Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder

Journal of NeuroVirology

Volumn 22, Issue 3, 2016, Pages 327-335

  Ramos, Félix M ^a   Delgado Vélez, Manuel ^a   Ortiz, Ángel L ^a   Báez Pagán, Carlos A ^a   Quesada, Orestes ^a   Lasalde Dominicci, José A ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

CHRFAM7A; CHRNA7; gp120; HAND; HIV; Nicotinic acetylcholine receptor

Indexed keywords

ABACAVIR; AMPRENAVIR; BUNGAROTOXIN RECEPTOR; CHRFAM7A PROTEIN; EFAVIRENZ; EMTRICITABINE; ENVELOPE PROTEIN GP120 IIIB; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; NICOTINIC RECEPTOR; PLERIXAFOR; RITONAVIR; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; ZIDOVUDINE; CHRNA7 PROTEIN, HUMAN; GLYCOPROTEIN GP 120; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; ARTICLE; AUTOPSY; BASAL GANGLION; BRAIN; BRAIN TISSUE; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE DUPLICATION; GENE EXPRESSION; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN TISSUE; IN VITRO STUDY; MALE; NERVE CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TUMOR CELL LINE; VIROLOGY;

ADULT; AIDS DEMENTIA COMPLEX; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; AUTOPSY; BASAL GANGLIA; BRAIN; CELL DEATH; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION; HIV ENVELOPE PROTEIN GP120; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MALE; MIDDLE AGED; NEURONS; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION;

EID: 84946934972     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-015-0401-8     Document Type: Article

References (67)

