Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality

Reproduction

Volumn 150, Issue 4, 2015, Pages 269-277

  Pirianov, Grisha ^d   MacIntyre, David A ^a   Lee, Yun ^a   Waddington, Simon N ^b   Terzidou, Vasso ^a   Mehmet, Huseyin ^c   Bennett, Phillip R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Proteostasis Therapeutics   (United States)

^d ANGLIA RUSKIN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CXCL1 CHEMOKINE; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 12; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; CASP3 PROTEIN, MOUSE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 10; PHOSPHOLIPASE A2 GROUP II;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; FETUS; IN VITRO STUDY; LABOR INDUCTION; MOUSE; MYOMETRIUM; NEWBORN MORTALITY; NONHUMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SALMONELLA ENTERICA SEROVAR ABORTUS; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN; BRUCELLA ABORTUS; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; FETUS DEATH; GENETICS; INFLAMMATION; OBSTETRIC LABOR, PREMATURE; PREGNANCY; PREVENTION AND CONTROL; UTERUS;

ANIMALS; BRAIN; BRUCELLA ABORTUS; CASPASE 3; ENZYME INHIBITORS; FEMALE; FETAL DEATH; GROUP II PHOSPHOLIPASES A2; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 10; MYOMETRIUM; OBSTETRIC LABOR, PREMATURE; PREGNANCY; SIGNAL TRANSDUCTION; UTERUS;

EID: 84947259656     PISSN: 14701626     EISSN: 17417899     Source Type: Journal    
DOI: 10.1530/REP-15-0258     Document Type: Article

References (45)

