Antibiotics alone versus appendectomy to treat uncomplicated acute appendicitis in adults: What do meta-analyses say?

World Journal of Emergency Surgery

Volumn 10, Issue 1, 2015, Pages

  Rocha, Leonardo Lima ^a   Rossi, Felipe Martin Bianco ^a   Pessoa, Camila Menezes Souza ^a   Campos, Flavia Nunes Dias ^a   Pires, Carlos Eduardo Fonseca ^a   Steinman, Milton ^a  

^a HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

Author keywords

Antibiotics; Appendectomy; Appendicitis; Conservative; Meta analysis; Surgery

Indexed keywords

EID: 84946498444     PISSN: None     EISSN: 17497922     Source Type: Journal    
DOI: 10.1186/s13017-015-0046-1     Document Type: Review

References (38)

1. Humes DJ, Simpson J. Acute appendicitis. BMJ. 2006;333:530-4.
2. Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990;132:910-25.
3. Davies GM, Dasbach EJ, Teutsch S. The burden of appendicitis-related hospitalizations in the United States in 1997. Surg Infect (Larchmt). 2004;5:160-5.
4. Fitz RH. Perforating inflammation of the vermiform appendix. Am J Med Sci. 1886;92:321-46.
5. McBurney C. Experiences with early operative interference in cases of disease of the vermiform appendix. N Y Med J. 1889;50:1676-84.
6. Blomqvist P, Ljung H, Nyren O, Ekbom A. Appendectomy in Sweden 1989-1993 assessed by the Inpatient Registry. J Clin Epidemiol. 1998;51:859-65.
7. Margenthaler JA, Longo WE, Virgo KS, Johnson FE, Oprian CA, Henderson WG, et al. Risk factors for adverse outcomes after the surgical treatment of appendicitis in adults. Ann Surg. 2003;238:59-66.
8. Coldrey E. Five years convervative treatment of acute appendicitis. J Int Coll Surg. 1959;32:255-61.
9. Simillis C, Symeonides P, Shorthouse AJ, Tekkis PP. A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon). Surgery. 2010;147:818-29.
10. Wong WD, Wexner SD, Lowry A, Vernava 3rd A, Burnstein M, Denstman F, et al. Practice parameters for the treatment of sigmoid diverticulitis--supporting documentation. The Standards Task Force. The American Society of Colon and Rectal Surgeons. Dis Colon Rectum. 2000;43:290-7.
11. Kirby A, Hobson RP, Burke D, Cleveland V, Ford G, West RM. Appendicectomy for suspected uncomplicated appendicitis is associated with fewer complications than conservative antibiotic management: a meta-analysis of post-intervention complications. J Infect. 2015;70:105-10.
12. Mason RJ. Surgery for appendicitis: is it necessary? Surg Infect (Larchmt). 2008;9:481-8.
13. Varadhan KK, Humes DJ, Neal KR, Lobo DN. Antibiotic therapy versus appendectomy for acute appendicitis: a meta-analysis. World J Surg. 2010;34:199-209.
14. Liu K, Fogg L. Use of antibiotics alone for treatment of uncomplicated acute appendicitis: a systematic review and meta-analysis. Surgery. 2011;150:673-83.
15. Ansaloni L, Catena F, Coccolini F, Ercolani G, Gazzotti F, Pasqualini E, et al. Surgery versus conservative antibiotic treatment in acute appendicitis: a systematic review and meta-analysis of randomized controlled trials. Dig Surg. 2011;28:210-21.
16. Wilms IM, de Hoog DE, de Visser DC, Janzing HM. Appendectomy versus antibiotic treatment for acute appendicitis. Cochrane Database Syst Rev. 2011;11:CD008359.
17. Mason RJ, Moazzez A, Sohn H, Katkhouda N. Meta-analysis of randomized trials comparing antibiotic therapy with appendectomy for acute uncomplicated (no abscess or phlegmon) appendicitis. Surg Infect (Larchmt). 2012;13:74-84.
18. Varadhan KK, Neal KR, Lobo DN. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ. 2012;344:e2156.
