메뉴 건너뛰기




Volumn 39, Issue 6, 2015, Pages 822-831

Melatonin as a stabilizer of mitochondrial function: Role in diseases and aging

Author keywords

Aging; Alzheimer and Parkinson diseases; Diseases; Melatonin; Mitochondria

Indexed keywords


EID: 84946724137     PISSN: 13000152     EISSN: 13036092     Source Type: Journal    
DOI: 10.3906/biy-1504-26     Document Type: Review
Times cited : (36)

References (63)
  • 2
    • 3142713361 scopus 로고    scopus 로고
    • Direct inhibition of the mitochondrial permeability transition pore: A possible mechanism responsible for antiapoptotic effects of melatonin
    • Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF (2004). Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for antiapoptotic effects of melatonin. FASEB J 18: 869–871.
    • (2004) FASEB J , vol.18 , pp. 869-871
    • Andrabi, S.A.1    Sayeed, I.2    Siemen, D.3    Wolf, G.4    Horn, T.F.5
  • 3
    • 84928769975 scopus 로고    scopus 로고
    • Melatonin and amfenac modulate calcium entry, apoptosis, and oxidative stress in ARPE-19 cell culture exposed to blue light irradiation (405 nm)
    • Argun M, Tök L, Uğuz AC, Çelik Ö, Tök ÖY, Naziroğlu M (2014). Melatonin and amfenac modulate calcium entry, apoptosis, and oxidative stress in ARPE-19 cell culture exposed to blue light irradiation (405 nm). Eye (Lond) 28: 752–760.
    • (2014) Eye (Lond) , vol.28 , pp. 752-760
    • Argun, M.1    Tök, L.2    Uğuz, A.C.3    Çelik, Ö.4    Tök, M.5    Naziroğlu, M.6
  • 11
    • 84928584203 scopus 로고    scopus 로고
    • Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats
    • Carrasco C, Rodriguez AB, Pariente JA (2014b). Effects of melatonin on the oxidative damage and pancreatic antioxidant defenses in cerulein-induced acute pancreatitis in rats. Hepatobiliary Pancreat Dis Int 13: 442–446.
    • (2014) Hepatobiliary Pancreat Dis Int , vol.13 , pp. 442-446
    • Carrasco, C.1    Rodriguez, A.B.2    Pariente, J.A.3
  • 12
    • 70349266564 scopus 로고    scopus 로고
    • Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect
    • Chen Y, Cairns R, Papandreou I, Koong A, Denko NC (2009). Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One 4: e7033.
    • (2009) Plos One , vol.4
    • Chen, Y.1    Cairns, R.2    Papandreou, I.3    Koong, A.4    Denko, N.C.5
  • 13
    • 0035170284 scopus 로고    scopus 로고
    • Melatonin protects against 6-OHDA-induced neurotoxicity in rats: A role for mitochondrial complex I activity
    • Dabbeni-Sala F, Di Santo S, Franceschini D, Skaper SD, Giusti P (2001). Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity. FASEB J 15: 164–170.
    • (2001) FASEB J , vol.15 , pp. 164-170
    • Dabbeni-Sala, F.1    Di Santo, S.2    Franceschini, D.3    Skaper, S.D.4    Giusti, P.5
  • 14
    • 77956307408 scopus 로고    scopus 로고
    • Melatonin induces calcium release from CCK-8-and thapsigarginsensitive cytosolic stores in pancreatic AR42J cells
    • del Castillo-Vaquero A, Salido GM, Gonzalez A (2010). Melatonin induces calcium release from CCK-8-and thapsigarginsensitive cytosolic stores in pancreatic AR42J cells. J Pineal Res 49: 256–263.
    • (2010) J Pineal Res , vol.49 , pp. 256-263
    • Del Castillo-Vaquero, A.1    Salido, G.M.2    Gonzalez, A.3
  • 16
    • 80755169431 scopus 로고    scopus 로고
    • Melatonin is able to delay endoplasmic reticulum stress-induced apoptosis in leukocytes from elderly humans
    • Espino J, Bejarano I, Paredes SD, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2011). Melatonin is able to delay endoplasmic reticulum stress-induced apoptosis in leukocytes from elderly humans. Age 33: 497–507.
