Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 42, 2015, Pages E5706-E5714

  Siggs, Owen M ^a,b   Popkin, Daniel L ^a,d   Krebs, Philippe ^a,e   Li, Xiaohong ^a,c   Tang, Miao ^c   Zhan, Xiaoming ^c   Zeng, Ming ^c   Lin, Pei ^a   Xia, Yu ^a   Oldstone, Michael B A ^b   Cornall, Richard J ^a,c   Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Lymphocytes; N ethyl N nitrosourea; Positive selection; T cell development; T cell survival

Indexed keywords

CELL MEMBRANE PROTEIN; HERMES ANTIGEN; KDELR1 PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; KDELR1 PROTEIN, HUMAN; RECEPTOR;

ALLELE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION; GERMLINE MUTATION; HOMOZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOCYTOPENIA; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MISSENSE MUTATION; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENE; VIRUS IMMUNITY; VIRUS INFECTION; ANIMAL; CHRONIC DISEASE; GENETIC PREDISPOSITION; GENETICS; MALE; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; VIRUS DISEASES;

ANIMALS; CHRONIC DISEASE; ENDOPLASMIC RETICULUM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; LYMPHOPENIA; MALE; MICE; MICE, MUTANT STRAINS; MUTATION; RECEPTORS, PEPTIDE; VIRUS DISEASES;

EID: 84947246337     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1515619112     Document Type: Article

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