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Volumn 7, Issue OCT, 2015, Pages

Probing astrocyte metabolism in vivo: Proton magnetic resonance spectroscopy in the injured and aging brain

Author keywords

Aging; Astrocytes; Glutamic acid; Glutathione; Lactic acid; Myo inositol; Proton magnetic resonance spectroscopy; Traumatic brain injury (TBI)

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; DRUG METABOLITE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; INOSITOL; LACTIC ACID;

EID: 84946556821     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00202     Document Type: Article
Times cited : (62)

References (68)
  • 1
    • 79551591722 scopus 로고    scopus 로고
    • Astrocyte-neuron metabolic relationships: for better and for worse
    • Allaman, I., Bélanger, M., and Magistretti, P. J. (2011). Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci. 34, 76-87. doi: 10.1016/j.tins.2010.12.001.
    • (2011) Trends Neurosci , vol.34 , pp. 76-87
    • Allaman, I.1    Bélanger, M.2    Magistretti, P.J.3
  • 2
    • 46649098179 scopus 로고    scopus 로고
    • Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury
    • Ansari, M. A., Roberts, K. N., and Scheff, S. W. (2008a). Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic. Biol. Med. 45, 443-452. doi: 10.1016/j.freeradbiomed.2008.04.038.
    • (2008) Free Radic. Biol. Med , vol.45 , pp. 443-452
    • Ansari, M.A.1    Roberts, K.N.2    Scheff, S.W.3
  • 3
    • 43649103735 scopus 로고    scopus 로고
    • A time course of contusion-induced oxidative stress and synaptic proteins in cortex in a rat model of TBI
    • Ansari, M. A., Roberts, K. N., and Scheff, S. W. (2008b). A time course of contusion-induced oxidative stress and synaptic proteins in cortex in a rat model of TBI. J. Neurotrauma 25, 513-526. doi: 10.1089/neu.2007.0451.
    • (2008) J. Neurotrauma , vol.25 , pp. 513-526
    • Ansari, M.A.1    Roberts, K.N.2    Scheff, S.W.3
  • 4
    • 8744261832 scopus 로고    scopus 로고
    • Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury
    • Ashwal, S., Holshouser, B., Tong, K., Serna, T., Osterdock, R., Gross, M., et al. (2004a). Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury. J. Neurotrauma 21, 1539-1552. doi: 10.1089/0897715042441756.
    • (2004) J. Neurotrauma , vol.21 , pp. 1539-1552
    • Ashwal, S.1    Holshouser, B.2    Tong, K.3    Serna, T.4    Osterdock, R.5    Gross, M.6
  • 5
    • 4644354184 scopus 로고    scopus 로고
    • Proton spectroscopy detected myoinositol in children with traumatic brain injury
    • Ashwal, S., Holshouser, B., Tong, K., Serna, T., Osterdock, R., Gross, M., et al. (2004b). Proton spectroscopy detected myoinositol in children with traumatic brain injury. Pediatr. Res. 56, 630-638. doi: 10.1203/01.pdr.0000139928.60530.7d.
    • (2004) Pediatr. Res , vol.56 , pp. 630-638
    • Ashwal, S.1    Holshouser, B.2    Tong, K.3    Serna, T.4    Osterdock, R.5    Gross, M.6
  • 6
    • 0033804261 scopus 로고    scopus 로고
    • Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury
    • Ashwal, S., Holshouser, B. A., Shu, S. K., Simmons, P. L., Perkin, R. M., Tomasi, L. G., et al. (2000). Predictive value of proton magnetic resonance spectroscopy in pediatric closed head injury. Pediatr. Neurol. 23, 114-125. doi: 10.1016/s0887-8994(00)00176-4.
    • (2000) Pediatr. Neurol , vol.23 , pp. 114-125
    • Ashwal, S.1    Holshouser, B.A.2    Shu, S.K.3    Simmons, P.L.4    Perkin, R.M.5    Tomasi, L.G.6
  • 7
    • 0030612038 scopus 로고    scopus 로고
    • 1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurological outcomes in children with central nervous system disease
    • Ashwal, S., Holshouser, B. A., Tomasi, L. G., Shu, S., Perkin, R. M., Nystrom, G. A., et al. (1997). 1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurological outcomes in children with central nervous system disease. Ann. Neurol. 41, 470-481. doi: 10.1002/ana.410410410.