1. Adams Waldorf KM, Persing D, Novy MJ, Sadowsky DW & Gravett MG 2008 Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys. Reproductive Sciences 15 121-127. (doi:10.1177/1933719107310992)
2. Baggia S, Gravett MG,Witkin SS, Haluska GJ & NovyMJ 1996 Interleukin-1 b intra-amniotic infusion induces tumor necrosis factor - a, prostaglandin production, and preterm contractions in pregnant rhesus monkeys. Journal of the Society for Gynecologic Investigation 3 121-126. (doi:10.1016/1071-5576(96)00002-0)
3. Barr RK, Kendrick TS & Bogoyevitch MA 2002 Identification of the critical features of a small peptide inhibitor of JNK activity. Journal of Biological Chemistry 277 10987-10997. (doi:10.1074/jbc.M107565200)
4. Bell MJ, Hallenbeck JM & Gallo V 2004 Determining the fetal inflammatory response in an experimental model of intrauterine inflammation in rats. Pediatric Research 56 541-546. (doi:10.1203/01.PDR.0000139407. 89883.6B)
5. Blencowe H, Cousens S, Chou D, Oestergaard M, Say L, Moller A-B, Kinney M & Lawn J 2013 Born too soon: the global epidemiology of 15 million preterm births. Reproductive Health 10 (Suppl 1) S2. (doi:10.1186/1742-4755-10-S1-S2)
6. Bonny C, Oberson A, Negri S, Sauser C & Schorderet DF 2001 Cellpermeable peptide inhibitors of JNK: novel blockers of b-cell death. Diabetes 50 77-82. (doi:10.2337/diabetes.50.1.77)
7. Casas J, Meana C, Esquinas E, Valdearcos M, Pindado J, Balsinde J & Balboa MA 2009 Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages. Journal of Immunology 183 2767-2774. (doi:10.4049/jimmunol.0901530)
8. Chessa D, Spiga L, De Riu N, Delaconi P, Mazzarello V, Ganau G & Rubino S 2014 Lipopolysaccharides belonging to different Salmonella serovars are differentially capable of activating Toll-like receptor 4. Infection and Immunity 82 4553-4562. (doi:10.1128/IAI.02297-14)
9. Choi SJ, Oh Sy, Kim JH & Roh CR 2007 Changes of nuclear factor k B (NF-kB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor. European Journal of Obstetrics, Gynecology, and Reproductive Biology 132 182-188. (doi:10.1016/j.ejogrb.2006.07.024)
10. Condon JC, Hardy DB, Kovaric K & Mendelson CR 2006 Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-kB may contribute to the onset of labor through inhibition of PR function. Molecular Endocrinology 20 764-775. (doi:10.1210/me.2005-0242)
11. Debillon T, Gras-Leguen C, Vérielle V, Winer N, Caillon J, RozéJC & Gressens P 2000 Intrauterine infection induces programmed cell death in rabbit periventricular white matter. Pediatric Research 47 736-742. (doi:10.1203/00006450-200006000-00009)
12. Dreskin SC, Thomas GW, Dale SN & Heasley LE 2001 Isoforms of Jun kinase are differentially expressed and activated in human monocyte/macrophage (THP-1) cells. Journal of Immunology 166 5646-5653. (doi:10.4049/jimmunol.166.9.5646)
13. Drougia A, Giapros V, Krallis N, Theocharis P, Nikaki A, Tzoufi M & Andronikou S 2007 Incidence and risk factors for cerebral palsy in infants with perinatal problems: a 15-year review. Early Human Development 83 541-547. (doi:10.1016/j.earlhumdev.2006.10.004)
14. Dyet LE, Kennea N, Counsell SJ, Maalouf EF, Ajayi-Obe M, Duggan PJ, Harrison M, Allsop JM, Hajnal J, Herlihy AH et al. 2006 Natural history of brain lesions in extremely preterm infants studied with serial magnetic resonance imaging from birth and neurodevelopmental assessment. Pediatrics 118 536-548. (doi:10.1542/peds. 2005-1866)
15. Elovitz MA & Mrinalini C 2004 Animal models of preterm birth. Trends in Endocrinology and Metabolism 15 479-487. (doi:10.1016/j.tem.2004. 10.009)
16. Elovitz MA, Wang Z, Chien EK, Rychlik DF & Phillippe M 2003 A new model for inflammation-induced preterm birth: the role of plateletactivating factor and Toll-like receptor-4. American Journal of Pathology 163 2103-2111. (doi:10.1016/S0002-9440(10)63567-5)
17. Elovitz MA, Mrinalini C & Sammel MD 2006 Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth. Pediatric Research 59 50-55. (doi:10.1203/01.pdr.0000191141. 21932.b6)
18. Ghosh M, Tucker DE, Burchett SA & Leslie CC 2006 Properties of the Group IV phospholipase A2 family. Progress in Lipid Research 45 487-510. (doi:10.1016/j.plipres.2006.05.003)
19. Gravett MG,Witkin SS, Haluska GJ, Edwards JL, Cook MJ & Novy MJ 1994 An experimental model for intraamniotic infection and preterm labor in rhesus monkeys. American Journal of Obstetrics and Gynecology 171 1660-1667. (doi:10.1016/0002-9378(94)90418-9)
20. Hirsch E, Saotome I & Hirsh D 1995 A model of intrauterine infection and preterm delivery in mice. American Journal of Obstetrics and Gynecology 172 1598-1603. (doi:10.1016/0002-9378(95)90503-0)
21. Jin H-O, Seo S-K, Woo S-H, Kim E-S, Lee H-C, Yoo D-H, Choe T-B, Hong S-I, Kim J-I & Park I-C 2009 SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression. FEBS Letters 583 123-127. (doi:10.1016/j.febslet.2008.11.035)
