Fracture Risk Prediction by Non-BMD DXA Measures: The 2015 ISCD Official Positions Part 1: Hip Geometry

Journal of Clinical Densitometry

Volumn 18, Issue 3, 2015, Pages 287-308

  Broy, Susan B ^a   Cauley, Jane A ^b   Lewiecki, Michael E ^c   Schousboe, John T ^d   Shepherd, John A ^e   Leslie, William D ^f  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Dual energy X ray absorptiometry; Fracture risk; Hip axis length; Hip structural analysis; Neck shaft angle

Indexed keywords

ALENDRONIC ACID; DENOSUMAB; IBANDRONIC ACID; MEDROXYPROGESTERONE; PARATHYROID HORMONE[1-34]; RALOXIFENE; RISEDRONIC ACID; STRONTIUM RANELATE;

ARTICLE; BONE DENSITY; BONE LENGTH; CLINICAL PRACTICE; COMPUTER ASSISTED TOMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMUR NECK; FEMUR SHAFT; FRAGILITY FRACTURE; HIP; HIP FRACTURE; HUMAN; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; FEMUR; FRACTURES, BONE; MEDICAL SOCIETY; PATHOLOGY; PELVIC GIRDLE; PHOTON ABSORPTIOMETRY; PRACTICE GUIDELINE; RADIOGRAPHY; RISK ASSESSMENT;

ABSORPTIOMETRY, PHOTON; BONE DENSITY; FEMUR; FRACTURES, BONE; HUMANS; PELVIC BONES; PRACTICE GUIDELINES AS TOPIC; RISK ASSESSMENT; SOCIETIES, MEDICAL;

EID: 84946917716     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2015.06.005     Document Type: Article

References (79)