    • (1997) Ann. Neurol , vol.41 , pp. 470-481
    • Ashwal, S.1    Holshouser, B.A.2    Tomasi, L.G.3    Shu, S.4    Perkin, R.M.5    Nystrom, G.A.6
  • 8
    • 84904741500 scopus 로고    scopus 로고
    • Insights into the metabolic response to traumatic brain injury as revealed by (13)C NMR spectroscopy
    • Bartnik-Olson, B. L., Harris, N. G., Shijo, K., and Sutton, R. L. (2013). Insights into the metabolic response to traumatic brain injury as revealed by (13)C NMR spectroscopy. Front. Neuroenergetics 5:8. doi: 10.3389/fnene.2013.00008.
    • (2013) Front. Neuroenergetics , vol.5 , pp. 8
    • Bartnik-Olson, B.L.1    Harris, N.G.2    Shijo, K.3    Sutton, R.L.4
  • 9
    • 0032706872 scopus 로고    scopus 로고
    • Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy
    • Bitsch, A., Bruhn, H., Vougioukas, V., Stringaris, A., Lassmann, H., Frahm, J., et al. (1999). Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am. J. Neuroradiol. 20, 1619-1627.
    • (1999) AJNR Am. J. Neuroradiol , vol.20 , pp. 1619-1627
    • Bitsch, A.1    Bruhn, H.2    Vougioukas, V.3    Stringaris, A.4    Lassmann, H.5    Frahm, J.6
  • 10
    • 84923206890 scopus 로고    scopus 로고
    • 'Magnetic resonance spectroscopy: basics,'
    • eds S. Blüml and A. Panigrahy (Heidelberg: Springer)
    • Blüml, S. (2013). "Magnetic resonance spectroscopy: basics," in MR Spectroscopy of Pediatric Brain Disorders, eds S. Blüml and A. Panigrahy (Heidelberg: Springer), 11-23. doi: 10.1007/978-1-4419-5864-8_2.
    • (2013) MR Spectroscopy of Pediatric Brain Disorders , pp. 11-23
    • Blüml, S.1
  • 11
    • 73949084714 scopus 로고    scopus 로고
    • Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy
    • Boumezbeur, F., Mason, G. F., de Graaf, R. A., Behar, K. L., Cline, G. W., Shulman, G. I., et al. (2010). Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J. Cereb. Blood Flow Metab. 30, 211-221. doi: 10.1038/jcbfm.2009.197.
    • (2010) J. Cereb. Blood Flow Metab , vol.30 , pp. 211-221
    • Boumezbeur, F.1    Mason, G.F.2    de Graaf, R.A.3    Behar, K.L.4    Cline, G.W.5    Shulman, G.I.6
  • 12
    • 0027749707 scopus 로고
    • Multinuclear NMR studies on the energy metabolism of glial and neuronal cells
    • Brand, A., Richter-Landsberg, C., and Leibfritz, D. (1993). Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev. Neurosci. 15, 289-298. doi: 10.1159/000111347.
    • (1993) Dev. Neurosci , vol.15 , pp. 289-298
    • Brand, A.1    Richter-Landsberg, C.2    Leibfritz, D.3
  • 13
    • 0032588570 scopus 로고    scopus 로고
    • Reproducibility of 1H-MRS in vivo
    • Brooks, W. M., Friedman, S. D., and Stidley, C. A. (1999). Reproducibility of 1H-MRS in vivo. Magn. Reson. Med. 41, 193-197. doi: 10.1002/(SICI)1522-2594(199901)41:1193::AID-MRM273.0.CO;2-P.
    • (1999) Magn. Reson. Med , vol.41 , pp. 193-197
    • Brooks, W.M.1    Friedman, S.D.2    Stidley, C.A.3
  • 14
    • 0033859547 scopus 로고    scopus 로고
    • Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study
    • Brooks, W. M., Stidley, C. A., Petropoulos, H., Jung, R. E., Weers, D. C., Friedman, S. D., et al. (2000). Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study. J. Neurotrauma 17, 629-640. doi: 10.1089/089771500415382.
    • (2000) J. Neurotrauma , vol.17 , pp. 629-640
    • Brooks, W.M.1    Stidley, C.A.2    Petropoulos, H.3    Jung, R.E.4    Weers, D.C.5    Friedman, S.D.6
  • 15
    • 0028199786 scopus 로고
    • Glutathione protects signal transduction in type II cells under oxidant stress
    • Brown, L. A. (1994). Glutathione protects signal transduction in type II cells under oxidant stress. Am. J. Physiol. 266, L172-L177.
    • (1994) Am. J. Physiol , vol.266 , pp. L172-L177
    • Brown, L.A.1
  • 16
    • 0029978560 scopus 로고    scopus 로고
    • In vivo proton magnetic resonance spectroscopy of the normal aging human brain
    • Chang, L., Ernst, T., Poland, R. E., and Jenden, D. J. (1996). In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci. 58, 2049-2056. doi: 10.1016/0024-3205(96)00197-x.
