We need to move more: Neurobiological hypotheses of physical exercise as a treatment for Parkinson's disease

Medical Hypotheses

Volumn 85, Issue 5, 2015, Pages 537-541

  Monteiro Junior, Renato S ^a,b,d,e   Cevada, Thais ^b   Oliveira, Bruno R R ^b   Lattari, Eduardo ^a,b   Portugal, Eduardo M M ^a,b   Carvalho, Alessandro ^c   Deslandes, Andrea C ^b,f  

^a Laureate International Universities (IBMR)   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c Center of Study and Research of Ageing   (Brazil)

^d FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^e SALGADO DE OLIVEIRA UNIVERSITY   (Brazil)

^f STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DOPAMINE; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NEUROTRANSMITTER; SOMATOMEDIN C; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; BIOGENESIS; DOPAMINERGIC NERVE CELL; ENERGY METABOLISM; ENZYME ACTIVITY; EXERCISE INTENSITY; HUMAN; KINESIOTHERAPY; MITOCHONDRIAL RESPIRATION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROBIOLOGY; NEUROCHEMISTRY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOPHYSIOLOGY; PROTEIN SYNTHESIS; SYMPTOM; SYNAPTOGENESIS; THERAPY EFFECT; UPREGULATION; EXERCISE; METABOLISM; THEORETICAL MODEL;

EXERCISE; HUMANS; MODELS, THEORETICAL; OXIDATIVE STRESS; PARKINSON DISEASE;

EID: 84946495791     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2015.07.011     Document Type: Article

References (49)