    • (2011) Age , vol.33 , pp. 497-507
    • Espino, J.1    Bejarano, I.2    Paredes, S.D.3    Barriga, C.4    Reiter, R.J.5    Pariente, J.A.6    Rodríguez, A.B.7
  • 17
    • 77649231477 scopus 로고    scopus 로고
    • Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: Evidence for the involvement of mitochondria and Bax activation
    • Espino J, Bejarano I, Redondo PC, Rosado JA, Barriga C, Reiter RJ, Pariente JA, Rodríguez AB (2010). Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: evidence for the involvement of mitochondria and Bax activation. J Membr Biol 233: 105–118.
    • (2010) J Membr Biol , vol.233 , pp. 105-118
    • Espino, J.1    Bejarano, I.2    Redondo, P.C.3    Rosado, J.A.4    Barriga, C.5    Reiter, R.J.6    Pariente, J.A.7    Rodríguez, A.B.8
  • 18
    • 84872770002 scopus 로고    scopus 로고
    • Oxidative stress and immunosenescence: Therapeutic effects of melatonin
    • Espino J, Pariente JA, Rodríguez AB (2012). Oxidative stress and immunosenescence: Therapeutic effects of melatonin. Oxid Med Cell Longev 2012: 670294.
    • (2012) Oxid Med Cell Longev , vol.2012
    • Espino, J.1    Pariente, J.A.2    Rodríguez, A.B.3
  • 20
    • 33646590263 scopus 로고    scopus 로고
    • Inhibition of mitochondria responsible for the anti-apoptotic effects of melatonin during ischemia-reperfusion
    • Han YX, Zhang SH, Wang XM, Wu JB (2006). Inhibition of mitochondria responsible for the anti-apoptotic effects of melatonin during ischemia-reperfusion. J Zhejiang Univ Sci B 7: 142–147.
    • (2006) J Zhejiang Univ Sci B , vol.7 , pp. 142-147
    • Han, Y.X.1    Zhang, S.H.2    Wang, X.M.3    Wu, J.B.4
  • 21
    • 46449116418 scopus 로고    scopus 로고
    • Melatonin, hormone of darkness and more: Occurrence, control mechanisms, actions and bioactive metabolites
    • Hardeland R (2008). Melatonin, hormone of darkness and more: occurrence, control mechanisms, actions and bioactive metabolites. Cell Mol Life Sci 65: 2001–2018.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2001-2018
    • Hardeland, R.1
  • 22
    • 26844450246 scopus 로고    scopus 로고
    • Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug
    • Hardeland R, Pandi-Perumal SR (2005). Melatonin, a potent agent in antioxidative defense: actions as a natural food constituent, gastrointestinal factor, drug and prodrug. Nutr Metab 2: 22.
    • (2005) Nutr Metab , vol.2 , pp. 22
    • Hardeland, R.1    Pandi-Perumal, S.R.2
  • 23
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D (1956). Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298–300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 24
    • 84896702052 scopus 로고    scopus 로고
    • MtDNA T8993G mutationinduced F1F0-ATP synthase defect augments mitochondrial dysfunction associated with hypoxia/reoxygenation: The protective role of melatonin
    • Huang WY, Jou MJ, Peng TI (2013). mtDNA T8993G mutationinduced F1F0-ATP synthase defect augments mitochondrial dysfunction associated with hypoxia/reoxygenation: the protective role of melatonin. PLoS One 8: e81546.
    • (2013) Plos One , vol.8
    • Huang, W.Y.1    Jou, M.J.2    Peng, T.I.3
  • 26
    • 79951804509 scopus 로고    scopus 로고
    • Differential effects of melatonin as a broad range UV-damage preventive dermatoendocrine regulator
    • Kleszczyl Re K, Hardkop LH, Fischer TW (2011). Differential effects of melatonin as a broad range UV-damage preventive dermatoendocrine regulator. Dermatoendocrinol 3: 27–31.