    • (1996) Life Sci , vol.58 , pp. 2049-2056
    • Chang, L.1    Ernst, T.2    Poland, R.E.3    Jenden, D.J.4
  • 17
    • 84878771307 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain
    • Chang, L., Munsaka, S. M., Kraft-Terry, S., and Ernst, T. (2013). Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain. J. Neuroimmune Pharmacol. 8, 576-593. doi: 10.1007/s11481-013-9460-x.
    • (2013) J. Neuroimmune Pharmacol , vol.8 , pp. 576-593
    • Chang, L.1    Munsaka, S.M.2    Kraft-Terry, S.3    Ernst, T.4
  • 18
    • 84862965631 scopus 로고    scopus 로고
    • (1)H-MRS evaluation of therapeutic effect of neural stem cell transplantation on Alzheimer's disease in AβPP/PS1 double transgenic mice
    • Chen, S. Q., Cai, Q., Shen, Y. Y., Wang, P. J., Teng, G. J., Li, M. H., et al. (2012). (1)H-MRS evaluation of therapeutic effect of neural stem cell transplantation on Alzheimer's disease in AβPP/PS1 double transgenic mice. J. Alzheimers Dis. 28, 71-80. doi: 10.3233/JAD-2010-110893.
    • (2012) J. Alzheimers Dis , vol.28 , pp. 71-80
    • Chen, S.Q.1    Cai, Q.2    Shen, Y.Y.3    Wang, P.J.4    Teng, G.J.5    Li, M.H.6
  • 19
    • 77951642086 scopus 로고    scopus 로고
    • Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice
    • Chen, S. Q., Wang, P. J., Ten, G. J., Zhan, W., Li, M. H., and Zang, F. C. (2009). Role of myo-inositol by magnetic resonance spectroscopy in early diagnosis of Alzheimer's disease in APP/PS1 transgenic mice. Dement. Geriatr. Cogn. Disord. 28, 558-566. doi: 10.1159/000261646.
    • (2009) Dement. Geriatr. Cogn. Disord , vol.28 , pp. 558-566
    • Chen, S.Q.1    Wang, P.J.2    Ten, G.J.3    Zhan, W.4    Li, M.H.5    Zang, F.C.6
  • 20
    • 0037314008 scopus 로고    scopus 로고
    • Astrocytes and brain injury
    • Chen, Y., and Swanson, R. A. (2003). Astrocytes and brain injury. J. Cereb. Blood Flow Metab. 23, 137-149. doi: 10.1097/01.WCB.0000044631.80210.3C.
    • (2003) J. Cereb. Blood Flow Metab , vol.23 , pp. 137-149
    • Chen, Y.1    Swanson, R.A.2
  • 21
    • 79953232727 scopus 로고    scopus 로고
    • Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T
    • Choi, I. Y., Lee, S. P., Denney, D. R., and Lynch, S. G. (2011). Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T. Mult. Scler. 17, 289-296. doi: 10.1177/1352458510384010.
    • (2011) Mult. Scler , vol.17 , pp. 289-296
    • Choi, I.Y.1    Lee, S.P.2    Denney, D.R.3    Lynch, S.G.4
  • 22
    • 0036141003 scopus 로고    scopus 로고
    • Astrocytes in the aging brain
    • Cotrina, M. L., and Nedergaard, M. (2002). Astrocytes in the aging brain. J. Neurosci. Res. 67, 1-10. doi: 10.1002/jnr.10121.
    • (2002) J. Neurosci. Res , vol.67 , pp. 1-10
    • Cotrina, M.L.1    Nedergaard, M.2
  • 23
    • 84894436009 scopus 로고    scopus 로고
    • Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat
    • Di Pietro, V., Lazzarino, G., Amorini, A. M., Tavazzi, B., D'urso, S., Longo, S., et al. (2014). Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat. Free Radic. Biol. Med. 69, 258-264. doi: 10.1016/j.freeradbiomed.2014.01.032.
    • (2014) Free Radic. Biol. Med , vol.69 , pp. 258-264
    • Di Pietro, V.1    Lazzarino, G.2    Amorini, A.M.3    Tavazzi, B.4    D'urso, S.5    Longo, S.6
  • 24
    • 84903363165 scopus 로고    scopus 로고
    • Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy
    • Duarte, J. M., Do, K. Q., and Gruetter, R. (2014). Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy. Neurobiol. Aging 35, 1660-1668. doi: 10.1016/j.neurobiolaging.2014.01.135.
