메뉴 건너뛰기




Volumn 28, Issue 2, 2016, Pages 101-109

No effect of escitalopram versus placebo on brain-derived neurotrophic factor in healthy individuals: A randomised trial

Author keywords

affective disorders; brain derived neurotrophic factor (BDNF); escitalopram; healthy; trial

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ESCITALOPRAM; MESSENGER RNA; PLACEBO; ANTIDEPRESSANT AGENT; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; CITALOPRAM;

EID: 84947087531     PISSN: 09242708     EISSN: 16015215     Source Type: Journal    
DOI: 10.1017/neu.2015.55     Document Type: Article
Times cited : (5)

References (34)
  • 2
    • 84968648773 scopus 로고    scopus 로고
    • New hypothesis and treatment targets of depression: An integrated view of key findings
    • CAI S, HUANG S, HAO W. New hypothesis and treatment targets of depression: an integrated view of key findings. Neurosci Bull 2015;3:161-174.
    • (2015) Neurosci Bull , vol.3 , pp. 161-174
    • Cai, S.1    Huang, S.2    Hao, W.3
  • 3
    • 34547410247 scopus 로고    scopus 로고
    • Consensus paper of the WFSBP Task Force on Biological Markers: Biological markers in depression
    • MOSSNER R, MIKOVA O, KOUTSILIERI E et al. Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J Biol Psychiatry 2007;8:141-174.
    • (2007) World J Biol Psychiatry , vol.8 , pp. 141-174
    • Mossner, R.1    Mikova, O.2    Koutsilieri, E.3
  • 4
    • 84900417868 scopus 로고    scopus 로고
    • Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes
    • FRAZIER TW, YOUNGSTROM EA, FRANKEL BA et al. Candidate gene associations with mood disorder, cognitive vulnerability, and fronto-limbic volumes. Brain Behav 2014;4:418-430.
    • (2014) Brain Behav , vol.4 , pp. 418-430
    • Frazier, T.W.1    Youngstrom, E.A.2    Frankel, B.A.3
  • 5
    • 84902080295 scopus 로고    scopus 로고
    • Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system
    • MARTINEZ-LEVY GA, CRUZ-FUENTES CS. Genetic and epigenetic regulation of the brain-derived neurotrophic factor in the central nervous system. Yale J Biol Med 2014;87:173-186.
    • (2014) Yale J Biol Med , vol.87 , pp. 173-186
    • Martinez-Levy, G.A.1    Cruz-Fuentes, C.S.2
  • 6
    • 77958021917 scopus 로고    scopus 로고
    • Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models
    • SCHMIDT HD, DUMAN RS. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 2010;35:2378-2391.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 2378-2391
    • Schmidt, H.D.1    Duman, R.S.2
  • 7
    • 45449091717 scopus 로고    scopus 로고
    • Activity-dependent expression of brain-derived neurotrophic factor in dendrites: Facts and open questions
    • TONGIORGI E. Activity-dependent expression of brain-derived neurotrophic factor in dendrites: facts and open questions. Neurosci Res 2008;61:335-346.
    • (2008) Neurosci Res , vol.61 , pp. 335-346
    • Tongiorgi, E.1
  • 8
    • 84903584769 scopus 로고    scopus 로고
    • Serum BDNF concentrations as peripheral manifestations of depression: Evidence from a systematic review and meta-analyses on 179 associations (N = 9484)
    • MOLENDIJK ML, SPINHOVEN P, POLAK M, BUS BA, PENNINX BW, ELZINGA BM. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9484). Mol Psychiatry 2014;19:791-800.
    • (2014) Mol Psychiatry , vol.19 , pp. 791-800
    • Molendijk, M.L.1    Spinhoven, P.2    Polak, M.3    Bus, B.A.4    Penninx, B.W.5    Elzinga, B.M.6
  • 9
    • 84864564487 scopus 로고    scopus 로고
    • Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder
    • YOSHIDA T, ISHIKAWA M, NIITSU T et al. Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS One 2012;7:e42676.
    • (2012) PLoS One , vol.7
    • Yoshida, T.1    Ishikawa, M.2    Niitsu, T.3
  • 10
    • 84888308686 scopus 로고    scopus 로고
    • Upregulation of blood proBDNF and its receptors in major depression
    • ZHOU L, XIONG J, LIM Y et al. Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord 2013;150:776-784.
    • (2013) J Affect Disord , vol.150 , pp. 776-784
    • Zhou, L.1    Xiong, J.2    Lim, Y.3
  • 11
    • 80054848287 scopus 로고    scopus 로고
    • Serum levels of brain-derived neurotrophic factor in major depressive disorder: State-trait issues, clinical features and pharmacological treatment
    • MOLENDIJK ML, BUS BA, SPINHOVEN P et al. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry 2011;16:1088-1095.
