-
1
-
-
84881230220
-
Biomarkers (BM) France: Results of routine EGFR, HER2, KRAS, BRAF, PI3KCA mutations detection and EML4-ALK gene fusion assessment on the first 10, 000 nonsmall cell lung cancer (NSCLC) patients (pts)
-
8000
-
Barlesi F, Blons H, Beau-Faller M, et al. Biomarkers (BM) France: results of routine EGFR, HER2, KRAS, BRAF, PI3KCA mutations detection and EML4-ALK gene fusion assessment on the first 10, 000 nonsmall cell lung cancer (NSCLC) patients (pts). J Clin Oncol. 2013;31; suppl; abstr 8000.
-
(2013)
J Clin Oncol.
, vol.31
-
-
Barlesi, F.1
Blons, H.2
Beau-Faller, M.3
-
2
-
-
84947741236
-
Why has active immunotherapy not worked in lung cancer?
-
Thomas A, Giaccone G. Why has active immunotherapy not worked in lung cancer? Ann Oncol. 2015;26(11):2213-2220.
-
(2015)
Ann Oncol.
, vol.26
, Issue.11
, pp. 2213-2220
-
-
Thomas, A.1
Giaccone, G.2
-
3
-
-
84880706152
-
Oncology meets immunology: The cancer-immunity cycle
-
Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1-10. A very elegant and exhaustive review of antitumor immunity.
-
(2013)
Immunity.
, vol.39
, Issue.1
, pp. 1-10
-
-
Chen, D.S.1
Mellman, I.2
-
4
-
-
84884561907
-
Molecular pathways: Coexpression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy
-
Nirschl CJ, Drake CG. Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin Cancer Res. 2013;19(18):4917-4924.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.18
, pp. 4917-4924
-
-
Nirschl, C.J.1
Drake, C.G.2
-
5
-
-
79955529454
-
Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
-
Qureshi OS, Zheng Y, Nakamura K, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011;332(6029):600-603.
-
(2011)
Science
, vol.332
, Issue.6029
, pp. 600-603
-
-
Qureshi, O.S.1
Zheng, Y.2
Nakamura, K.3
-
6
-
-
55949083407
-
Anti-cytotoxic T-lymphocyte antigen-4 antibody: The first in an emerging class of immunomodulatory antibodies for cancer treatment
-
Fong L, Small EJ. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol. 2008;26(32):5275-5283.
-
(2008)
J Clin Oncol.
, vol.26
, Issue.32
, pp. 5275-5283
-
-
Fong, L.1
Small, E.J.2
-
7
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027-1034.
-
(2000)
J Exp Med.
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
8
-
-
84905975277
-
B7-H1/PD-1 blockade therapy in non-small cell lung cancer: Current status and future direction
-
Gettinger S, Herbst RS. B7-H1/PD-1 blockade therapy in non-small cell lung cancer: current status and future direction. Cancer J. 2014;20(4):281-289.
-
(2014)
Cancer J.
, vol.20
, Issue.4
, pp. 281-289
-
-
Gettinger, S.1
Herbst, R.S.2
-
10
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry RV, Chemnitz JM, Frauwirth KA, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol. 2005;25(21):9543-9553.
-
(2005)
Mol Cell Biol.
, vol.25
, Issue.21
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
-
11
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28(19):3167-3175.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
12
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-2454.
-
(2012)
N Engl J Med.
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
13
-
-
84936749833
-
Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
-
Gettinger SN, Horn L, Gandhi L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015;33(18):2004-2012.
-
(2015)
J Clin Oncol.
, vol.33
, Issue.18
, pp. 2004-2012
-
-
Gettinger, S.N.1
Horn, L.2
Gandhi, L.3
-
14
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
-
Rizvi NA, Mazières J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16(3):257-265. One of the pivotal trials targeting squamous NSCLC.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.3
, pp. 257-265
-
-
Rizvi, N.A.1
Mazières, J.2
Planchard, D.3
-
15
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373(2):123-135. A major Phase III trial that led to approval for advanced squamous NSCLC.