    • (2014) Neurobiol. Aging , vol.35 , pp. 1660-1668
    • Duarte, J.M.1    Do, K.Q.2    Gruetter, R.3
  • 25
    • 80051598013 scopus 로고    scopus 로고
    • Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain
    • Emir, U. E., Raatz, S., Mcpherson, S., Hodges, J. S., Torkelson, C., Tawfik, P., et al. (2011). Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brain. NMR Biomed. 24, 888-894. doi: 10.1002/nbm.1646.
    • (2011) NMR Biomed , vol.24 , pp. 888-894
    • Emir, U.E.1    Raatz, S.2    Mcpherson, S.3    Hodges, J.S.4    Torkelson, C.5    Tawfik, P.6
  • 26
    • 84869082704 scopus 로고    scopus 로고
    • In vivo imaging of glia activation using 1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity
    • Filibian, M., Frasca, A., Maggioni, D., Micotti, E., Vezzani, A., and Ravizza, T. (2012). In vivo imaging of glia activation using 1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity. Epilepsia 53, 1907-1916. doi: 10.1111/j.1528-1167.2012.03685.x.
    • (2012) Epilepsia , vol.53 , pp. 1907-1916
    • Filibian, M.1    Frasca, A.2    Maggioni, D.3    Micotti, E.4    Vezzani, A.5    Ravizza, T.6
  • 27
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., et al. (2007). Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 128, 92-105. doi: 10.1016/j.mad.2006.11.016.
    • (2007) Mech. Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 28
    • 77952997175 scopus 로고    scopus 로고
    • Age-related mitochondrial changes after traumatic brain injury
    • Gilmer, L. K., Ansari, M. A., Roberts, K. N., and Scheff, S. W. (2010). Age-related mitochondrial changes after traumatic brain injury. J. Neurotrauma 27, 939-950. doi: 10.1089/neu.2009.1181.
    • (2010) J. Neurotrauma , vol.27 , pp. 939-950
    • Gilmer, L.K.1    Ansari, M.A.2    Roberts, K.N.3    Scheff, S.W.4
  • 29
    • 0141891196 scopus 로고    scopus 로고
    • Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose and lactate metabolism
    • Glenn, T. C., Kelly, D. F., Boscardin, W. J., Mcarthur, D. L., Vespa, P., Oertel, M., et al. (2003). Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose and lactate metabolism. J. Cereb. Blood Flow Metab. 23, 1239-1250. doi: 10.1097/01.wcb.0000089833.23606.7f.
    • (2003) J. Cereb. Blood Flow Metab , vol.23 , pp. 1239-1250
    • Glenn, T.C.1    Kelly, D.F.2    Boscardin, W.J.3    Mcarthur, D.L.4    Vespa, P.5    Oertel, M.6
  • 30
    • 72949115293 scopus 로고    scopus 로고
    • Antioxidant therapies for traumatic brain injury
    • Hall, E. D., Vaishnav, R. A., and Mustafa, A. G. (2010). Antioxidant therapies for traumatic brain injury. Neurotherapeutics 7, 51-61. doi: 10.1016/j.nurt.2009.10.021.
    • (2010) Neurotherapeutics , vol.7 , pp. 51-61
    • Hall, E.D.1    Vaishnav, R.A.2    Mustafa, A.G.3
  • 31
    • 84870622846 scopus 로고    scopus 로고
    • Altered neurochemical profile after traumatic brain injury: (1)H-MRS biomarkers of pathological mechanisms
    • Harris, J. L., Yeh, H. W., Choi, I. Y., Lee, P., Berman, N. E., Swerdlow, R. H., et al. (2012). Altered neurochemical profile after traumatic brain injury: (1)H-MRS biomarkers of pathological mechanisms. J. Cereb. Blood Flow Metab. 32, 2122-2134. doi: 10.1038/jcbfm.2012.114.
    • (2012) J. Cereb. Blood Flow Metab , vol.32 , pp. 2122-2134
    • Harris, J.L.1    Yeh, H.W.2    Choi, I.Y.3    Lee, P.4    Berman, N.E.5    Swerdlow, R.H.6
  • 32
    • 84903363379 scopus 로고    scopus 로고
    • High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging
    • Harris, J. L., Yeh, H. W., Swerdlow, R. H., Choi, I. Y., Lee, P., and Brooks, W. M. (2014). High-field proton magnetic resonance spectroscopy reveals metabolic effects of normal brain aging. Neurobiol. Aging 35, 1686-1694. doi: 10.1016/j.neurobiolaging.2014.01.018.