    • (2011) Dermatoendocrinol , vol.3 , pp. 27-31
    • Kleszczyl Re, K.1    Hardkop, L.H.2    Fischer, T.W.3
  • 27
    • 79960488053 scopus 로고    scopus 로고
    • Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis
    • Lowes DA, Almawash AM, Webster NR, Reid VL, Galley HF (2011). Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis. Br J Anaesth 107: 193–201.
    • (2011) Br J Anaesth , vol.107 , pp. 193-201
    • Lowes, D.A.1    Almawash, A.M.2    Webster, N.R.3    Reid, V.L.4    Galley, H.F.5
  • 28
    • 84874355329 scopus 로고    scopus 로고
    • Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis
    • Lowes DA, Webster NR, Murphy MP, Galley HF (2013). Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. Br J Anaesth 110: 472–480.
    • (2013) Br J Anaesth , vol.110 , pp. 472-480
    • Lowes, D.A.1    Webster, N.R.2    Murphy, M.P.3    Galley, H.F.4
  • 30
    • 0034913895 scopus 로고    scopus 로고
    • Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: Protective effects of antioxidants
    • Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B (2001). Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther 298: 737–743.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 737-743
    • Mansouri, A.1    Demeilliers, C.2    Amsellem, S.3    Pessayre, D.4    Fromenty, B.5
  • 31
    • 0033822805 scopus 로고    scopus 로고
    • Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butylhydroperoxide induced mitochondrial oxidative stress
    • Martin M, Macias M, Escames G, Leon J, Acunmesrcolscles: D (2000a). Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butylhydroperoxide induced mitochondrial oxidative stress. FASEB J 14: 1677–1679.
    • (2000) FASEB J , vol.14 , pp. 1677-1679
    • Martin, M.1    Macias, M.2    Escames, G.3    Leon, J.4    Acunmesrcolscles:, D.5
  • 32
    • 0006295841 scopus 로고    scopus 로고
    • Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vitro
    • Martin M, Macias M, Escames G, Reiter RJ, Agapito MT, Ortiz GG, Acuiztondrial oxi D (2000b). Melatonin-induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vitro. J Pineal Res 28: 242–248.
    • (2000) J Pineal Res , vol.28 , pp. 242-248
    • Martin, M.1    Macias, M.2    Escames, G.3    Reiter, R.J.4    Agapito, M.T.5    Ortiz, G.G.6    Acuiztondrial Oxi, D.7
  • 33
    • 0033902601 scopus 로고    scopus 로고
    • Aging enhances the activation of the permeability transition pore in mitochondria
    • Mather M, Rottenberg H (2000). Aging enhances the activation of the permeability transition pore in mitochondria. Biochem Bioph Res Co 273: 603–608.
    • (2000) Biochem Bioph Res Co , vol.273 , pp. 603-608
    • Mather, M.1    Rottenberg, H.2
  • 34
    • 84858157217 scopus 로고    scopus 로고
    • The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer’s disease
    • Morley JE, Armbrecht HJ, Farr SA, Kumar VB (2012). The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer’s disease. Biochem Biophys Acta 1822: 650–656.
    • (2012) Biochem Biophys Acta , vol.1822 , pp. 650-656
    • Morley, J.E.1    Armbrecht, H.J.2    Farr, S.A.3    Kumar, V.B.4
  • 36
    • 79960334940 scopus 로고    scopus 로고
    • Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson’s disease
    • Patki G, Lau YS (2011). Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson’s disease. Pharmacol Biochem Behav 99: 704–711.
    • (2011) Pharmacol Biochem Behav , vol.99 , pp. 704-711
    • Patki, G.1    Lau, Y.S.2
  • 40
    • 84891365207 scopus 로고    scopus 로고
    • Management of the aging risk factor for Parkinson’s disease
    • Phillipson OT (2014). Management of the aging risk factor for Parkinson’s disease. Neurobiol Aging 35: 847–857.
    • (2014) Neurobiol Aging , vol.35 , pp. 847-857
    • Phillipson, O.T.1
  • 42
    • 2342535627 scopus 로고    scopus 로고
    • Melatonin as an antioxidant: Biochemical mechanisms and pathophysiological implications in humans
    • Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z (2003). Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol 50: 1129–1146.
