HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

Thrombosis and Haemostasis

Volumn 114, Issue 5, 2015, Pages 994-1003

  Ahrens, Ingo ^a,b   Chen, Yung Chih ^b   Topcic, Danijal ^b   Bode, Michael ^b,c   Haenel, David ^a   Hagemeyer, Christoph E ^b   Seeba, Hannah ^a   Duerschmied, Daniel ^a   Bassler, Nicole ^b   Jandeleit Dahm, Karin A ^d   Sweet, Matthew J ^e   Agrotis, Alex ^f   Bobik, Alex ^f   Peter, Karlheinz ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Atherothrombosis and Vascular Biology Laboratory   (Australia)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Diabetes Division   (Australia)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f Baker IDI   (Australia)

Author keywords

ACS; HMGB1; Platelets; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; PROTEIN BINDING; THROMBIN; TOLL LIKE RECEPTOR 4;

ACUTE CORONARY SYNDROME; ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CONTROLLED STUDY; CORONARY ARTERY THROMBOSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE ACTIVATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CORONARY BLOOD VESSEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; THROMBOCYTE;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; BLOOD PLATELETS; CELLS, CULTURED; CORONARY THROMBOSIS; CORONARY VESSELS; HMGB1 PROTEIN; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLATELET ACTIVATION; PROTEIN BINDING; THROMBIN; TOLL-LIKE RECEPTOR 4;

EID: 84946615460     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH14-12-1073     Document Type: Article

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