    • (2014) Neurobiol. Aging , vol.35 , pp. 1686-1694
    • Harris, J.L.1    Yeh, H.W.2    Swerdlow, R.H.3    Choi, I.Y.4    Lee, P.5    Brooks, W.M.6
  • 34
    • 13644265605 scopus 로고    scopus 로고
    • Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T
    • Kaiser, L. G., Schuff, N., Cashdollar, N., and Weiner, M. W. (2005). Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T. Neurobiol. Aging 26, 665-672. doi: 10.1016/j.neurobiolaging.2004.07.001.
    • (2005) Neurobiol. Aging , vol.26 , pp. 665-672
    • Kaiser, L.G.1    Schuff, N.2    Cashdollar, N.3    Weiner, M.W.4
  • 35
    • 84894093170 scopus 로고    scopus 로고
    • Myoinositol and glutamate complex neurometabolite abnormality after mild traumatic brain injury
    • Kierans, A. S., Kirov, I. I., Gonen, O., Haemer, G., Nisenbaum, E., Babb, J. S., et al. (2014). Myoinositol and glutamate complex neurometabolite abnormality after mild traumatic brain injury. Neurology 82, 521-528. doi: 10.1212/wnl.0000000000000105.
    • (2014) Neurology , vol.82 , pp. 521-528
    • Kierans, A.S.1    Kirov, I.I.2    Gonen, O.3    Haemer, G.4    Nisenbaum, E.5    Babb, J.S.6
  • 36
    • 0022881755 scopus 로고
    • Oxygen radicals in brain injury
    • Kontos, H. A., and Povlishock, J. T. (1986). Oxygen radicals in brain injury. Cent. Nerv. Syst. Trauma 3, 257-263. doi: 10.1007/978-3-642-73987-3_208.
    • (1986) Cent. Nerv. Syst. Trauma , vol.3 , pp. 257-263
    • Kontos, H.A.1    Povlishock, J.T.2
  • 37
    • 0026541298 scopus 로고
    • Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy
    • Kreis, R., Ross, B. D., Farrow, N. A., and Ackerman, Z. (1992). Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy. Radiology 182, 19-27. doi: 10.1148/radiology.182.1.1345760.
    • (1992) Radiology , vol.182 , pp. 19-27
    • Kreis, R.1    Ross, B.D.2    Farrow, N.A.3    Ackerman, Z.4
  • 38
    • 63949087557 scopus 로고    scopus 로고
    • Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain
    • Lei, H., Berthet, C., Hirt, L., and Gruetter, R. (2009). Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. J. Cereb. Blood Flow Metab. 29, 811-819. doi: 10.1038/jcbfm.2009.8.
    • (2009) J. Cereb. Blood Flow Metab , vol.29 , pp. 811-819
    • Lei, H.1    Berthet, C.2    Hirt, L.3    Gruetter, R.4
  • 39
    • 76349115151 scopus 로고    scopus 로고
    • Temporal and regional changes after focal traumatic brain injury
    • Lescot, T., Fulla-Oller, L., Po, C., Chen, X. R., Puybasset, L., Gillet, B., et al. (2010). Temporal and regional changes after focal traumatic brain injury. J. Neurotrauma 27, 85-94. doi: 10.1089/neu.2009.0982.
    • (2010) J. Neurotrauma , vol.27 , pp. 85-94
    • Lescot, T.1    Fulla-Oller, L.2    Po, C.3    Chen, X.R.4    Puybasset, L.5    Gillet, B.6
  • 40
    • 84927945011 scopus 로고    scopus 로고
    • Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy
    • Lin, A. P., Ramadan, S., Stern, R. A., Box, H. C., Nowinski, C. J., Ross, B. D., et al. (2015). Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy. Alzheimers Res. Ther. 7:13. doi: 10.1186/s13195-015-0094-5.
    • (2015) Alzheimers Res. Ther , vol.7 , pp. 13
    • Lin, A.P.1    Ramadan, S.2    Stern, R.A.3    Box, H.C.4    Nowinski, C.J.5    Ross, B.D.6
  • 41
    • 23644432822 scopus 로고    scopus 로고
    • The effects of stress and aging on glutathione metabolism
    • Maher, P. (2005). The effects of stress and aging on glutathione metabolism. Ageing Res. Rev. 4, 288-314. doi: 10.1016/j.arr.2005.02.005.
