Ghrelin inhibition restores glucose homeostasis in hepatocyte nuclear factor-1a (MODY3)-deficient mice

Diabetes

Volumn 64, Issue 9, 2015, Pages 3314-3320

  Brial, François ^a   Lussier, Carine R ^a   Belleville, Karine ^b   Sarret, Philippe ^b   Boudreau, François ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GHRELIN RECEPTOR; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; GHRP-6, LYS(3)-; GLUCOSE BLOOD LEVEL; HNF1A PROTEIN, MOUSE; INSULIN; MESSENGER RNA; OLIGOPEPTIDE;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; GENE MUTATION; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; HYPOINSULINEMIA; IN VITRO STUDY; INSULIN RELEASE; JEJUNUM; MOUSE; NEWBORN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; HOMEOSTASIS; KNOCKOUT MOUSE; METABOLISM; SECRETION (PROCESS); STOMACH;

ANIMALS; BLOOD GLUCOSE; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HOMEOSTASIS; INSULIN; INSULIN-SECRETING CELLS; JEJUNUM; MICE; MICE, KNOCKOUT; OLIGOPEPTIDES; RECEPTORS, GHRELIN; RNA, MESSENGER; STOMACH; UP-REGULATION;

EID: 84947340162     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0124     Document Type: Article

References (25)

1. Fajans SS, Bell GI, Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 2001; 345:971-980
2. Shih DQ, Stoffel M. Molecular etiologies of MODY and other early-onset forms of diabetes. Curr Diab Rep 2002;2:125-134
3. Yamagata K, Oda N, Kaisaki PJ, et al. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature 1996;384:455-458
4. Vaxillaire M, Rouard M, Yamagata K, et al. Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3). Hum Mol Genet 1997;6:583-586
5. Lee YH, Sauer B, Gonzalez FJ. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol 1998;18:3059-3068
6. Pontoglio M, Barra J, Hadchouel M, et al. Hepatocyte nuclear factor 1 in-activation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 1996;84:575-585
7. Pontoglio M, Sreenan S, Roe M, et al. Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest 1998;101:2215-2222
8. Dukes ID, Sreenan S, Roe MW, et al. Defective pancreatic beta-cell gly-colytic signaling in hepatocyte nuclear factor-1alpha-deficient mice. J Biol Chem 1998;273:24457-24464
9. Lin WY, Hu YJ, Lee YH. Hepatocyte nuclear factor-1alpha regulates glu-cocorticoid receptor expression to control postnatal body growth. Am J Physiol Gastrointest Liver Physiol 2008;295:G542-G551
10. Drucker DJ. The role of gut hormones in glucose homeostasis. J Clin Invest 2007;117:24-32
11. Lussier CR, Brial F, Roy SA, et al. Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS ONE 2010;5:e12378
12. Depoortere I, Thijs T, Peeters T. The contractile effect of the ghrelin receptor antagonist, D-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors. Eur J Pharmacol 2006;537:160-165
13. Erriquez J, Bernascone S, Ciarletta M, Filigheddu N, Graziani A, Distasi C. Calcium signals activated by ghrelin and D-Lys(3)-GHRP-6 ghrelin antagonist in developing dorsal root ganglion glial cells. Cell Calcium 2009;46:197-208
14. Patel K, Dixit VD, Lee JH, et al. Identification of ghrelin receptor blocker, D-[Lys3] GHRP-6 as a CXCR4 receptor antagonist. Int J Biol Sci 2012;8:108-117
15. Asakawa A, Inui A, Kaga T, et al. Antagonism of ghrelin receptor reduces food intake and body weight gain in mice. Gut 2003;52:947-952
16. Cheng K, Wei L, Chaung LY, Chan WW, Butler B, Smith RG. Inhibition of L-692, 429-stimulated rat growth hormone release by a weak substance P antagonist: L-756, 867. J Endocrinol 1997;152:155-158
17. Babeu JP, Darsigny M, Lussier CR, Boudreau F. Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation. Am J Physiol Gastrointest Liver Physiol 2009;297:G124-G134
18. Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 1995;136:3585-3596
19. Erickson RH, Lai RS, Kim YS. Role of hepatocyte nuclear factor 1alpha and 1beta in the transcriptional regulation of human dipeptidyl peptidase IV during differentiation of Caco-2 cells. Biochem Biophys Res Commun 2000;270:235-239
20. Dezaki K, Hosoda H, Kakei M, et al. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 2004;53:3142-3151
21. Kaestner KH. Collecting new targets in MODY. Cell Metab 2005;2:342-344
22. Wierup N, Sundler F, Heller RS. The islet ghrelin cell. J Mol Endocrinol 2014; 52:R35-R49
23. Wang Q, Elghazi L, Martin S, et al. Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum. Dev Dyn 2008;237:51-61
24. Vollmer K, Holst JJ, Baller B, et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes 2008;57:678-687
25. Alssema M, Rijkelijkhuizen JM, Holst JJ, et al. Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT. Eur J Endocrinol 2013;169:421-430