Use of estimated glomerular filtration rate for drug dosing in the chronic kidney disease patient

Current Opinion in Nephrology and Hypertension

Volumn 20, Issue 5, 2011, Pages 482-491

  Hudson, Joanna Q ^a   Nyman, Heather A ^b  

^a UNIVERSITY OF TENNESSEE COLLEGE OF PHARMACY   (United States)

^b UNIVERSITY OF UTAH HOSPITAL   (United States)

Author keywords

Chronic Kidney Disease Epidemiology Collaboration equation; Cockcroft Gault; drug dosing; glomerular filtration rate; Modification of Diet in Renal Disease equation

Indexed keywords

AMANTADINE; AMINOGLYCOSIDE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBOPLATIN; CREATININE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GENTAMICIN; HYDRALAZINE; LOOP DIURETIC AGENT; METHYLDOPA; PIPERACILLIN PLUS TAZOBACTAM; POTASSIUM SPARING DIURETIC AGENT; SOTALOL; TENOFOVIR; THIAZIDE DIURETIC AGENT;

AGED; ANTIHYPERTENSIVE THERAPY; BODY SIZE; CHRONIC KIDNEY DISEASE; CHRONIC KIDNEY DISEASE EPIDEMIOLOGY COLLABORATION EQUATION; COCKCROFT GAULT EQUATION; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DIETARY INTAKE; DRUG DOSE REGIMEN; GLOMERULUS FILTRATION RATE; GROUPS BY AGE; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; MATHEMATICAL ANALYSIS; METHODOLOGY; MODIFICATION OF DIET IN RENAL DISEASE EQUATION; OBESITY; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW;

AGE FACTORS; BIOLOGICAL MARKERS; BODY SURFACE AREA; BODY WEIGHT; CHRONIC DISEASE; CREATININE; DRUG DOSAGE CALCULATIONS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; KIDNEY DISEASES; MODELS, BIOLOGICAL; PHARMACOKINETICS; PREDICTIVE VALUE OF TESTS; SEVERITY OF ILLNESS INDEX;

EID: 80051786576     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328348c11f     Document Type: Review

References (45)