    • (2005) Ageing Res. Rev , vol.4 , pp. 288-314
    • Maher, P.1
  • 42
    • 0027535032 scopus 로고
    • Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra
    • Michaelis, T., Merboldt, K. D., Bruhn, H., Hänicke, W., and Frahm, J. (1993). Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 187, 219-227. doi: 10.1148/radiology.187.1.8451417.
    • (1993) Radiology , vol.187 , pp. 219-227
    • Michaelis, T.1    Merboldt, K.D.2    Bruhn, H.3    Hänicke, W.4    Frahm, J.5
  • 43
    • 84914706377 scopus 로고    scopus 로고
    • Early Alzheimer's disease neuropathology detected by proton MR spectroscopy
    • Murray, M. E., Przybelski, S. A., Lesnick, T. G., Liesinger, A. M., Spychalla, A., Zhang, B., et al. (2014). Early Alzheimer's disease neuropathology detected by proton MR spectroscopy. J. Neurosci. 34, 16247-16255. doi: 10.1523/jneurosci.2027-14.2014.
    • (2014) J. Neurosci , vol.34 , pp. 16247-16255
    • Murray, M.E.1    Przybelski, S.A.2    Lesnick, T.G.3    Liesinger, A.M.4    Spychalla, A.5    Zhang, B.6
  • 44
    • 0025182940 scopus 로고
    • Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats
    • Nilsson, P., Hillered, L., Ponten, U., and Ungerstedt, U. (1990). Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J. Cereb. Blood Flow Metab. 10, 631-637. doi: 10.1038/jcbfm.1990.115.
    • (1990) J. Cereb. Blood Flow Metab , vol.10 , pp. 631-637
    • Nilsson, P.1    Hillered, L.2    Ponten, U.3    Ungerstedt, U.4
  • 45
    • 77949556929 scopus 로고    scopus 로고
    • Age-related changes in metabolic profiles of rat hippocampus and cortices
    • Paban, V., Fauvelle, F., and Alescio-Lautier, B. (2010). Age-related changes in metabolic profiles of rat hippocampus and cortices. Eur. J. Neurosci. 31, 1063-1073. doi: 10.1111/j.1460-9568.2010.07126.x.
    • (2010) Eur. J. Neurosci , vol.31 , pp. 1063-1073
    • Paban, V.1    Fauvelle, F.2    Alescio-Lautier, B.3
  • 46
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • Pellerin, L., and Magistretti, P. J. (1994). Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. U. S. A. 91, 10625-10629. doi: 10.1073/pnas.91.22.10625.
    • (1994) Proc. Natl. Acad. Sci. U. S. A , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 47
    • 0029609260 scopus 로고
    • Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate and GABA content of the epileptic human brain
    • Petroff, O. A., Pleban, L. A., and Spencer, D. D. (1995). Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate and GABA content of the epileptic human brain. Magn. Reson. Imaging 13, 1197-1211. doi: 10.1016/0730-725x(95)02033-p.
    • (1995) Magn. Reson. Imaging , vol.13 , pp. 1197-1211
    • Petroff, O.A.1    Pleban, L.A.2    Spencer, D.D.3
  • 48
    • 0033226834 scopus 로고    scopus 로고
    • Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain
    • Pfeuffer, J., Tkàc, I., Provencher, S. W., and Gruetter, R. (1999). Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain. J. Magn. Reson. 141, 104-120. doi: 10.1006/jmre.1999.1895.
    • (1999) J. Magn. Reson , vol.141 , pp. 104-120
    • Pfeuffer, J.1    Tkàc, I.2    Provencher, S.W.3    Gruetter, R.4
  • 49
    • 78650230589 scopus 로고    scopus 로고
    • Perturbed cellular response to brain injury during aging
    • Popa-Wagner, A., Buga, A. M., and Kokaia, Z. (2011). Perturbed cellular response to brain injury during aging. Ageing Res. Rev. 10, 71-79. doi: 10.1016/j.arr.2009.10.008.
    • (2011) Ageing Res. Rev , vol.10 , pp. 71-79
    • Popa-Wagner, A.1    Buga, A.M.2    Kokaia, Z.3
  • 50
    • 84892676659 scopus 로고    scopus 로고
    • A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra
    • Rae, C. D. (2014). A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra. Neurochem. Res. 39, 1-36. doi: 10.1007/s11064-013-1199-5.
    • (2014) Neurochem. Res , vol.39 , pp. 1-36
    • Rae, C.D.1
  • 51
    • 84856972514 scopus 로고    scopus 로고
    • Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study
    • Reyngoudt, H., Claeys, T., Vlerick, L., Verleden, S., Acou, M., Deblaere, K., et al. (2012). Age-related differences in metabolites in the posterior cingulate cortex and hippocampus of normal ageing brain: a 1H-MRS study. Eur. J. Radiol. 81, e223-e231. doi: 10.1016/j.ejrad.2011.01.106.
