Mechanisms of ricin toxin neutralization revealed through engineered homodimeric and heterodimeric camelid antibodies

Journal of Biological Chemistry

Volumn 290, Issue 46, 2015, Pages 27880-27889

  Herrera, Cristina ^a,b   Tremblay, Jacqueline M ^c   Shoemaker, Charles B ^c   Mantis, Nicholas J ^a,b  

^a WADSWORTH CENTER   (United States)

^b UNIVERSITY AT ALBANY   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; TOXIC MATERIALS;

AGGREGATION IN SOLUTIONS; CELL SURFACES; CLOSTRIDIUM DIFFICILE; CYTOTOXICITY ASSAYS; HEAVY CHAIN; HETERODIMERS; NEUTRALIZING AGENTS; PEPTIDE LINKERS;

ANTIBODIES;

CAMELID HEAVY CHAIN ONLY ANTIBODY; HETERODIMER; HOMODIMER; PROTEIN ANTIBODY; RICIN; UNCLASSIFIED DRUG; IMMUNOGLOBULIN HEAVY CHAIN; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; BINDING AFFINITY; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; HOST CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; ULTRACENTRIFUGATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMISTRY; CHLOROCEBUS AETHIOPS; IC50; IMMUNOLOGY; NEW WORLD CAMELID; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; VERO CELL LINE;

ANIMALS; ANTIBODIES, NEUTRALIZING; CAMELIDS, NEW WORLD; CERCOPITHECUS AETHIOPS; FEMALE; IMMUNOGLOBULIN HEAVY CHAINS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED BALB C; PROTEIN ENGINEERING; PROTEIN MULTIMERIZATION; RICIN; ULTRACENTRIFUGATION; VERO CELLS;

EID: 84946944111     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.658070     Document Type: Article

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