Clinical decision making in a patient with stage 5 CKD-Is eGFR good enough?

Clinical Journal of the American Society of Nephrology

Volumn 10, Issue 11, 2015, Pages 2065-2072

  Berns, Jeffrey S ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CIMETIDINE; CONTRAST MEDIUM; CREATINE; CREATININE; CYSTATIN C; EDETATE CHROMIUM CR 51; EPIDERMAL GROWTH FACTOR RECEPTOR; INULIN; IOHEXOL; IOTALAMIC ACID; IOTALAMIC ACID I 125; PENTETATE TECHNETIUM TC 99M; SODIUM;

ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL DECISION MAKING; DIALYSIS; DIET RESTRICTION; DISEASE CLASSIFICATION; GLOMERULUS FILTRATION RATE; GRAFT RECIPIENT; HUMAN; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EXCRETION; MALNUTRITION; MATHEMATICAL PHENOMENA; RANDOMIZED CONTROLLED TRIAL (TOPIC); RENAL CLEARANCE; SEX ROLE; SYSTEMATIC REVIEW (TOPIC); UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; UREMIA; CASE REPORT; FEMALE; MIDDLE AGED; PATHOPHYSIOLOGY; RENAL INSUFFICIENCY, CHRONIC; SEVERITY OF ILLNESS INDEX;

CLINICAL DECISION-MAKING; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; MIDDLE AGED; RENAL INSUFFICIENCY, CHRONIC; SEVERITY OF ILLNESS INDEX;

EID: 84946739129     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.00340115     Document Type: Article

References (76)

1. Levey AS, Inker LA, Coresh J: GFR estimation: Fromphysiology to public health. Am J Kidney Dis 63: 820-834, 2014
2. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group: KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 3: 1-150, 2013
3. Schwartz GJ, Work DF: Measurement and estimation of GFR in children and adolescents. Clin JAmSoc Nephrol 4: 1832-1843, 2009
4. Israni AK, Kasiske BL: Laboratory assessment of kidney disease: Glomerular filtration rate, urinalysis, and proteinuria. In: Brenner and Rector’s The Kidney, edited by Taal MW, Chertow GM, Marsden PA, Skorecki K, Yu ASL, Brenner BM, Philadelphia, PA, Elsevier, 2012, pp 868-896
5. Smith HW, Goldring W, Chasis H: The measurement of the tubular excretory mass, effective blood flow and filtration rate in the normal human kidney. J Clin Invest 17: 263-278, 1938
6. Smith HW: Measurement of the Filtration Rate. The Kidney: Structure and Function, Oxford, NY, Oxford University Press, 1951, pp 39-62
7. Soveri I, Berg UB, Björk J, Elinder CG, Grubb A, Mejare I, Sterner G, Bäck SE; SBU GFR Review Group: Measuring GFR: A systematic review. Am J Kidney Dis 64: 411-424, 2014
8. SBU: Methods to Estimate and Measure Kidney Function (Glomerular Filtration Rate). A Systematic Review, 2013. Available at: http://www.sbu.se/upload/Publikationer/Content1/1/Renal_%20Function.pdf. Accessed January 3, 2015
9. Perrone RD, Madias NE, Levey AS: Serum creatinine as an index of renal function: New insights into old concepts. Clin Chem 38: 1933-1953, 1992
10. Reznichenko A, Sinkeler SJ, Snieder H, van den Born J, de Borst MH, Damman J, van Dijk MC, van Goor H, Hepkema BG, Hillebrands JL, Leuvenink HG, Niesing J, Bakker SJ, Seelen M, Navis G.: SLC22A2 is associatedwith tubular creatinine secretion and bias of estimated GFR in renal transplantation. Physiol Genomics 45: 201-209, 2013
11. Burgess E, Blair A, Krichman K, Cutler RE: Inhibition of renal creatinine secretion by cimetidine in humans. Ren Physiol 5: 27-30, 1982
12. Hilbrands LB, Artz MA, Wetzels JF, Koene RA: Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. Kidney Int 40: 1171-1176, 1991
13. Serdar MA, Kurt I, Ozcelik F, Urhan M, Ilgan S, Yenicesu M, Kenar L, Kutluay T: A practical approach to glomerular filtration rate measurements: Creatinine clearance estimation using cimetidine. Ann Clin Lab Sci 31: 265-273, 2001
14. Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, Hostetter T, Levey AS, Panteghini M, Welch M, Eckfeldt JH; National Kidney Disease Education Program Laboratory Working Group: Recommendations for improving serum creatinine measurement: A report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem 52: 5-18, 2006
15. Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 16: 31-41, 1976
16. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D; Modification of Diet in Renal Disease Study Group: A more accurate method to estimate glomerular filtration rate fromserumcreatinine: A new prediction equation. Ann Intern Med 130: 461-470, 1999
17. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration: Using standardized serumcreatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 145: 247-254, 2006
18. Geddes CC, Woo YM, Brady S.: Glomerular filtration rate—what is the rationale and justification of normalizing GFR for body surface area? Nephrol Dial Transplant 23: 4-6, 2008
19. Milic R, Colombini A, Lombardi G, Lanteri P, Banfi G: Estimation of glomerular filtration rate by MDRD equation in athletes: Role of body surface area. Eur J Appl Physiol 112: 201-206, 2012
20. Peters AM, Snelling HL, Glass DM, Love S, Bird NJ: Estimated lean body mass is more appropriate than body surface area for scaling glomerular filtration rate and extracellular fluid volume. Nephron Clin Pract 116: c75-c80, 2010
21. Fotheringham J, Weatherley N, Kawar B, G Fogarty D, Ellam T: The body composition and excretory burden of lean, obese, and severely obese individuals has implications for the assessment of chronic kidney disease. Kidney Int 86: 1221-1228, 2014
22. Hsu CY, Chertow GM, Curhan GC: Methodological issues in studying the epidemiology of mild to moderate chronic renal insufficiency. Kidney Int 61: 1567-1576, 2002
23. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J; CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration): A new equation to estimate glomerular filtration rate. Ann Intern Med 150: 604-612, 2009
24. Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J, Rossert J, Van Lente F, Bruce RD 3rd, Zhang YL, Greene T, Levey AS: Estimating GFR using serum cystatin C alone and in combination with serum creatinine: A pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis 51: 395-406, 2008
25. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS; CKD-EPI Investigators: Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 367: 20-29, 2012
26. Nyman U, Grubb A, Larsson A, Hansson LO, Flodin M, Nordin G, Lindström V, Björk J: The revised Lund-Malmö GFR estimating equation outperforms MDRD and CKD-EPI across GFR, age and BMI intervals in a large Swedish population. Clin ChemLab Med 52: 815-824, 2014
27. Rule AD, Larson TS, Bergstralh EJ, Slezak JM, Jacobsen SJ, Cosio FG: Using serum creatinine to estimate glomerular filtration rate: Accuracy in good health and in chronic kidney disease. Ann Intern Med 141: 929-937, 2004
28. Schaeffner ES, Ebert N, Delanaye P, Frei U, Gaedeke J, Jakob O, Kuhlmann MK, Schuchardt M, Tölle M, Ziebig R, van der Giet M, Martus P: Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med 157: 471-481, 2012
29. Anderson AH, Yang W, Hsu CY, Joffe MM, Leonard MB, Xie D, Chen J, Greene T, Jaar BG, Kao P, Kusek JW, Landis JR, Lash JP, Townsend RR, Weir MR, Feldman HI; CRIC Study Investigators: Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 60: 250-261, 2012