    • (2012) Eur. J. Radiol , vol.81 , pp. e223-e231
    • Reyngoudt, H.1    Claeys, T.2    Vlerick, L.3    Verleden, S.4    Acou, M.5    Deblaere, K.6
  • 52
    • 0343131929 scopus 로고    scopus 로고
    • Differential compartmentalization of brain ascorbate and glutathione between neurons and glia
    • Rice, M. E., and Russo-Menna, I. (1998). Differential compartmentalization of brain ascorbate and glutathione between neurons and glia. Neuroscience 82, 1213-1223. doi: 10.1016/s0306-4522(97)00347-3.
    • (1998) Neuroscience , vol.82 , pp. 1213-1223
    • Rice, M.E.1    Russo-Menna, I.2
  • 54
    • 33846808998 scopus 로고    scopus 로고
    • Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol
    • Rothermundt, M., Ohrmann, P., Abel, S., Siegmund, A., Pedersen, A., Ponath, G., et al. (2007). Glial cell activation in a subgroup of patients with schizophrenia indicated by increased S100B serum concentrations and elevated myo-inositol. Prog. Neuropsychopharmacol. Biol. Psychiatry 31, 361-364. doi: 10.1016/j.pnpbp.2006.09.013.
    • (2007) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.31 , pp. 361-364
    • Rothermundt, M.1    Ohrmann, P.2    Abel, S.3    Siegmund, A.4    Pedersen, A.5    Ponath, G.6
  • 55
    • 0041464462 scopus 로고    scopus 로고
    • Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study
    • Schuhmann, M. U., Stiller, D., Skardelly, M., Bernarding, J., Klinge, P. M., Samii, A., et al. (2003). Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study. J. Neurotrauma 20, 725-743. doi: 10.1089/089771503767869962.
    • (2003) J. Neurotrauma , vol.20 , pp. 725-743
    • Schuhmann, M.U.1    Stiller, D.2    Skardelly, M.3    Bernarding, J.4    Klinge, P.M.5    Samii, A.6
  • 57
    • 84946608296 scopus 로고    scopus 로고
    • "Proton Magnetic Resonance Spectroscopy Predictors of Tissue Loss After Traumatic Brain Injury,"
    • (New Rochelle, NY: Mary Ann Liebert, Inc.), A-1-A-152
    • Sharrock, M., Brooks, W. M., Yeh, H. W. and Harris, J. L. (2015). "Proton Magnetic Resonance Spectroscopy Predictors of Tissue Loss After Traumatic Brain Injury," in National Neurotrauma Symposium, (New Rochelle, NY: Mary Ann Liebert, Inc.), A-1-A-152. doi: 10.1089/neu.2015.29000.abstracts.
    • (2015) National Neurotrauma Symposium
    • Sharrock, M.1    Brooks, W.M.2    Yeh, H.W.3    Harris, J.L.4
  • 58
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: biology and pathology
    • Sofroniew, M. V., and Vinters, H. V. (2010). Astrocytes: biology and pathology. Acta Neuropathol. 119, 7-35. doi: 10.1007/s00401-009-0619-8.
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.V.1    Vinters, H.V.2
  • 59
    • 0028500135 scopus 로고
    • Osmoregulatory changes in myo-inositol content and Na+/myo-inositol cotransport in rat cortical astrocytes
    • Strange, K., Emma, F., Paredes, A., and Morrison, R. (1994). Osmoregulatory changes in myo-inositol content and Na+/myo-inositol cotransport in rat cortical astrocytes. Glia 12, 35-43. doi: 10.1002/glia.440120105.
    • (1994) Glia , vol.12 , pp. 35-43
    • Strange, K.1    Emma, F.2    Paredes, A.3    Morrison, R.4
  • 60
    • 33745199171 scopus 로고    scopus 로고
    • Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface
    • Sun, X., Shih, A. Y., Johannssen, H. C., Erb, H., Li, P., and Murphy, T. H. (2006). Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface. J. Biol. Chem. 281, 17420-17431. doi: 10.1074/jbc.m601567200.
    • (2006) J. Biol. Chem , vol.281 , pp. 17420-17431
    • Sun, X.1    Shih, A.Y.2    Johannssen, H.C.3    Erb, H.4    Li, P.5    Murphy, T.H.6
  • 61
    • 0038262775 scopus 로고    scopus 로고
    • Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra
    • Terpstra, M., Henry, P. G., and Gruetter, R. (2003). Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra. Magn. Reson. Med. 50, 19-23. doi: 10.1002/mrm.10499.
