CFTR-regulated MAPK/NF-κ B signaling in pulmonary inflammation in thermal inhalation injury

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Dong, Zhi Wei ^a   Chen, Jing ^a   Ruan, Ye Chun ^b   Zhou, Tao ^a   Chen, Yu ^a   Chen, Yajie ^a   Tsang, Lai Ling ^b   Chan, Hsiao Chang ^b   Peng, Yi Zhi ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Prince of Wales Hospital   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; CURCUMIN; CYCLOOXYGENASE 2; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LUMACAFTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENETICS; HEAT; INFLAMMATION; INHALATION; LUNG DISEASES; MALE; METABOLISM; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION;

AMINOPYRIDINES; ANIMALS; BENZODIOXOLES; CELL LINE; CURCUMIN; CYCLOOXYGENASE 2; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DINOPROSTONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HOT TEMPERATURE; INFLAMMATION; INHALATION; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG DISEASES; MALE; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84946593420     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15946     Document Type: Article

References (40)

1. Chen, J., et al. Characteristics of burn deaths from 2003 to 2009 in a burn center: A retrospective study. Burns & Trauma 1, 80-86 (2013).
2. Sterner, J. B., Zanders, T. B., Morris, M. J. & Cancio, L. C. Inflammatory mediators in smoke inhalation injury. Inflamm Allergy Drug Targets 8, 63-69 (2009).
3. Wright, M. J. & Murphy, J. T. Smoke inhalation enhances early alveolar leukocyte responsiveness to endotoxin. J Trauma 59, 64-70 (2005).
4. Brinkmann, B. & Puschel, K. Heat injuries to the respiratory system. Virchows Arch A Pathol Anat Histol 379, 299-311 (1978).
5. Rodriguez, J. L. et al. Correlation of the local and systemic cytokine response with clinical outcome following thermal injury. J Trauma 34, 684-694 (1993).
6. Sio, S. W., Ang, S. F., Lu, J., Moochhala, S. & Bhatia, M. Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute lung injury. J Immunol 185, 6265-6276 (2010).
7. Chong, S. J. et al. Parecoxib reduces systemic inflammation and acute lung injury in burned animals with delayed fluid resuscitation. Int J Inflam 2014, 972645 (2014).
8. Menczer, J. Cox-2 expression in ovarian malignancies: a review of the clinical aspects. Eur J Obstet Gynecol Reprod Biol 146, 129-132 (2009).
9. Wang, P. et al. Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases. Faseb J 27, 4664-4677 (2013).
10. Liu, R. et al. Multi-allergen challenge stimulates steriod-resistant airway inflammation via NF-kappaB-mediated IL-8 expression. Inflammation 36, 845-854 (2013).
11. Tomaru, M. & Matsuoka, M. The role of mitogen-activated protein kinases in crystalline silica-induced cyclooxygenase-2 expression in A549 human lung epithelial cells. Toxicol Mech Methods 21, 513-519 (2011).
12. Lin, C. C. et al. Functional coupling expression of COX-2 and cPLA2 induced by ATP in rat vascular smooth muscle cells: role of ERK1/2, p38 MAPK, and NF-kappaB. Cardiovasc Res 82, 522-531 (2009).
13. Stoltz, D. A., Meyerholz, D. K. & Welsh, M. J. Origins of cystic fibrosis lung disease. N Engl J Med 372, 351-362 (2015).
14. Profita, M. et al. Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism. Eur J Pharmacol 582, 145-153 (2008).
15. Mizumura, K. et al. Role of mitogen-activated protein kinases in influenza virus induction of prostaglandin E2 from arachidonic acid in bronchial epithelial cells. Clin Exp Allergy 33, 1244-1251 (2003).
16. Chen, J. et al. CFTR negatively regulates cyclooxygenase-2-PGE(2) positive feedback loop in inflammation. J Cell Physiol 227, 2759-2766 (2012).
