Increased Expression of Aldehyde Dehydrogenase 2 Reduces Renal Cell Apoptosis During Ischemia/Reperfusion Injury After Hypothermic Machine Perfusion

Artificial Organs

Volumn 40, Issue 6, 2016, Pages 596-603

  Zhong, Zibiao ^a   Hu, Qianchao ^a   Fu, Zhen ^b   Wang, Ren ^a   Xiong, Yan ^a   Zhang, Yang ^b   Liu, Zhongzhong ^a   Wang, Yanfeng ^a   Ye, Qifa ^a,b  

^a WUHAN UNIVERSITY   (China)

^b THE THIRD XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Aldehyde dehydrogenase 2; Apoptosis; Hypothermic machine perfusion; Mitogen activated protein kinase pathway; Organ donation

Indexed keywords

ALDEHYDES; BLOOD; COLD STORAGE; UREA;

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 2; CELL APOPTOSIS; HYPOTHERMIC; HYPOTHERMIC MACHINE PERFUSION; MITOGEN-ACTIVATED PROTEIN KINASE; MITOGEN-ACTIVATED PROTEIN KINASE PATHWAY; ORGAN DONATIONS; PROTEIN KINASE PATHWAYS; STORAGE GROUPS;

CELL DEATH;

4 HYDROXYNONENAL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; BETA ACTIN; CASPASE 3; CREATININE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITROGEN; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; UREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTERY CLAMP; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE URINE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HYPOTHERMIC MACHINE PERFUSION; IMMUNOHISTOCHEMISTRY; ISCHEMIA; KIDNEY CELL; KIDNEY TRANSPLANTATION; MALE; NEPHRECTOMY; NEW ZEALAND RABBIT; NONHUMAN; ORGAN DONOR; ORGAN INJURY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REPERFUSION INJURY; TUNEL ASSAY; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; CYTOLOGY; INDUCED HYPOTHERMIA; KIDNEY; KIDNEY FUNCTION TEST; METABOLISM; ORGAN PRESERVATION; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RABBITS AND HARES; SIGNAL TRANSDUCTION;

ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ANIMALS; APOPTOSIS; HYPOTHERMIA, INDUCED; KIDNEY; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; MALE; MAP KINASE SIGNALING SYSTEM; ORGAN PRESERVATION; RABBITS; REPERFUSION INJURY;

EID: 84947460831     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/aor.12607     Document Type: Article

References (36)