-
(2015)
N Engl J Med.
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
16
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373(17):1627-1639. A pivotal Phase III trial that will probably lead to approval in advanced nonsquamous NSCLC.
-
(2015)
N Engl J Med.
, vol.373
, Issue.17
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
17
-
-
84920031180
-
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
-
Wang C, Thudium KB, Han M, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014;2(9):846-856.
-
(2014)
Cancer Immunol Res.
, vol.2
, Issue.9
, pp. 846-856
-
-
Wang, C.1
Thudium, K.B.2
Han, M.3
-
18
-
-
84938210278
-
Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): An open-label randomised controlled phase 3 trial
-
Soria J-C, Felip E, Cobo M, et al. Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial. Lancet Oncol. 2015;16(8):897-907.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.8
, pp. 897-907
-
-
Soria, J.-C.1
Felip, E.2
Cobo, M.3
-
19
-
-
84964442872
-
Nivolumab survival benefit sustained in squamous non-small cell lung cancer
-
Sep. 6-9; Denver CO. Abstract
-
Ramalingam S. Nivolumab survival benefit sustained in squamous non-small cell lung cancer. Presented at: 16th World Conference on Lung Cancer; Sep. 6-9; Denver (CO). Abstract
-
16th World Conference on Lung Cancer
-
-
Ramalingam, S.1
-
20
-
-
84964435806
-
Longer follow-up confirms nivolumab OS benefit in nonsquamous nonsmall cell lung cancer
-
Sep. 6-9; Denver CO. Abstract
-
Horn L. Longer follow-up confirms nivolumab OS benefit in nonsquamous nonsmall cell lung cancer. Presented at: 16th World Conference on Lung Cancer; Sep. 6-9; Denver (CO). Abstract
-
16th World Conference on Lung Cancer
-
-
Horn, L.1
-
21
-
-
84930719096
-
Targeting the immune system to treat lung cancer: Rationale and clinical experience
-
Guibert N, Delaunay M, Mazières J. Targeting the immune system to treat lung cancer: rationale and clinical experience. Ther Adv Respir Dis. 2015;9(3):105-120.
-
(2015)
Ther Adv Respir Dis.
, vol.9
, Issue.3
, pp. 105-120
-
-
Guibert, N.1
Delaunay, M.2
Mazières, J.3
-
22
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immunerelated response criteria
-
Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immunerelated response criteria. Clin Cancer Res. 2009;15(23):7412-7420.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.23
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
-
23
-
-
84902504669
-
Trial watch: Chemotherapy with immunogenic cell death inducers
-
Vacchelli E, Aranda F, Eggermont A, et al. Trial watch: chemotherapy with immunogenic cell death inducers. Oncoimmunology. 2014;3(1):e27878.
-
(2014)
Oncoimmunology.
, vol.3
, Issue.1
, pp. e27878
-
-
Vacchelli, E.1
Aranda, F.2
Eggermont, A.3
-
24
-
-
84907486895
-
Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
-
Dovedi SJ, Adlard AL, Lipowska-Bhalla G, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 2014;74(19):5458-5468.
-
(2014)
Cancer Res.
, vol.74
, Issue.19
, pp. 5458-5468
-
-
Dovedi, S.J.1
Adlard, A.L.2
Lipowska-Bhalla, G.3
-
25
-
-
84921456279
-
Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo
-
Das R, Verma R, Sznol M, et al. Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo. J Immunol. 2015;194(3):950-959.
-
(2015)
J Immunol.
, vol.194
, Issue.3
, pp. 950-959
-
-
Das, R.1
Verma, R.2
Sznol, M.3
-
26
-
-
84929481482
-
Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
-
Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015;372(21):2006-2017.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2006-2017
-
-
Postow, M.A.1
Chesney, J.2
Pavlick, A.C.3
-
27
-
-
84908269560
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase I results
-
8023
-
Antonia S, Gettinger S, Chow LQ, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results. J Clin Oncol. 2014;32:5s; suppl; abstr 8023).