1. Osteoporosis prevention, diagnosis, and therapy. JAMA 2001, 285(6):785-795. NIH Consensus Development Panel.
2. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis 1994, WHO, World Health Organization, Geneva.
3. Hans D., Downs R.W., Duboeuf F., et al. Skeletal sites for osteoporosis diagnosis: the 2005 ISCD Official Positions. J Clin Densitom 2006, 9(1):15-21.
4. Leslie W.D., Adler R.A., El-Hajj Fuleihan G., et al. Application of the 1994 WHO classification to populations other than postmenopausal Caucasian women: the 2005 ISCD Official Positions. J Clin Densitom 2006, 9(1):22-30.
5. Siris E.S., Miller P.D., Barrett-Connor E., et al. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 2001, 286(22):2815-2822.
6. Stone K.L., Seeley D.G., Lui L., et al. BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res 2003, 18(11):1947-1954.
7. Sornay-Rendu E., Munoz F., Garnero P., et al. Identification of osteopenic women at high risk of fracture: the OFELY study. J Bone Miner Res 2005, 20(10):1813-1819.
8. Schuit S.C., van der Klift M., Weel A.E., et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 2004, 34(1):195-202.
9. Moro M., Hecker A.T., Bouxsein M.L., Myers E.R. Failure load of thoracic vertebrae correlates with lumbar bone mineral density measured by DXA. Calcif Tissue Int 1995, 56(3):206-209.
10. Cheng X.G., Nicholson P.H., Boonen S., Low G. Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound. J Bone Miner Res 1997, 12(10):1721-1728.
11. Bousson V., Le Bras A., Roqueplan F., et al. Volumetric quantitative computed tomography of the proximal femur: relationships linking geometric and densitometric variables to bone strength. Role for compact bone. Osteoporos Int 2006, 17:855-864.
12. Felsenberg D., Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther 2005, 27(1):1-11.
13. Bouxsein M.L. Bone quality: where do we go from here?. Osteoporos Int 2003, 14(Suppl. 5):118-127.
14. Seeman E., Delmas P.D. Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 2006, 354:2250-2261.
15. Szulc P., Duboeuf F., Schott A.M., et al. Structural determinants of hip fracture in elderly women: re-analysis of the data from the EPIDOS study. Osteoporos Int 2006, 17:231-236.
16. Duboeuf F., Hans D., Schott A.M., et al. Different morphometric and densitometric parameters predict cervical and trochanteric hip fracture: The EPIDOS Study. J Bone Miner Res 1997, 12(11):1895-1902.
17. Dretakis E.K., Papakitsou E., Kontakis G.M., et al. Bone mineral density, body mass index, and hip axis length in postmenopausal Cretan women with cervical and trochanteric fractures. Calcif Tissue Int 1999, 64:257-258.
18. Faulkner K.G., Cummings S.R., Black D. Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J Bone Miner Res 1993, 8(10):1211-1217.
19. Nissen N., Hauge E.M., Abrahamsen B., et al. Geometry of the proximal femur in relation to age and sex: a cross-sectional study in healthy adult Danes. Acta Radiol 2005, 46(5):514-518.
20. Nieves J.W., Formica C., Ruffing J., et al. Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res 2005, 20(3):529-535.
21. Wang M.C., Aguirre M., Bhudhikanok G.S., et al. Bone mass and hip axis length in healthy Asian, black, Hispanic, and white American youths. J Bone Miner Res 1997, 12(11):1922-1935.
22. Yan L., Crabtree N.J., Reeve J., et al. Does hip strength analysis explain the lower incidence of hip fracture in the People's Republic of China ?. Bone 2004, 34(3):584-588.
23. Brownbill R.A., Ilich J.Z. Hip geometry and its role in fracture: what do we know so far?. Curr Osteoporos Rep 2003, 1(1):25-31.
24. Leslie W.D., Pahlavan P.S., Tsang J.F., Lix L.M. Prediction of hip and other osteoporotic fractures from hip geometry in a large clinical cohort. Osteoporos Int 2009, 20(10):1767-1774.
25. Gnudi S., Malavolta N., Testi D., Eng M., et al. Differences in proximal femur geometry distinguish vertebral from femoral neck fractures in osteoporotic women. Br J Radiol 2004, 77:219-223.
26. Alonso C.G., Curiel M.D., Carranza F.H., et al. Femoral bone mineral density, neck-shaft angle and mean femoral neck width as predictors of hip fracture in men and women. Osteoporos Int 2000, 11:714-720.
27. Faulkner K.G., Wacker W.K., Barden H.S., et al. Femur strength index predicts hip fracture independent of bone density and hip axis length. Osteoporos Int 2006, 17:593-599.
28. Zhang H., Hu Y.Q., Zhang Z.L. Age trends for hip geometry in Chinese men and women and the association with femoral neck fracture. Osteoporos Int 2011, 22:2513-2522.
29. Karlsson K.M., Sernbo I., Obrant K.J., et al. Femoral neck geometry and radiographic signs of osteoporosis as predictors of hip fracture. Bone 1996, 18(4):327-330.