19. Liu ZH, Li C, Zhang XW, Kang L, Wang JP. Meta-analysis of the therapeutic effects of antibiotic versus appendicectomy for the treatment of acute appendicitis. Exp Ther Med. 2014;7:1181-6.
20. Hansson J, Korner U, Khorram-Manesh A, Solberg A, Lundholm K. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg. 2009;96:473-81.
21. Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, et al. Appendectomy versus antibiotic treatment in acute appendicitis. a prospective multicenter randomized controlled trial. World J Surg. 2006;30:1033-7.
22. Eriksson S, Granstrom L. Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis. Br J Surg. 1995;82:166-9.
23. Liu K, Ahanchi S, Pisaneschi M, Lin I, Walter R. Can acute appendicitis be treated by antibiotics alone? Am Surg. 2007;73:1161-5.
24. Malik AA, Bari SU. Conservative management of acute appendicitis. J Gastrointest Surg. 2009;13:966-70.
25. Turhan AN, Kapan S, Kutukcu E, Yigitbas H, Hatipoglu S, Aygun E. Comparison of operative and non operative management of acute appendicitis. Ulus Travma Acil Cerrahi Derg. 2009;15:459-62.
26. Vons C, Barry C, Maitre S, Pautrat K, Leconte M, Costaglioli B, et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377:1573-9.
27. Gibeily GJ, Ross MN, Manning DB, Wherry DC, Kao TC. Late-presenting appendicitis: a laparoscopic approach to a complicated problem. Surg Endosc. 2003;17:725-9.
28. Cobben LP, de Van Otterloo AM, Puylaert JB. Spontaneously resolving appendicitis: frequency and natural history in 60 patients. Radiology. 2000;215:349-52. 28. Paulson EK, Kalady MF, Pappas TN (2003) Clinical practice. Suspected appendicitis. N Engl J Med 348: 236-242.
29. Barreto SG, Travers E, Thomas T, Mackillop C, Tiong L, Lorimer M, et al. Acute perforated appendicitis: an analysis of risk factors to guide surgical decision making. Indian J Med Sci. 2010;64:58-65.
30. Sheu BF, Chiu TF, Chen JC, Tung MS, Chang MW, Young WR. Risk factors associated with perforated appendicitis in elderly patients presenting with signs and symptoms of acute appendicitis. ANZ J Surg. 2007;77:662-6.
31. McGowan DR, Sims HM, Zia K, Uheba M, Shaikh IA. The value of biochemical markers in predicting a perforation in acute appendicitis. ANZ J Surg. 2013;83:79-83.
32. Nomura O, Ishiguro A, Meakawa T, Nagai A, Kuroda T, Sakai H. Antibiotic administration can be an independent risk factor for therapeutic delay of pediatric acute appendicitis. Pediatr Emerg Care. 2012;28:792-5.
33. Petrosyan M, Estrada J, Chan S, Somers S, Yacoub WN, Kelso RL, et al. CT scan in patients with suspected appendicitis: clinical implications for the acute care surgeon. Eur Surg Res. 2008;40:211-9.
34. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986;15:557-64.
35. Saverio D, Sibilio A, Giorgini E, Biscardi A, Villani S, Coccolini F, et al. The NOTA Study (Non Operative Treatment for Acute Appendicitis): prospective study on the efficacy and safety of antibiotics (amoxicillin and clavulanic acid) for treating patients with right lower quadrant abdominal pain and long-term follow-up of conservatively treated suspected appendicitis. Ann Surg. 2014;260:109-17.
36. Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. 2015;313:2340-8.
37. Andersen BR, Kallehave FL, Andersen HK. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev. 2005;20:CD001439.
38. Sauerland S, Jaschinski T, Neugebauer EA. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2010;10:CD001546.