    • (2003) Magn. Reson. Med , vol.50 , pp. 19-23
    • Terpstra, M.1    Henry, P.G.2    Gruetter, R.3
  • 62
    • 33749985378 scopus 로고    scopus 로고
    • Traumatic brain injury in older adults: epidemiology, outcomes and future implications
    • Thompson, H. J., Mccormick, W. C., and Kagan, S. H. (2006). Traumatic brain injury in older adults: epidemiology, outcomes and future implications. J. Am. Geriatr. Soc. 54, 1590-1595. doi: 10.1111/j.1532-5415.2006.00894.x.
    • (2006) J. Am. Geriatr. Soc , vol.54 , pp. 1590-1595
    • Thompson, H.J.1    Mccormick, W.C.2    Kagan, S.H.3
  • 63
    • 0035091067 scopus 로고    scopus 로고
    • Improved selectivity of double quantum coherence filtering for the detection of glutathione in the human brain in vivo
    • Trabesinger, A. H., and Boesiger, P. (2001). Improved selectivity of double quantum coherence filtering for the detection of glutathione in the human brain in vivo. Magn. Reson. Med. 45, 708-710. doi: 10.1002/mrm.1094.
    • (2001) Magn. Reson. Med , vol.45 , pp. 708-710
    • Trabesinger, A.H.1    Boesiger, P.2
  • 64
    • 3042656565 scopus 로고    scopus 로고
    • Stimulus-induced brain lactate: effects of aging and prolonged wakefulness
    • Urrila, A. S., Hakkarainen, A., Heikkinen, S., Vuori, K., Stenberg, D., Hakkinen, A. M., et al. (2004). Stimulus-induced brain lactate: effects of aging and prolonged wakefulness. J. Sleep Res. 13, 111-119. doi: 10.1111/j.1365-2869.2004.00401.x.
    • (2004) J. Sleep Res , vol.13 , pp. 111-119
    • Urrila, A.S.1    Hakkarainen, A.2    Heikkinen, S.3    Vuori, K.4    Stenberg, D.5    Hakkinen, A.M.6
  • 65
    • 80054726671 scopus 로고    scopus 로고
    • Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study
    • Xu, S., Zhuo, J., Racz, J., Shi, D., Roys, S., Fiskum, G., et al. (2011). Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study. J. Neurotrauma 28, 2091-2102. doi: 10.1089/neu.2010.1739.
    • (2011) J. Neurotrauma , vol.28 , pp. 2091-2102
    • Xu, S.1    Zhuo, J.2    Racz, J.3    Shi, D.4    Roys, S.5    Fiskum, G.6
  • 66
    • 81455140923 scopus 로고    scopus 로고
    • Time course of recovery from cerebral vulnerability after severe traumatic brain injury: a microdialysis study
    • Yokobori, S., Watanabe, A., Matsumoto, G., Onda, H., Masuno, T., Fuse, A., et al. (2011). Time course of recovery from cerebral vulnerability after severe traumatic brain injury: a microdialysis study. J. Trauma 71, 1235-1240. doi: 10.1097/ta.0b013e3182140dd7.
    • (2011) J. Trauma , vol.71 , pp. 1235-1240
    • Yokobori, S.1    Watanabe, A.2    Matsumoto, G.3    Onda, H.4    Masuno, T.5    Fuse, A.6
  • 67
    • 84875839620 scopus 로고    scopus 로고
    • Age-and gender-related metabonomic alterations in striatum and cerebellar cortex in rats
    • Zhang, X., Wu, J., Liu, H., and Zhang, X. (2013). Age-and gender-related metabonomic alterations in striatum and cerebellar cortex in rats. Brain Res. 1507, 28-34. doi: 10.1016/j.brainres.2013.02.033.
    • (2013) Brain Res , vol.1507 , pp. 28-34
    • Zhang, X.1    Wu, J.2    Liu, H.3    Zhang, X.4
  • 68
    • 0242291129 scopus 로고    scopus 로고
    • Early loss of astrocytes after experimental traumatic brain injury
    • Zhao, X., Ahram, A., Berman, R. F., Muizelaar, J. P., and Lyeth, B. G. (2003). Early loss of astrocytes after experimental traumatic brain injury. Glia 44, 140-152. doi: 10.1002/glia.10283.
    • (2003) Glia , vol.44 , pp. 140-152
    • Zhao, X.1    Ahram, A.2    Berman, R.F.3    Muizelaar, J.P.4    Lyeth, B.G.5


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