Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 23, 2015, Pages 5546-5550

  Wang, Zhulun ^a   Sun, Daqing ^a   Johnstone, Sheree ^a   Cao, Zhaodan ^a   Gao, Xiong ^a   Jaen, Juan C ^a   Liu, Jingqian ^a   Lively, Sarah ^a   Miao, Shichang ^a   Sudom, Athena ^a   Tomooka, Craig ^a   Walker, Nigel P C ^a   Wright, Matthew ^a   Yan, Xuelei ^a   Ye, Qiuping ^a   Powers, Jay P ^a  

^a AMGEN INC   (United States)

Author keywords

Inflammation; Interleukin 1 receptor associate kinase 4; N Acyl 2 aminobenzimidazole

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; 2-AMINOBENZIMIDAZOLE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; PROTEIN BINDING; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG PENETRATION; DRUG SOLUBILITY; DRUG SYNTHESIS; IC50; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME ACTIVATION; ORAL DRUG ADMINISTRATION; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; BENZIMIDAZOLES; DRUG DISCOVERY; ENZYME ACTIVATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84946544846     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.10.060     Document Type: Article

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