Circulating platelet-progenitor cell coaggregate formation is increased in patients with acute coronary syndromes and augments recruitment of cd341 cells in the ischaemic microcirculation

European Heart Journal

Volumn 34, Issue 32, 2013, Pages 2548-2556

  Stellos, Konstantinos ^a,b   Bigalke, Boris ^a   Borst, Oliver ^a   Pfaff, Florian ^a   Elskamp, Alexandra ^a   Sachsenmaier, Saskia ^a   Zachmann, Ruben ^a   Stamatelopoulos, Kimon ^c   Schönberger, Tanja ^a   Geisler, Tobias ^a   Langer, Harald ^a   Gawaz, Meinrad ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Acute coronary syndrome; Microcirculation; Platelets; Progenitor cells

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; CD34 ANTIGEN; CLOPIDOGREL; COLLAGEN; CREATINE KINASE; GLYCOPROTEIN IB ALPHA; PADGEM PROTEIN; STROMAL CELL DERIVED FACTOR 1; TROPONIN I;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ARTICLE; CARDIAC PATIENT; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR RISK; CELL ADHESION; COMPARATIVE STUDY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; FOLLOW UP; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART STROKE VOLUME; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MICROCIRCULATION; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PRIORITY JOURNAL; REPERFUSION INJURY; SHEAR RATE; SHEAR STRESS; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; STEM CELL; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ACUTE CORONARY SYNDROME; MICROCIRCULATION; PLATELETS; PROGENITOR CELLS;

ACUTE CORONARY SYNDROME; AGED; ANGINA, STABLE; ANIMALS; ANTIGENS, CD34; BLOOD PLATELETS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICROCIRCULATION; MYOCARDIAL INFARCTION; PILOT PROJECTS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; RISK FACTORS; STEM CELLS;

EID: 84883157053     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/eht131     Document Type: Article

References (47)