    • (2011) Mol Psychiatry , vol.16 , pp. 1088-1095
    • Molendijk, M.L.1    Bus, B.A.2    Spinhoven, P.3
  • 13
    • 84926052339 scopus 로고    scopus 로고
    • Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants
    • DUCLOT F, KABBAJ M. Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. J Exp Biol 2015;218(Pt 1): 21-31.
    • (2015) J Exp Biol , vol.218 , pp. 21-31
    • Duclot, F.1    Kabbaj, M.2
  • 14
    • 84920116533 scopus 로고    scopus 로고
    • BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis
    • POLYAKOVA M, STUKE K, SCHUEMBERG K, MUELLER K, SCHOENKNECHT P, SCHROETER ML. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord 2014;174C: 432-440.
    • (2014) J Affect Disord , vol.174 C , pp. 432-440
    • Polyakova, M.1    Stuke, K.2    Schuemberg, K.3    Mueller, K.4    Schoenknecht, P.5    Schroeter, M.L.6
  • 15
    • 3042631898 scopus 로고    scopus 로고
    • Antidepressants and brain monoaminergic systems: A dimensional approach to understanding their behavioural effects in depression and anxiety disorders
    • MORILAK DA, FRAZER A. Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders. Int J Neuropsychopharmacol 2004;7:193-218.
    • (2004) Int J Neuropsychopharmacol , vol.7 , pp. 193-218
    • Morilak, D.A.1    Frazer, A.2
  • 16
    • 84903868548 scopus 로고    scopus 로고
    • Serum proBDNF/BDNF and response to fluvoxamine in drug-naive first-episode major depressive disorder patients
    • YOSHIMURA R, KISHI T, HORI H et al. Serum proBDNF/BDNF and response to fluvoxamine in drug-naive first-episode major depressive disorder patients. Ann Gen Psychiatry 2014;13:19.
    • (2014) Ann Gen Psychiatry , vol.13 , pp. 19
    • Yoshimura, R.1    Kishi, T.2    Hori, H.3
  • 17
    • 84872500205 scopus 로고    scopus 로고
    • Candidate genes expression profile associated with antidepressants response in the GENDEP study: Differentiating between baseline 'predictors' and longitudinal 'targets'
    • CATTANEO A, GENNARELLI M, UHER R et al. Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline 'predictors' and longitudinal 'targets'. Neuropsychopharmacology 2012;38:377-385.
    • (2012) Neuropsychopharmacology , vol.38 , pp. 377-385
    • Cattaneo, A.1    Gennarelli, M.2    Uher, R.3
  • 19
    • 69749088328 scopus 로고    scopus 로고
    • Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: The effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression
    • KNORR U, VINBERG M, KLOSE M et al. Rationale and design of the participant, investigator, observer, and data-analyst-blinded randomized AGENDA trial on associations between gene-polymorphisms, endophenotypes for depression and antidepressive intervention: the effect of escitalopram versus placebo on the combined dexamethasone-corticotrophine releasing hormone test and other potential endophenotypes in healthy first-degree relatives of persons with depression. Trials 2009;10:66.
    • (2009) Trials , vol.10 , pp. 66
    • Knorr, U.1    Vinberg, M.2    Klose, M.3
  • 20
    • 79959655098 scopus 로고    scopus 로고
    • Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients - A randomized placebo-controlled trial
    • KNORR U, VINBERG M, HANSEN A et al. Escitalopram and neuroendocrine response in healthy first-degree relatives to depressed patients - a randomized placebo-controlled trial. PLoS One 2011;6:e2124.
    • (2011) PLoS One , vol.6
    • Knorr, U.1    Vinberg, M.2    Hansen, A.3
  • 22
    • 0025439099 scopus 로고
    • SCAN. Schedules for Clinical Assessment in Neuropsychiatry
    • WING JK, BABOR T, BRUGHA T et al. SCAN. Schedules for Clinical Assessment in Neuropsychiatry. Arch Gen Psychiatry 1990;47:589-593.
    • (1990) Arch Gen Psychiatry , vol.47 , pp. 589-593
    • Wing, J.K.1    Babor, T.2    Brugha, T.3
  • 23
    • 0022589659 scopus 로고
    • Mini-compendium of rating scales for states of anxiety depression mania schizophrenia with corresponding DSM-III syndromes
    • BECH P, KASTRUP M, RAFAELSEN OJ. Mini-compendium of rating scales for states of anxiety depression mania schizophrenia with corresponding DSM-III syndromes. Acta Psychiatr Scand Suppl 1986;326:1-37.
    • (1986) Acta Psychiatr Scand Suppl , vol.326 , pp. 1-37
    • Bech, P.1    Kastrup, M.2    Rafaelsen, O.J.3
  • 24
    • 0029052174 scopus 로고
