Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

Neuropharmacology

Volumn 102, Issue , 2016, Pages 59-71

  Volpi, Claudia ^a   Mondanelli, Giada ^a   Pallotta, Maria T ^a   Vacca, Carmine ^a   Iacono, Alberta ^a   Gargaro, Marco ^a   Albini, Elisa ^a   Bianchi, Roberta ^a   Belladonna, Maria L ^a   Celanire, Sylvain ^b   Mordant, Céline ^b   Heroux, Madeleine ^b   Royer Urios, Isabelle ^b   Schneider, Manfred ^b   Vitte, Pierre Alain ^b   Cacquevel, Mathias ^b   Galibert, Laurent ^b   Poli, Sonia Maria ^b   Solari, Aldo ^c   Bicciato, Silvio ^d   Calvitti, Mario ^a   Antognelli, Cinzia ^a   Puccetti, Paolo ^a   Orabona, Ciriana ^a   Fallarino, Francesca ^a   Grohmann, Ursula ^a   more..

^a UNIVERSITY OF PERUGIA   (Italy)

^b Addex Therapeutics SA   (Switzerland)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Autoimmunity; Dendritic cells; Immune regulation; Indoleamine 2 3 dioxygenase 1; mGluR4; Neuroinflammation; Noncanonical GPCR signaling; PI3K; Src kinase; Tryptophan metabolism

Indexed keywords

5 METHYL N (4 METHYLPYRIMIDIN 2 YL) 4 (1H PYRAZOL 4 YL)THIAZOL 2 AMINE; IMMUNOMODULATING AGENT; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 1; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; METABOTROPIC RECEPTOR 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 5-METHYL-N-(4-METHYLPYRIMIDIN-2-YL)-4-(1H-PYRAZOL-4-YL)THIAZOL-2-AMINE; IDO1 PROTEIN, MOUSE; METABOTROPIC RECEPTOR; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ALLOSTERISM; ANIMAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ALLOSTERIC REGULATION; ANIMALS; DENDRITIC CELLS; FEMALE; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PYRIMIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIAZOLES;

EID: 84946854879     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.10.036     Document Type: Article

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