1. Yeh ET, Zhang S, Wu HD, Korbling M, Willerson JT, Estrov Z. Transdifferentiation of human peripheral blood cd34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 2003;108: 2070-2073. (Pubitemid 37337581)
2. Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004;95:343-353. (Pubitemid 39100452)
3. Feugier P, Li N, Jo DY, Shieh JH, MacKenzie KL, Lesesve JF, Latger-Cannard V, Bensoussan D, Crystal RG, Rafii S, Stoltz JF, Moore MA. Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized cd34+ hematopoiesis in vitro. Stem Cells Dev 2005;14:505-516. (Pubitemid 41780803)
4. Shintani S, Murohara T, Ikeda H, Ueno T, Honma T, Katoh A, Sasaki K, Shimada T, Oike Y, Imaizumi T. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 2001;103:2776-2779. (Pubitemid 32550062)
5. Wojakowski W, Tendera M, Michalowska A, Majka M, Kucia M, Maslankiewicz K, Wyderka R, Ochala A, Ratajczak MZ. Mobilization of cd34/cxcr4+, cd34/cd117+, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myo-cardial infarction. Circulation 2004;110:3213-3220. (Pubitemid 39525068)
6. Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, Dunn A, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, Rafii S. Cytokine-mediated deployment of sdf-1 induces revascularization through recruitment of cxcr4+ hemangiocytes. Nat Med 2006;12:557-567.
7. Langer H, May AE, Daub K, Heinzmann U, Lang P, Schumm M, Vestweber D, Massberg S, Schonberger T, Pfisterer I, Hatzopoulos AK, Gawaz M. Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro. Circ Res 2006;98:e2-e10.
8. Massberg S, Konrad I, Schurzinger K, Lorenz M, Schneider S, Zohlnhoefer D, Hoppe K, Schiemann M, Kennerknecht E, Sauer S, Schulz C, Kerstan S, Rudelius M, Seidl S, Sorge F, Langer H, Peluso M, Goyal P, Vestweber D, Emambokus NR, Busch DH, Frampton J, Gawaz M. Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivo. J Exp Med 2006;203:1221-1233. (Pubitemid 43736592)
9. de Boer HC, Verseyden C, Ulfman LH, Zwaginga JJ, Bot I, Biessen EA, Rabelink TJ, van Zonneveld AJ. Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell pheno-type. Arterioscler Thromb Vasc Biol 2006;26:1653-1659. (Pubitemid 44288997)
10. Daub K, Langer H, Seizer P, Stellos K, May AE, Goyal P, Bigalke B, Schonberger T, Geisler T, Siegel-Axel D, Oostendorp RA, Lindemann S, Gawaz M. Platelets induce differentiation of human cd34+ progenitor cells into foam cells and endo-thelial cells. FASEB J 2006;20:2559-2561.
11. Stellos K, Langer H, Daub K, Schoenberger T, Gauss A, Geisler T, Bigalke B, Mueller I, Schumm M, Schaefer I, Seizer P, Kraemer BF, Siegel-Axel D, May AE, Lindemann S, Gawaz M. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human cd34+ cells to endothelial progenitor cells. Circulation 2008;117:206-215.
12. Stellos K, Bigalke B, Langer H, Geisler T, Schad A, Kogel A, Pfaff F, Stakos D, Seizer P, Muller I, Htun P, Lindemann S, Gawaz M. Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of cd34+ progenitor cells. Eur Heart J 2009;30:584-593.
13. Stellos K, Langer H, Gnerlich S, Panagiota V, Paul A, Schonberger T, Ninci E, Menzel D, Mueller I, Bigalke B, Geisler T, Bultmann A, Lindemann S, Gawaz M. Junctional adhesion molecule a expressed on human cd34+ cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells. Arterios-cler Thromb Vasc Biol 2010;30:1127-1136.
14. Wurster T, Stellos K, Haap M, Seizer P, Geisler T, Otton J, Indermuehle A, Ishida M, Schuster A, Nagel E, Gawaz M, Bigalke B. Platelet expression of stromal-cell-derived factor-1 (sdf-1): an indicator for acs? Int J Cardiol 2013;164: 111-115.
15. Geisler T, Fekecs L, Wurster T, Chiribiri A, Schuster A, Nagel E, Miller S, Gawaz M, Stellos K, Bigalke B. Association of platelet-sdf-1 with hemodynamic function and infarct size using cardiac mr in patients with ami. Eur J Radiol 2012; 81:e486-e490.
16. Scanlon PJ, Faxon DP, Audet AM, Carabello B, Dehmer GJ, Eagle KA, Legako RD, Leon DF, Murray JA, Nissen SE, Pepine CJ, Watson RM, Ritchie JL, Gibbons RJ, Cheitlin MD, Gardner TJ, Garson A Jr., Russell RO Jr., Ryan TJ, Smith SC Jr. Acc/aha guidelines for coronary angiography: executive summary and recommendations. A report of the american college of cardiology/american heart association task force on practice guidelines (committee on coronary angiography) developed in collaboration with the society for cardiac angiography and interventions. Circulation 1999;99:2345-2357.
