett, J.A.3
Angell, R.4
Hedgethorne, K.5
Meanwell, N.A.6
-
36
-
-
4644260669
-
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A
-
15247283 Sep 24
-
Penin F, Brass V, Appel N, Ramboarina S, Montserret R, Ficheux D, et al. Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem. 2004 Sep 24; 279 (39):40835-43. doi: 10.1074/jbc.M404761200 PMID: 15247283
-
(2004)
J Biol Chem.
, vol.279
, Issue.39
, pp. 40835-40843
-
-
Penin, F.1
Brass, V.2
Appel, N.3
Ramboarina, S.4
Montserret, R.5
Ficheux, D.6
|