1. US Renal Data System (2010). USRDS 2010 annual data report: atlas of endstage renal disease in the United States. Bethesda (MD): National Institutes of Health, National Institue of Diabetes and Digestive and Kidney Diseases; 2010.
2. Snyder S, Perdergraph B. Detection and evaluation of chronic kidney disease. Am Fam Physician 2005;72:1723-1732.
3. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002;39:S1-S266.
4. NKDEP. National Kidney Disease Education Program (2010). Chronic kidney disease and drug dosing: information for providers. National Kidney Disease Education Program. http://www.nkdep.nih.gov/professionals/CKD-DrugDosing-508. pdf. [Accessed 3 March 2011] This document provides the rationale of the NKDEP for recommending use of either the Cockcroft-Gault or MDRD equation for determining drug dosing. Importantly, the NKDEP recommends converting the MDRD equation to units of ml/min when used for drug dosing in patients with very large or small BSAs and the use of measures of GFR or ClCr in patients in whom the estimating equations would not be expected to be accurate.
5. Levey AS, Stevens LA. Estimating GFR using the CKD epidemiology collaboration (CKD-EPI) creatinine equations: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions. Am J Kidney Dis 2010;55:622-627. This editorial contains a concise table comparing the characteristics, performance, and application of the Cockcroft-Gault, MDRD, and CKD-EPI equations. The authors propose using Cockcroft-Gault, MDRD, and CKD-EPI for drug dosing.
6. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
7. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999;130:461-470. (Pubitemid 29135798)
8. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604-612.
9. Stevens LA, Coresh J, Feldman HI, et al. Evaluation of the modification of diet in renal disease study equation in a large diverse population. J Am Soc Nephrol 2007;18:2749-2757. (Pubitemid 47531202)
10. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006;145:247-254. (Pubitemid 46768608)
11. Myers GL, Miller WG, Coresh J, et al. Recommendations for improving serum creatinine measurement: a report from the laboratory working group of the National Kidney Disease Education Program. Clin Chem 2006;52:5-18. (Pubitemid 43032461)
12. National Kidney Disease Education Program (2010). Laboratory professionals: creatinine standardization recommendations. http://www.nkdep.nih. gov/labprofessionals/cs-recommendations.htm. [Accessed 24 March 2011] This website provides the most up-to-date recommendations for the implementation of the creatinine assay standardization.
13. 2. Am J Kidney Dis 2010;56:486-495.
14. Dowling TC, Matzke GR, Murphy JE, Burckart GJ. Evaluation of renal drug dosing: prescribing information and clinical pharmacist approaches. Pharmacotherapy 2010;30:776-786.
15. Huang S-M, Temple R, Xiao S, et al. When to conduct a renal impairment study during drug development: US Food and Drug Administration perspective. Clin Pharmacol Ther 2009;86:475-479.
16. US Department of Health and Human Services: Food and Drug Administration (1998). Guidance for industry: pharmacokinetics in patients with impaired renal function-study design, data analysis, and impact on dosing and labeling. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/ Guidances/ucm072127.pdf. [Accessed 3 March 2011]
17. CAP (2010). Current status of reporting estimated glomerular filtration rate (eGFR). http://www.cap.org/apps/docs/committees/chemistry/current-status- of-reporting-eGFR.pdf. [Accessed 26 March 2011]
18. Helou R. Should we continue to use the Cockcroft-Gault formula? Nephron Clin Pract 2010;116:c172-c185; discussion c86. Review of studies comparing MDRD and Cockcroft-Gault equations in terms of bias, precision, and accuracy and a discussion of whether the Cockcroft-Gault equation should continue to have a role in assessment of kidney function.
19. Spruill WJ, Wade WE, Cobb HH 3rd. Continuing the use of the Cockcroft-Gault equation for drug dosing in patients with impaired renal function. Clin Pharmacol Ther 2009;86:468-470.
20. Spruill WJ, Wade WE, Cobb HH 3rd. Estimating glomerular filtration rate with a Modification of Diet in Renal Disease equation: implications for pharmacy. Am J Health Syst Pharm 2007;64:652-660. (Pubitemid 46481868)
21. Stevens LA, Nolin TD, Richardson MM, et al. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis 2009;54:33-42.
22. US Food and Drug Administration (2010). Draft guidance for industry: pharmacokinetics in patient with impaired kidney function - study design DA, and impact on dosing and labeling. http://www.fda.gov/downloads/Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/UCM204959.pdf. [Accessed 20 March 2011] This FDA draft guidance is a summary from a recently convened advisory panel that discusses pharmacokinetic studies performed by industry to determine the effect of kidney dysfunction on drug disposition and subsequent dosing recommendations. The draft includes statements regarding use of the MDRD and Cockcroft-Gault equations for determining drug dosing.