30. Stevens LA, Claybon MA, Schmid CH, Chen J, Horio M, Imai E, Nelson RG, Van Deventer M, Wang HY, Zuo L, Zhang YL, Levey AS: Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating the glomerular filtration rate in multiple ethnicities. Kidney Int 79: 555-562, 2011
31. Lee CS, Cha RH, Lim YH, Kim H, Song KH, Gu N, Yu KS, Lim CS, Han JS, Kim S, Kim YS: Ethnic coefficients for glomerular filtration rate estimation by the Modification of Diet in Renal Disease study equations in the Korean population. J Korean Med Sci 25: 1616-1625, 2010
32. Stevens LA, Schmid CH, Greene T, Zhang YL, Beck GJ, Froissart M, Hamm LL, Lewis JB, Mauer M, Navis GJ, Steffes MW, Eggers PW, Coresh J, Levey AS: Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60 mL/min/1.73 m2. Am J Kidney Dis 56: 486-495, 2010
33. Earley A, Miskulin D, Lamb EJ, Levey AS, Uhlig K: Estimating equations for glomerular filtration rate in the era of creatinine standardization: a systematic review. Ann Intern Med 156: 785-795, W-270, W-271, W-272, W-273, W-274, W-275, W-276, W-277, W-278, 2012
34. Murata K, Baumann NA, Saenger AK, Larson TS, Rule AD, Lieske JC: Relative performance of the MDRD and CKD-EPI equations for estimating glomerular filtration rate among patients with varied clinical presentations. Clin J Am Soc Nephrol 6: 1963-1972, 2011
35. Cooper BA, Branley P, Bulfone L, Collins JF, Craig JC, Fraenkel MB, Harris A, Johnson DW, Kesselhut J, Li JJ, Luxton G, Pilmore A, Tiller DJ, Harris DC, Pollock CA; IDEAL Study: A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med 363: 609-619, 2010
36. Xie D, Joffe MM, Brunelli SM, Beck G, Chertow GM, Fink JC, Greene T, Hsu CY, Kusek JW, Landis R, Lash J, Levey AS, O’Conner A, Ojo A, Rahman M, Townsend RR, Wang H, Feldman HI: A comparison of change in measured and estimated glomerular filtration rate in patients with nondiabetic kidney disease. Clin J Am Soc Nephrol 3: 1332-1338, 2008
37. Lewis J, Greene T, Appel L, Contreras G, Douglas J, Lash J, Toto R, Van Lente F, Wang X, Wright JT Jr.; AASK Study Group: A comparison of iothalamate-GFR and serum creatinine-based outcomes: Acceleration in the rate of GFR decline in the African American Study of Kidney Disease and Hypertension. J Am Soc Nephrol 15: 3175-3183, 2004
38. Rossing P, Rossing K, Gaede P, Pedersen O, Parving HH: Monitoring kidney function in type 2 diabetic patients with incipient and overt diabetic nephropathy. Diabetes Care 29: 1024-1030, 2006
39. Evans M, van Stralen KJ, Schön S, Prütz KG, Stendahl M, Rippe B, Jager KJ; ERA-EDTA Registry; Swedish Renal Registry Collaboration: Glomerular filtration rate-estimating equations for patients with advanced chronic kidney disease. Nephrol Dial Transplant 28: 2518-2526, 2013
40. Botev R, Mallié JP, Couchoud C, Schück O, Fauvel JP, Wetzels JF, Lee N, De Santo NG, Cirillo M.: Estimating glomerular filtration rate: Cockcroft-Gault and Modification of Diet in Renal Disease formulas compared to renal inulin clearance. Clin J Am Soc Nephrol 4: 899-906, 2009
41. Fontseré N, Bonal J, Navarro M, Riba J, Fraile M, Torres F, Romero R.: A comparison of prediction equations for estimating glomerular filtration rate in adult patients with chronic kidney disease stages 4-5. Effect of nutritional status and age. Nephron Clin Pract 104: c160-c168, 2006
42. Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P: Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 16: 763-773, 2005
