Inhibition of kynurenine aminotransferase II reduces activity of midbrain dopamine neurons

Neuropharmacology

Volumn 102, Issue , 2016, Pages 42-47

  Linderholm, Klas R ^a   Alm, Maximilian Tufvesson ^a   Larsson, Markus K ^a   Olsson, Sara K ^a   Goiny, Michel ^a   Hajos, Mihaly ^b   Erhardt, Sophie ^a   Engberg, Göran ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CGP 52432; d Cycloserine; Dopamine; Firing; GABA receptor; Kynurenic acid; Kynurenine transferase; NMDA receptor; PF 04859989; Picrotoxin; Ventral tegmental area

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; AMINOTRANSFERASE INHIBITOR; CYCLOSERINE; DOPAMINE; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; KYNURENINE AMINOTRANSFERASE II; METHYLLYCACONITINE; PF 04859989; PICROTOXIN; UNCLASSIFIED DRUG; [3 (3,4 DICHLOROBENZYLAMINO)PROPYL](DIETHOXYMETHYL)PHOSPHINIC ACID; AMINOTRANSFERASE; KYNURENINE-OXOGLUTARATE TRANSAMINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PF-04859989; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; ENZYME INHIBITION; IN VIVO STUDY; MALE; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; MESENCEPHALON; METABOLISM; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; ANIMALS; DOPAMINERGIC NEURONS; MALE; MESENCEPHALON; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSAMINASES;

EID: 84946601361     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.10.028     Document Type: Article

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