Evaluation of the genotoxic and cytotoxic potential of mainstream whole smoke and smoke condensate from a cigarette containing a novel carbon filter

Fundamental and Applied Toxicology

Volumn 39, Issue 1, 1997, Pages 11-17

  Bombick, D W ^a   Bombick, B Reed ^a   Ayres, P H ^a   Putnam, K ^a   Avalos, J ^a   Borgerding, M F ^a   Doolittle, D J ^a  

^a R J REYNOLDS TOBACCO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ACROLEIN; ACRYLONITRILE; AMMONIA; BENZENE; CIGARETTE SMOKE; CIGARETTE SMOKE CONDENSATE; FORMALDEHYDE; ISOPRENE; NITROGEN OXIDE; TOBACCO SMOKE;

AMES TEST; ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; MUTAGENICITY; NONHUMAN; SISTER CHROMATID EXCHANGE;

ANIMALIA; BACTERIA (MICROORGANISMS); CRICETINAE; CRICETULUS GRISEUS; NICOTIANA TABACUM; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 26844559073     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1997.2334     Document Type: Article

References (41)

1. Ayres P. H., Mosberg A. T., Coggins C. R. E. Modernization of nose-only smoking machines for use in animal inhalation studies. J. Am. Coll. Toxicol. 9:1990;441-446.
2. Baumgartner H., Coggins C. R. E. Description of a continuous-smoking inhalation machine for exposing small animals to tobacco smoke. Beitr. Tabakforsch. Int. 10:1980;169-174.
3. Benner J. F., Burton H. R., Burdick D. Composition of cigarette smoke from high and low nitrate burley tobacco. Tob. Sci. 12:1968;37.
4. Bombick B. R., Murli H., Bombick D., Morgan W., Doolittle D. J. Comparative studies on the genotoxic potential of mainstream smoke condensate from cigarettes which burn or primarily heat tobacco. Int. Toxicologist. 7:1995b.
5. Bombick D. W., Ayres P. H., Nelson P. R., Coggins C. R. E., France D., Fulp C., Lee C., Doolittle D. J. Assessment of the biological activity of mainstream or environmental tobacco smoke (ETS) using a cellular smoke exposure technique. Environ. Mol. Mutagen. 17:1991;11.
6. D. W. Bombick, P. H. Ayres, D. J. Doolittle, Cytotoxicity assessment of whole smoke and vapor phase of mainstream and sidestream cigarette smoke from three Kentucky reference cigarettes, Toxicol. Methods.
7. D. W. Bombick, P. H. Ayres, K. Putnam, B. R. Bombick, D. J. Doolittle, Chemical and biological studies on a new cigarette that primarily heats tobacco. III. In vitro toxicology of whole smoke, Food Chem. Toxicol.
8. Bombick D. W., Doolittle D. J. The role of chemical structure and cell type in the cytotoxicity of low molecular weight aldehydes and pyridines. In Vitro Toxicol. 8:1995;349-356.
9. Bombick D. W., Putnam K., Bombick B. R., Morgan W. T., Ayres P. H., Doolittle D. J. In vitro assessment of biological activity of mainstream smoke from cigarettes which burn or primarily heat tobacco. Int. Toxicologist. 7:1995a.
10. Borenfreund E., Puerner J. A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 24:1985;119-124.
11. Borenfreund E., Puerner J. A. A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). J. Tissue Culture Methods. 65:1984;55-63.
12. M. F. Borgerding, 1995, Approaches to characterizing smoke from new cigarette designs - A product evaluation strategy, 49th Tobacco Chemists' Research Conference, 49, Lexington, KY.
13. M. F. Borgerding, R. S. Dunn, F. A. Thome, H. L. Chung, D. S. Moore, T. R. Conner, D. L. Heavner, P. H. Ayres, 1984, An improved method for the determination of carbonyl compounds in smoke, 38th Tobacco Chemists Research Conference, Atlanta, GA.
14. Byrd G. D., Fowler K. W., Hicks R. D., Lovette M. E., Borgerding M. F. Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene, and acrylonitrile in mainstream cigarette smoke. J. Chromatogr. 503:1990;359-368.
15. Cannon W. C., Blanton E. F., McDonald K. E. The flow past chamber: An improved nose-only exposure system for rodents. Am. Ind. Hyg. Assoc. J. 44:1983;923-928.
16. Collins P. F., Sarji N. M., Williams J. F. An automated method for determination of hydrogen cyanide in cigarette smoke. Tob. Sci. 14:1970;12-15.
17. Doolittle D. J., Lee C. K., Ivett J. L., Mirsalis J. C., Riccio E., Rudd C. J., Burger G. T., Hayes A. W. Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco. Environ. Mol. Mutag. 15:1990;93-105.
