Prophylactic mRNA Vaccination against Allergy Confers Long-Term Memory Responses and Persistent Protection in Mice

Journal of Immunology Research

Volumn 2015, Issue , 2015, Pages

  Hattinger, E ^a   Scheiblhofer, S ^a   Roesler, E ^a   Thalhamer, T ^a   Thalhamer, J ^a   Weiss, R ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; MESSENGER RNA; POLLEN ANTIGEN; RECOMBINANT ALLERGEN; ALLERGEN; CYTOKINE; IMMUNOGLOBULIN G; RECOMBINANT VACCINE;

ALLERGIC ASTHMA; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; LOEFFLER PNEUMONIA; LONG TERM MEMORY; LUNG COMPLIANCE; LUNG FUNCTION; LUNG RESISTANCE; MOUSE; NONHUMAN; PNEUMONIA; PROVOCATION TEST; RESPIRATORY TRACT ALLERGY; RNA IMMUNIZATION; SENSITIZATION; TH1 CELL; TH2 CELL; ANIMAL; BLOOD; DISEASE MODEL; GENETICS; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; SPLEEN; T LYMPHOCYTE SUBPOPULATION;

ALLERGENS; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; MICE; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTE SUBSETS; VACCINES, SYNTHETIC;

EID: 84947087001     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2015/797421     Document Type: Article

References (33)

