Dexmedetomidine versus remifentanil in postoperative pain control after spinal surgery: A randomized controlled study

BMC Anesthesiology

Volumn 15, Issue 1, 2015, Pages

  Hwang, Wonjung ^a   Lee, Jaemin ^a   Park, Jihyun ^a   Joo, Jin ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Dexmedetomidine; Postoperative pain; Remifentanil; Total intravenous anesthesia

Indexed keywords

DEXMEDETOMIDINE; HYDROMORPHONE; PROPOFOL; REMIFENTANIL; ANALGESIC AGENT; INTRAVENOUS ANESTHETIC AGENT; PIPERIDINE DERIVATIVE;

AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENERAL ANESTHESIA; HUMAN; MALE; PAIN INTENSITY; PATIENT CONTROLLED ANALGESIA; POSTERIOR LUMBAR INTERBODY FUSION SURGERY; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; RANDOMIZED CONTROLLED TRIAL; RECOVERY ROOM; SPINE SURGERY; VISUAL ANALOG SCALE; ANALGESIA; CHEMICALLY INDUCED; MIDDLE AGED; PAIN, POSTOPERATIVE; PROCEDURES; SPINAL CORD; SURGERY;

AGED; ANALGESICS, NON-NARCOTIC; ANESTHETICS, INTRAVENOUS; DEXMEDETOMIDINE; FEMALE; HUMANS; MALE; MIDDLE AGED; PAIN MANAGEMENT; PAIN, POSTOPERATIVE; PIPERIDINES; POSTOPERATIVE NAUSEA AND VOMITING; SPINAL CORD;

EID: 84925220968     PISSN: None     EISSN: 14712253     Source Type: Journal    
DOI: 10.1186/s12871-015-0004-1     Document Type: Article

References (29)

1. Sekimoto K, Nishikawa K, Ishizeki J, Kubo K, Saito S, Goto F. The effects of volatile anesthetics on intraoperative monitoring of myogenic motor-evoked potentials to transcranial electrical stimulation and on partial neuromuscular blockade during propofol/fentanyl/nitrous oxide anesthesia in humans. J Neurosurg Anesthesiol. 2006;18(2):106-11.
2. Pechstein U, Nadstawek J, Zentner J, Schramm J. Isoflurane plus nitrous oxide versus propofol for recording of motor evoked potentials after high frequency repetitive electrical stimulation. Electroencephalogr Clin Neurophysiol. 1998;108(2):175-81.
3. Zheng Y, Cui S, Liu Y, Zhang J, Zhang W, Zhang J, et al. Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit. Brain Res Bull. 2012;87(4-5):427-31.
4. Lee C, Kim YD, Kim JN. Antihyperalgesic effects of dexmedetomidine on high-dose remifentanil-induced hyperalgesia. Kor J Anesthesiol. 2013;64(4):301-7.
5. De Kock M, Wiederkher P, Laghmiche A, Scholtes JL. Epidural clonidine used as the sole analgesic agent during and after abdominal surgery. A dose-response study. Anesthesiology. 1997;86(2):285-92.
6. Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Crit Care. 2000;4(5):302-8.
7. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988;150(1-2):9-14.
8. McQueen-Shadfar LA, Megalla SA, White WD, Olufolabi AJ, Jones CA, Habib AS. Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery. Curr Med Res Opin. 2011;27(11):2091-7.
9. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000;93(2):382-94.
10. Bulow NM, Barbosa NV, Rocha JB. Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery. J Clin Anesth. 2007;19(4):280-5.
11. Salman N, Uzun S, Coskun F, Salman MA, Salman AE, Aypar U. Dexmedetomidine as a substitute for remifentanil in ambulatory gynecologic laparoscopic surgery. Saudi Med J. 2009;30(1):77-81.
12. Turgut N, Turkmen A, Ali A, Altan A. Remifentanil-propofol vs dexmedetomidine-propofol-anesthesia for supratentorial craniotomy. Middle East J Anaesthesiol. 2009;20(1):63-70.
13. Turgut N, Turkmen A, Gökkaya S, Altan A, Hatiboglu MA. Dexmedetomidine-based versus fentanyl-based total intravenous anesthesia for lumbar laminectomy. Minerva Anestesiol. 2008;74(9):469-74.
14. Venn RM, Karol MD, Grounds RM. Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive caret. Br J Anaesth. 2002;88(5):669-75.
15. Park JH, Kwon JY. Remifentanil or dexmedetomidine for monitored anesthesia care during cataract surgery under topical anesthesia. Kor J Anesthesiol. 2012;63(1):92-3.
16. Kissin I. Preemptive analgesia: problems with assessment of clinical significance. Methods Mol Biol. 2010;617:475-82.
17. Feld JM, Hoffman WE, Stechert MM, Hoffman IW, Ananda RC. Fentanyl or dexmedetomidine combined with desflurane for bariatric surgery. J Clin Anesth. 2006;18(1):24-8.
18. Calvillo O, Ghignone M. Presynaptic effect of clonidine on unmyelinated afferent fibers in the spinal cord of the cat. Neurosci Lett. 1986;64(3):335-9.
19. Carr DB, Goudas LC. Acute pain. Lancet. 1999;353(9169):2051-8.
20. Kehlet H. Multimodal approach to control postoperative pathophysiology and rehabilitation. Br J Anaesth. 1997;78(5):606-17.
21. Kauppila T, Kemppainen P, Tanila H, Pertovaara A. Effect of systemic medetomidine, an alpha 2 adrenoceptor agonist, on experimental pain in humans. Anesthesiology. 1991;74(1):3-8.
22. Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L. A comprehensive review of opioid-induced hyperalgesia. Pain Physician. 2011;14(2):145-61.
23. Angst MS, Clark JD. Opioid-induced hyperalgesia: a qualitative systematic review. Anesthesiology. 2006;104(3):570-87.
24. Lenz H, Raeder J, Draegni T, Heyerdahl F, Schmelz M, Stubhaug A. Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. Pain. 2011;152(6):1289-97.
25. Koppert W, Sittl R, Scheuber K, Alsheimer M, Schmelz M, Schüttler J. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology. 2003;99(1):152-9.
26. Angst MS, Koppert W, Pahl I, Clark DJ, Schmelz M. Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain. 2003;106(1-2):49-57.
27. Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg. 1999;89(3):652-8.
28. Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology. 1992;77(1):162-84.
29. Kenny GN. Risk factors for postoperative nausea and vomiting. Anaesthesia. 1994;49(Suppl):6-10.