1. Adle-Biassette H, Levy Y, Colombel M et al (1995) Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neurobiol 21:218–227
2. Antinori A, Arendt G, Becker JT et al (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69:1789–1799. doi:10.1212/01.WNL.0000287431.88658.8b
3. Araud T, Graw S, Berger R et al (2011) The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function. Biochem Pharmacol 82:904–914. doi:10.1016/j.bcp.2011.06.018
4. Azam L, Winzer-Serhan U, Leslie FM (2003) Co-expression of alpha7 and beta2 nicotinic acetylcholine receptor subunit mRNAs within rat brain cholinergic neurons. Neuroscience 119:965–977
5. Ballester LY, Capó-Vélez CM, García-Beltrán WF et al (2012) Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder. J Biol Chem 287:3079–3086. doi:10.1074/jbc.M111.262543
6. Bardi G, Sengupta R, Khan MZ et al (2006) Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization. J Neurovirol 12:211–218. doi:10.1080/13550280600848373
7. Benfante R, Antonini RA, De Pizzol M et al (2011) Expression of the α7 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS. J Neuroimmunol 230:74–84. doi:10.1016/j.jneuroim.2010.09.008
8. Berger JR, Arendt G (2000) HIV dementia: the role of the basal ganglia and dopaminergic systems. J Psychopharmacol Oxf Engl 14:214–221
9. Berger JR, Nath A (1997) HIV dementia and the basal ganglia. Intervirology 40:122–131
10. Berger JR, Nath A, Greenberg RN et al (2000) Cerebrovascular changes in the basal ganglia with HIV dementia. Neurology 54:921–926
11. Berrada F, Ma D, Michaud J et al (1995) Neuronal expression of human immunodeficiency virus type 1 env proteins in transgenic mice: distribution in the central nervous system and pathological alterations. J Virol 69:6770–6778
12. Bhaskaran K, Mussini C, Antinori A et al (2008) Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy. Ann Neurol 63:213–221. doi:10.1002/ana.21225
13. Bonsi P, Cuomo D, Martella G et al (2011) Centrality of striatal cholinergic transmission in basal ganglia function. Front Neuroanat 5:6. doi:10.3389/fnana.2011.00006
14. Brew BJ, Rosenblum M, Cronin K, Price RW (1995) AIDS dementia complex and HIV-1 brain infection: clinical-virological correlations. Ann Neurol 38:563–570. doi:10.1002/ana.410380404
15. Buzy JM, Brenneman DE, Siegal FP et al (1989) Cerebrospinal fluid from cognitively impaired patient with acquired immunodeficiency syndrome shows gp120-like neuronal killing in vitro. Am J Med 87:361–362
16. Cashion MF, Banks WA, Bost KL, Kastin AJ (1999) Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res 822:26–33
17. Catani MV, Corasaniti MT, Navarra M et al (2000) gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors. J Neurochem 74:2373–2379
18. Clifford DB, Ances BM (2013) HIV-associated neurocognitive disorder. Lancet Infect Dis 13:976–986. doi:10.1016/S1473-3099(13)70269-X
19. Corboy JR, Buzy JM, Zink MC, Clements JE (1992) Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 258:1804–1808
20. Costantini TW, Dang X, Coimbra R et al (2014) CHRFAM7A, a human-specific and partially duplicated α7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury. J Leukoc Biol. doi:10.1189/jlb.4RU0814-381R
21. Cysique LA, Brew BJ (2011) Prevalence of non-confounded HIV-associated neurocognitive impairment in the context of plasma HIV RNA suppression. J Neurovirol 17:176–183. doi:10.1007/s13365-011-0021-x
22. Cysique LA, Maruff P, Brew BJ (2004) Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: a combined study of two cohorts. J Neurovirol 10:350–357. doi:10.1080/13550280490521078
23. Dani JA, Lester RA (2001) Nicotinic acetylcholine receptors in neurons. In: eLS. John Wiley & Sons, Ltd
24. Davis CB, Dikic I, Unutmaz D et al (1997) Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med 186:1793–1798
25. De Luca V, Likhodi O, Van Tol HHM et al (2006) Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia. Acta Psychiatr Scand 114:211–215. doi:10.1111/j.1600-0447.2006.00785.x
26. de Lucas-Cerrillo AM, Maldifassi MC, Arnalich F et al (2011) Function of partially duplicated human α7 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response. J Biol Chem 286:594–606. doi:10.1074/jbc.M110.180067
27. Desai M, Hu N, Byrd D, Yu Q (2013) Neuronal apoptosis in HIV-1-associated central nervous diseases and neuropathic pain. In: Rudner J (ed) Apoptosis. InTech
28. Di Stefano M, Gray F, Leitner T, Chiodi F (1996) Analysis of ENV V3 sequences from HIV-1-infected brain indicates restrained virus expression throughout the disease. J Med Virol 49:41–48. doi:10.1002/(SICI)1096-9071(199605)49:1<41::AID-JMV7>3.0.CO;2-K
29. Everall I, Barnes H, Spargo E, Lantos P (1995) Assessment of neuronal density in the putamen in human immunodeficiency virus (HIV) infection. Application of stereology and spatial analysis of quadrats. J Neurovirol 1:126–129
30. Gault J, Robinson M, Berger R et al (1998) Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics 52:173–185. doi:10.1006/geno.1998.5363
31. Gelbard HA, James HJ, Sharer LR et al (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy. Neuropathol Appl Neurobiol 21:208–217
32. Ghafouri M, Amini S, Khalili K, Sawaya BE (2006) HIV-1 associated dementia: symptoms and causes. Retrovirology 3:28. doi:10.1186/1742-4690-3-28
33. Gilbert M, Kirihara J, Mills J (1991) Enzyme-linked immunoassay for human immunodeficiency virus type 1 envelope glycoprotein 120. J Clin Microbiol 29:142–147
34. González-Scarano F, Martín-García J (2005) The neuropathogenesis of AIDS. Nat Rev Immunol 5:69–81. doi:10.1038/nri1527
