Characterisation of (R)-2-(2-fluorobiphenyl-4-yl)-N-(3-methylpyridin-2-yl)propanamide as a dual fatty acid amide hydrolase: Cyclooxygenase inhibitor

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Gouveia Figueira, Sandra ^a   Karlsson, Jessica ^a   Deplano, Alessandro ^b   Hashemian, Sanaz ^a   Svensson, Mona ^a   Sundbom, Marcus Fredriksson ^a   Congiu, Cenzo ^b   Onnis, Valentina ^b   Fowler, Christopher J ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 FLUOROBIPHENYL 4 YL)N (3 METHYLPYRIDIN 2 YL)PROPANAMIDE; ANANDAMIDE; ARACHIDONIC ACID; CYCLOHEXYLCARBAMIC ACID 3' CARBAMOYLBIPHENYL 3 YL ESTER; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FATTY ACID AMIDASE; FLURBIPROFEN; PROSTAGLANDIN D2; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; AMIDASE; AMIDE; ARACHIDONIC ACID DERIVATIVE; BENZAMIDE DERIVATIVE; CARBAMIC ACID DERIVATIVE; CYCLOHEXYL CARBAMIC ACID 3'-CARBAMOYLBIPHENYL-3-YL ESTER; CYCLOOXYGENASE 1; ENDOCANNABINOID; FATTY-ACID AMIDE HYDROLASE; GAMMA INTERFERON; IONOMYCIN; ISOENZYME; LIPOPOLYSACCHARIDE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HYDROLYSIS; IC50; IN VITRO STUDY; LIPID ANALYSIS; MALE; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; LIPID METABOLISM; METABOLISM; RAW 264.7 CELL LINE; STEREOISOMERISM;

AMIDES; AMIDOHYDROLASES; ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; BENZAMIDES; BRAIN; CARBAMATES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ENDOCANNABINOIDS; FLURBIPROFEN; HUMANS; HYDROLYSIS; INTERFERON-GAMMA; IONOMYCIN; ISOENZYMES; LIPID METABOLISM; LIPOPOLYSACCHARIDES; MALE; MICE; POLYUNSATURATED ALKAMIDES; PROSTAGLANDINS; RAW 264.7 CELLS; STEREOISOMERISM;

EID: 84947261212     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139212     Document Type: Article

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