22. Kaga N, Katsuki Y, Obata M & Shibutani Y 1996 Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery. American Journal of Obstetrics and Gynecology 174 754-759. (doi:10.1016/S0002-9378(96)70460-X)
23. Kelly RW 2002 Inflammatory mediators and cervical ripening. Journal of Reproductive Immunology 57 217-224. (doi:10.1016/S0165-0378 (02)00007-4)
24. Kuan C-Y, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA et al. 2003 A critical role of neural-specific JNK3 for ischemic apoptosis. PNAS 100 15184-15189. (doi:10.1073/pnas.2336254100)
25. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J & Woodgett JR 1994 The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369 156-160. (doi:10.1038/369156a0)
26. Leslie CC 1997 Properties and regulation of cytosolic phospholipase A2. Journal of Biological Chemistry 272 16709-16712. (doi:10.1074/jbc.272.27.16709)
27. Li L, Kang J & Lei W 2010 Role of toll-like receptor 4 in inflammationinduced preterm delivery. Molecular Human Reproduction 16 267-272. (doi:10.1093/molehr/gap106)
28. Macdonald LJ, Boddy SC, Denison FC, Sales KJ & Jabbour HN 2011 A role for lipoxin A4 as an anti-inflammatory mediator in the human endometrium. Reproduction 142 345-352. (doi:10.1530/REP-11-0021)
29. MacIntyre DA, Sykes L, Teoh TG & Bennett PR 2012 Prevention of preterm labour via the modulation of inflammatory pathways. Journal of Maternal-Fetal & Neonatal Medicine 1 17-20. (doi:10.3109/14767058. 2012.666114)
30. MacIntyre DA, Lee YS, Migale R, Herbert BR, Waddington SN, Peebles D, Hagberg H, Johnson MR & Bennett PR 2014 Activator protein 1 is a key terminal mediator of inflammation-induced preterm labor in mice. FASEB Journal 28 2358-2368. (doi:10.1096/fj.13-247783)
31. Nath CA, Ananth CV, Smulian JC & Peltier MR 2010 Can sulfasalazine prevent infection-mediated pre-term birth in a murine model? American Journal of Reproductive Immunology 63 144-149. (doi:10.1111/j.1600-0897.2009.00773.x)
32. Park BS & Lee J-O 2013 Recognition of lipopolysaccharide pattern by TLR4 complexes. Experimental & Molecular Medicine 45 e66. (doi:10.1038/emm.2013.97)
33. Pirianov G, Jesurasa A & Mehmet H 2006 Developmentally regulated changes in c-Jun N-terminal kinase signalling determine the apoptotic response of oligodendrocyte lineage cells. Cell Death and Differentiation 13 531-533. (doi:10.1038/sj.cdd.4401805)
34. Pirianov G, Brywe KG, Mallard C, Edwards AD, Flavell RA, Hagberg H & Mehmet H 2007 Deletion of the c-Jun N-terminal kinase 3 gene protects neonatal mice against cerebral hypoxic-ischaemic injury. Journal of Cerebral Blood Flow and Metabolism 27 1022-1032. (doi:10.1038/sj. jcbfm.9600413)
35. Pirianov G, Waddington SN, Lindström TM, Terzidou V, Mehmet H & Bennett PR 2009 The cyclopentenone 15-deoxy-d 12,14-prostaglandin J(2) delays lipopolysaccharide-induced preterm delivery and reduces mortality in the newborn mouse. Endocrinology 150 699-706. (doi:10.1210/en.2008-1178)
36. Pollard JK & Mitchell MD 1996 Intrauterine infection and the effects of inflammatory mediators on prostaglandin production by myometrial cells from pregnant women. American Journal of Obstetrics and Gynecology 174 682-686. (doi:10.1016/S0002-9378(96)70450-7)
37. Rinaldi SF, Hutchinson JL, Rossi AG & Norman JE 2011 Anti-inflammatory mediators as physiological and pharmacological regulators of parturition. Expert Review of Clinical Immunology 7 675-696. (doi:10.1586/eci.11.58)
38. Rodts-Palenik S, Wyatt-Ashmead J, Pang Y, Thigpen B, Cai Z, Rhodes P, Martin JN, Granger J & Bennett WA 2004 Maternal infection-induced white matter injury is reduced by treatment with interleukin-10. American Journal of Obstetrics and Gynecology 191 1387-1392. (doi:10.1016/j.ajog.2004.06.093)
39. Romero R, Espinoza J, Kusanovic JP, Gotsch F, Hassan S, Erez O, Chaiworapongsa T & Mazor M 2006 The preterm parturition syndrome. BJOG 113 (Suppl) 17-42. (doi:10.1111/j.1471-0528.2006.01120.x)
40. Sykes L, MacIntyre DA, Teoh TG & Bennett PR 2014 Anti-inflammatory prostaglandins for the prevention of preterm labour. Reproduction 148 R29-R40. (doi:10.1530/REP-13-0587)
41. Terrone DA, Rinehart BK, Granger JP, Barrilleaux PS, Martin JN & Bennett WA 2001 Interleukin-10 administration and bacterial endotoxin-induced preterm birth in a rat model. Obstetrics and gynecology 98 476-480. (doi:10.1016/S0029-7844(01)01424-7)
42. Voltolini C, Battersby S, Etherington SL, Petraglia F,Norman JE&JabbourHN 2012 A novel antiinflammatory role for the short-chain fatty acids in human labor. Endocrinology 153 395-403. (doi:10.1210/en.2011-1457)
43. Wang H & Hirsch E 2003 Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Biology of Reproduction 69 1957-1963. (doi:10. 1095/biolreprod.103.019620)
44. Wu YW & Colford JM 2000 Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. Journal of the American Medical Association 284 1417-1424. (doi:10.1001/jama.284.11.1417)
45. Yang DD, Kuan CY, Whitmarsh AJ, Rincón M, Zheng TS, Davis RJ, Rakic P & Flavell RA 1997 Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389 865-870. (doi:10.1038/39899)