-
(2014)
J Clin Oncol.
, vol.32
, Issue.5 S
-
-
Antonia, S.1
Gettinger, S.2
Chow, L.Q.3
-
28
-
-
84890020587
-
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
-
Akbay EA, Koyama S, Carretero J, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3(12):1355-1363.
-
(2013)
Cancer Discov.
, vol.3
, Issue.12
, pp. 1355-1363
-
-
Akbay, E.A.1
Koyama, S.2
Carretero, J.3
-
29
-
-
84907651085
-
Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
-
8022
-
Rivzi N, Chow LQ, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. J Clin Oncol. 2014;32:5s; suppl; abstr 8022.
-
(2014)
J Clin Oncol.
, vol.32
, pp. 5s
-
-
Rivzi, N.1
Chow, L.Q.2
Borghaei, H.3
-
30
-
-
84942849158
-
Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer
-
Ota K, Azuma K, Kawahara A, et al. Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer. Clin Cancer Res. 2015;21(17):4014-4021.
-
(2015)
Clin Cancer Res.
, vol.21
, Issue.17
, pp. 4014-4021
-
-
Ota, K.1
Azuma, K.2
Kawahara, A.3
-
31
-
-
84929481480
-
Pembrolizumab for the treatment of nonsmall-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of nonsmall-cell lung cancer. N Engl J Med 2015;372(21):2018-2028.
-
(2015)
N Engl J Med
, vol.372
, Issue.21
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
32
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria J-C, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515(7528):563-567.
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.-C.2
Kowanetz, M.3
-
33
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer. N Engl J Med. 2006;355(24):2542-2550.
-
(2006)
N Engl J Med.
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
34
-
-
84886385462
-
Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089)
-
Barlesi F, Scherpereel A, Rittmeyer A, et al. Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089). J Clin Oncol. 2013;31(24):3004-3011.
-
(2013)
J Clin Oncol.
, vol.31
, Issue.24
, pp. 3004-3011
-
-
Barlesi, F.1
Scherpereel, A.2
Rittmeyer, A.3
-
35
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348(6230):124-128.
-
(2015)
Science
, vol.348
, Issue.6230
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
36
-
-
84923101013
-
PD-L1 expression and genotype in non-small cell lung cancer
-
7517
-
Ansen S, Schultheis AM, Hellmich M, et al. PD-L1 expression and genotype in non-small cell lung cancer. J Clin Oncol. 2014;32:5s, a; suppl; abstr 7517.
-
(2014)
J Clin Oncol.
, vol.32
, pp. 5
-
-
Ansen, S.1
Schultheis, A.M.2
Hellmich, M.3
-
37
-
-
84930697267
-
Differential expression of LKB1, PD-L1, and PD-L2 in KRAS-mutant non-small cell lung cancer in never-smokers
-
8032
-
Calles A, Liao X, Sholl LM, et al. Differential expression of LKB1, PD-L1, and PD-L2 in KRAS-mutant non-small cell lung cancer in never-smokers. J Clin Oncol. 2014;32:5s; suppl; abstr 8032.
-
(2014)
J Clin Oncol.
, vol.32
, pp. 5s
-
-
Calles, A.1
Liao, X.2
Sholl, L.M.3
-
38
-
-
5044233409
-
Biomarkers in non-small cell lung cancer prevention
-
Hilbe W, Dirnhofer S, Greil R, et al. Biomarkers in non-small cell lung cancer prevention. Eur J Cancer Prev. 2004;13(5):425-436.
-
(2004)
Eur J Cancer Prev.
, vol.13
, Issue.5
, pp. 425-436
-
-
Hilbe, W.1
Dirnhofer, S.2
Greil, R.3
|