43. Kuan Y, Hossain M, Surman J, El Nahas AM, Haylor J: GFR prediction using the MDRD and Cockcroft and Gault equations in patients with end-stage renal disease. Nephrol Dial Transplant 20: 2394-2401, 2005
44. Lee D, Levin A, Roger SD, McMahon LP.: Longitudinal analysis of performance of estimated glomerular filtration rate as renal function declines in chronic kidney disease. Nephrol Dial Transplant 24: 109-116, 2009
45. Poggio ED, Wang X, Greene T, Van Lente F, Hall PM.: Performance of the modification of diet in renal disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease. J Am Soc Nephrol 16: 459-466, 2005
46. Michels WM, Grootendorst DC, Verduijn M, Elliott EG, Dekker FW, Krediet RT: Performance of the Cockcroft-Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size. Clin J Am Soc Nephrol 5: 1003-1009, 2010
47. Stevens LA, Coresh J, Feldman HI, Greene T, Lash JP, Nelson RG, Rahman M, Deysher AE, Zhang YL, Schmid CH, Levey AS: Evaluation of the modification of diet in renal disease study equation in a large diverse population. J Am Soc Nephrol 18: 2749-2757, 2007
48. Lewis J, Agodoa L, Cheek D, Greene T, Middleton J, O’Connor D, Ojo A, Phillips R, Sika M, Wright J Jr.; African-American Study of Hypertension and Kidney Disease: Comparison of crosssectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate. Am J Kidney Dis 38: 744-753, 2001
49. Udler MS, Nadkarni GN, Belbin G, Lotay V, Wyatt C, Gottesman O, Bottinger EP, Kenny EE, Peter I.: Effect of genetic African ancestry on eGFR and kidney disease [published online ahead of print October 27, 2014]. J Am Soc Nephrol
50. Kalantar-Zadeh K, Amin AN: Toward more accurate detection and risk stratification of chronic kidney disease. JAMA 307: 1976-1977, 2012
51. Glassock RJ: Estimated glomerular filtration rate: Time for a performance review? Kidney Int 75: 1001-1003, 2009
52. Glassock RJ, Winearls C: The global burden of chronic kidney disease: How valid are the estimates? Nephron Clin Pract 110: c39-c46, 2008
53. Rule AD, Glassock RJ: GFR estimating equations: Getting closer to the truth? Clin J Am Soc Nephrol 8: 1414-1420, 2013
54. Cheng MH, Zeng FW, Xie LJ, Li JF, Zhang F, Jiang H: A new quantitative method for estimating glomerular filtration rate and its clinical value [published online ahead of print November 21, 2014]. Clin Physiol Funct Imaging
55. Wang E, Meier DJ, Sandoval RM, Von Hendy-Willson VE, Pressler BM, Bunch RM, Alloosh M, Sturek MS, Schwartz GJ, Molitoris BA: A portable fiberoptic ratiometric fluorescence analyzer provides rapid point-of-care determination of glomerular filtration rate in large animals. Kidney Int 81: 112-117, 2012
56. Yu W, Sandoval RM, Molitoris BA: Rapid determination of renal filtration function using an optical ratiometric imaging approach. Am J Physiol Renal Physiol 292: F1873-F1880, 2007
57. Hermsen ED, Maiefski M, Florescu MC, Qiu F, Rupp ME: Comparison of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for dosing antimicrobials. Pharmacotherapy 29: 649-655, 2009
58. Hudson JQ, Nyman HA: Use of estimated glomerular filtration rate for drug dosing in the chronic kidney disease patient. Curr Opin Nephrol Hypertens 20: 482-491, 2011
59. Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, Townsend R, Okparavero A, Zhang YL, Schmid CH, Levey AS; Chronic Kidney Disease Epidemiology Collaboration: Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis 54: 33-42, 2009
60. Issa N, Meyer KH, Arrigain S, Choure G, Fatica RA, Nurko S, Stephany BR, Poggio ED: Evaluation of creatinine-based estimates of glomerular filtration rate in a large cohort of living kidney donors. Transplantation 86: 223-230, 2008
