Matrix-assisted transplantation of functional beige adipose tissue

Diabetes

Volumn 64, Issue 11, 2015, Pages 3713-3724

  Tharp, Kevin M ^a,b   Jha, Amit K ^b   Kraiczy, Judith ^a   Yesian, Alexandra ^a   Karateev, Grigory ^d   Sinisi, Riccardo ^d   Dubikovskaya, Elena A ^d   Healy, Kevin E ^b,c   Stahl, Andreas ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

^c University of California Berkeley   (United States)

^d EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYALURONIC ACID; LIPID; MESSENGER RNA; UNCOUPLING PROTEIN 1; ION CHANNEL; MITOCHONDRIAL PROTEIN; UCP1 PROTEIN, HUMAN; UCP1 PROTEIN, MOUSE;

ADIPOSE DERIVED STEM CELL; ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOPHYSICS; BREATHING RATE; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; COLD; CONTROLLED STUDY; CORE TEMPERATURE; FEASIBILITY STUDY; GLUCOSE HOMEOSTASIS; HYDROGEL; IN VIVO STUDY; MALE; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE ENGINEERING; TISSUE EXPANSION; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE; ADIPOCYTE; ANIMAL; BODY TEMPERATURE; CELL ADHESION; ENERGY METABOLISM; METABOLISM; PHYSIOLOGY; STEM CELL; THERMOGENESIS; TISSUE SCAFFOLD; TRANSPLANTATION;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; BODY TEMPERATURE; CELL ADHESION; CELL DIFFERENTIATION; COLD TEMPERATURE; ENERGY METABOLISM; ION CHANNELS; MICE; MITOCHONDRIAL PROTEINS; STEM CELLS; THERMOGENESIS; TISSUE SCAFFOLDS; UNCOUPLING PROTEIN 1;

EID: 84947121050     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0728     Document Type: Article

References (50)

1. Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell 2014;156:20-44
2. Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 1984;64:1-64
3. Fedorenko A, Lishko PV, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 2012;151:400-413
4. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359
5. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517
6. Van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med 2009;360:1500-1508
7. Ma SW, Foster DO. Uptake of glucose and release of fatty acids and glycerol by rat brown adipose tissue in vivo. Can J Physiol Pharmacol 1986;64:609-614
8. Ouellet V, Routhier-Labadie A, Bellemare W, et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 2011;96:192-199
9. Gunawardana SC, Piston DW. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 2012;61:674-682
10. Stanford KI, Middelbeek RJ, Townsend KL, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013;123:215-223
11. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARg agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 2012;15:395-404
12. Elabd C, Chiellini C, Carmona M, et al. Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells 2009;27:2753-2760
13. Schulz TJ, Huang TL, Tran TT, et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad Sci U S A 2011;108:143-148
14. Ahfeldt T, Schinzel RT, Lee YK, et al. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol 2012;14:209-219
15. Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell 2008;135:240-249
16. Kajimura S, Seale P, Kubota K, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009;460:1154-1158
17. Edelstein ML, Abedi MR, Wixon J, Edelstein RM. Gene therapy clinical trials worldwide 1989-2004-an overview. J Gene Med 2004;6:597-602
18. Huang SJ, Fu RH, Shyu WC, et al. Adipose-derived stem cells: isolation, characterization, and differentiation potential. Cell Transplant 2013;22:701-709
19. Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008;454:1000-1004
20. Jha AK, Tharp KM, Ye J, et al. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials 2015;47:1-12
21. Jha AK, Hule RA, Jiao T, et al. Structural analysis and mechanical characterization of hyaluronic acid-based doubly cross-linked networks. Macromolecules 2009;42:537-546
22. Lee MW, Odegaard JI, Mukundan L, et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 2015;160:74-87
23. Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 2006;7:211-224
24. Nakahara H, Nomizu M, Akiyama SK, Yamada Y, Yeh Y, Chen WT. A mechanism for regulation of melanoma invasion. Ligation of alpha6beta1 integrin by laminin G peptides. J Biol Chem 1996;271:27221-27224
25. Nomizu M, Kim WH, Yamamura K, et al. Identification of cell binding sites in the laminin alpha 1 chain carboxyl-terminal globular domain by systematic screening of synthetic peptides. J Biol Chem 1995;270:20583-20590
26. Ponce ML, Nomizu M, Kleinman HK. An angiogenic laminin site and its antagonist bind through the alpha (v) beta3 and alpha5beta1 integrins. FASEB J 2001;15:1389-1397
27. Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 2006;126:677-689
28. Shapira-Schweitzer K, Seliktar D. Matrix stiffness affects spontaneous contraction of cardiomyocytes cultured within a PEGylated fibrinogen biomaterial. Acta Biomater 2007;3:33-41
29. Saha K, Keung AJ, Irwin EF, et al. Substrate modulus directs neural stem cell behavior. Biophys J 2008;95:4426-4438
30. Kim S, Chung EH, Gilbert M, Healy KE. Synthetic MMP-13 degradable ECMs based on poly (N-isopropylacrylamide-co-acrylic acid) semi-interpenetrating polymer networks. I. Degradation and cell migration. J Biomed Mater Res A 2005;75:73-88
31. Chung EH, Gilbert M, Virdi AS, Sena K, Sumner DR, Healy KE. Biomimetic artificial ECMs stimulate bone regeneration. J Biomed Mater Res A 2006;79:815-826
32. Wall ST, Yeh CC, Tu RY, Mann MJ, Healy KE. Biomimetic matrices for myocardial stabilization and stem cell transplantation. J Biomed Mater Res A 2010;95:1055-1066
33. Mather BD, Viswanathan K, Miller KM, Long TE. Michael addition reactions in macromolecular design for emerging technologies. Prog Polym Sci 2006;31:487-531
34. Lutolf MP, Raeber GP, Zisch AH, Tirelli N, Hubbell JA. Cell-responsive synthetic hydrogels. Adv Mater 2003;15:888-892
35. Nguyen KD, Qiu Y, Cui X, et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 2011;480:104-108
36. Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 1998;102:412-420
37. Stillaert FB, Di Bartolo C, Hunt JA, et al. Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds. Biomaterials 2008;29:3953-3959
38. Kim YM, Oh SH, Choi JS, et al. Adipose-derived stem cell-containing hyaluronic acid/alginate hydrogel improves vocal fold wound healing. Laryngoscope 2014;124:E64-E72
39. Henkin AH, Cohen AS, Dubikovskaya EA, et al. Real-time noninvasive imaging of fatty acid uptake in vivo. ACS Chem Biol 2012;7:1884-1891
40. Wu Q, Kazantzis M, Doege H, et al. Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue. Diabetes 2006;55:3229-3237
41. Boss O, Farmer SR. Recruitment of brown adipose tissue as a therapy for obesity-associated diseases. Front Endocrinol (Lausanne) 2012;3:14
42. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med 2015;21:760-768
43. Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366-376
44. O'Cearbhaill ED, Ng KS, Karp JM. Emerging medical devices for minimally invasive cell therapy. Mayo Clin Proc 2014;89:259-273
45. Chopra A, Murray ME, Byfield FJ, et al. Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials 2014;35:71-82
46. Bellahcène A, Bonjean K, Fohr B, et al. Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Circ Res 2000;86:885-891
47. Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 2012;26:271-281
48. Rosenwald M, Perdikari A, Rülicke T, Wolfrum C. Bi-directional interconversion of brite and white adipocytes. Nat Cell Biol 2013;15:659-667
49. Lederle W, Hartenstein B, Meides A, et al. MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma. Carcinogenesis 2010;31:1175-1184
50. Maquoi E, Munaut C, Colige A, Collen D, Lijnen HR. Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes 2002;51:1093-1101