17. Geisler T, Fekecs L, Wurster T, Chiribiri A, Schuster A, Nagel E, Miller S, Gawaz M, Stellos K, Bigalke B. Association of platelet-sdf-1 with hemodynamic function and infarct size using cardiac mr in patients with ami. Eur J Radiol 2012; 81:e486-e490.
18. Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E, Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized P. Standardized cardiovascular magnetic resonance imaging (cmr) protocols, society for cardiovascular magnetic resonance: board of trustees task force on standardized protocols. J Cardiovasc Magn Reson 2008;10:35.
19. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS, American Heart Association Writing Group on Myocardial S, Registration for Cardiac I. Standardized myocar-dial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the american heart association. Circulation 2002;105:539-542. (Pubitemid 34262671)
20. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, Bohm M, Nickenig G. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;353:999-1007. (Pubitemid 41262334)
21. Gawaz M, Neumann FJ, Schomig A. Evaluation of platelet membrane glycopro-teins in coronary artery disease: consequences for diagnosis and therapy. Circulation 1999;99:E1-E11.
22. Langer HF, von der Ruhr JW, Daub K, Schoenberger T, Stellos K, May AE, Schnell H, Gauss A, Hafner R, Lang P, Schumm M, Buhring HJ, Klingel K, Conrad S, Schaller M, van Zandvoort M, Jung G, Dimmeler S, Skutella T, Gawaz M. Capture of endothelial progenitor cells by a bispecific protein/monoclonal antibody molecule induces reendothelialization of vascular lesions. J Mol Med (Berl) 2010;88:687-699.
23. Porto I, Leone AM, De Maria GL, Hamilton Craig C, Tritarelli A, Camaioni C, Natale L, Niccoli G, Biasucci LM, Crea F. Are endothelial progenitor cells mobilized by myocardial ischemia or myocardial necrosis? A cardiac magnetic resonance study. Atherosclerosis 2011;216:355-358.
24. Petit I, Goichberg P, Spiegel A, Peled A, Brodie C, Seger R, Nagler A, Alon R, Lapidot T. Atypical pkc-zeta regulates sdf-1-mediated migration and development of human cd34+ progenitor cells. J Clin Invest 2005;115:168-176. (Pubitemid 40385518)
25. Grote K, Salguero G, Ballmaier M, Dangers M, Drexler H, Schieffer B. The angio-genic factor ccn1 promotes adhesion and migration of circulating cd34+ progenitor cells: potential role in angiogenesis and endothelial regeneration. Blood 2007; 110:877-885. (Pubitemid 47267424)
26. Maruyama S, Taguchi A, Iwashima S, Ozaki T, Yasuda K, Kikuchi-Taura A, Soma T, Ishii H, Murohara T, Takahashi H, Kasuga H, Kumada Y, Toriyama T, Ito Y, Kawahara H, Yuzawa Y, Matsuo S. Low circulating cd34+ cell count is associated with poor prognosis in chronic hemodialysis patients. Kidney Int 2008;74: 1603-1609.
27. Fadini GP, de Kreutzenberg S, Agostini C, Boscaro E, Tiengo A, Dimmeler S, Avogaro A. Low cd34+ cell count and metabolic syndrome synergistically increase the risk of adverse outcomes. Atherosclerosis 2009;207:213-219.
28. Schwartzenberg S, Afek A, Charach G, Rubinstein A, Ben-Shoshan Y, Kissil S, Maisel-Auslender S, Keren G, George J. Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome. World J Cardiol 2010;2:299-304.
29. Ma N, Stamm C, Kaminski A, Li W, Kleine HD, Muller-Hilke B, Zhang L, Ladilov Y, Egger D, Steinhoff G. Human cord blood cells induce angiogenesis following myo-cardial infarction in nod/scid-mice. Cardiovasc Res 2005;66:45-54. (Pubitemid 40357867)
30. Leor J, Guetta E, Feinberg MS, Galski H, Bar I, Holbova R, Miller L, Zarin P, Castel D, Barbash IM, Nagler A. Human umbilical cord blood-derived cd133+ cells enhance function and repair of the infarcted myocardium. Stem Cells 2006; 24:772-780. (Pubitemid 44464782)
31. Iwasaki H, Kawamoto A, Ishikawa M, Oyamada A, Nakamori S, Nishimura H, Sadamoto K, Horii M, Matsumoto T, Murasawa S, Shibata T, Suehiro S, Asahara T. Dose-dependent contribution of cd34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction. Circulation 2006;113:1311-1325. (Pubitemid 43739453)
