Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth

Pediatric Research

Volumn 59, Issue 1, 2006, Pages 50-55

  Elovitz, Michal A ^a,b   Mrinalini, Conjeevaram ^a   Sammel, Mary D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Center for Research on Reproduction and Women's Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NERVE GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL DEATH; CEREBRAL PALSY; CYTOKINE PRODUCTION; FETUS; FETUS LIVER; IMMUNE RESPONSE; INFECTION; INFLAMMATION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; OLIGODENDROGLIA; PLACENTA; PREMATURITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; ANIMAL; ASTROCYTE; BRAIN; BRAIN DISEASE; FEMALE; FETUS DISEASE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PREGNANCY; PRENATAL DEVELOPMENT;

ANIMALS; ASTROCYTES; BRAIN; BRAIN DISEASES; CELL DEATH; CYTOKINES; FEMALE; FETAL DISEASES; FETUS; INFLAMMATION; MICE; NERVE GROWTH FACTORS; OLIGODENDROGLIA; PREGNANCY; PREMATURE BIRTH; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

EID: 33644826312     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000191141.21932.b6     Document Type: Article

References (39)

1. Goldenberg RL, Hauth JC, Andrews WW 2000 Intrauterine infection and preterm delivery. N Engl J Med 342:1500-1507
2. Yoon BH, Romero R, Park JS, Kim M, Oh SY, Kim CJ, Jun JK 2000 The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 183:1124-1129
3. Hagberg H, Wennerholm UB, Savman K 2002 Sequelae of chorioamnionitis. Curr Opin Infect Dis 15:301-306
4. Goncalves LF, Chaiworapongsa T, Romero R 2002 Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 8:3-13
5. Dammann O, Leviton A 1997 Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res 42:1-8
6. DiSalvo D 1998 The correlation between placental pathology and intraventricular hemorrhage in the preterm infant. The Developmental Epidemiology Network Investigators. Pediatr Res 43:15-19
7. Rezaie P, Dean A 2002 Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 22:106-132
8. Nelson KB, Willoughby RE 2000 Infection, inflammation and the risk of cerebral palsy. Curr Opin Neurol 13:133-139
9. De Vries LS, Van Haastert IL, Rademaker KJ, Koopman C, Groenendaal F 2004 Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. J Pediatr 144:815-820
10. Yoon BH, Park CW, Chaiworapongsa T 2003 Intrauterine infection and the development of cerebral palsy. BJOG 110:124-127
11. Ben-Hur T, Ben-Menachem O, Furer V, Einstein O, Mizrachi-Kol R, Grigoriadis N 2003 Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol Cell Neurosci 24:623-631
12. Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW 1994 Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14:846-856
13. Hisahara S, Okano H, Miura M 2003 Caspase-mediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination. Neurosci Res 46:387-397
14. Appel E, Kolman O, Kazimirsky G, Blumberg PM, Brodie C 1997 Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli. Neuroreport 8:3309-3312
15. Moalem G, Gdalyahu A, Shani Y, Otten U, Lazarovici P, Cohen IR, Schwartz M 2000 Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity. J Autoimmun 15:331-345
16. Elovitz M, Wang Z 2004 Medroxyprogesterane acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise. Am J Obstet Gynecol 190:693-701
17. Elovitz MA, Wang Z, Chien EK, Rychlik DF, Phillippe M 2003 A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol 163:2103-2111
18. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM 1998 The fetal inflammatory response syndrome. Am J Obstet Gynecol 179:194-202
19. Yang X, Yang S, Zhang J, Xue L, Hu Z 2002 Role of caspase 3 in neuronal apoptosis after acute brain injury. Chin J Traumatol 5:250-253
20. Feng Y, Fratkin JD, LeBlanc MH 2003 Inhibiting caspase-9 after injury reduces hypoxic ischemic neuronal injury in the cortex in the newborn rat. Neurosci Lett 344:201-204
21. Takashima S, Iida K, Deguchi K 1995 Periventricular leukomalacia, glial development and myelination. Early Hum Dev 43:177-184
22. Dammann O, Hagberg H, Leviton A 2001 Is periventricular leukomalacia an axonopathy as well as an oligopathy? Pediatr Res 49:453-457
23. Grinspan J 2002 Cells and signaling in oligodendrocyte development. J Neuropathol Exp Neurol 61:297-306
24. Griffiths IR, Montague P, Dickinson P 1995 The proteolipid protein gene. Neuropathol Appl Neurobiol 21:85-96
25. Peyron F, Timsit S, Thomas JL, Kagawa T, Ikenaka K, Zalc B 1997 In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP. J Neurosci Res 50:190-201
26. Duggal N, Schmidt-Kastner R, Hakim AM 1997 Nestin expression in reactive astrocytes following focal cerebral ischemia in rats. Brain Res 768:1-9
27. See J, Zhang X, Eraydin N, Mun SB, Mamontov P, Golden JA, Grinspan JB 2004 Oligodendrocyte maturation is inhibited by bone morphogenetic protein. Mol Cell Neurosci 26:481-492
28. Hirsch E, Saotome I, Hirsh D 1995 A model of intrauterine infection and preterm delivery in mice. Am J Obstet Gynecol 172:1598-1603
29. Bell MJ, Hallenbeck JM 2002 Effects of intrauterine inflammation on developing rat brain. J Neurosci Res 70:570-579
30. Debillon T, Gras-Leguen C, Verielle V, Winer N, Caillon J, Roze JC, Gressens P 2000 Intrauterine infection induces programmed cell death in rabbit periventricular white matter. Pediatr Res 47:736-742
31. Nagelkerken L 1998 Role of Th1 and Th2 cells in autoimmune demyelinating disease. Braz J Med Biol Res 31:55-60
32. Vieira PL, Heystek HC, Wormmeester J, Wierenga EA, Kapsenberg ML 2003 Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells. J Immunol 170:4483-4488
33. Gimsa U, Wolf SA, Haas D, Bechmann I, Nitsch R 2001 Th2 cells support intrinsic anti-inflammatory properties of the brain. J Neuroimmunol 119:73-80
34. Dammann O, Kuban KC, Leviton A 2002 Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children bom preterm. Ment Retard Dev Disabil Res Rev 8:46-50
35. Yoon BH, Romero R, Yang SH, Jun JK, Kim IO, Choi JH, Syn HC 1996 Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 174:1433-1440
36. Meng SZ, Arai Y, Deguchi K, Takashima S 1997 Early detection of axonal and neuronal lesions in prenatal-onset periventricular leukomalacia. Brain Dev 19:480-484
37. Kinney HC, Back SA 1998 Human oligodendroglial development: relationship to periventricular leukomalacia. Semin Pediatr Neurol 5:180-189
38. Fanarraga ML, Dickinson PJ, Sommer I, Montague P, Kyriakides E, Griffiths IR 1996 Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene. Glia 18:282-292
39. Clarke SR, Shetty AK, Bradley JL, Turner DA 1994 Reactive astrocytes express the embryonic intermediate neurofilament nestin. Neuroreport 5:1885-1888