35. Grant I, Franklin DR, Deutsch R et al (2014) Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology 82:2055–2062. doi:10.1212/WNL.0000000000000492
36. Heaton RK, Franklin DR, Ellis RJ et al (2011) HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 17:3–16. doi:10.1007/s13365-010-0006-1
37. Hesselgesser J, Halks-Miller M, DelVecchio V et al (1997) CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 7:112–121
38. Hesselgesser J, Taub D, Baskar P et al (1998) Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Curr Biol 8:595–598
39. Jana A, Pahan K (2004) Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase. J Neurosci Off J Soc Neurosci 24:9531–9540. doi:10.1523/JNEUROSCI.3085-04.2004
40. Joint United Nations Programme on HIV/AIDS (UNAIDS) (2013) Global Report: UNAIDS report on global AIDS epidemic 2013.
41. Jones MV, Bell JE, Nath A (2000) Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia. AIDS Lond Engl 14:2709–2713
42. Kaul M, Zheng J, Okamoto S et al (2005) HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ 12(Suppl 1):878–892. doi:10.1038/sj.cdd.4401623
43. Kaul M, Ma Q, Medders KE et al (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ 14:296–305. doi:10.1038/sj.cdd.4402006
44. Koneru R, Olive MF, Tyor WR (2014) Combined antiretroviral therapy reduces brain viral load and pathological features of HIV encephalitis in a mouse model. J Neurovirol 20:9–17. doi:10.1007/s13365-013-0223-5
45. Kong LY, Wilson BC, McMillian MK et al (1996) The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and proinflammatory cytokines in mixed glial cell cultures. Cell Immunol 172:77–83. doi:10.1006/cimm.1996.0217
46. Kure K, Weidenheim KM, Lyman WD, Dickson DW (1990) Morphology and distribution of HIV-1 gp41-positive microglia in subacute AIDS encephalitis. Pattern of involvement resembling a multisystem degeneration. Acta Neuropathol (Berl) 80:393–400
47. Lee C, Liu Q-H, Tomkowicz B et al (2003) Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. J Leukoc Biol 74:676–682. doi:10.1189/jlb.0503206
48. Lucey DR, VanCott TC, Loomis LD et al (1993) Measurement of cerebrospinal fluid antibody to the HIV-1 principal neutralizing determinant (V3 loop). J Acquir Immune Defic Syndr 6:994–1001
49. Meucci O, Miller RJ (1996) gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1. J Neurosci Off J Soc Neurosci 16:4080–4088
50. Mothobi NZ, Brew BJ (2012) Neurocognitive dysfunction in the highly active antiretroviral therapy era. Curr Opin Infect Dis 25:4–9. doi:10.1097/QCO.0b013e32834ef586
51. Oh SK, Cruikshank WW, Raina J et al (1992) Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients. J Acquir Immune Defic Syndr 5:251–256
52. Ohagen A, Devitt A, Kunstman KJ et al (2003) Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS. J Virol 77:12336–12345
53. Okamoto S, Kang Y-J, Brechtel CW et al (2007) HIV/gp120 decreases adult neural progenitor cell proliferation via checkpoint kinase-mediated cell-cycle withdrawal and G1 arrest. Cell Stem Cell 1:230–236. doi:10.1016/j.stem.2007.07.010
54. Pillai SK, Pond SLK, Liu Y et al (2006) Genetic attributes of cerebrospinal fluid-derived HIV-1 env. Brain J Neurol 129:1872–1883. doi:10.1093/brain/awl136
55. Rolfs A, Schumacher HC (1990) Early findings in the cerebrospinal fluid of patients with HIV-1 infection of the central nervous system. N Engl J Med 323:418–419. doi:10.1056/NEJM199008093230614
56. Ruţă SM, Mătuşa R, Cernescu CC (1998) Cerebrospinal fluid Western blot profiles in the evolution of HIV-1 pediatric encephalopathy. Rom J Virol 49:61–71
57. Rychert J, Strick D, Bazner S et al (2010) Detection of HIV gp120 in plasma during early HIV infection is associated with increased proinflammatory and immunoregulatory cytokines. AIDS Res Hum Retroviruses 26:1139–1145. doi:10.1089/aid.2009.0290
58. Sacktor N, McDermott MP, Marder K et al (2002) HIV-associated cognitive impairment before and after the advent of combination therapy. J Neurovirol 8:136–142. doi:10.1080/13550280290049615
59. Santosuosso M, Righi E, Lindstrom V et al (2009) HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection. J Infect Dis 200:1050–1053. doi:10.1086/605695
60. Toggas SM, Masliah E, Rockenstein EM et al (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367:188–193. doi:10.1038/367188a0
61. Trujillo JR, Navia BA, Worth J et al (1996) High levels of anti-HIV-1 envelope antibodies in cerebrospinal fluid as compared to serum from patients with AIDS dementia complex. J Acquir Immune Defic Syndr Hum Retrovirol Off Publ Int Retrovirol Assoc 12:19–25
62. van der Zanden EP, Hilbers FW, Verseijden C et al (2012) Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals. Neuroimmunomodulation 19:255–265. doi:10.1159/000335185
63. von Giesen HJ, Wittsack HJ, Wenserski F et al (2001) Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1. Arch Neurol 58:1281–1286
64. Wang Y, Xiao C, Indersmitten T et al (2014) The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7. J Biol Chem 289:26451–26463. doi:10.1074/jbc.M114.582858
65. Woods SP, Moore DJ, Weber E, Grant I (2009) Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19:152–168. doi:10.1007/s11065-009-9102-5
66. Xu Y, Kulkosky J, Acheampong E et al (2004) HIV-1-mediated apoptosis of neuronal cells: proximal molecular mechanisms of HIV-1-induced encephalopathy. Proc Natl Acad Sci U S A 101:7070–7075. doi:10.1073/pnas.0304859101
67. Zheng J, Thylin MR, Ghorpade A et al (1999) Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. J Neuroimmunol 98:185–200