    • Stressful life events, genetic liability, and onset of an episode of major depression in women
    • KENDLER KS, KESSLER RC, WALTERS EE et al. Stressful life events, genetic liability, and onset of an episode of major depression in women. Am J Psychiatry 1995;152:833-842.
    • (1995) Am J Psychiatry , vol.152 , pp. 833-842
    • Kendler, K.S.1    Kessler, R.C.2    Walters, E.E.3
  • 25
    • 40949120201 scopus 로고    scopus 로고
    • Whole blood BDNF levels in healthy twins discordant for affective disorder: Association to life events and neuroticism
    • TRAJKOVSKA V, VINBERG M, AZNAR S, KNUDSEN GM, KESSING LV. Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism. J Affect Disord 2008;108:165-169.
    • (2008) J Affect Disord , vol.108 , pp. 165-169
    • Trajkovska, V.1    Vinberg, M.2    Aznar, S.3    Knudsen, G.M.4    Kessing, L.V.5
  • 26
  • 27
    • 0002294347 scopus 로고
    • A simple sequentially rejective multiple test procedure
    • HOLM S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979;6:65-70.
    • (1979) Scand J Stat , vol.6 , pp. 65-70
    • Holm, S.1
  • 28
    • 80051802478 scopus 로고    scopus 로고
    • Association between plasma paroxetine concentration and changes in plasma brain-derived neurotrophic factor levels in patients with major depressive disorder
    • YASUI-FURUKORI N, TSUCHIMINE S, NAKAGAMI T et al. Association between plasma paroxetine concentration and changes in plasma brain-derived neurotrophic factor levels in patients with major depressive disorder. Hum Psychopharmacol 2011;26:194-200.
    • (2011) Hum Psychopharmacol , vol.26 , pp. 194-200
    • Yasui-Furukori, N.1    Tsuchimine, S.2    Nakagami, T.3
  • 29
    • 0031885081 scopus 로고    scopus 로고
    • Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders
    • MODELL S, LAUER CJ, SCHREIBER W, HUBER J, KRIEG JC, HOLSBOER F. Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology 1998;18:253-262.
    • (1998) Neuropsychopharmacology , vol.18 , pp. 253-262
    • Modell, S.1    Lauer, C.J.2    Schreiber, W.3    Huber, J.4    Krieg, J.C.5    Holsboer, F.6
  • 30
    • 77957727502 scopus 로고    scopus 로고
    • Salivary cortisol in depressed patients versus control persons: A systematic review and meta-analysis
    • KNORR U, VINBERG M, KESSING LV, WETTERSLEV J. Salivary cortisol in depressed patients versus control persons: a systematic review and meta-analysis. Psychoneuroendocrinology 2010;35:1275-1286.
    • (2010) Psychoneuroendocrinology , vol.35 , pp. 1275-1286
    • Knorr, U.1    Vinberg, M.2    Kessing, L.V.3    Wetterslev, J.4
  • 31
    • 84856971737 scopus 로고    scopus 로고
    • No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression
    • HAASTRUP E, KNORR U, ERIKSTRUP C, KESSING LV, ULLUM H. No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression. J Neuroimmunol 2012;243:69-72.
    • (2012) J Neuroimmunol , vol.243 , pp. 69-72
    • Haastrup, E.1    Knorr, U.2    Erikstrup, C.3    Kessing, L.V.4    Ullum, H.5
  • 32
    • 79951860575 scopus 로고    scopus 로고
    • Role of macrophage migration inhibitory factor in glucocorticoid release and glucocorticoid receptor function in rats
    • JING L, BU M. Role of macrophage migration inhibitory factor in glucocorticoid release and glucocorticoid receptor function in rats. Ann Clin Lab Sci 2011;41:14-19.
    • (2011) Ann Clin Lab Sci , vol.41 , pp. 14-19
    • Jing, L.1    Bu, M.2
  • 33
    • 38349049478 scopus 로고    scopus 로고
    • Selective publication of antidepressant trials and its influence on apparent efficacy
    • TURNER EH, MATTHEWS AM, LINARDATOS E, TELL RA, ROSENTHAL R. Selective publication of antidepressant trials and its influence on apparent efficacy. N Engl J Med 2008;358:252-260.
    • (2008) N Engl J Med , vol.358 , pp. 252-260
    • Turner, E.H.1    Matthews, A.M.2    Linardatos, E.3    Tell, R.A.4    Rosenthal, R.5
  • 34
    • 84896531281 scopus 로고    scopus 로고
    • Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: A study of two independent cohorts
    • SODERSTEN K, PALSSON E, ISHIMA T et al. Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: a study of two independent cohorts. J Affect Disord 2014;160:1-9.
    • (2014) J Affect Disord , vol.160 , pp. 1-9
    • Sodersten, K.1    Palsson, E.2    Ishima, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.