18. Federal Register, 1967, 32, 11178.
19. Finney D. J. Probit Analysis. 1971;Cambridge Univ. Press, New York. p. 20-49.
20. Gad S., Weil C. S. Statistics and Experimental Design for Toxicologists. 1986;Telford Press, Caldwell. p. 93-110.
21. Goto K., Maeda S., Kano Y., Sugiyama T. Factors involved in differential Giemsa-staining of sister chromatids. Chromosoma. 66:1978;351-359.
22. R. C. Grafstrom, J. C. Willey, K. Sundqvist, C. C. Harris, 1986, Pathobiological effects of tobacco smoke-related aldehydes in cultured human bronchial epithelial cells, Banbury Report 23: Mechanisms in Tobacco Carcinogenesis, 273, 285, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. Guerin M. R., Jenkins R. A., Tomkins B. A. The Chemistry of Environmental Tobacco Smoke: Composition and Measurement. 1992;Lewis Publishers, Boca Raton. p. 43-62.
24. Harrell T. G., Rush K. L., Sensabaugh A. J. Colorimetric method for the determination of ammonia in cigarette smoke. Tob. Sci. 19:1975;145-147.
25. Harris C. C., Willey J. C., Saladino A. J., Grafstrom R. C. Effects of tumor promoters, aldehydes, peroxides and tobacco smoke condensate on growth and differentiation of cultured normal and transformed human bronchial cells. Mass M. Cancer of the Respiratory Tract: Predisposing Factors. 1985;159 Plenum Press, New York.
26. Healy M. J. R. The disciplining of medical data. Br. Med. Bull. 24:1968;210-214.
27. D. Hoffmann, C.-H. B. Chen, S. S. Hecht, 1980, The role of volatile and nonvolatile n-nitrosamines in tobacco carcinogenesis, Banbury Report 3: A Safe Cigarette?, G. B. GoriF. G. Bock, 113, 127, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
28. Horton A. D., Guerin M. R. Gas-solid chromatographic determination of carbon monoxide and carbon dioxide in cigarette smoke. J. Assoc. Off. Anal. Chem. 57:1974;1-7.
29. Maron D. M., Ames B. N. Revised methods for the Salmonella mutagenicity test. Mut. Res. 113:1983;173-215.
30. Mizusaki S., Okamoto H., Akiyama A., Fukuhara Y. Relation between chemical constituents of tobacco and mutagenic activity of cigarette smoke condensate. Mut. Res. 48:1977;319-325.
31. C. C. Morrison, D. E. Wingate, K. A. Beard, L. S. Winkler, D. F. Simmons, J. C. Rogers, M. F. Borgerding, 1995, The effects of cigarette design modifications on selected mainstream vapor phase smoke constituent yields, 49th Tobacco Chemists' Research Conference, 49, Lexington, KY.
32. Munoz N., Correa P., Bock F. G. Comparative carcinogenic effect of two types of tobacco. Cancer. 21:1968;376-389.
33. G. B. Neurath, M. Dunger, F. G. Pein, 1976, Interaction of nitrogen oxides, oxygen and amines in gaseous mixtures, IARC Scientific Publication No. 14. Environmental N-Nitroso Compounds Analysis and Formation, E. A. WalkerP. BogovskiL. Griciute, 215, 225, International Agency for Research on Cancer, Lyon, France.
34. Perry P., Wolff S. New Giemsa method for the differential staining of sister chromatids. Nature. 251:1974;156-158.
35. Pillsbury H. C., Bright C. C., O'Connor K. J., Irish F. W. Tar and nicotine in cigarette smoke. J. Assoc. Off. Anal. Chem. 52:1969;458-462.
36. J. C. Rogers, L. S. Winkler, M. F. Borgerding, 1995, Chromatographic profiling as a tool in the development and evaluation of new cigarettes, 49th Tobacco Chemists' Research Conference, 49, Lexington, KY.
37. Saladino A. J., Willey J. C., Lechner J. F., Grafstrom R. C., LaVeck M., Harris C. C. Effects of formaldehyde, acetaldehyde, benzoyl peroxide and hydrogen peroxide on cultured normal human bronchial epithelial cells. Cancer Res. 45:1985;2522.
38. Salsburg D. S. Statistics for Toxicologists. 1986;Dekker, New York. p. 3-62.
39. Schmeltz I., Hoffmann D. Nitrogen-containing compounds in tobacco and tobacco smoke. Chem. Rev. 71:1977;295.
40. Wynder E. L., Hoffmann D. Tobacco and Tobacco Smoke. Studies in Experimental Carcinogenesis. 1967;Academic Press, New York.
41. Yahagi T., Degawa M., Seino Y., Matsushima J., Nagao M., Sugimura T., Hashimoto Y. Mutagenicity of carcinogenic azo dyes and their derivatives. Cancer Lett. 1:1975;91-97.