Intraoperative dexmedetomidine promotes postoperative analgesia and recovery in patients after abdominal colectomy: A CONSORT-prospective, randomized, controlled clinical trial

Medicine (United States)

Volumn 94, Issue 43, 2015, Pages

  Ge, Dong Jian ^a   Qi, Bin ^a   Tang, Gang ^a   Li, Jin Yu ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CISATRACURIUM; DEXMEDETOMIDINE; MIDAZOLAM; MORPHINE; ONDANSETRON; PROPOFOL; REMIFENTANIL; SODIUM CHLORIDE; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT;

ABDOMINAL COLECTOMY; ABDOMINAL SURGERY; ADULT; ANESTHESIA LEVEL; ARTICLE; BISPECTRAL INDEX; BRADYCARDIA; COLON RESECTION; CONTROLLED STUDY; DIZZINESS; EXTUBATION; FATIGUE; FEMALE; GENERAL ANESTHESIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NAUSEA; PATIENT CONTROLLED ANALGESIA; PEROPERATIVE CARE; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; VISUAL ANALOG SCALE; VOMITING; ADVERSE EFFECTS; PAIN, POSTOPERATIVE;

ANALGESIA, PATIENT-CONTROLLED; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANESTHESIA, GENERAL; COLECTOMY; DEXMEDETOMIDINE; FATIGUE; FEMALE; HUMANS; INTRAOPERATIVE CARE; MALE; MIDDLE AGED; MORPHINE; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES;

EID: 84946569837     PISSN: 00257974     EISSN: 15365964     Source Type: Journal    
DOI: 10.1097/MD.0000000000001727     Document Type: Article

References (26)

1. Bekker A, Haile M, Kline R, et al. The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. J Neurosurg Anesthesiol. 2013;25:16-24.
2. Zhu Q, Sun Y, Yun X, et al. Antinociceptive effectsof curcumin in a rat model of postoperative pain. Sci Rep. 2014 doi:10.1038/srep04932.
3. An LX, Chen X, Ren XJ, et al. Electro-acupuncture decreases postoperative pain and improves recovery in patients undergoing a supratentorial craniotomy. Am J Chin Med. 2014;42:1099-1109.
4. Walder B, Schafer M, Henzi I, et al. Efficacy and safety of patientcontrolled opioid analgesia for acute postoperative pain. A quantitative systematic review. Acta Anaesthesiol Scand. 2001;45:795-804.
5. Grosu I, Lavand'homme P. Use of dexmedetomidine for pain control. F1000 Med Rep. 1000;2:M2-90.
6. Kim SY, Kim JM, Lee JH, et al. Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Br J Anaesth. 2013;111:222-228.
7. Gupta N, Rath GP, Prabhakar H, et al. Effect of intraoperative dexmedetomidine on postoperative recovery profile of children undergoing surgery for spinal dysraphism. J Neurosurg Anesthesiol. 2013;25:271-278.
8. Kim SH, Oh YJ, Park BW, et al. Effects of single-dose dexmedetomidine on the quality of recovery after modified radical mastectomy: a randomised controlled trial. Minerva Anestesiol. 2013;79:1248-1258.
9. Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013;35:121-126.
10. Hwang W, Lee J, Park J, et al. Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: a randomized controlled study. BMC Anesthesiol. 2015;15:015-24.
11. Gornall BF, Myles PS, Smith CL, et al. Measurement of quality of recovery using the QoR-40: a quantitative systematic review. Br J Anaesth. 2013;111:161-169.
12. Myles PS, Weitkamp B, Jones K, et al. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br J Anaesth. 2000;84:11-15.
13. Movafegh A, Shoeibi G, Ansari M, et al. Naloxone infusion and post-hysterectomy morphine consumption: a double-blind, placebocontrolled study. Acta Anaesthesiol Scand. 2012;56:1241-1249.
14. George RB, McKeen DM, Andreou P, et al. A randomized placebocontrolled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. Can J Anaesth. 2014;61:551-557.
15. Liu H, Hu X, Duan X, et al. Thoracic epidural analgesia (TEA) vs. patient controlled analgesia (PCA) in laparoscopic colectomy: a meta-analysis. Hepatogastroenterology. 2014;61:1213-1219.
16. Engelman E, Marsala C. Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis. Br J Anaesth. 2013;110:21-27.
17. Lambert P, Cyna AM, Knight N, et al. Clonidine premedicationfor postoperative analgesia in children. Cochrane Database Syst Rev. 2014 doi:10.1002/14651858.
18. Gil DW, Cheevers CV, Kedzie KM, et al. Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia. Anesthesiology. 2009;110:401-407.
19. Rajan S, Hutcherson MT, Sessler DI, et al. The effects of dexmedetomidine andremifentanil on hemodynamic stability and analgesic requirement after craniotomy: a randomized controlled trial. J Neurosurg Anesthesiol. 2015;28: DOI: 10.1097/ANA.0000000000000221.
20. Jones JS, Cotugno RE, Singhal NR, et al. Evaluation of dexmedetomidine and postoperative pain management in patients with adolescent idiopathic scoliosis: conclusions based on a retrospective study at a tertiary pediatric hospital. Pediatr Crit Care Med. 2014;15:0000000000000119.
21. McQueen-Shadfar LA, Megalla SA, White WD, et al. Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery. Curr Med Res Opin. 2011;27:2091-2097.
22. Bhana N, Goa KL, McClellan KJ. Dexmedetomidine. Drugs. 2000;59:263-268.
23. Buyukkocak U, Ozcan S, Daphan C, et al. A comparison of four intravenous sedation techniques and Bispectral Index monitoring in sinonasal surgery. Anaesth Intensive Care. 2003;31:164-171.
24. Ozturk L, Kesimci E, Albayrak T, et al. Bispectral index-guided general anaesthesia in combination with interscalene block reduces desflurane consumption in arthroscopic shoulder surgery: a clinical comparison of bupivacaine versus levobupivacaine. BMC Anesthesiol. 2015;15:015-0087.
25. Chattopadhyay U, Mallik S, Ghosh S, et al. Comparison between propofol and dexmedetomidine on depth of anesthesia: a prospective randomized trial. J Anaesthesiol Clin Pharmacol. 2014;30:550-554.
26. Zhang H, Zhou F, Li C, et al. Molecular mechanisms underlying the analgesic property of intrathecal dexmedetomidine and its neurotoxicity evaluation: an in vivo and in vitro experimental study. PLoS One. 2013;8:doi: 10.1371/journal.pone.0055556.