메뉴 건너뛰기




Volumn 15, Issue 12, 2015, Pages 1789-1797

Nivolumab for treating non-small cell lung cancer

Author keywords

Antitumor immunotherapy; Immune checkpoint inhibitors; Nivolumab; PD 1; PD 1 inhibitor; PD L1

Indexed keywords

AFATINIB; BIOLOGICAL MARKER; CORTICOSTEROID; DOCETAXEL; ERLOTINIB; NIVOLUMAB; PROGRAMMED DEATH 1 LIGAND 1; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84947256630     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2015.1114097     Document Type: Article
Times cited : (28)

References (38)
  • 1
    • 84881230220 scopus 로고    scopus 로고
    • Biomarkers (BM) France: Results of routine EGFR, HER2, KRAS, BRAF, PI3KCA mutations detection and EML4-ALK gene fusion assessment on the first 10, 000 nonsmall cell lung cancer (NSCLC) patients (pts)
    • 8000
    • Barlesi F, Blons H, Beau-Faller M, et al. Biomarkers (BM) France: results of routine EGFR, HER2, KRAS, BRAF, PI3KCA mutations detection and EML4-ALK gene fusion assessment on the first 10, 000 nonsmall cell lung cancer (NSCLC) patients (pts). J Clin Oncol. 2013;31; suppl; abstr 8000.
    • (2013) J Clin Oncol. , vol.31
    • Barlesi, F.1    Blons, H.2    Beau-Faller, M.3
  • 2
    • 84947741236 scopus 로고    scopus 로고
    • Why has active immunotherapy not worked in lung cancer?
    • Thomas A, Giaccone G. Why has active immunotherapy not worked in lung cancer? Ann Oncol. 2015;26(11):2213-2220.
    • (2015) Ann Oncol. , vol.26 , Issue.11 , pp. 2213-2220
    • Thomas, A.1    Giaccone, G.2
  • 3
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1-10. A very elegant and exhaustive review of antitumor immunity.
    • (2013) Immunity. , vol.39 , Issue.1 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 4
    • 84884561907 scopus 로고    scopus 로고
    • Molecular pathways: Coexpression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy
    • Nirschl CJ, Drake CG. Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin Cancer Res. 2013;19(18):4917-4924.
    • (2013) Clin Cancer Res. , vol.19 , Issue.18 , pp. 4917-4924
    • Nirschl, C.J.1    Drake, C.G.2
  • 5
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011;332(6029):600-603.
    • (2011) Science , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 6
    • 55949083407 scopus 로고    scopus 로고
    • Anti-cytotoxic T-lymphocyte antigen-4 antibody: The first in an emerging class of immunomodulatory antibodies for cancer treatment
    • Fong L, Small EJ. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. J Clin Oncol. 2008;26(32):5275-5283.
    • (2008) J Clin Oncol. , vol.26 , Issue.32 , pp. 5275-5283
    • Fong, L.1    Small, E.J.2
  • 7
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192:1027-1034.
    • (2000) J Exp Med. , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 8
    • 84905975277 scopus 로고    scopus 로고
    • B7-H1/PD-1 blockade therapy in non-small cell lung cancer: Current status and future direction
    • Gettinger S, Herbst RS. B7-H1/PD-1 blockade therapy in non-small cell lung cancer: current status and future direction. Cancer J. 2014;20(4):281-289.
    • (2014) Cancer J. , vol.20 , Issue.4 , pp. 281-289
    • Gettinger, S.1    Herbst, R.S.2
  • 9
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • Keir ME, Butte MJ, Freeman GJ, et al. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008;26:677-704.
    • (2008) Annu Rev Immunol. , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3
  • 10
    • 27144496045 scopus 로고    scopus 로고
    • CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
    • Parry RV, Chemnitz JM, Frauwirth KA, et al. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol. 2005;25(21):9543-9553.
    • (2005) Mol Cell Biol. , vol.25 , Issue.21 , pp. 9543-9553
    • Parry, R.V.1    Chemnitz, J.M.2    Frauwirth, K.A.3
  • 11
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28(19):3167-3175.
    • (2010) J Clin Oncol. , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 12
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-2454.
    • (2012) N Engl J Med. , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 13
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • Gettinger SN, Horn L, Gandhi L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015;33(18):2004-2012.