61. Lujan PR, Chiurchiu C, Douthat W, de Arteaga J, de la Fuente J, Capra RH, Massari PU: CKD-EPI instead ofMDRD for candidates to kidney donation. Transplantation 94: 637-641, 2012
62. Macías LB, Poblet MS, Jerez RI, Roncero FM, Blanco GB, Palomo PP, Govantes MA: Study of renal function in living kidney donors: Estimated or measured glomerular filtration. Transplant Proc 45: 3612-3615, 2013
63. Shaffi K, Uhlig K, Perrone RD, Ruthazer R, Rule A, Lieske JC, Navis G, Poggio ED, Inker LA, Levey AS: Performance of creatinine-based GFR estimating equations in solid-organ transplant recipients. Am J Kidney Dis 63: 1007-1018, 2014
64. Fan L, Levey AS, Gudnason V, Eiriksdottir G, Andresdottir MB, Gudmundsdottir H, Indridason OS, Palsson R, Mitchell G, Inker LA: Comparing GFR estimating equations using cystatin C and creatinine in elderly individuals [published online ahead of print December 19, 2014]. J Am Soc Nephrol
65. Gerchman F, Tong J, Utzschneider KM, Zraika S, Udayasankar J, McNeely MJ, Carr DB, Leonetti DL, Young BA, de Boer IH, Boyko EJ, Fujimoto WY, Kahn SE: Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution. J Clin Endocrinol Metab 94: 3781-3788, 2009
66. Wilson FP, Xie D, Anderson AH, Leonard MB, Reese PP, Delafontaine P, Horwitz E, Kallem R, Navaneethan S, Ojo A, Porter AC, Sondheimer JH, Sweeney HL, Townsend RR, Feldman HI; CRIC Study Investigators: Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD: The CRIC study. Clin J AmSoc Nephrol 9: 2095-2103, 2014
67. Knight EL, Verhave JC, Spiegelman D, Hillege HL, de Zeeuw D, Curhan GC, de Jong PE: Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int 65: 1416-1421, 2004
68. Stevens LA, Levey AS: Measured GFR as a confirmatory test for estimated GFR. J Am Soc Nephrol 20: 2305-2313, 2009
69. Kazmi WH, Gilbertson DT, Obrador GT, Guo H, Pereira BJ, Collins AJ, Kausz AT: Effect of comorbidity on the increased mortality associated with early initiation of dialysis. Am J Kidney Dis 46: 887-896, 2005
70. Rosansky SJ, Eggers P, Jackson K, Glassock R, Clark WF: Early start of hemodialysis may be harmful. Arch Intern Med 171: 396-403, 2011
71. Stel VS, Dekker FW, Ansell D, Augustijn H, Casino FG, Collart F, Finne P, Ioannidis GA, Salomone M, Traynor JP, Zurriaga O, Verrina E, Jager KJ: Residual renal function at the start of dialysis and clinical outcomes. Nephrol Dial Transplant 24: 3175-3182, 2009
72. Susantitaphong P, Altamimi S, Ashkar M, Balk EM, Stel VS, Wright S, Jaber BL: GFR at initiation of dialysis and mortality in CKD: A meta-analysis. Am J Kidney Dis 59: 829-840, 2012
73. Evans M, Tettamanti G, Nyrén O, Bellocco R, Fored CM, Elinder CG: No survival benefit from early-start dialysis in a populationbased, inception cohort study of Swedish patients with chronic kidney disease. J Intern Med 269: 289-298, 2011
74. Nesrallah GE, Mustafa RA, Clark WF, Bass A, Barnieh L, Hemmelgarn BR, Klarenbach S, Quinn RR, Hiremath S, Ravani P, Sood MM, Moist LM; Canadian Society of Nephrology: Canadian Society of Nephrology 2014 clinical practice guideline for timing the initiation of chronic dialysis. CMAJ 186: 112-117, 2014
75. Jones GR: Estimating renal function for drug dosing decisions. Clin Biochem Rev 32: 81-88, 2011
76. Dowling TC, Wang ES, Ferrucci L, Sorkin JD: Glomerular filtration rate equations overestimate creatinine clearance in older individuals enrolled in the Baltimore Longitudinal Study on Aging: Impact on renal drug dosing. Pharmacotherapy 33: 912-921, 2013