17. Weber, A. J., Soong, G., Bryan, R., Saba, S. & Prince, A. Activation of NF-kappaB in airway epithelial cells is dependent on CFTR trafficking and Cl-channel function. Am J Physiol Lung Cell Mol Physiol 281, 71-78 (2001).
18. Berube, J., Roussel, L., Nattagh, L. & Rousseau, S. Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. J Biol Chem 285, 22299-22307 (2010).
19. Roque, T. et al. Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling. J Pharmacol Exp Ther 326, 949-956 (2008).
20. Rennolds, J., Boyaka, P. N., Bellis, S. L. & Cormet-Boyaka, E. Low temperature induces the delivery of mature and immature CFTR to the plasma membrane. Biochem Biophys Res Commun 366, 1025-1029 (2008).
21. Chen, J. et al. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through upregulation of NF-kappaB/COX-2/PGE2. Hum Reprod 27, 2585-2597 (2012).
22. Harada, K. et al. Curcumin enhances cystic fibrosis transmembrane regulator expression by down-regulating calreticulin. Biochem Biophys Res Commun 353, 351-356 (2007).
23. Dong, H. J. et al. Curcumin attenuates ischemia-like injury induced IL-1beta elevation in brain microvascular endothelial cells via inhibiting MAPK pathways and nuclear factor-kappaB activation. Neurol Sci 35, 1387-1392 (2014).
24. Goel, A., Boland, C. R. & Chauhan, D. P. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett 172, 111-118 (2001).
25. Rossi, A., Coccia, M., Trotta, E., Angelini, M. & Santoro, M. G. Regulation of cyclooxygenase-2 expression by heat: a novel aspect of heat shock factor 1 function in human cells. PLoS One 7, e31304 (2012).
26. Lukacs, G. L. et al. Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP. Embo J 13, 6076-6086 (1994).
27. Joyner, B. L. et al. DNA and inflammatory mediators in bronchoalveolar lavage fluid from children with acute inhalational injuries. J Burn Care Res 34, 326-333 (2013).
28. Wang, G. Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity. Biochemistry 54, 2828-2840 (2015).
29. Zhang, X., Chen, Q., Wang, Y., Peng, W. & Cai, H. Effects of curcumin on ion channels and transporters. Front Physiol 5, 94 (2014).
30. Perez, A. et al. CFTR inhibition mimics the cystic fibrosis inflammatory profile. Am J Physiol Lung Cell Mol Physiol 292, L383-395 (2007).
31. Braun, A. P. Cigarette smoke and calcium conspire to impair CFTR function in airway epithelia. Channels (Austin) 8, 172-173 (2014).
32. Liu, H. et al. Resveratrol protects against cigarette smoke-induced oxidative damage and pulmonary inflammation. J Biochem Mol Toxicol 28, 465-471 (2014).
33. Sharma, C., Kaur, J., Shishodia, S., Aggarwal, B. B. & Ralhan, R. Curcumin down regulates smokeless tobacco-induced NFkappaB activation and COX-2 expression in human oral premalignant and cancer cells. Toxicology 228, 1-15 (2006).
34. Bernard, K., Wang, W., Narlawar, R., Schmidt, B. & Kirk, K. L. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol Chem 284, 30754-30765 (2009).
35. Chipps, B. E. Inhaled corticosteroid therapy for patients with persistent asthma: learnings from studies of inhaled budesonide. Allergy Asthma Proc 30, 217-228 (2009).
36. Brandsma, C. A. et al. Differential effects of fluticasone on extracellular matrix production by airway and parenchymal fibroblasts in severe COPD. Am J Physiol Lung Cell Mol Physiol 305, L582-589 (2013).
37. Ajonuma, L. C. et al. Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome. Mol Endocrinol 19, 3038-3044 (2005).
38. Koeppen, K., Coutermarsh, B. A., Madden, D. R. & Stanton, B. A. Serum-and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein. J Biol Chem 289, 17142-17150 (2014).
39. Rong, Y. H., Liu, W., Wang, C., Ning, F. G. & Zhang, G. A. Temperature distribution in the upper airway after inhalation injury. Burns 37, 1187-1191 (2011).
40. Xie, C. et al. CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer. Oncogene 32, 2282-2291, 2291 e2281-2287 (2013).