1. Neurological disorders: public health challenges. Chapter 3, neurological disorders: a public health approach - Parkinsońs disease. World Health Organization; 2006.
2. Obeso J.A., Marin C., Rodriguez-Oroz C., et al. The basal ganglia in Parkinson's disease: current concepts and unexplained observations. Ann Neurol 2008, 64(Suppl 2):S30-46.
3. Wider C., Wszolek Z.K. Etiology and pathophysiology of frontotemporal dementia, Parkinson disease and Alzheimer disease: lessons from genetic studies. Neuro-degenerative Dis 2008, 5:122-125.
4. Ibanez P., Bonnet A.M., Debarges B., et al. Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 2004, 364:1169-1171.
5. Nuytemans K., Theuns J., Cruts M., Van Broeckhoven C. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Human Mutation 2010, 31:763-780.
6. Bloomer R.J., Schilling B.K., Karlage R.E., Ledoux M.S., Pfeiffer R.F., Callegari J. Effect of resistance training on blood oxidative stress in Parkinson disease. Med Sci Sports Exercise 2008, 40:1385-1389.
7. Ashburn A., Fazakarley L., Ballinger C., Pickering R., McLellan L.D., Fitton C. A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson's disease. J Neurol Neurosurg Psychiatry 2007, 78:678-684.
8. Voon V., Fernagut P.O., Wickens J., et al. Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. Lancet Neurol 2009, 8:1140-1149.
9. Xu Q., Park Y., Huang X., et al. Physical activities and future risk of Parkinson disease. Neurology 2010, 75:341-348.
10. Ahlskog J.E. Does vigorous exercise have a neuroprotective effect in Parkinson disease?. Neurology 2011, 77:288-294.
11. Blankevoort C.G., van Heuvelen M.J., Boersma F., Luning H., de Jong J., Scherder E.J. Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia. Dementia Geriatric Cognitive Disorders 2010, 30:392-402.
12. Allen N.E., Sherrington C., Paul S.S., Canning C.G. Balance and falls in Parkinson's disease: a meta-analysis of the effect of exercise and motor training. Movement Disorders: Official J Movement Disorder Soc 2011, 26:1605-1615.
13. PDF. Parkinsońs Disease Foundation. Understanding Parkinsonśs. Statistics on Parkinsońs. 20132014. http://www.pdf.org/en/parkinson_statistics.
14. Ahlskog J.E. Cheaper, simpler, and better: tips for treating seniors with Parkinson disease. Mayo Clinic Proc 2011, 86:1211-1216.
15. Hwang O. Role of oxidative stress in Parkinson's disease. Exp Neurobiol 2013, 22:11-17.
16. Qian L., Flood P., Hong J.-S. Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Trans 2010, 117:971-979.
17. Duman R.S. Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism. Neurobiol Aging 2005, 26(Suppl 1):88-93.
18. Keeler B.E., Liu G., Siegfried R.N., Zhukareva V., Murray M., Houle J.D. Acute and prolonged hindlimb exercise elicits different gene expression in motoneurons than sensory neurons after spinal cord injury. Brain Res 2012, 1438:8-21.
19. Lie D.C., Song H., Colamarino S.A., Ming G.L., Gage F.H. Neurogenesis in the adult brain: new strategies for central nervous system diseases. Ann Rev Pharmacol Toxicol 2004, 44:399-421.
20. Hirsch M.A., Toole T., Maitland C.G., Rider R.A. The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson's disease. Arch Phys Med Rehabil 2003, 84:1109-1117.
21. Katzel L.I., Sorkin J.D., Macko R.F., Smith B., Ivey F.M., Shulman L.M. Repeatability of aerobic capacity measurements in Parkinson disease. Med Sci Sports Exercose 2011, 43:2381-2387. 2310.1249/MSS.2380b2013e31822432d31822434.
22. Smith A.D., Zigmond M.J. Can the brain be protected through exercise? Lessons from an animal model of Parkinsonism. Exp Neurol 2003, 184:31-39.
23. Aguiló A., Tauler P., Fuentespina E., Tur J.A., Córdova A., Pons A. Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol Behav 2005, 84:1-7.
24. Mastaloudis A., Leonard S.W., Traber M.G. Oxidative stress in athletes during extreme endurance exercise. Free Rad Biol Med 2001, 31:911-922.
25. Elokda A., DiFrancisco-Donoghue J., Lamberg E., Werner W. Effects of exercise induced oxidative stress on glutathione levels in Parkinson's disease on and off medication. J Neurol 2010, 257:1648-1653.
26. Finaud J., Lac G., Filaire E. Oxidative stress: relationship with exercise and training. Sports Med 2006, 36:327-358.
27. Radak Z., Chung H.Y., Goto S. Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology 2005, 6:71-75.
28. Friedrich M.J. PArkinson disease studies yield insights. JAMA 2005, 293:409-414.
29. Tuon T., Valvassori S.S., Lopes-Borges J., et al. Physical training exerts neuroprotective effects in the regulation of neurochemical factors in an animal model of Parkinson's disease. Neuroscience 2012, 227:305-312.
30. Buchheit M., Laursen P.B. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med 2013, 43:927-954.
31. Tjonna A.E., Lee S.J., Rognmo O., et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation 2008, 118:346-354.
32. Wisloff U., Stoylen A., Loennechen J.P., et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 2007, 115:3086-3094.
33. Lu K., Wang L., Wang C., Yang Y., Hu D., Ding R. Effects of high-intensity interval versus continuous moderateintensity aerobic exercise on apoptosis, oxidative stress and metabolism of the infarcted myocardium in a rat model. Mol Med Rep 2015, 12(2):2374-2382.
34. Deslandes A., Moraes H., Ferreira C., et al. Exercise and mental health: many reasons to move. Neuropsychobiology 2009, 59:191-198.
35. Sutoo D.E., Akiyama K. Regulation of brain function by exercise. Neurobiol Dis 2003, 13:1-14.
36. Archer T., Fredriksson A., Johansson B. Exercise alleviates Parkinsonism: clinical and laboratory evidence. Acta Neurol Scand 2011, 123:73-84.
37. Foley T., Fleshner M. Neuroplasticity of dopamine circuits after exercise: implications for central fatigue. Neuromol Med 2008, 10:67-80.
38. Yoon M.-C., Shin M.-S., Kim T.-S., et al. Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats. Neurosci Lett 2007, 423:12-17.
39. Neeper S.A., Gomez-Pinilla F., Choi J., Cotman C. Exercise and brain neurotrophins. Nature 1995, 373:109.
40. Al-Jarrah M., Obaidat H., Bataineh Z., Walton L., Al-Khateeb A. Endurance exercise training protects against the upregulation of nitric oxide in the striatum of MPTP/probenecid mouse model of Parkinson's disease. NeuroRehabilitation 2013, 32:141-147.
41. Lau Y.S., Patki G., Das-Panja K., Le W.D., Ahmad S.O. Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration. Eur J Neurosci 2011, 33:1264-1274.
42. Oliff H.S., Berchtold N.C., Isackson P., Cotman C.W. Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus. Brain Res Mol Brain Res 1998, 61:147-153.
43. Rasmussen P., Brassard P., Adser H., et al. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 2009, 94:1062-1069.
44. Wagner P.D. The critical role of VEGF in skeletal muscle angiogenesis and blood flow. Biochem Soc Trans 2011, 39:1556-1559.
45. Querido J.S., Sheel A.W. Regulation of cerebral blood flow during exercise. Sports Med 2007, 37:765-782.
46. Al-Jarrah M., Jamous M., Al Zailaey K., Bweir S.O. Endurance exercise training promotes angiogenesis in the brain of chronic/progressive mouse model of Parkinson's disease. NeuroRehabilitation 2010, 26:369-373.
47. Dietrich A., McDaniel W.F. Endocannabinoids and exercise. Br J Sports Med 2004, 38:536-541.
48. Dietrich M.O., Andrews Z.B., Horvath T.L. Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci: Official J Soc Neurosci 2008, 28:10766-10771.
49. Alonso-Frech F., Sanahuja J.J., Rodriguez A.M. Exercise and physical therapy in early management of Parkinson disease. The Neurol 2011, 17:S47-53.