Multiple surface regions on the Niemann-pick C2 protein facilitate intracellular cholesterol transport

Journal of Biological Chemistry

Volumn 290, Issue 45, 2015, Pages 27321-27331

  McCauliff, Leslie A ^a   Xu, Zhi ^a   Li, Ran ^a   Kodukula, Sarala ^a   Ko, Dennis C ^c   Scott, Matthew P ^d   Kahn, Peter C ^b   Storch, Judith ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINS;

CONTACT SITES; INTRACELLULAR CHOLESTEROL; LYSOSOMAL MEMBRANES; MEMBRANE INTERACTIONS; MULTIPLE SURFACES; TRANSFER PROPERTIES;

CHOLESTEROL;

CELL PROTEIN; NIEMANN PICK C2 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; CHOLESTEROL; GLYCOPROTEIN; MEMBRANE LIPID; MUTANT PROTEIN; NPC2 PROTEIN, HUMAN;

ARTICLE; BIOACCUMULATION; BIOASSAY; CHOLESTEROL TRANSPORT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LIPID MEMBRANE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; STRUCTURE ANALYSIS; ACTIVE TRANSPORT; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; BOVINE; CHEMISTRY; GENETICS; INTRACELLULAR FLUID; KINETICS; METABOLISM; MOLECULAR MODEL; MOUSE; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STATIC ELECTRICITY;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CATTLE; CHOLESTEROL; GLYCOPROTEINS; HUMANS; INTRACELLULAR FLUID; KINETICS; MEMBRANE LIPIDS; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; POINT MUTATION; PROTEIN CONFORMATION; STATIC ELECTRICITY;

EID: 84946811086     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.667469     Document Type: Article

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