Hormone therapy improves femur geometry among ethnically diverse postmenopausal participants in the women's health initiative hormone intervention trials

Journal of Bone and Mineral Research

Volumn 23, Issue 12, 2008, Pages 1935-1945

  Chen, Zhao ^a   Beck, Thomas J ^b   Cauley, Jane A ^c   Lewis, Cora E ^d   LaCroix, Andrea ^e   Bassford, Tamsen ^f   Wu, Guanglin ^a   Sherrill, Duane ^a   Going, Scott ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d University of Alabama at Birmingham   (United States)

^e Fred Hutchinson Cancer Research Center   (United States)

^f UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Bone densitometry; Clinical trial; Epidemiology; Osteoporosis

Indexed keywords

CONJUGATED ESTROGEN; ESTROGEN; GESTAGEN; MEDROXYPROGESTERONE ACETATE; PLACEBO;

ADULT; AGED; ARTICLE; BONE DENSITOMETRY; BONE STRENGTH; BREAST CANCER; CLINICAL TRIAL; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG WITHDRAWAL; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; FOLLOW UP; GEOMETRY; HIP FRACTURE; HIP STRUCTURAL ANALYSIS; HORMONAL THERAPY; HUMAN; MAJOR CLINICAL STUDY; MONOTHERAPY; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; STRESS; STROKE; WOMEN'S HEALTH;

AGED; BONE DENSITY; DENSITOMETRY; ESTROGENS; ETHNIC GROUPS; FEMALE; FEMUR; HIP; HORMONES; HUMANS; MIDDLE AGED; PLACEBOS; POSTMENOPAUSE; PROGESTINS; SENSITIVITY AND SPECIFICITY;

EID: 56749177525     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.080707     Document Type: Article

References (38)

1. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, Bonds D, Brunner R, Brzyski R, Caan B, Chlebowski R, Curb D, Gass M, Hays J, Heiss G, Hendrix S, Howard BV, Hsia J, Hubbell A, Jackson R, Johnson KC, Judd H, Kotchen JM, Kuller L, LaCroix AZ, Lane D, Langer RD, Lasser N, Lewis CE, Manson J, Margolis K, Ockene J, O'Sullivan MJ, Phillips L, Prentice RL, Ritenbaugh C, Robbins J, Rossouw JE, Sarto G, Stefanick ML, Van Horn L, Wactawski-Wende J, Wallace R, Wassertheil-Smoller S 2004 Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial. JAMA 291:1701-1712.
2. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 288:321-333.
3. Delmas PD, Seeman E 2004 Changes in bone mineral density explain little of the reduction in vertebral or nonvertebral fracture risk with anti-resorptive therapy. Bone 34:599-604.
4. Chen Z, Bassford T, Green SB, Cauley JA, Jackson RD, LaCroix AZ, Leboff M, Stefanick ML, Margolis KL 2005 Postmenopausal hormone therapy and body composition - a substudy of the estrogen plus progestin trial of the Women's Health Initiative. Am J Clin Nutr 82:651-656.
5. Taaffe DR, Newman AB, Haggerty CL, Colbert LH, de Rekeneire N, Visser M, Goodpaster BH, Nevitt MC, Tylavsky FA, Harris TB 2005 Estrogen replacement, muscle composition, and physical function: The Health ABC Study. Med Sci Sports Exerc 37:1741-1747.
6. Naessen T, Lindmark B, Lagerstrom C, Larsen HC, Persson I 2007 Early postmenopausal hormone therapy improves postural balance. Menopause 14:14-19.
7. Naessen T, Lindmark B, Larsen HC 1997 Better postural balance in elderly women receiving estrogens. Am J Obstet Gynecol 177:412-416.
8. Wronski TJ, Cintron M, Doherty AL, Dann LM 1988 Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123:681-686.
9. Van Rietbergen B, Huiskes R, Eckstein F, Ruegsegger P 2003 Trabecular bone tissue strains in the healthy and osteoporotic human femur. J Bone Miner Res 18:1781-1788.
10. Greenspan SL, Beck TJ, Resnick NM, Bhattacharya R, Parker RA 2005 Effect of hormone replacement, alendronate, or combination therapy on hip structural geometry: A 3-year, double-blind, placebo-controlled clinical trial. J Bone Miner Res 20:1525-1532.
11. Uusi-Rasi K, Beck TJ, Semanick LM, Daphtary MM, Crans GG, Desaiah D, Harper KD 2006 Structural effects of raloxifene on the proximal femur: Results from the multiple outcomes of raloxifene evaluation trial. Osteoporos Int 17:575-586.
12. Uusi-Rasi K, Semanick LM, Zanchetta JR, Bogado CE, Eriksen EF, Sato M, Beck TJ 2005 Effects of teriparatide [rhPTH (1-34)] treatment on structural geometry of the proximal femur in elderly osteoporotic women. Bone 36:948-958.
13. Beck TJ, Stone KL, Oreskovic TL, Hochberg MC, Nevitt MC, Genant HK, Cummings SR 2001 Effects of current and discontinued estrogen replacement therapy on hip structural geometry: The study of osteoporotic fractures. J Bone Miner Res 16:2103-2110.
14. The Women's Health Initiative Study Group 1998 Design of the Women's Health Initiative clinical trial and observational study. Control Clin Trials 19:61-109.
15. Martin RB, Burr DB 1984 Non-invasive measurement of long bone cross-sectional moment of inertia by photon absorptiometry. J Biomech 17:195-201.
16. Rivadeneira F, Zillikens MC, De Laet CE, Hofman A, Uitterlinden AG, Beck TJ, Pols HA 2007 Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: The Rotterdam Study. J Bone Miner Res 22:1781-1790.
17. Kaptoge S, Beck TJ, Reeve J, Stone KL, Hillier TA, Cauley J, Cummings SR 2008 Prediction of incident hip fracture risk by femur geometry variables measured by hip structural analysis in the study of osteoporotic fractures. J Bone Miner Res (in press).
18. Mayhew PM, Thomas CD, Clement JG, Loveridge N, Beck TJ, Bonfield W, Burgoyne CJ, Reeve J 2005 Relation between age, femoral neck cortical stability, and hip fracture risk. Lancet 366:129-135.
19. Block G, Woods M, Potosky A, Clifford C 1990 Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol 43:1327-1335.
20. Patterson RE, Kristal AR, Coates RJ, Tylavsky FA, Ritenbaugh C, Van Horn L, Caggiula AW, Snetselaar L 1996 Low-fat diet practices of older women: Prevalence and implications for dietary assessment. J Am Diet Assoc 96:670-679.
21. Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, Paffenbarger RS Jr 1993 Compendium of physical activities: Classification of energy costs of human physical activities. Med Sci Sports Exerc 25:71-80.
22. Ware JE Jr, Sherbourne CD 1992 The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473-483.
23. The Writing Group for the PEPI 1996 Effects of hormone therapy on bone mineral density: Results from the postmenopausal estrogen/progestin interventions (PEPI) trial. JAMA 276:1389-1396.
24. Komulainen M, Kroger H, Tuppurainen MT, Heikkinen AM, Alhava E, Honkanen R, Jurvelin J, Saarikoski S 1999 Prevention of femoral and lumbar bone loss with hormone replacement therapy and vitamin D3 in early postmenopausal women: A population-based 5-year randomized trial. J Clin Endocrinol Metab 84:546-552.
25. Heikkinen J, Kyllonen E, Kurttila-Matero E, Wilen-Rosenqvist G, Lankinen KS, Rita H, Vaananen HK 1997 HRT and exercise: Effects on bone density, muscle strength and lipid metabolism. A placebo controlled 2-year prospective trial on two estrogen-progestin regimens in healthy postmenopausal women. Maturitas 26:139-149.
26. Jacobsen DE, Samson MM, Kezic S, Verhaar HJ 2007 Postmenopausal HRT and tibolone in relation to muscle strength and body composition. Maturitas 58:7-18.
27. Frost HM 1996 Perspectives: A proposed general model of the "mechanostat" (suggestions from a new skeletal-biologic paradigm). Anat Rec 244:139-147.
28. Jarvinen TL, Kannus P, Sievanen H 2003 Estrogen and bone - a reproductive and locomotive perspective. J Bone Miner Res 18:1921-1931.
29. Frost HM 1999 On the estrogen-bone relationship and postmenopausal bone loss: A new model. J Bone Miner Res 14:1473-1477.
30. Bakker AD, Klein-Nulend J, Tanck E, Albers GH, Lips P, Burger EH 2005 Additive effects of estrogen and mechanical stress on nitric oxide and prostaglandin E2 production by bone cells from osteoporotic donors. Osteoporos Int 16:983-989.
31. Kaptoge S, Jakes RW, Dalzell N, Wareham N, Khaw KT, Loveridge N, Beck TJ, Reeve J 2007 Effects of physical activity on evolution of proximal femur structure in a younger elderly population. Bone 40:506-515.
32. Young W 1989 Elastic stability formulas for stress and strain. In: Crawford HB, Thomas S (eds.) Roark's Formulas for Stress and Strain, 6th ed. McGraw-Hill, New York, NY, USA, p. 688.
33. Schafer BW 2002 Local, distortional, and Euler buckling in thin-walled columns. J Struct Eng 128:289-299.
34. Duan Y, Beck TJ, Wang XF, Seeman E 2003 Structural and biomechanical basis of sexual dimorphism in femoral neck fragility has its origins in growth and aging. J Bone Miner Res 18:1766-1774.
35. Beck TJ, Lewiecki EM, Miller PD, Felsenberg D, Liu Y, Ding B, Libanati C 2008 Effects of denosumab on the geometry of the proximal femur in postmenopausal women in comparison with alendronate. J Clin Densitom 11:351-359.
36. Khoo BC, Beck TJ, Qiao OH, Parakh P, Semanick L, Prince RL, Singer KP, Price RI 2005 In vivo short-term precision of hip structure analysis variables in comparison with bone mineral density using paired dual-energy X-ray absorptiometry scans from multi-center clinical trials. Bone 37:112-121.
37. Boivin G, Vedi S, Purdie DW, Compston JE, Meunier PJ 2005 Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: A quantitative microradiographic analysis in postmenopausal women. Bone 36:562-567.
38. Cummings S 2002 How drugs decrease fracture risk: Lessons from trials. Musculoskelet Neuronal Interact. 2:198-220.