1. Lindell SL, Muir H, Brassil J, Mangino MJ. Hypothermic machine perfusion preservation of the dcd kidney: machine effects. J Transplant 2013;2013:1-7.
2. Wolfe RA, Ashby VB, Milford EL, etal. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999;341:1725-1730.
3. Morrissey PE, Monaco AP. Donation after circulatory death: current practices, ongoing challenges, and potential improvements. Transplantation 2014;97:258-264.
4. Deng R, Gu G, Wang D, etal. Machine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysis. PLoS ONE 2013;8:e56368.
5. Kootstra G, van Heurn E. Non-heartbeating donation of kidneys for transplantation. Nat Clin Pract Nephrol 2007;3:154-163.
6. Miranda-Utrera N, Medina-Polo J, Pamplona M, etal. Donation after cardiac death: results of the SUMMA 112 - Hospital 12 de Octubre Program. Clin Transplant 2013;27:283-288.
7. Kootstra G, van Heurn E. Non-heartbeating donation of kidneys for transplantation. Nat Clin Pract Nephrol 2007;3:154-163.
8. Moers C, Leuvenink HG, Ploeg RJ. Non-heart beating organ donation: overview and future perspectives. Transpl Int 2007;20:567-575.
9. Kokkinos C, Antcliffe D, Nanidis T, etal. Outcome of kidney transplantation from nonheart-beating versus heart-beating cadaveric donors. Transplantation 2007;83:1193-1199.
10. Gallinat A, Lüer B, Swoboda S, Rauen U, Paul A, Minor T. Use of the new preservation solution Custodiol-N supplemented with dextran for hypothermic machine perfusion of the kidney. Cryobiology 2013;66:131-135.
11. Hoyer DP, Gallinat A, Swoboda S, etal. Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death model. Transpl Int 2014;27:1097-1106.
12. Jomaa A, Gurusamy K, Siriwardana PN, etal. Does hypothermic machine perfusion of human donor livers affect risks of sinusoidal endothelial injury and microbial infection? A feasibility study assessing flow parameters, sterility, and sinusoidal endothelial ultrastructure. Transplant Proc 2013;45:1677-1683.
13. Lam VW, Laurence JM, Richardson AJ, Pleass HC, Allen RD. Hypothermic machine perfusion in deceased donor kidney transplantation: a systematic review. J Surg Res 2013;180:176-182.
14. Sedigh A, Tufveson G, Bäckman L, Biglarnia AR, Lorant T. Initial experience with hypothermic machine perfusion of kidneys from deceased donors in the Uppsala region in Sweden. Transplant Proc 2013;45:1168-1171.
15. O'Callaghan JM, Morgan RD, Knight SR, Morris PJ. Systematic review and meta-analysis of hypothermic machine perfusion versus static cold storage of kidney allografts on transplant outcomes. Br J Surg 2013;100:991-1001.
16. Gingell-Littlejohn M, Koh H, Aitken E, etal. Below-target postoperative arterial blood pressure but not central venous pressure is associated with delayed graft function. Transplant Proc 2013;45:46-50.
17. Jiao B, Liu S, Liu H, Cheng D, Cheng Y, Liu Y. Hypothermic machine perfusion reduces delayed graft function and improves one-year graft survival of kidneys from expanded criteria donors: a meta-analysis. PLoS ONE 2013;8:e81826.
18. Cannon RM, Brock GN, Garrison RN, Smith JW, Marvin MR, Franklin GA. To pump or not to pump: a comparison of machine perfusion vs cold storage for deceased donor kidney transplantation. J Am Coll Surg 2013;216:625-633, discussion 633-4.
19. Zhang Y, Ren J. ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. Pharmacol Ther 2011;132:86-95.
20. Zhong Z, Ye Q, Wang Y, etal. Detection and identification of aldehyde dehydrogenase as a indicator in the assessment of liver quality in rabbits with brain death. Chinese J Hepatobiliary Surg 2013;7:534-538.
21. Du B, Li L, Zhong Z, etal. Brain death induces the alteration of liver protein expression profiles in rabbits. Int J Mol Med 2014;34:578-584.
22. Li S-Y, Gomelsky M, Duan J, etal. Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells. J Biol Chem 2004;279:11244-11252.
23. McElhanon KE, Bose C, Sharma R, Wu L, Awasthi YC, Singh SP. Gsta4 null mouse embryonic fibroblasts exhibit enhanced sensitivity to oxidants: role of 4-hydroxynonenal in oxidant toxicity. Open J Apoptosis 2013;2. doi: 10.4236/ojapo.2013.21001.
24. Xu D, Guthrie JR, Mabry S, Sack TM, Truog W. Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2006;291:L966-975.
25. Lin MH, Yen JH, Weng CY, Wang L, Ha CL, Wu MJ. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: roles of ROS and MAPK pathways. Toxicology 2014;315:24-37.
26. Nee LE, McMorrow T, Campbell E, Slattery C, Ryan MP. TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells. Kidney Int 2004;66:1376-1386.
27. Fahy GM, Ali SE. Cryopreservation of the mammalian kidney II. Demonstration of immediate ex vivo function after introduction and removal of 7.5M cryoprotectant. Cryobiology 1997;35:114-131.
28. Hozumi A, Nishimura Y, Nishiuma T, Kotani Y, Yokoyama M. Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway. Am J Physiol Lung Cell Mol Physiol 2001;281:L1444-1452.
29. Brand-Herrmann SM. Where do we go for atherothrombotic disease genetics? Stroke 2008;39:1070-1075.
30. Degnan JH, Lasky-Su J, Raby BA, etal. Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics 2008;92:129-133.
31. Schulz UG, Flossmann E, Rothwell PM. Heritability of ischemic stroke in relation to age, vascular risk factors, and subtypes of incident stroke in population-based studies. Stroke 2004;35:819-824.
32. Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 2007;26:3100-3112.
33. Darling NJ, Cook SJ. The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. Biochim Biophys Acta 2014;1843:2150-2163.
34. Li S-Y, Li Q, Shen JJ, etal. Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J Mol Cell Cardiol 2006;40:283-294.
35. Churchill EN, Disatnik M-H, Mochly-Rosen D. Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol 2009;46:278-284.
36. Robador PA, Seyedi N, Chan NY, Koda K, Levi R. Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase C. J Pharmacol Exp Ther 2012;343:97-105.