Appendicectomy for suspected uncomplicated appendicitis is associated with fewer complications than conservative antibiotic management: A meta-analysis of post-intervention complications

Journal of Infection

Volumn 70, Issue 2, 2015, Pages 105-110

  Kirby, Andrew ^a,b   Hobson, Richard P ^a,b   Burke, Dermot ^b,c   Cleveland, Victoria ^b   Ford, Georgia ^b   West, Robert M ^d  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Antimicrobial; Appendicectomy; Appendicitis

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ABDOMINAL ABSCESS; ANTIBIOTIC THERAPY; APPENDECTOMY; APPENDICITIS; ARTICLE; CONSERVATIVE TREATMENT; DISEASE ASSOCIATION; DRUG EFFECT; DRUG SAFETY; HUMAN; INTERMETHOD COMPARISON; META ANALYSIS; PERITONITIS; POSTOPERATIVE COMPLICATION; RISK ASSESSMENT; TREATMENT OUTCOME; TREATMENT PLANNING; ADOLESCENT; ADULT; ADVERSE EFFECTS; FEMALE; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; APPENDECTOMY; APPENDICITIS; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; YOUNG ADULT;

EID: 84921030260     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2014.08.009     Document Type: Article

References (12)

1. Vons C., Barry C., Maitre S., Pautrat K., Leconte M., Costaglioli B., et al. Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet 2011, 377:1573-1579.
2. Andersson R.E. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg 2007, 31:86-92.
3. Varadhan K.K., Neal K.R., Lobo D.N. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ 2012, 344:e2156.
4. Addiss D.G., Shaffer N., Fowler B.S., Tauxe R.V. The epidemiology of appendicitis and appendectomy in the United States. AmJEpidemiol 1990, 132:910-925.
5. R Core Team R: a language and environment for statistical computing 2013, R Foundation for Statistical Computing, Vienna, Austria, URL:. http://www.R-project.org/.
6. meta: meta-analysis with R. R package version 2.3-0 2013, Available from:. http://CRAN.R-project.org/package=meta.
7. Styrud J., Eriksson S., Nilsson I., Ahlberg G., Haapaniemi S., Neovius G., et al. Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg 2006, 30:1033-1037.
8. Eriksson S., Granstrom L. Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis. Br J Surg 1995, 82:166-169.
9. Hansson J., Körner U., Khorram-Manesh A., Solberg A., Lundholm K. Randomized clinical trial of antibiotic therapy versus appendicectomy as primary treatment of acute appendicitis in unselected patients. Br J Surg 2009, 96:473-481.
10. Andersen B.R., Kallehave F.L., Andersen H.K. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev 2005, 20:CD001439.
11. Nomura O., Ishiguro A., Maekawa T., Nagai A., Kuroda T., Sakai H. Antibiotic administration can be an independent risk factor for therapeutic delay of pediatric acute appendicitis. Pediatr Emerg Care 2012, 28:792-795.
12. England R.J., Crabbe D.C. Delayed diagnosis of appendicitis in children treated with antibiotics. Pediatr Surg Int 2006, 22:541-545.