    • (2003) Acta Biochim Pol , vol.50 , pp. 1129-1146
    • Reiter, R.J.1    Tan, D.X.2    Mayo, J.C.3    Sainz, R.M.4    Leon, J.5    Czarnocki, Z.6
  • 43
    • 34748854311 scopus 로고    scopus 로고
    • Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice
    • Rodriguez MI, Escames G, L cam LC, Garcme JA, Ortiz F, L tiz A, Acuizeszchimogica D (2007). Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice. J Endocrinol 194: 637–643.
    • (2007) J Endocrinol , vol.194 , pp. 637-643
    • Rodriguez, M.I.1    Escames, G.2    L Cam, L.C.3    Garcme, J.A.4    Ortiz, F.5    L Tiz, A.6    Acuizeszchimogica, D.7
  • 44
    • 84912031723 scopus 로고    scopus 로고
    • Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells
    • Santofimia-Castace P, Ruy DC, Fernandez-Bermejo M, Salido GM, Gonzalez A (2014). Pharmacological dose of melatonin reduces cytosolic calcium load in response to cholecystokinin in mouse pancreatic acinar cells. Mol Cell Biochem 397: 75–86.
    • (2014) Mol Cell Biochem , vol.397 , pp. 75-86
    • Santofimia-Castace, P.1    Ruy, D.C.2    Fernandez-Bermejo, M.3    Salido, G.M.4    Gonzalez, A.5
  • 45
    • 84878424820 scopus 로고    scopus 로고
    • New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide
    • Sarti P, Magnifico MC, Altieri F, Mastronicola D, Arese M (2013). New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide. Int J Mol Sci 14: 11259–11276.
    • (2013) Int J Mol Sci , vol.14 , pp. 11259-11276
    • Sarti, P.1    Magnifico, M.C.2    Altieri, F.3    Mastronicola, D.4    Arese, M.5
  • 46
    • 0033017076 scopus 로고    scopus 로고
    • Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts
    • Schoop VM, Mirancea N, Fusenig NE (1999). Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts. J Invest Dermatol 112: 343–353.
    • (1999) J Invest Dermatol , vol.112 , pp. 343-353
    • Schoop, V.M.1    Mirancea, N.2    Fusenig, N.E.3
  • 47
    • 29344446328 scopus 로고    scopus 로고
    • Targeting antioxidants to mitochondria: A new therapeutic direction
    • Sheu SS, Nauduri D, Ander MW (2006). Targeting antioxidants to mitochondria: a new therapeutic direction. Biochem Biophys Acta 1762: 256–265.
    • (2006) Biochem Biophys Acta , vol.1762 , pp. 256-265
    • Sheu, S.S.1    Nauduri, D.2    Er, M.W.3
  • 48
    • 79954487781 scopus 로고    scopus 로고
    • Critical diaphragm failure in sudden infant death syndrome
    • Siren PM, Siren MJ (2011). Critical diaphragm failure in sudden infant death syndrome. Ups J Med Sci 116: 115–123.
    • (2011) Ups J Med Sci , vol.116 , pp. 115-123
    • Siren, P.M.1    Siren, M.J.2
  • 49
    • 74849093849 scopus 로고    scopus 로고
    • New data on biochemical mechanism of programmed senescence of organisms and antioxidant defense of mitochondria
    • Skulachev VP (2009). New data on biochemical mechanism of programmed senescence of organisms and antioxidant defense of mitochondria. Biochemistry (Mosc) 74: 1400–1403.
    • (2009) Biochemistry (Mosc) , vol.74 , pp. 1400-1403
    • Skulachev, V.P.1
  • 52
    • 84908610692 scopus 로고    scopus 로고
    • Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: Protective role of melatonin
    • Stacchiotti A, Favero G, Giugno L, Lavazza A, Reiter RJ, Rodella LF, Rezzani R (2014). Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. PLoS One 9: e111141.