32. Kawamoto A, Iwasaki H, Kusano K, Murayama T, Oyamada A, Silver M, Hulbert C, Gavin M, Hanley A, Ma H, Kearney M, Zak V, Asahara T, Losordo DW. Cd34-positive cells exhibit increased potency and safety for therapeutic neovas-cularization after myocardial infarction compared with total mononuclear cells. Circulation 2006;114:2163-2169. (Pubitemid 44747897)
33. Yoshioka T, Ageyama N, Shibata H, Yasu T, Misawa Y, Takeuchi K, Matsui K, Yamamoto K, Terao K, Shimada K, Ikeda U, Ozawa K, Hanazono Y. Repair of infarcted myocardium mediated by transplanted bone marrow-derived cd34+ stem cells in a nonhuman primate model. Stem Cells 2005;23:355-364. (Pubitemid 40404454)
34. Mackie AR, Klyachko E, Thorne T, Schultz KM, Millay M, Ito A, Kamide CE, Liu T, Gupta R, Sahoo S, Misener S, Kishore R, Losordo DW. Sonic hedgehog-modified human cd34+ cells preserve cardiac function after acute myocardial infarction. Circ Res 2012;111:312-321.
35. Losordo DW, Schatz RA, White CJ, Udelson JE, Veereshwarayya V, Durgin M, Poh KK, Weinstein R, Kearney M, Chaudhry M, Burg A, Eaton L, Heyd L, Thorne T, Shturman L, Hoffmeister P, Story K, Zak V, Dowling D, Traverse JH, Olson RE, Flanagan J, Sodano D, Murayama T, Kawamoto A, Kusano KF, Wollins J, Welt F, Shah P, Soukas P, Asahara T, Henry TD. Intramyocardial transplantation of autologous cd34+ stem cells for intractable angina: a phase i/iia double-blind, randomized controlled trial. Circulation 2007;115:3165-3172. (Pubitemid 47018140)
36. Losordo DW, Henry TD, Davidson C, Sup Lee J, Costa MA, Bass T, Mendelsohn F, Fortuin FD, Pepine CJ, Traverse JH, Amrani D, Ewenstein BM, Riedel N, Story K, Barker K, Povsic TJ, Harrington RA, Schatz RA, Investigators AC. Intramyocardial, autologous cd34+ cell therapy for refractory angina. Circ Res 2011;109:428-436.
37. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schumichen C, Nienaber CA, Freund M, Steinhoff G. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 2003;361:45-46. (Pubitemid 36050962)
38. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mono-nuclear bone marrow cell transplantation in humans. Circulation 2002;106: 1913-1918. (Pubitemid 35176294)
39. Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. Effects of intracoronary cd34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up. Circ Res 2013;112:165-173.
40. Klein HM, Ghodsizad A, Marktanner R, Poll L, Voelkel T, Mohammad Hasani MR, Piechaczek C, Feifel N, Stockschlaeder M, Burchardt ER, Kar BJ, Gregoric I, Gams E. Intramyocardial implantation of cd133+ stem cells improved cardiac function without bypass surgery. Heart Surg Forum 2007;10:E66-E69.
41. Stamm C, Kleine HD, Choi YH, Dunkelmann S, Lauffs JA, Lorenzen B, David A, Liebold A, Nienaber C, Zurakowski D, Freund M, Steinhoff G. Intramyocardial delivery of cd133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J Thorac Cardiovasc Surg 2007;133:717-725.
42. Friedrich EB, Walenta K, Scharlau J, Nickenig G, Werner N. Cd34-/cd133+/vegfr-2+ endothelial progenitor cell subpopulation with potent vasoregenerative capacities. Circ Res 2006;98:e20-e25.
43. Mause SF, Ritzel E, Liehn EA, Hristov M, Bidzhekov K, Muller-Newen G, Soehnlein O, Weber C. Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation 2010;122:495-506.
44. de Boer HC, Hovens MM, van Oeveren-Rietdijk AM, Snoep JD, de Koning EJ, Tamsma JT, Huisman MV, Rabelink AJ, van Zonneveld AJ. Human cd34+/kdr+ cells are generated from circulating cd34+ cells after immobilization on activated platelets. Arterioscler Thromb Vasc Biol 2011;31:408-415.
45. Stellos K, Seizer P, Bigalke B, Daub K, Geisler T, Gawaz M. Platelet aggregates-induced human cd34+ progenitor cell proliferation and differentiation to macrophages and foam cells is mediated by stromal cell derived factor 1 in vitro. Semin Thromb Hemost 2010;36:139-145.
46. Fadini GP, Losordo D, Dimmeler S. Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Circ Res 2012; 110:624-637.
47. Ziegler M, Elvers M, Baumer Y, Leder C, Ochmann C, Schonberger T, Jurgens T, Geisler T, Schlosshauer B, Lunov O, Engelhardt S, Simmet T, Gawaz M. The bispecific sdf1-gpvi fusion protein preserves myocardial function after transient ischemia in mice. Circulation 2012;125:685-696.