23. Barry A, O'Cearbhaill R, Griffin D, et al. Evaluation of carboplatin dosage based on 4-variable Modification of Diet in Renal Disease equation. Ir J Med Sci 2009;178:301-307.
24. de Lemos ML, Hsieh T, Hamata L, et al. Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies. Gynecol Oncol 2006;103:1063-1069. (Pubitemid 44821334)
25. Gill J, Malyuk R, Djurdjev O, Levin A. Use of GFR equations to adjust drug doses in an elderly multiethnic group: a cautionary tale. Nephrol Dial Transplant 2007;22:2894-2899. (Pubitemid 350093425)
26. Golik MV, Lawrence KR. Comparison of dosing recommendations for antimicrobial drugs based on two methods for assessing kidney function: Cockcroft-Gault and Modification of Diet in Renal Disease. Pharmacotherapy 2008;28:1125-1132.
27. Hermsen ED, Maiefski M, Florescu MC, et al. Comparison of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for dosing antimicrobials. Pharmacotherapy 2009;29:649-655.
28. Jennings S, de Lemos ML, Levin A, Murray N. Evaluation of creatinine-based formulas in dosing adjustment of cancer drugs other than carboplatin. J Oncol Pharm Pract 2010;16:113-119.
29. Moranville MP, Jennings HR. Implications of using modification of diet in renal disease versus Cockcroft-Gault equations for renal dosing adjustments. Am J Health Syst Pharm 2009;66:154-161.
30. Wargo KA, Eiland EH 3rd, Hamm W, et al. Comparison of the modification of diet in renal disease and Cockcroft-Gault equations for antimicrobial dosage adjustments. Ann Pharmacother 2006;40:1248-1253. (Pubitemid 44204952)
31. Wargo KA, English TM. Evaluation of the chronic kidney disease epidemiology collaboration equation for dosing antimicrobials. Ann Pharmacother 2010;44:439-446. This is the first study to evaluate the performance of the CKD-EPI equation for the purpose of drug dosing.
32. Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989;7:1 748-1756. (Pubitemid 19272848)
33. Smythe M, Hoffman J, Kizy K, Dmuchowski C. Estimating creatinine clearance in elderly patients with low serum creatinine concentrations. Am J Hosp Pharm 1994;51:198-204. (Pubitemid 24037798)
34. Spruill WJ, Wade WE, Cobb HH 3rd. Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function. Am J Geriatr Pharmacother 2008;6:153-160.
35. Pai MP. Estimating the glomerular filtration rate in obese adult patients for drug dosing. Adv Chronic Kidney Dis 2010;17:e53-e62. Review of controversies with estimation of GFR and ClCr in the obese population. Proposes use of lean body weight to estimate ClCr in these individuals.
36. Cirillo M, Anastasio P, De Santo NG. Relationship of gender, age, and body mass index to errors in predicted kidney function. Nephrol Dial Transplant 2005;20:1791-1798. (Pubitemid 41222590)
37. Drusano GL, Munice HL Jr, Hoopes JM, et al. Commonly used methods of estimating creatinine clearance are inadequate for elderly debilitated nursing home patients. J Am Geriatr Soc 1988;36:437-441.
38. Corsonello A, Pedone C, Lattanzio F, et al. Agreement between equations estimating glomerular filtration rate in elderly nursing home residents and in hospitalised patients: implications for drug dosing. Age Ageing 2011 [Epub ahead of print]. Evaluation of the CKD-EPI, MDRD, and Cockcroft-Gault estimates of kidney function in elderly nursing home and hospitalized patients showing agreement in the MDRD and CKD-EPI estimates, but variable results for Cockcroft-Gault in one-third of nursing home residents. Suggests these differences have clinical implications when drug dosing is determined by these methods.
39. Michels WM, Grootendorst DC, Verduijn M, et al. Performance of the Cockcroft-Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size. Clin J Am Soc Nephrol 2010;5:1003-1009. Comparison of estimates of kidney function to measured GFR evaluated over the range of age and BMI.
40. Roberts GW, Ibsen PM, Schioler CT. Modified Diet in Renal Disease method overestimates renal function in selected elderly patients. Age Ageing 2009;38:698-703.
41. Nair S, Mishra V, Hayden K, et al. The four-variable Modification of Diet in Renal Disease formula underestimates glomerular filtration rate in obese type 2 diabetic individuals with chronic kidney disease. Diabetologia 2011;54:1304-1307.
42. Demirovic JA, Pai AB, Pai MP. Estimation of creatinine clearance in morbidly obese patients. Am J Health Syst Pharm 2009;66:642-648.
43. Hudson JQ, Mason DL, Huch KM. Estimates of kidney function in obese African Americans with chronic kidney disease. Nephron Clin Pract 2010;118:c101-c108.
44. Schwartz SN, Pazin GJ, Lyon JA, et al. A controlled investigation of the pharmacokinetics of gentamicin and tobramycin in obese subjects. J Infect Dis 1978;138:499-505. (Pubitemid 9032744)
45. Traynor AM, Nafziger AN, Bertino JS Jr. Aminoglycoside dosing weight correction factors for patients of various body sizes. Antimicrob Agents Chemother 1995;39:545-548.