1. L.Weiner, B.Mackler, B.Hearl, andD.Fitz-Patrick, "Poster 2011: a DNA vaccine immunotherapy for japanese red cedar allergy," World Allergy Organization Journal, vol. 7, article P23, 2014, WAO Symposium on Immunotherapy and Biologics, Chicago.
2. NCT01707069, "A Safety and Immunogenicity Phase I Study of CryJ2-DNA-Lysosomal Associated Membrane Protein (CryJ2-DNA-LAMP) Plasmid," 2012, http://clinicaltrials.gov/show/ NCT01707069.
3. Immunomic Therapeutics, 2015, http://www.immunomix.com/ japanese-red-cedar.
4. R. Valenta, R. Campana, K. Marth, andM. vanHage, "Allergenspecific immunotherapy: from therapeutic vaccines to prophylactic approaches," Journal of Internal Medicine, vol. 272, no. 2, pp. 144-157, 2012.
5. P. G. Holt, P. D. Sly, H. A. Sampson et al., "Prophylactic use of sublingual allergen immunotherapy in high-risk children: a pilot study," Journal of Allergy and Clinical Immunology, vol. 132, no. 4, pp. 991-993.e1, 2013.
6. M. Kulig, R. Bergmann, B.Niggemann, G. Burow, andU.Wahn, "Prediction of sensitization to inhalant allergens in childhood: evaluating family history, atopic dermatitis and sensitization to food allergens," Clinical and Experimental Allergy, vol. 28, no. 11, pp. 1397-1403, 1998.
7. D. E. Campbell, R. J. Boyle, C. A.Thornton, and S. L. Prescott, "Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy," Clinical & Experimental Allergy, vol. 45, no. 5, pp. 844-858, 2015.
8. T. Ball, W. R. Sperr, P. Valent et al., "Induction of antibody responses to new B cell epitopes indicates vaccination character of allergen immunotherapy," European Journal of Immunology, vol. 29, no. 6, pp. 2026-2036, 1999.
9. R. Van Ree,W. A. Van Leeuwen, P. H. Dieges et al., "Measurement of IgE antibodies against purified grass pollen allergens (Lol p 1, 2, 3 and 5) during immunotherapy," Clinical & Experimental Allergy, vol. 27, no. 1, pp. 68-74, 1997.
10. R. Movérare, L. Elfman, E. Vesterinen, T. Metso, and T. Haahtela, "Development of new IgE specificities to allergenic components in birch pollen extract during specific immunotherapy studied with immunoblotting and Pharmacia CAP System," Allergy, vol. 57, no. 5, pp. 423-430, 2002.
11. R. Weiss, S. Scheiblhofer, E. Roesler, E. Weinberger, and J. Thalhamer, "MRNA vaccination as a safe approach for specific protection from type i allergy," Expert Review of Vaccines, vol. 11, no. 1, pp. 55-67, 2012.
12. B.Weide, C. Garbe,H.-G.Rammensee, andS. Pascolo, "Plasmid DNA-and messenger RNA-based anti-cancer vaccination," Immunology Letters, vol. 115, no. 1, pp. 33-42, 2008.
13. M. Fotin-Mleczek, K. M. Duchardt, C. Lorenz et al., "Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity," Journal of Immunotherapy, vol. 34, no. 1, pp. 1-15, 2011.
14. B. Petsch,M. Schnee, A. B. Vogel et al., "Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection," Nature Biotechnology, vol. 30, no. 12, pp. 1210-1216, 2012.
15. H. Kubler, A. Stenzl,W. Schultze-Seemann et al., "Final analysis of a phase I/IIa study with CV9103, an intradermally administered prostate cancer immunotherapy based on self adjuvanted mRNA," European Journal of Cancer, vol. 47, pp. S498-S499, 2011.
16. M. Sebastian, L. von Boehmer, A. Zippelius et al., "Messenger RNA vaccination and B-cell responses in NSCLC patients," Journal of Clinical Oncology, vol. 30, no. 15, abstract 2573, 2012.
17. E. Roesler, R. Weiss, E. E. Weinberger et al., "Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens," Journal of Allergy and Clinical Immunology, vol. 124, no. 5, pp. 1070.e11-1077.e11, 2009.
18. D. Gray and P. Matzinger, "T cell memory is short-lived in the absence of antigen," Journal of Experimental Medicine, vol. 174, no. 5, pp. 969-974, 1991.
19. A. Hartl, R. Weiss, R. Hochreiter, S. Scheiblhofer, and J. Thalhamer, "DNA vaccines for allergy treatment," Methods, vol. 32, no. 3, pp. 328-339, 2004.
20. R. Hochreiter, T. Stepanoska, F. Ferreira et al., "Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen," European Journal of Immunology, vol. 33, no. 6, pp. 1667-1676, 2003.
21. M. Gabler, S. Scheiblhofer, K. Kern et al., "Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization," Journal of Allergy and Clinical Immunology, vol. 118, no. 3, pp. 734-741, 2006.
22. E. Hamelmann, J. Schwarze, K. Takeda et al., "Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography," American Journal of Respiratory and Critical Care Medicine, vol. 156, no. 3, part 1, pp. 766-775, 1997.
23. C. Mitchell, K. Provost, N. Niu, R. Homer, and L. Cohn, "IFN-gamma acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease," Journal of Immunology, vol. 187, no. 7, pp. 3815-3820, 2011.
24. M. Koch, M. Witzenrath, C. Reuter et al., "Role of local pulmonary IFN-γ expression in murine allergic airway inflammation," American Journal of Respiratory Cell and Molecular Biology, vol. 35, no. 2, pp. 211-219, 2006.
25. L. K. Teixeira, B. P. F. Fonseca, B. A. Barboza, and J. P. B. Viola, "The role of interferon-γ on immune and allergic responses," Memorias do Instituto Oswaldo Cruz, vol. 100, no. 1, pp. 137-144, 2005.
26. C. A. Akdis and M. Akdis, "Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs," The Journal of Clinical Investigation, vol. 124, no. 11, pp. 4678-4680, 2014.
27. M. J. Duechs, C. Hahn, E. Benediktus et al., "TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways," Pulmonary Pharmacology andTherapeutics, vol. 24, no. 2, pp. 203-214, 2011.
28. P. Ye, F. H. Rodriguez, S. Kanaly et al., "Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense," Journal of Experimental Medicine, vol. 194, no. 4, pp. 519-527, 2001.
29. M.-L. Michel, A. C. Keller, C. Paget et al., "Identification of an IL-17-producing NK1.1neg iNKT cell population involved in airway neutrophilia," Journal of ExperimentalMedicine, vol. 204, no. 5, pp. 995-1001, 2007.
30. Y. Liu, M. Zeng, and Z. Liu, "Clinical relevance ofTh17 response in allergic rhinitis: more evidence," Clinical & Experimental Allergy, 2015.
31. R. M. McLoughlin, J. Witowski, R. L. Robson et al., "Interplay between IFN-γ and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation," The Journal of Clinical Investigation, vol. 112, no. 4, pp. 598-607, 2003.
32. N. W. Lukacs, R. M. Strieter, S. W. Chensue, M. Widmer, and S. L. Kunkel, "TNF-α mediates recruitment of neutrophils and eosinophils during airway inflammation," Journal of Immunology, vol. 154, no. 10, pp. 5411-5417, 1995.
33. P. Pulsawat, P. Pitakpolrat, E. Prompetchara et al., "Optimization of aDer p 2-based prophylacticDNAvaccine against house dust mite allergy," Immunology Letters, vol. 151, no. 1-2, pp. 23-30, 2013.