    • (2015) J Clin Oncol. , vol.33 , Issue.18 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3
  • 14
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • Rizvi NA, Mazières J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16(3):257-265. One of the pivotal trials targeting squamous NSCLC.
    • (2015) Lancet Oncol. , vol.16 , Issue.3 , pp. 257-265
    • Rizvi, N.A.1    Mazières, J.2    Planchard, D.3
  • 15
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373(2):123-135. A major Phase III trial that led to approval for advanced squamous NSCLC.
    • (2015) N Engl J Med. , vol.373 , Issue.2 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 16
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373(17):1627-1639. A pivotal Phase III trial that will probably lead to approval in advanced nonsquamous NSCLC.
    • (2015) N Engl J Med. , vol.373 , Issue.17 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 17
    • 84920031180 scopus 로고    scopus 로고
    • In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates
    • Wang C, Thudium KB, Han M, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014;2(9):846-856.
    • (2014) Cancer Immunol Res. , vol.2 , Issue.9 , pp. 846-856
    • Wang, C.1    Thudium, K.B.2    Han, M.3
  • 18
    • 84938210278 scopus 로고    scopus 로고
    • Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): An open-label randomised controlled phase 3 trial
    • Soria J-C, Felip E, Cobo M, et al. Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial. Lancet Oncol. 2015;16(8):897-907.
    • (2015) Lancet Oncol. , vol.16 , Issue.8 , pp. 897-907
    • Soria, J.-C.1    Felip, E.2    Cobo, M.3
  • 19
    • 84964442872 scopus 로고    scopus 로고
    • Nivolumab survival benefit sustained in squamous non-small cell lung cancer
    • Sep. 6-9; Denver CO. Abstract
    • Ramalingam S. Nivolumab survival benefit sustained in squamous non-small cell lung cancer. Presented at: 16th World Conference on Lung Cancer; Sep. 6-9; Denver (CO). Abstract
    • 16th World Conference on Lung Cancer
    • Ramalingam, S.1
  • 20
    • 84964435806 scopus 로고    scopus 로고
    • Longer follow-up confirms nivolumab OS benefit in nonsquamous nonsmall cell lung cancer
    • Sep. 6-9; Denver CO. Abstract
    • Horn L. Longer follow-up confirms nivolumab OS benefit in nonsquamous nonsmall cell lung cancer. Presented at: 16th World Conference on Lung Cancer; Sep. 6-9; Denver (CO). Abstract
    • 16th World Conference on Lung Cancer
    • Horn, L.1
  • 21
    • 84930719096 scopus 로고    scopus 로고
    • Targeting the immune system to treat lung cancer: Rationale and clinical experience
    • Guibert N, Delaunay M, Mazières J. Targeting the immune system to treat lung cancer: rationale and clinical experience. Ther Adv Respir Dis. 2015;9(3):105-120.
    • (2015) Ther Adv Respir Dis. , vol.9 , Issue.3 , pp. 105-120
    • Guibert, N.1    Delaunay, M.2    Mazières, J.3
  • 22
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immunerelated response criteria
    • Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immunerelated response criteria. Clin Cancer Res. 2009;15(23):7412-7420.
    • (2009) Clin Cancer Res. , vol.15 , Issue.23 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 23
    • 84902504669 scopus 로고    scopus 로고
    • Trial watch: Chemotherapy with immunogenic cell death inducers
    • Vacchelli E, Aranda F, Eggermont A, et al. Trial watch: chemotherapy with immunogenic cell death inducers. Oncoimmunology. 2014;3(1):e27878.
    • (2014) Oncoimmunology. , vol.3 , Issue.1 , pp. e27878
    • Vacchelli, E.1    Aranda, F.2    Eggermont, A.3
  • 24
    • 84907486895 scopus 로고    scopus 로고
    • Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade
    • Dovedi SJ, Adlard AL, Lipowska-Bhalla G, et al. Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade. Cancer Res. 2014;74(19):5458-5468.
    • (2014) Cancer Res. , vol.74 , Issue.19 , pp. 5458-5468
    • Dovedi, S.J.1    Adlard, A.L.2    Lipowska-Bhalla, G.3
  • 25
    • 84921456279 scopus 로고    scopus 로고
    • Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo
    • Das R, Verma R, Sznol M, et al. Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes in vivo. J Immunol. 2015;194(3):950-959.
    • (2015) J Immunol. , vol.194 , Issue.3 , pp. 950-959
    • Das, R.1    Verma, R.2    Sznol, M.3
  • 26
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N Engl J Med 2015;372(21):2006-2017.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 27
    • 84908269560 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase I results
    • 8023
    • Antonia S, Gettinger S, Chow LQ, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: interim phase I results. J Clin Oncol. 2014;32:5s; suppl; abstr 8023).
    • (2014) J Clin Oncol. , vol.32 , Issue.5 S
    • Antonia, S.1    Gettinger, S.2    Chow, L.Q.3
  • 28
    • 84890020587 scopus 로고    scopus 로고
    • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
    • Akbay EA, Koyama S, Carretero J, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3(12):1355-1363.
    • (2013) Cancer Discov. , vol.3 , Issue.12 , pp. 1355-1363
    • Akbay, E.A.1    Koyama, S.2    Carretero, J.3
  • 29
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
    • 8022
    • Rivzi N, Chow LQ, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. J Clin Oncol. 2014;32:5s; suppl; abstr 8022.
    • (2014) J Clin Oncol. , vol.32 , pp. 5s
    • Rivzi, N.1    Chow, L.Q.2    Borghaei, H.3
  • 30
    • 84942849158 scopus 로고    scopus 로고
    • Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer
    • Ota K, Azuma K, Kawahara A, et al. Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer. Clin Cancer Res. 2015;21(17):4014-4021.
    • (2015) Clin Cancer Res. , vol.21 , Issue.17 , pp. 4014-4021
    • Ota, K.1    Azuma, K.2    Kawahara, A.3
  • 31
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of nonsmall-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of nonsmall-cell lung cancer. N Engl J Med 2015;372(21):2018-2028.
    • (2015) N Engl J Med , vol.372 , Issue.21 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 32
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria J-C, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515(7528):563-567.
    • (2014) Nature , vol.515 , Issue.7528 , pp. 563-567
    • Herbst, R.S.1    Soria, J.-C.2    Kowanetz, M.3
  • 33
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer. N Engl J Med. 2006;355(24):2542-2550.
    • (2006) N Engl J Med. , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 34
    • 84886385462 scopus 로고    scopus 로고
    • Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089)
    • Barlesi F, Scherpereel A, Rittmeyer A, et al. Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089). J Clin Oncol. 2013;31(24):3004-3011.
    • (2013) J Clin Oncol. , vol.31 , Issue.24 , pp. 3004-3011
    • Barlesi, F.1    Scherpereel, A.2    Rittmeyer, A.3
  • 35
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348(6230):124-128.
    • (2015) Science , vol.348 , Issue.6230 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 36
    • 84923101013 scopus 로고    scopus 로고
    • PD-L1 expression and genotype in non-small cell lung cancer
    • 7517
    • Ansen S, Schultheis AM, Hellmich M, et al. PD-L1 expression and genotype in non-small cell lung cancer. J Clin Oncol. 2014;32:5s, a; suppl; abstr 7517.
    • (2014) J Clin Oncol. , vol.32 , pp. 5
    • Ansen, S.1    Schultheis, A.M.2    Hellmich, M.3
  • 37
    • 84930697267 scopus 로고    scopus 로고
    • Differential expression of LKB1, PD-L1, and PD-L2 in KRAS-mutant non-small cell lung cancer in never-smokers
    • 8032
    • Calles A, Liao X, Sholl LM, et al. Differential expression of LKB1, PD-L1, and PD-L2 in KRAS-mutant non-small cell lung cancer in never-smokers. J Clin Oncol. 2014;32:5s; suppl; abstr 8032.
    • (2014) J Clin Oncol. , vol.32 , pp. 5s
    • Calles, A.1    Liao, X.2    Sholl, L.M.3
  • 38
    • 5044233409 scopus 로고    scopus 로고
    • Biomarkers in non-small cell lung cancer prevention
    • Hilbe W, Dirnhofer S, Greil R, et al. Biomarkers in non-small cell lung cancer prevention. Eur J Cancer Prev. 2004;13(5):425-436.
    • (2004) Eur J Cancer Prev. , vol.13 , Issue.5 , pp. 425-436
    • Hilbe, W.1    Dirnhofer, S.2    Greil, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.