30. Gao G., Zhang Z.L., Zhang H., et al. Hip axis length changes in 10,554 males and females and the association with femoral neck fracture. J Clin Densitom 2008, 11(3):360-366.
31. Wang Q., Teo J.W., Ghasem-Zadeh A., Seeman E. Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall. Osteoporos Int 2009, 20:1151-1156.
32. Pande I., O'Neill T.W., Pritchard C., et al. Bone mineral density, hip axis length and risk of hip fracture in men: results from the Cornwall Hip Fracture Study. Osteoporos Int 2000, 11:866-870.
33. Ripamonti C., Lisi L., Avella M. Femoral neck shaft angle width is associated with hip-fracture risk in males but not independently of femoral neck bone density. Br J Radiol 2014, 87:20130358.
34. Leslie W.D., Lix L.M., Morin S.N., et al. Hip Axis Length is a FRAX and bone density independent risk factor for hip fracture in men and women. J Clin Endocrinol Metab 2015, 100:2063-2070. Presented at the WCO-IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, Milan, Italy, March 2015. Abstract published in Osteoporos Int. (in press).
35. Li G.W., Chang S.X., Xu Z., et al. Prediction of hip osteopororic fractures from composite indices of femoral neck strength. Skeletal Radiol 2013, 42:195-201.
36. Kaptoge S., Beck T.J., Reeve J., et al. Prediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fractures. J Bone Miner Res 2008, 23(12):1892-1904.
37. Gnudi S., Ripamonti C., Gualtieri G., Malavolta N. Geometry of proximal femur in the prediction of hip fracture in osteoporotic women. Br J Radiol 1999, 72:729-733.
38. Gnudi S., Ripamonti C., Lisi L., et al. Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women. Osteoporos Int 2002, 13:69-73.
39. Bergot C., Bousson V., Meunier A., et al. Hip fracture risk and proximal femur geometry from DXA scans. Osteoporos Int 2002, 13:542-550.
40. Gnudi S., Sitta E., Pignotti E. Prediction of incident hip fracture by femoral neck bone mineral density and neck-shaft angle: a 5-year longitudinal study in post-menopausal females. Br J Radiol 2012, 85:e467-e473.
41. Boonen S., Koutri R., Dequeker J., et al. Measurement of femoral geometry in type I and type II osteoporosis: differences in hip axis length consistent with heterogeneity in the pathogenesis of osteoporotic fractures. J Bone Miner Res 1995, 10(12):1908-1912.
42. Rosso R., Minisola S. Hip axis length in an Italian osteoporotic population. Br J Radiol 2000, 73:969-972.
43. Testi D., Viceconti M., Cappello A., Gnudi S. Prediction of hip fracture can be significantly improved by a single biomedical indicator. Ann Biomed Eng 2002, 30:801-807.
44. Crabtree N.J., Kroger H., Martin A., et al. Improving risk assessment: hip geometry, bone mineral distribution and bone strength in hip fracture cases and controls. The EPOS study. Osteoporos Int 2002, 13:48-54.
45. Pinheiro M.M., Castro C.H.M., Frisoli A., Szejnfeld V.L. Discriminatory ability of quantitative ultrasound measurements is similar to dual-energy X-ray absorptiometry in a Brazilian women population with osteoporotic fracture. Calcif Tissue Int 2003, 73:555-564.
46. Chin K., Evans M.C., Cornish J., et al. Differences in hip axis and femoral neck length in premenopausal of Polynesian, Asian and European origin. Osteoporos Int 1997, 7:344-347.
47. Clark P., Tesoriero L.J., Morton D.J., et al. Hip axis length variation: its correlation with anthropometric measurements in women from three ethnic groups. Osteoporos Int 2008, 19(9):1301-1306.
48. El-Kaissi S., Pasco J.A., Henry M.J., et al. Femoral neck geometry and hip fracture risk: the Geelong osteoporosis study. Osteoporos Int 2005, 16(10):1299-1303.
49. Frisoli A., Paul A.P., Pinheiro M., et al. Hip axis length as an independent risk factor for hip fracture independently of femoral bone mineral density in Caucasian elderly Brazilian women. Bone 2005, 37:871-875.
50. Leslie W.D., Lix L.M., Morin S.N., et al. Hip axis length is a FRAX and bone density independent risk factor for hip fracture in women. J Clin Endocrinol Metab 2015, 100:2063-2070.
51. Yang L., Peel N., Clowes J.A., et al. Use of DXA-based structural engineering models of the proximal femur to discriminate hip fracture. J Bone Miner Res 2009, 24(1):33-40.
52. Tenne M., McGuigan F.E., Ahlborg H., et al. Variation in the PTH gene, hip fracture, and femoral neck geometry in elderly women. Calcif Tissue Int 2010, 86:359-366.
53. Tuck S.P., Rawlings D.J., Scane A.C., et al. Femoral neck shaft angle in men with fragility fractures. J Osteoporos 2011, 2011. Article ID 903726:1-7.