    • (2014) Plos One , vol.9
    • Stacchiotti, A.1    Favero, G.2    Giugno, L.3    Lavazza, A.4    Reiter, R.J.5    Rodella, L.F.6    Rezzani, R.7
  • 53
    • 0036019976 scopus 로고    scopus 로고
    • In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives
    • Stetinove V, Smetanovn L, Grossmann V, Anzenbacher P (2002). In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives. Gen Physiol Biophys 21: 153–162.
    • (2002) Gen Physiol Biophys , vol.21 , pp. 153-162
    • Stetinove, V.1    Smetanovn, L.2    Grossmann, V.3    Anzenbacher, P.4
  • 54
    • 3042806534 scopus 로고    scopus 로고
    • A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
    • Swerdlow RH, Khan SM (2004). A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease. Med Hypotheses 63: 8–20.
    • (2004) Med Hypotheses , vol.63 , pp. 8-20
    • Swerdlow, R.H.1    Khan, S.M.2
  • 55
    • 23744485610 scopus 로고    scopus 로고
    • Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and cell-free systems by melatonin
    • Tan DX, Manchester LC, Sainz RM, Mayo JC, Leon J, Hardeland R, Poeggeler B, Reiter RJ (2005). Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and cell-free systems by melatonin. J Pineal Res 39: 185–194.
    • (2005) J Pineal Res , vol.39 , pp. 185-194
    • Tan, D.X.1    Manchester, L.C.2    Sainz, R.M.3    Mayo, J.C.4    Leon, J.5    Hardeland, R.6    Poeggeler, B.7    Reiter, R.J.8
  • 56
    • 84908339437 scopus 로고    scopus 로고
    • Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: Relation to their biological functions
    • Tan DX, Zheng X, Kong J, Manchester LC, Hardeland R, Kim SJ, Xu X, Reiter RJ (2014). Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions. Int J Mol Sci 15: 15858–15890.
    • (2014) Int J Mol Sci , vol.15 , pp. 15858-15890
    • Tan, D.X.1    Zheng, X.2    Kong, J.3    Manchester, L.C.4    Hardeland, R.5    Kim, S.J.6    Xu, X.7    Reiter, R.J.8
  • 58
    • 84890348781 scopus 로고    scopus 로고
    • Elevated levels of mitochondrial respiratory complexes activities and ATP production in 17-β-estradiol-induced prolactin-secretory tumor cells in male rats are inhibited by melatonin in vitro and in vitro
    • Wang BQ, Yang QH, Xu RK, Xu JN (2013). Elevated levels of mitochondrial respiratory complexes activities and ATP production in 17-β-estradiol-induced prolactin-secretory tumor cells in male rats are inhibited by melatonin in vitro and in vitro. Chin Med J (Engl) 126: 4724–4730.
    • (2013) Chin Med J (Engl) , vol.126 , pp. 4724-4730
    • Wang, B.Q.1    Yang, Q.H.2    Xu, R.K.3    Xu, J.N.4
  • 59
    • 65549160834 scopus 로고    scopus 로고
    • Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury
    • Wang X, Figueroa BE, Stavrovskaya IG, Zhang Y, Sirianni AC, Zhu S, Day AL, Kristal BS, Friedlander RM (2009). Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke 40: 1877–1885.
    • (2009) Stroke , vol.40 , pp. 1877-1885
    • Wang, X.1    Figueroa, B.E.2    Stavrovskaya, I.G.3    Zhang, Y.4    Sirianni, A.C.5    Zhu, S.6    Day, A.L.7    Kristal, B.S.8    Friedlander, R.M.9
  • 61
    • 0036171091 scopus 로고    scopus 로고
    • Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential
    • Xu M, Ashraf M (2002). Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential. J Mol Cell Cardiol 34: 75–79.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 75-79
    • Xu, M.1    Ashraf, M.2
  • 63
    • 84876721837 scopus 로고    scopus 로고
    • Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis
    • Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K, Cormier K, Bennett E, Browser RP, Day AL et al. (2013). Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 55: 26–35.
    • (2013) Neurobiol Dis , vol.55 , pp. 26-35
    • Zhang, Y.1    Cook, A.2    Kim, J.3    Baranov, S.V.4    Jiang, J.5    Smith, K.6    Cormier, K.7    Bennett, E.8    Browser, R.P.9    Day, A.L.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.