54. Beck T.J., Petit M.A., Wu G., et al. Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the women's health initiative-observational study. J Bone Miner Res 2009, 24(8):1369-1379.
55. Rivadeneira F., Zillikens M.C., De Laet C.E., et al. Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study. J Bone Miner Res 2007, 22(11):1781-1790.
56. LaCroix A.Z., Beck T.J., Cauley J.A., et al. Hip structural geometry and incidence of hip fracture in postmenopausal women: what does it add to conventional bone mineral density?. Osteoporos Int 2010, 21(6):919-929.
57. Ahlborg H.G., Nguyen N.D., Nguyen T.V., et al. Contribution of hip strength indices to hip fracture risk in elderly men and women. J Bone Miner Res 2005, 20(10):1820-1827.
58. Melton L.J., Beck T.J., Amin S., et al. Contributions of bone density and structure to fracture risk assessment in men and women. Osteoporos Int 2005, 16(5):460-467.
59. Cosman F., de Beur S.J., LeBoffM.S., et al. Clinician's guide to prevention and treatment of osteoporosis. Osteoporos Int 2014, 25(10):2359-2381.
60. Papaioannou A., Morin S., Cheung A.M., et al. Clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary. CMAJ 2010, 182:1864-1873.
61. Compston J., Cooper A., Cooper C., et al. Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas 2009, 62:105-108.
62. Kanis J.A., McCloskey E.V., Johansson H., et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2013, 24(1):23-57.
63. Khoo B.C., Beck T.J., Qiao Q.H., et al. In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials. Bone 2005, 37:112-121.
64. Hind K., Oldroyd B., Prajapati A., Rhodes L. In vivo precision of dual-energy X-ray absorptiometry-derived hip structural analysis in adults. J Clin Densitom 2012, 15:302-307.
65. Crabtree N., Lunt M., Holt G., et al. Hip geometry, bone mineral distribution, and bone strength in European men and women: the EPOS study. Bone 2000, 27:151-159.
66. Shepherd JA, Fan B, Lewiecki EM, et al. Hip structure analysis precision and agreement between Hologic and GE-Lunar DXA systems.2015 Abstract presented at ISCD annual meeting, published in J Clin Densitom.
67. Leslie WD. 2015 Short-term precision and cross-calibration for GE advanced hip assessment. Abstract presented at ISCD annual meeting, published in J Clin Densitom.
68. Chen Z., Beck T.J., Cauley J.A., et al. Hormone therapy improves femur geometry among ethnically diverse postmenopausal participants in the Women's Health Initiative hormone intervention trials. J Bone Miner Res 2008, 23:1935-1945.
69. van Londen G.J., Perera S., Vujevich K.T., et al. Effect of risedronate on hip structural geometry: a 1-year, double-blind trial in chemotherapy-induced postmenopausal women. Bone 2008, 43:274-278.
70. Beck T.J., Lewiecki E.M., Miller P.D., et al. Effects of denosumab on the geometry of the proximal femur in postmenopausal women in comparison with alendronate. J Clin Densitom 2008, 11:351-359.
71. Lewiecki E.M., Keaveny T.M., Kopperdahl D.L., et al. Once-monthly oral ibandronate improves biomechanical determinants of bone strength in women with postmenopausal osteoporosis. J Clin Endocrinol Metab 2009, 94:171-180.
72. van Londen G.J., Perera S., Vujevich K.T., et al. The effect of risedronate on hip structural geometry in chemotherapy-induced postmenopausal women with or without use of aromatase inhibitors: a 2-year trial. Bone 2010, 46:655-659.
73. Genant H.K., Lewiecki E.M., Fuerst T., Fries M. Effect of monthly ibandronate on hip structural geometry in men with low bone density. Osteoporos Int 2012, 23:257-265.
74. Uusi-Rasi K., Semanick L.M., Zanchetta J.R., et al. Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone 2005, 36:948-958.
75. Briot K., Benhamou C.L., Roux C. Hip cortical thickness assessment in postmenopausal women with osteoporosis and strontium ranelate effect on hip geometry. J Clin Densitom 2012, 15:176-185.
76. Sone T., Ito M., Fukunaga M., et al. The effects of once-weekly teriparatide on hip geometry assessed by hip structural analysis in postmenopausal osteoporotic women with high fracture risk. Bone 2014, 64:75-81.
77. Bone H.G., Bolognese M.A., Yuen C.K., et al. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women. J Clin Endocrinol Metab 2008, 93:2149-2157.
78. Uusi-Rasi K., Beck T.J., Semanick L.M., et al. Structural effects of raloxifene on the proximal femur: results from the multiple outcomes of raloxifene evaluation trial. Osteoporos Int 2006, 17:575-586.
79. Bruno A.G., Broe K.E., Zhang X., et al. Vertebral size, bone density and strength in men and women matched for age and areal spine BMD. J Bone Miner Res 2014, 29(3):562-569.